Yellow fever, severe acute respiratory syndrome virus, and H1N1 influenza infections

Tubular Necrosis ◽

Yellow Fever Vaccination

Serious yellow fever infections are associated with acute kidney injury (AKI) on the basis of haemorrhagic shock with acute tubular necrosis, although a direct viral effect on renal tissue has been suggested. A single yellow fever vaccination provides sufficient immunity against the disease, negating the need for booster vaccinations every 10 years; vaccination failures are extremely rare. Severe SARS infections may be complicated by multi-organ dysfunction syndrome including AKI. Hypotension caused by nosocomial infections, gastrointestinal bleeding, or SARS per se, and rhabdomyolysis were associated with AKI in addition to prerenal factors. Serious H1N1 viral infections are often complicated by AKI (mostly caused by acute tubular necrosis and rhabdomyolysis) with a need for renal replacement therapy. Timely oseltamivir administration has a beneficial effect on outcomes in hospitalized adults with H1N1 infection.

Nucleic Acid Detection of Severe Acute Respiratory Syndrome Virus 2 (SARS-CoV-2): A Research in the Field of Health Economics

SSRN Electronic Journal ◽

10.2139/ssrn.3558020 ◽

2020 ◽

Author(s):

Yanfen Zeng ◽

Min Dou ◽

Yaqian Mao ◽

Yao Li ◽

Xijun Chen ◽

...

Keyword(s):

Nucleic Acid ◽

Health Economics ◽

Nucleic Acid Detection

Rapid, sensitive, full genome sequencing of Severe Acute Respiratory Syndrome Virus Coronavirus 2 (SARS-CoV-2)

10.1101/2020.04.22.055897 ◽

2020 ◽

Cited By ~ 8

Author(s):

Clinton R Paden ◽

Ying Tao ◽

Krista Queen ◽

Jing Zhang ◽

Yan Li ◽

...

Keyword(s):

Sanger Sequencing ◽

Full Genome ◽

Miseq Sequencing ◽

Genomic Information ◽

Rt Pcr ◽

Full Genome Sequencing ◽

High Quality ◽

Global Pandemic

AbstractSARS-CoV-2 recently emerged, resulting a global pandemic. Rapid genomic information is critical to understanding transmission and pathogenesis. Here, we describe validated protocols for generating high-quality full-length genomes from primary samples. The first employs multiplex RT-PCR followed by MinION or MiSeq sequencing. The second uses singleplex, nested RT-PCR and Sanger sequencing.

Vaccines for Severe Acute Respiratory Syndrome Virus and Other Coronaviruses

Nidoviruses ◽

10.1128/9781555815790.ch25 ◽

2014 ◽

pp. 379-407 ◽

Cited By ~ 3

Author(s):

Luis Enjuanes ◽

Marta L. DeDiego ◽

Enrique Alvarez ◽

Carmen Capiscol ◽

Ralph Baric

Keyword(s):

Respiratory Syndrome Virus

Fulminant H1N1 and severe acute respiratory syndrome coronavirus-2 infections with a 4-year interval without an identifiable underlying cause: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-03113-9 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Terese L. Katzenstein ◽

Sofie E. Jørgensen ◽

Jann Mortensen ◽

Marie Helleberg ◽

Anna Kalhauge ◽

...

Keyword(s):

Mononuclear Cells ◽

Viral Infections ◽

Influenza Virus Infection ◽

H1n1 Influenza ◽

Asymptomatic Infection ◽

Enzyme Linked Immunosorbent Assay ◽

Type I ◽

Peripheral Blood Mononuclear ◽

Genetic Changes

Abstract Background The clinical presentation of severe acute respiratory syndrome coronavirus-2 infection is highly variable from asymptomatic infection to fulminant disease. The reasons for the variation are only starting to unravel, with risk factors including age and certain comorbidities as well as genetic defects causing immunological perturbations in the interferon pathways. Case presentation We report the case of an otherwise healthy Caucasian man, who at ages 60 and 64 years suffered from severe H1N1 influenza virus infection and severe acute respiratory syndrome coronavirus-2 infections, respectively. In both cases, there were acute kidney impairment and the need for intensive care unit admission as well as mechanical ventilation. Fortunately, after both infections there was full clinical recovery. The severity of the infections indicates an underlying impairment in the ability to control these kinds of infections. Challenge of patient peripheral blood mononuclear cells showed impaired type I and III antiviral interferon responses and reduced interferon-stimulated gene expression. However, despite investigation of patient samples by whole exome sequencing and enzyme-linked immunosorbent assay, no known disease-causing genetic variants related to interferon pathways were found, nor were interferon autoantibodies demonstrated. Thus, any underlying immunological cause of this unusual susceptibility to severe viral infections remains unresolved. Conclusion The patient experienced very similar severe clinical pictures triggered by H1N1 and severe acute respiratory syndrome coronavirus-2 infections, indicating an underlying inability to contain these infections. We were unable to show that the patient had any of the currently known types of immune incompetence but identified genetic changes possibly contributing to the severe course of both infections. Further analyses to delineate contribution factors are needed.

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

10.1101/2021.12.24.474114 ◽

2021 ◽

Author(s):

Tina J Dafoe ◽

Theodore dos Santos ◽

Aliya F Spigelman ◽

James Lyon ◽

Nancy Smith ◽

...

Keyword(s):

Healthcare Systems ◽

Personal Health ◽

Islet Isolation ◽

Human Pancreatic Islets ◽

Transit Times ◽

Organ Quality ◽

New Guidelines

Designated a pandemic in March 2020, the spread of severe acute respiratory syndrome virus 2 (SARS-CoV2), the virus responsible for coronavirus disease 2019 (COVID-19), led to new guidelines and restrictions being implemented for individuals, businesses, and societies in efforts to limit the impacts of COVID-19 on personal health and healthcare systems. Here we report the impacts of the COVID-19 pandemic on pancreas processing and islet isolation/distribution outcomes at the Alberta Diabetes Institute IsletCore, a facility specialising in the processing and distribution of human pancreatic islets for research. While the number of organs processed was significantly reduced, organ quality and the function of cellular outputs were minimally impacted during the pandemic when compared to an equivalent period immediately prior. Despite the maintained quality of isolated islets, recipient groups reported poorer feedback regarding the samples. Our findings suggest this is likely due to disrupted distribution which led to increased transit times to recipient labs, particularly those overseas. Thus, to improve overall outcomes in a climate of limited research islet supply, prioritization of tissue recipients based on likely tissue transit times may be needed.

Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus

Journal of Genetics and Genomics ◽

10.1016/j.jgg.2020.01.003 ◽

2020 ◽

Vol 47 (2) ◽

pp. 115-117 ◽

Cited By ~ 14

Author(s):

Tianyi Qiu ◽

Tiantian Mao ◽

Yuan Wang ◽

Mengdi Zhou ◽

Jingxuan Qiu ◽

...

Keyword(s):

Protective Epitope ◽

New Type

Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2009.0093 ◽

2009 ◽

Vol 364 (1530) ◽

pp. 2725-2737 ◽

Cited By ~ 28

Author(s):

Ying Ma ◽

Youjun Feng ◽

Di Liu ◽

George F. Gao

Keyword(s):

Influenza Virus ◽

Avian Influenza ◽

Avian Influenza Virus ◽

Streptococcus Suis ◽

Animal Origin ◽

Streptococcal Toxic Shock Syndrome ◽

Human Beings ◽

Highly Pathogenic

The outbreak and spread of severe acute respiratory syndrome-associated coronavirus and the subsequent identification of its animal origin study have heightened the world's awareness of animal-borne or zoonotic pathogens. In addition to SARS, the highly pathogenic avian influenza virus (AIV), H5N1, and the lower pathogenicity H9N2 AIV have expanded their host ranges to infect human beings and other mammalian species as well as birds. Even the ‘well-known’ reservoir animals for influenza virus, migratory birds, became victims of the highly pathogenic H5N1 virus. Not only the viruses, but bacteria can also expand their host range: a new disease, streptococcal toxic shock syndrome, caused by human Streptococcus suis serotype 2 infection, has been observed in China with 52 human fatalities in two separate outbreaks (1998 and 2005, respectively). Additionally, enterohaemorrhagic Escherichia coli O157:H7 infection has increased worldwide with severe disease. Several outbreaks and sporadic isolations of this pathogen in China have made it an important target for disease control. A new highly pathogenic variant of porcine reproductive and respiratory syndrome virus (PRRSV) has been isolated in both China and Vietnam recently; although PRRSV is not a zoonotic human pathogen, its severe outbreaks have implications for food safety. All of these pathogens occur in Southeast Asia, including China, with severe consequences; therefore, we discuss the issues in this article by addressing the situation of the zoonotic threat in China.

A Review: Coronavirus, Its Types, And Impact of COVID-19 on Global Wealth

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl1.2811 ◽

2020 ◽

Vol 11 (SPL1) ◽

pp. 455-461

Author(s):

Ashish B. Budhrani

Keyword(s):

Stock Exchange ◽

Infected Individual ◽

Signs And Symptoms ◽

Plant Viruses ◽

Economic Effects ◽

Unique Strain ◽

Human Infections ◽

Respiratory Droplets

The virus can multiply itself and their genetic code mostly includes either RNA or DNA. In many different ways, the various types of viral species are spread. For examples, Human immunodeficiency virus is transferred through body fluids, plant viruses are transferred from plant to plant by insects and other organisms, Severe Acute Respiratory Syndrome virus transmitted by humans and animals, COVID-19 is a respiratory virus that transmitted mainly through direct contact with an infected individual by respiratory droplets when the infected person coughs or sneezes, or by saliva droplets or nose discharge. are the viruses that belong to the class and subclass , order . Some human infections are mild, but Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) human transmission from animals to humans, have caused more than ten thousand cumulative cases in the past two decades. And now a novel namely known as COVID-19 is a unique strain which has notbeen previously recognized in humans emerged as the most important global health threats. this study aims to assess the awareness of this COVID-19 among the general public and to provide basic information such as signs and symptoms, origin, diagnostic method, treatment, prevention recommended by WHO and impact of COVID-19 on global wealth. Global stock exchange has a drop-down rapidly as stock investors continue to worry about the broader economic effects of the COVID-19.