Blood Donation During Pregnancy Due to Anti-Ku Hemolytic Disease of the Fetus and Newborn

2019 ◽  
Vol 50 (4) ◽  
pp. 421-425
Author(s):  
Mrigender Virk ◽  
Kathy Papakonstantino ◽  
Wei Cai ◽  
David Oh ◽  
Jennifer Andrews
Keyword(s):  
Pregnant Woman ◽  
Blood Donation ◽  
Blood Group System ◽  
Severe Anemia ◽  
Hemolytic Disease ◽  
Delayed Cord Clamping ◽  
Immune Systems ◽  
Cord Clamping ◽  
Compatible Blood ◽  
First Time

AbstractBackgroundManagement of pregnancy in patients with Kell-null phenotype can be challenging. The immune systems of these patients form an antibody that is universally reactive against the Kell Blood Group System and can cause hemolytic disease of the fetus and newborn.MethodsA 29-year-old woman, pregnant for the first time, developed anti-D and anti-Ku. The mother had to have labor induced when her fetus showed signs of severe anemia, but no compatible blood was available for transfusion. The induction was delayed so that a unit of blood could be collected from the mother.ResultsDue to delayed cord clamping at delivery, the newborn did not have anemia and did not require a transfusion. The remaining blood was frozen for future needs.ConclusionBlood donation by a pregnant woman for potential transfusion to a newborn with anemia is safe for the mother and fetus, and is possibly the only option in hemolytic disease of the newborn due to a rare antibody.

A case study of a patient with anti-Yta alloantibodies against the high-prevalence antigen of red blood cells qualified for heart transplantation

2021 ◽  
Vol 56 (3) ◽  
pp. 1-7
Author(s):  
Monika Witoszek ◽  
Małgorzata Kalaga
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Donation ◽  
Heart Diseases ◽  
Blood Group System ◽  
Transfusion Reaction ◽  
Indirect Antiglobulin Test ◽  
High Prevalence ◽  
Compatible Blood

The Yta antigen from the Cartwright blood group system is a high-prevalence antigen found in 99.8% of the population. The literature data shows that antibodies anti-Yta demonstrate the variable clinical significance and are rarely the cause of a hemolytic post-transfusion reaction. The study aims to present the difficulties related to the selection and sustainable supply of blood for transfusion for the patient of the Silesian Centre for Heart Diseases with anti-Yta alloantibodies, qualified for a heart transplant. If Yt(a-) blood is not available Institute of Hematology and Transfusion Medicine in Warsaw, referring to reports in the publications, allowed transfusion of the least incompatible red blood cells in indirect antiglobulin test. One hour after transfusion of leucocyte-depleted concentrate of red blood cells (RBCs), issued in accordance with the above recommendations by Regional Blood Donation Center in Katowice as the least incompatible, the patient was observed to experience symptoms of an adverse post-transfusion reaction. For subsequent transfusions, RBCs from Yt(a-) donors were selected, of which only eight were registered in Poland at that time. Medical decisions on RBCs transfusion in patients for whom no compatible blood can be selected is very difficult, and the benefits of incompatible transfusion should be weighed against the risk of possible complications. To avoid this, it should be remembered that the early identification of antibodies increases the chance of finding serologically compatible blood and in many cases allows to supply blood for a patient with autologous donations.

scholarly journals Izdaja Kell skladnih krvnih komponent z namenom preprečevanja anti-K senzibilizacij pri ženskah v rodni dobi.

2016 ◽  
Vol 85 (4) ◽  
Author(s):  
Andreja Hrašovec-Lampret ◽  
Irena Bricl
Keyword(s):  
Pregnant Woman ◽  
Pregnant Women ◽  
Prenatal Testing ◽  
Perinatal Morbidity ◽  
Hemolytic Disease ◽  
The Past ◽  
Compatible Blood ◽  
Not At Risk ◽  
Transfusion History ◽  
In Pregnancy

 With selecting K compatible blood for transfusion, we prevent K immunization and many unnecessary prenatal testing and gynecological examinations for at least 78% of pregnant women with K negative partners, whose fetus is not at risk of hemolytic disease of fetus and newborn. Abstract  Background Kell antibodies are beside RhD and c antibodies one of most clinically important antibodies that can cause severe hemolytic disease of the fetus and newborn (HDFN) in pregnancy,which is still remaining one of the major causes of perinatal morbidity and mortality. Therefore, pregnant women with eryhrocyte alloantibodies anti-K need many prenatal testing and gynecological examinations. The major cause for anti-K immunisation is transfusion of incompatible blood in the past.    Methods We analysed retrospectively the data of 71 pregnant woman with alloantibodies anti-K, which were followed in Blood Transfusion Centre of Slovenia from 2004 -2014. We collected data of partner´s phenotype and woman´s transfusion history. Data were statistically analyzed with basic statistical methods.   Results 61 out of 71 partners were tested (86%) and 48 were K negative (78%).The transfusion history was available for only 23 women (32%). The transfusion history was available for 23 out of 48 women with K negative partner (48%). All of them were transfused. 78% received incompatible-K positive blood, for the rest 22% women donations they received were not K typed.    Conclusions From the obtained data, we found that in 78% of cases cause for K alloimunnization is transfusion of K incompatible blood in past. With selecting K compatible blood for transfusion, we can prevent K immunization and many unnecessary prenatal testing and gynecological examinations for 78% pregnant women with K negative partners . 

scholarly journals Immunized pregnant woman with rare Rh fenotype: Case report

2013 ◽  
Vol 66 (1-2) ◽  
pp. 81-85
Author(s):  
Zorana Budakov ◽  
Natasa Milosavljevic-Knezevic ◽  
Jasmina Grujic ◽  
Mirjana Krga-Milanovic
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Blood Type ◽  
Blood Group System ◽  
Transfusion Medicine ◽  
Gynecology And Obstetrics ◽  
Risk Pregnancy ◽  
Indirect Antiglobulin Test ◽  
Antiglobulin Test ◽  
Compatible Blood

Introduction. Rh blood group system is one of the most polymorphic systems of human blood and consists of 50 antigens. Antigen D is the most important antigen in the Rh system and next to ABO, is the most clinically significant in transfusion medicine. The aim of this paper was to present a case of a rare Rh phenotype ccDEE in an immunized pregnant woman, whose fourth pregnancy ended with birth of a female newborn infant with hemolytic disease of the lower level. Case report. The history of a 42-year-old pregnant woman stated that she had had four pregnancies. She was transfused with 1500 ml of whole blood, three units of packed red cells and two units of fresh frozen plasma. Due to her high-risk pregnancy she was referred to the Clinic of Gynecology and Obstetrics in Novi Sad. Blood sample was tested in the Department of Prenatal Care of the Institute for Blood Transfusion Vojvodina. ABO and Rh were tested, antibody screening was done by indirect antiglobulin test and the detected antibodies were identified by gel technology. The results of testing were: O RhD positive, Rh phenotype ccDEE, positive screening for red blood cells antibodies by indirect antiglobulin test, alo anti-e antibody. According to the literature data, it is a very rare Rh phenotype whose incidence in the population ranges from 0.34% to 1.99%. The compatible blood products for the patient and her newborn were searched for on the basis of the immunoserology tests. Conclusion. Two major problems within transfusion medicine have emerged in our case: the problem of immunization of pregnant woman with a rare blood type and the problem of finding compatible blood. Health care of pregnant women can be improved by following pregnancies according to the national antenatal testing algorithm and better teamwork of gynecologists and transfusions.

Obstetrical and neonatal factors associated with optimal public banking of umbilical cord blood in the context of delayed cord clamping

2019 ◽  
Vol 42 (3) ◽  
pp. E56-E63 ◽  
Author(s):  
Anna Munro ◽  
Daniel J. Corsi ◽  
Lisa Martin ◽  
Michael Halpenny ◽  
Nicholas Dibdin ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Delayed Cord Clamping ◽  
Factors Associated ◽  
Cell Counts ◽  
Cord Clamping ◽  
Newborn Weight ◽  
Cord Blood Banks

Purpose: To assess the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to inform strategic collection strategies that could augment the quality of units in public cord blood banks. Methods: Data regarding 268 consecutive cord blood units (CBUs) banked by Canadian Blood Services were analyzed. Multivariate analysis was performed to identify factors associated with markers of hematopoietic potency and likelihood of utilization. Results: Delayed clamping of the cord beyond 60 s was associated with reduced volume collected. Any delay in clamping of the cord was associated with reduced total nucleated cell counts. Newborn weight >4,000 g was also associated with greater blood volume in the collection but not with other measures of hematopoietic potency. Cord blood acidosis at birth (pH

scholarly journals 898 Delayed cord clamping does not increase need for phototherapy in infants of women with diabetes

2021 ◽  
Vol 224 (2) ◽  
pp. S557
Author(s):  
Mollie Kotzen ◽  
Miren Dhudasia ◽  
Sagori Mukhopadhyay ◽  
Dustin Flannery ◽  
Celeste Durnwald ◽  
...  
Keyword(s):  
Delayed Cord Clamping ◽  
Cord Clamping
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