Parkinson’s Disease with an Unusual Tremor

Author(s):  
Richard A. Walsh

Multiple system atrophy represents a form of atypical parkinsonism that is challenging to manage and results in rapidly progressive disability and dependence in the absence of effective disease-modifying or symptomatic therapies. Two syndromes are recognized, both associated with autonomic dysfunction—MSA-C and MSA-P, with a predominance of parkinsonian and cerebellar features, respectively. Magnetic resonance imaging can assist with an early diagnosis, demonstrating certain features that can be considered diagnostic in the right clinical context. The typical changes described may not be apparent on an initial scan, so it is worth repeating imaging 1 or 2 years later if the clinical features and course are typical of multiple system atrophy.

2020 ◽  
Vol 10 (1) ◽  
pp. 14
Author(s):  
Cezary Grochowski ◽  
Kamil Jonak ◽  
Marcin Maciejewski ◽  
Andrzej Stępniewski ◽  
Mansur Rahnama-Hezavah

Purpose: The aim of this study was to assess the volumetry of the hippocampus in the Leber’s hereditary optic neuropathy (LHON) of blind patients. Methods: A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol. Results: Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail (p = 0.009), subiculum body (p = 0.018), CA1 body (p = 0.002), hippocampal fissure (p = 0.046), molecular layer hippocampus (HP) body (p = 0.014), CA3 body (p = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)–GC ML DG body (p = 0.003), CA4 body (p = 0.001), whole hippocampal body (p = 0.018), and the whole hippocampus volume (p = 0.023). Discussion: The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.


Author(s):  
Wael Hamza Kamr ◽  
Mohamed Gaber Eissawy ◽  
Amr Saadawy

Abstract Background Early diagnosis of meningitis with magnetic resonance imaging (MRI) would be useful for appropriate and effective management, decrease morbidity and mortality, and provide better diagnosis and treatment. The objective of the current study is to compare the accuracy of contrast-enhanced FLAIR (CE-FLAIR) and contrast-enhanced T1WI (CE-T1WI) in the detection of meningeal abnormalities in suspected cases of meningitis. Results Out of 45 patients, 37 patients were confirmed to have meningitis on CSF analysis. Out of the 37 patients, 34 patients were positive on CE-FLAIR sequence and 27 were positive on CE-T1WI. The sensitivity of CE-FLAIR sequence was 91.9% and specificity 100%, while the sensitivity of CE-T1WI sequence was 73% and specificity 100%. Conclusion CE-FLAIR is more sensitive than CE-T1WI in diagnosis of meningitis. It is recommended to be used in any cases with clinically suspected meningitis.


1995 ◽  
Vol 18 (2) ◽  
pp. 118-121 ◽  
Author(s):  
Tae Kyoung Kim ◽  
Yeon Hyoen Choe ◽  
Hak Soo Kim ◽  
Jae Kon Ko ◽  
Young Tak Lee ◽  
...  

2012 ◽  
Vol 54 (3) ◽  
pp. 231-245 ◽  
Author(s):  
A. Capelastegui Alber ◽  
E. Astigarraga Aguirre ◽  
M.A. de Paz ◽  
J.A. Larena Iturbe ◽  
T. Salinas Yeregui

2008 ◽  
Vol 125 (1) ◽  
pp. e4-e5 ◽  
Author(s):  
Faizel Osman ◽  
Aboo Foundon ◽  
Paco Leyva ◽  
Michael Pitt ◽  
R. Gordon Murray

Author(s):  
Gulnara Abdulkhakovna Kantyukova ◽  
Nataliya Ivanovna Valieva ◽  
Igor Aleksandrovich Kutuzov ◽  
Artem Andreevich Bogachev ◽  
Yuriy Olegovich Novikov

Introduction. Musculoskeletal pain (MSP) — has now assumed the character of a non-infectious epidemic and ranks second among the causes of disability, leading to a significant loss of productivity among the working-age population in all industrialized countries. Spondyloarthrosis of the lumbar region and gonarthrosis are the main diseases that doctors face at outpatient appointments. The pathogenesis of the disease develops according to one scenario, accompanied by aseptic inflammation, involvement of the muscular and ligamentous apparatus in the process, leading to the formation of dissimilar locomotor disorders, antinociceptive insufficiency, peripheral and central sensitization. Presents the results of magnetic resonance imaging (MRI), which can be used for early diagnosis of MSD, as well as dynamic control during treatment. Aim — to assess of neuroimaging signs in patients with spondyloarthrosis and gonarthrosis, depending on the genesis of the disease. Methods. An analytical single-stage study was performed with 123 patients with an established clinical diagnosis of MSP, who were divided into four groups: primary gonarthrosis (36 people), post-traumatic (38 people), spondylogenic (30 people) and x-ray negative (19 people). To study neuroimaging signs, MRI was performed on the devices «OPENMARK 4000» 0.42 T of the company «ANKE», «OPART» 0.35 T of the company «TOSHIBA» and «Superstar» 0.35 T of the company «Neusoft medikal systems» in transversal, sagittal and coronary projections, in T1W, T2W and STIR modes with adipose tissue suppression. Results. During MRI examination, 47.2 % of patients revealed spondyloarthrosis of the III grade, 30,1 % — II grade. 33,3 % had damage in the form of fragmentation of the internal and external meniscus of the knee joint, 30.1 % of cases revealed damage to the internal meniscus in the form of longitudinal splitting and the same number of osteophytes. The most common cases were intervertebral disc sequestration (2,4 %) and expansion of the articular gap of the knee joint (4,1 %), and spondyloarthritis of the I grade (7,3 %). When compared in groups, more pronounced neuroimaging signs were detected in posttraumatic and primary gonarthrosis, and they were significantly lower in spondylogenic genesis. When examining the spine, no differences were found in the groups. Conclusion. The study showed high information content of MRI in CA and GA, which allows for early diagnosis of the disease and differential diagnosis.


2021 ◽  
Vol 11 (6) ◽  
pp. 1753-1760
Author(s):  
Yuzhu Jia ◽  
Yibo Ying ◽  
Jianju Feng

Multi-parameter magnetic resonance imaging has been widely used in the diagnosis and evaluation of prostate cancer, and has important guiding significance for clinical diagnosis of prostate cancer and their treatment. This article studies the value of transrectal multiparametric ultrasound (mpUSS) in the diagnosis of clinically meaningful prostate cancer. 102 patients with high risk factors for prostate cancer were examined by mpUSS and mpMRI. The transrectal biopsy (SB) results of the prostate system were regarded as the excellent standard, and the diagnostic value of mpUSS, mpMRl and mpUSS combined with mpMRl examination for clinically meaningful prostate cancer was analyzed. The results showed that 58 of the 102 patients with SB were diagnosed with prostate cancer. Among them, 43 cases were detected by mpUSS, 50 cases were detected by mpMRl, 42 cases were detected by mpUSS combined with mpMRI (series), and 56 cases were detected by mpUSS combined with mpMRl (parallel). Grouped by Gleason score, the detection rate of mpUSS for clinically significant prostate cancer was 83.74%, and the detection rate of mpMRl was 93.5%. The comparison between the two was not statistically significant (P > 0.05), but when the two inspection methods were combined. The detection rate was 97.8%, which was significantly higher than the two inspection methods alone. Therefore, we conclude that mpUSS can be used as an imaging test for the diagnosis of prostate cancer. In addition, mpUSS has a high application value in the diagnosis of prostate cancer. The detection rate of mpUSS combined with mpMRl examination for clinically meaningful prostate cancer is significantly higher than that of mpMRl examination alone, which can be used as a diagnostic technique for early diagnosis of meaningful prostate cancer and can be used as a guide clinicians’ early diagnosis and treatment of meaningful prostate cancer.


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