The Treatment for Adolescents with Depression Study (TADS)
This chapter provides a summary of a landmark study in child and adolescent psychiatry. This study is also notable for addressing the relationship between suicidal thinking and behavior and treatment of depression in adolescents. Among adolescents with depression, is fluoxetine and cognitive behavioral therapy efficacious? If so, how does the efficacy of these treatments compare with each other and in combination? Starting with these questions, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.