scholarly journals Relapsing Polychondritis: An Updated Review

Biomedicines ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 84 ◽  
Author(s):  
Francesco Borgia ◽  
Roberta Giuffrida ◽  
Fabrizio Guarneri ◽  
Serafinella Cannavò
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Functional Impairment ◽  
Clinical Presentation ◽  
Systemic Disease ◽  
Relapsing Polychondritis ◽  
Review Article ◽  
Therapeutic Options ◽  
Immune Mediated ◽  
Specific Symptoms

Relapsing polychondritis is an immune-mediated systemic disease characterized by recurrent episodes of inflammation of cartilaginous and proteoglycan-rich tissues, resulting in progressive anatomical deformation and functional impairment of the involved structures. Auricular and nasal chondritis and/or polyarthritis represent the most common clinical features, but potentially all types of cartilage may be involved. Because of the pleomorphic nature of the disease, with non-specific symptoms at the onset, the diagnosis of relapsing polychondritis is often delayed. In this review article we provide a comprehensive look into clinical presentation, laboratory and instrumental investigations, diagnostic criteria, and therapeutic options.

Stiff Person Syndrome

2013 ◽  
Author(s):  
Aaron E. Miller ◽  
Teresa M. DeAngelis
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Therapeutic Options ◽  
Stiff Person Syndrome ◽  
Muscular Rigidity ◽  
Unexplained Pain ◽  
Electrophysiological Tests

Stiff person syndrome is an important autoimmune mediated disorder to consider in patients with unexplained pain and muscular rigidity. We review the proposed diagnostic criteria, common clinical features, and important serologic and electrophysiological tests to aid in diagnosis as well as medical and rehabilitative therapeutic options. In addition, we discuss the identification and management of possible paraneoplastic presentations.

scholarly journals Severe Fever with Thrombocytopenia Syndrome Virus Infection Associated with Hemophagocytic Lymphohistiocytosis as Poor Prognostic Factor

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S319-S319
Author(s):  
Sunmin Park ◽  
Juwon Kim ◽  
Hyo Youl Kim ◽  
Young Uh ◽  
Young Keun Kim
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Inflammatory Diseases ◽  
Clinical Feature ◽  
Poor Prognostic Factor ◽  
Immune Mediated ◽  
Life Threatening ◽  
Christian Hospital ◽  
Severe Fever

Abstract Background Severe fever with thrombocytopenia (SFTS) is an emerging infectious disease caused by a novel bunyavirus designated SFTS virus (SFTSV) with a high fatality rate. Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated life-threatening disease triggered by infections, neoplasms and noninfectious inflammatory diseases. A few HLH associated with SFTSV were reported. According to the diagnostic criteria of HLH, 11 patients with SFTS were reviewed. Methods During last 2 years (2015–2016), 11 SFTS patients were diagnosed at the Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea. Clinical features were analyzed using diagnostic criteria of 2004-HLH trial. We described if the prognosis of SFTSV-infected patients was associated with clinical features of HLH. Results Of 11 patients, four patients were fulfillled the diagnostic criteria of 2004-HLH trial (five of eight criteria). Two patients were fulfilled the four criteria. Five patients were fulfilled three or less criteria. Three of six patients who fulfilled four or more criteria were died. There was no mortality in five patients who fulfilled three or less criteria. Hemophagocytosis in bone marrow (BM) was observed in all six patients who were taken BM study. Conclusion In SFTS, HLH was severe clinical feature and it might be associated with poor prognosis. Disclosures All authors: No reported disclosures.

Psoriasis in HIV infection: an update

2019 ◽  
Vol 30 (6) ◽  
pp. 596-604
Author(s):  
Miguel Alpalhão ◽  
J. Borges-Costa ◽  
Paulo Filipe
Keyword(s):  
Drug Therapy ◽  
Hiv Infection ◽  
Clinical Features ◽  
Clinical Presentation ◽  
Treatment Options ◽  
Future Perspectives ◽  
Biological Drugs ◽  
Cutaneous Manifestations ◽  
Immune Mediated ◽  
Novel Drugs

Psoriasis is a prevalent systemic immune-mediated disease with cutaneous manifestations. In HIV-infected patients, psoriasis may have a higher incidence, present atypical and more exuberant clinical features, and is frequently recalcitrant to treatment. Despite this aggravated severity, treatment options for psoriasis in HIV-infected individuals remain limited due to the risk of fatal immunosuppression associated with both classical immunosuppressants and new biological drugs. Notwithstanding, drug therapy in psoriasis has been undergoing major advances for the last few years, with novel drugs approved, which could significantly add to the management of HIV-infected patients. It is therefore our aim to present a review of the available literature to highlight the updated evidence on psoriasis in HIV-infected individuals, particularly in regards to its epidemiology, proposed pathophysiology, clinical presentation, currently available therapeutic options, and future perspectives.

Neisseria gonorrhoeae

2010 ◽  
pp. 722-727
Author(s):  
D. Barlow ◽  
Jackie Sherrard ◽  
C. Ison
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Sexual Activity ◽  
Clinical Features ◽  
Genital Tract ◽  
Systemic Disease ◽  
Gonococcal Infection ◽  
Gram Negative ◽  
Urethral Discharge ◽  
Lower Genital Tract ◽  
Specific Symptoms

Neisseria gonorrhoeae is a Gram-negative, intracellular diplococcus that primarily colonizes the columnar epithelium of lower genital tract, only occasionally spreading to the upper genital tract or causing systemic disease. It is almost exclusively transmitted by sexual activity. Clinical features—(1) Oropharyngeal and rectal infections usually produce no symptoms; (2) men—dysuria (50%) and urethral discharge (98%) develop after a median of more than 5 days; complications, e.g. epididymitis, orchitis, are rare; (3) women—there are no specific symptoms in the absence of complications, e.g. salpingitis, bartholinitis; (4) disseminated gonococcal infection—a comparatively benign bacteraemia affecting joints (particularly shoulder and knee) and skin; more common in women than men....

scholarly journals The most important skin diseases of the sheep and the goat

2018 ◽  
Vol 51 (2) ◽  
pp. 107
Author(s):  
N. D. GIADINIS (Ν. Δ. ΓΙΑΔΙΝΗΣ) ◽  
M. N. SARIDOMICHELAKIS (Μ.Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ)
Keyword(s):  
Clinical Features ◽  
Skin Diseases ◽  
Small Ruminants ◽  
Review Article ◽  
Immune Mediated

Skin diseases of small ruminants may have an economical impact, apart from the fact that some of them can be transmitted to humans. In this review article, the most important environmental, nutritional, parasitic, bacterial, fungal, viral, immune-mediated and neoplastic skin diseases of the goat and sheep are presented, emphasising on the clinical features, the diagnosis and the treatment.

scholarly journals Swallow syncope: Clinical presentation, diagnostic criteria, and therapeutic options

2014 ◽  
Vol 20 (4) ◽  
pp. 207 ◽  
Author(s):  
Mohit Girotra ◽  
Stephen Glasser ◽  
SudhirK Dutta ◽  
Shashank Garg
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Presentation ◽  
Therapeutic Options

scholarly journals A 2021 Update on Syphilis: Taking Stock from Pathogenesis to Vaccines

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1364
Author(s):  
Giorgio Tiecco ◽  
Melania Degli Antoni ◽  
Samuele Storti ◽  
Valentina Marchese ◽  
Emanuele Focà ◽  
...  
Keyword(s):  
Global Health ◽  
Sexually Transmitted Infections ◽  
Clinical Manifestation ◽  
Clinical Presentation ◽  
Systemic Disease ◽  
Treponema Pallidum ◽  
Health Problems ◽  
Therapeutic Options ◽  
Sexually Transmitted

In 2021 the scientific community's efforts have been focused on solving the back-breaking challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of the most common global health problems. Syphilis is a systemic disease caused by the spirochaete Treponema pallidum (TP) and is one of the oldest known diseases. Its incidence has increased in the last few years and syphilis still remains a contemporary plague that continues to afflict millions of people worldwide. Despite research improvements, syphilis pathogenesis is not completely clear; clinical presentation is very heterogeneous and the diagnosis can sometimes be difficult. Furthermore, few therapeutic options are available, and a vaccine has not been found yet. In this review, we describe the most recent evidence concerning the clinical manifestation, diagnosis, treatment and vaccine prospectives for this disease.

scholarly journals Relapsing Polychondritis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Beata Sosada ◽  
Katarzyna Loza ◽  
Ewelina Bialo-Wojcicka
Keyword(s):  
Physical Examination ◽  
Clinical Response ◽  
Clinical Features ◽  
Systemic Disease ◽  
Correct Diagnosis ◽  
Relapsing Polychondritis ◽  
Oral Prednisolone ◽  
Clinical History ◽  
History Of ◽  
Laboratory Examinations

Relapsing polychondritis (RP) is a rare systemic disease characterized by recurrent, widespread chondritis of the auricular, nasal, and tracheal cartilages. Additional clinical features include audiovestibular dysfunction, ocular inflammation, vasculitis, myocarditis, and nonerosive arthritis. Although the cause remains unknown, the etiology is suspected to be autoimmune. We describe a case of a 31-year-old woman with a four-month history of bilateral auricular and nasal chondritis. Infectious and neoplastic diseases were excluded by imaging and laboratory examinations. RP was diagnosed based on three McAdam’s criteria. The patient was medicated with oral prednisolone and methotrexate with positive clinical response. In this case clinical history and detailed physical examination were fundamental in concluding the correct diagnosis and administrating the appropriate medication.

Clinical Presentation of Chronic Traumatic Encephalopathy

2020 ◽  
Vol 40 (04) ◽  
pp. 370-383
Author(s):  
Megan Mariani ◽  
Michael L. Alosco ◽  
Jesse Mez ◽  
Robert A. Stern
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Clinical Presentation ◽  
Chronic Traumatic Encephalopathy ◽  
Case Reports ◽  
Case Series ◽  
American Football ◽  
Next Of Kin ◽  
Motor Functioning

AbstractChronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive head impacts (RHI), such as those received in contact/collision sports, blast injury in military veterans, and domestic violence. Currently, CTE can only be diagnosed following death. Although the clinical features of former boxers have been described for almost a century, and there is increasing evidence of long-term cognitive and neuropsychiatric impairments in living former American football players, the specific clinical presentation associated with underlying CTE neuropathology remains unclear. These features include diverse and nonspecific changes in cognition, mood, behavior, and motor functioning. Currently, there are no validated and widely accepted clinical diagnostic criteria. Proposed criteria are primarily based on retrospective telephonic interviews with the next of kin of individuals who were diagnosed with CTE postmortem. Prospective studies involving individuals presumably at high risk for CTE are underway; these will hopefully clarify the clinical features and course of CTE, allow the diagnostic criteria to be refined, and lead to the development and validation of in vivo biomarkers. This article reviews what is currently known about the clinical presentation of CTE and describes the evolution of this knowledge from early case reports of “punch drunk” boxers through larger case series of neuropathologically confirmed CTE. This article concludes with a discussion of gaps in research and future directions to address these areas.

scholarly journals Immune mediated Lesions of the oral cavity: A scrupulously researched review

2021 ◽  
Vol 7 (4) ◽  
pp. 238-244
Author(s):  
Sunita Gupta ◽  
Shriya Khera
Keyword(s):  
Oral Cavity ◽  
Clinical Features ◽  
Oral Mucosa ◽  
Signs And Symptoms ◽  
Review Article ◽  
Oral Lesions ◽  
Immune Mediated ◽  
Salient Features

Oral mucosa may be the first site to manifest protean signs and symptoms in immune mediated diseases. Therefore, it is of paramount importance to have a thorough and vast knowledge about various diseases. It is the role of Oral and Maxillofacial Diagnostician to diagnose the lesions according to their salient features.In this review article, we aim to describe the immune mediated oral lesions, their clinical features, investigations and management.

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