Cognitive Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder

2018 ◽  
Author(s):  
Amanda Sun ◽  
Tobias Wasser
Keyword(s):  
Panic Disorder ◽  
Cognitive Behavioral Therapy ◽  
Anxiety Disorders ◽  
Study Design ◽  
Clinical Case ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study on anxiety disorders and the roles of psychotherapy and psychopharmacology in their treatment. When treating adults with panic disorder, is imipramine in combination with cognitive behavioral therapy more effective than monotherapy with either treatment alone? Furthermore, what is the durability and tolerability of their responses? Starting with these questions, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Cognitive Behavioral Therapy, Sertraline, or a Combination in Childhood Anxiety

2018 ◽  
Author(s):  
David Saunders ◽  
Andres Martin ◽  
Jerome H. Taylor
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Anxiety Disorders ◽  
Clinical Case ◽  
Behavioral Therapy ◽  
Childhood Anxiety ◽  
Child And Adolescent Psychiatry ◽  
Cognitive Behavioral ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study evaluating the treatment of anxiety disorders in child and adolescent psychiatry. Is sertraline in combination with cognitive behavioral therapy more effective than monotherapy with either treatment alone in children with anxiety disorders? Also, how do these treatments compare with placebo therapy? Starting with these questions, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Behavioral and/or Pharmacotherapy for Older Patients with Insomnia

2018 ◽  
Author(s):  
Robert Ross ◽  
Rajesh R. Tampi
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Older Patients ◽  
Clinical Case ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Healthy Elderly ◽  
Longterm Treatment ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study on short and longterm treatment of insomnia. Should older patients with insomnia be managed with cognitive behavioral therapy, benzodiazepines, or both? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. The study shows that bensodiazepines and cognitive behavioral therapy are equally effective for shorterm treatment of insomnia in otherwise healthy elderly participants but cognitive behavioral therapy is far more effective for longterm treatment of insomnia.

Fluoxetine, Comprehensive Cognitive Behavioral Therapy, and Placebo in Generalized Social Phobia

2018 ◽  
Author(s):  
Erin Habecker ◽  
Tobias Wasser
Keyword(s):  
Combination Therapy ◽  
Cognitive Behavioral Therapy ◽  
Social Phobia ◽  
Clinical Case ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Study Intervention ◽  
Landmark Study ◽  
Generalized Social Phobia

This chapter provides a summary of a landmark study on anxiety disorders. For generalized social phobia, are fluoxetine and comprehensive cognitive behavioral therapy efficacious? How do their efficacies compare? And is there an advantage to combination therapy? Starting with these questions, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. Results of the study indicate that fluoxetine and comprehensive cognitive behavioral therapy are superior to placebo for the treatment of generalized social phobia; neither treatment is superior to the other and there is no apparent advantage to combination therapy. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Comparison of 8 versus 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults

2018 ◽  
pp. 257-262
Author(s):  
Laurie O. Mark ◽  
Jean Kwo
Keyword(s):  
Antibiotic Therapy ◽  
Randomized Trial ◽  
Study Design ◽  
Clinical Case ◽  
Pulmonary Infection ◽  
Ventilator Associated Pneumonia ◽  
Icu Patients ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of the landmark study “Comparison of 8 versus 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial.” In adult patients with ventilator-associated pneumonia (VAP), is treatment with an 8-day course of antimicrobials as effective as a 15-day course? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. In ICU patients who develop microbiologically proven VAP, an 8-day antimicrobial course is not inferior to a 15-day course with respect to all-cause mortality or recurrence of pulmonary infection. However, these findings may not apply to patients who are immunocompromised, and shorter or longer duration of antibiotics may sometimes be indicated.

Cognitive Therapy versus Medication in the Treatment of Moderate to Severe Depression

2018 ◽  
Author(s):  
Daniel Barron ◽  
Robert Ostroff
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Therapy ◽  
Study Design ◽  
Clinical Case ◽  
Severe Depression ◽  
Major Depressive ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study on major depressive disorder. Is paroxetine or cognitive therapy more effective in treating patients with moderate to severe major depressive disorder? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Global Burden of Mental and Substance Use Disorders

2018 ◽  
Author(s):  
Stephanie Yarnell ◽  
Ellen Edens
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Study Design ◽  
Burden Of Disease ◽  
Clinical Case ◽  
Global Burden ◽  
Disease Study ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study in epidemiology. The Global Burden of Disease Study was a ground breaking venture in answering the question regarding the prevalence of various diseases. By analyzing this database, the current study was sought to determine the burden of disease attributable to mental and substance use disorders. With this in mind, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Gastroesophageal Junction Tumors Does Location Determine Treatment?

2017 ◽  
Author(s):  
Emily L. Siegel ◽  
Miguel Burch
Keyword(s):  
Study Design ◽  
Clinical Case ◽  
Classification Scheme ◽  
Treatment Approach ◽  
Gastroesophageal Junction ◽  
Design Study ◽  
Appropriate Treatment ◽  
Study Intervention ◽  
Landmark Study

This chapter summarizes a landmark study in treatment of gastroesophageal (GE) junction tumors. Should an anatomically based classification scheme of GE tumors define the appropriate treatment approach for these tumors? Starting with that question, it describes the basis of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving possible gastrectomy and esophagectomy.

Mastectomy versus Lumpectomy for Invasive Breast Cancer

2017 ◽  
Author(s):  
Michael E. Hochman
Keyword(s):  
Breast Cancer ◽  
Study Design ◽  
Invasive Breast Cancer ◽  
Clinical Case ◽  
Breast Conserving Therapy ◽  
Total Mastectomy ◽  
Design Study ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of the landmark study known as the B-06 trial, which compared total mastectomy versus breast-conserving therapy (i.e., lumpectomy) for treating women with invasive breast cancer. Do all women with invasive breast cancer require a total mastectomy, or is breast conserving therapy (i.e., lumpectomy) appropriate in some women? Starting with that question, it describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving total mastectomy versus lumpectomy.

Size as a Predictor of Malignancy of Adrenal Cortical Carcinoma

2017 ◽  
Author(s):  
Rachel J. Kwon
Keyword(s):  
Study Design ◽  
Adrenocortical Carcinoma ◽  
Clinical Case ◽  
Adrenal Incidentaloma ◽  
Adrenal Cortical Carcinoma ◽  
Postoperative Treatment ◽  
Endocrine Surgery ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study in endocrine surgery. Does size correlate with malignancy in adrenal cortical carcinoma? Starting with that question, it describes the basics of the study, including year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case involving postoperative treatment of a patient with adrenocortical carcinoma who has a large adrenal incidentaloma.

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