scholarly journals Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus

2020 ◽  
Vol 47 (2) ◽  
pp. 115-117 ◽  
Author(s):  
Tianyi Qiu ◽  
Tiantian Mao ◽  
Yuan Wang ◽  
Mengdi Zhou ◽  
Jingxuan Qiu ◽  
...  
Author(s):  
Clinton R Paden ◽  
Ying Tao ◽  
Krista Queen ◽  
Jing Zhang ◽  
Yan Li ◽  
...  

AbstractSARS-CoV-2 recently emerged, resulting a global pandemic. Rapid genomic information is critical to understanding transmission and pathogenesis. Here, we describe validated protocols for generating high-quality full-length genomes from primary samples. The first employs multiplex RT-PCR followed by MinION or MiSeq sequencing. The second uses singleplex, nested RT-PCR and Sanger sequencing.


Nidoviruses ◽  
2014 ◽  
pp. 379-407 ◽  
Author(s):  
Luis Enjuanes ◽  
Marta L. DeDiego ◽  
Enrique Alvarez ◽  
Carmen Capiscol ◽  
Ralph Baric

2021 ◽  
Vol 4 (2) ◽  
pp. 417
Author(s):  
Mega Elvianasti ◽  
Liszulfah Roza ◽  
Maesaroh Maesaroh ◽  
Husnin Nahry Yarza

ABSTRAKVirus Corona atau Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) adalah jenis virus yang menyerang sistem pernapasan dan kekebalan tubuh manusia. Di Indonesia sendiri jumlah orang yang terinfeksi terus meningkat karena masih kurangnya kesadaran masyarakat untuk menerapkan protokol kesehatan. Orang yang terinfeksi Covid-19 memiliki gejala yang berbeda satu sama lain. Ada yang menyebabkan gangguan ringan pada sistem pernapasan, infeksi paru-paru yang berat, hingga kematian. Virus Corona ini adalah jenis baru dari Coronavirus yang menular ke manusia. Virus ini bisa menyerang siapa saja, mulai dari bayi, anak-anak, orang dewasa, ibu hamil dan ibu menyusui serta lansia. Bahkan lansia menjadi kelompok orang yang paling beresiko tertular. Berdasarkan wawancara dengan beberapa lansia, mereka mereka belum memiliki pemahaman dan pengetahuan yang benar mengenai Covid-19, selain itu dalam penyampaian informasi kepada lansia tidak memungkinkan untuk dilakukan secara online. Tujuan dari kegiatan ini adalah untuk memberikan edukasi tentang COVID-19 kepada masyarakat khususnya kepada lansia yang berada di RW 05 Kelurahan Jaticempaka Pondokgede Bekasi. Langkah-langkah yang dilakukan dalam kegiatan pengabdian ini, yaitu 1) Sosialisasi kepada mitra 2) mendata jumlah lansia yang ada di Kelurahan Jaticempaka RW 05, 3) Menyiapkan media edukasi dengan menggunakan x banner, 4) Memberikan edukasi covid-19 dengan cara door to door untuk menghindari kerumunan , 5) Memberikan bantuan pangan kepada warga lansia dan warga yang terdampak covid-19. Hasil dari kegiatan para lansia dapat memahami apa itu virus Covid-19, bagaimana penyebarannya, dan bagaimana menerapkan protokol kesehatan sehingga terhindar dari infeksi virus Covid-19. Kata Kunci: edukasi; lansia; covid-19. ABSTRACTCoronavirus or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a type of virus that attacks the human respiratory and immune systems. In Indonesia, the number of infected people continues to increase due to the lack of public awareness to apply health protocols. People infected with Covid-19 have different symptoms from one another. Some cause minor problems in the respiratory system, severe lung infections, and death. This Corona virus is a new type of Coronavirus that is transmitted to humans. This virus can attack anyone, from infants, children, adults, pregnant and nursing mothers and the elderly. Even the elderly are the group of people most at risk of contracting it. Based on interviews with several elderly people, they do not have the correct understanding and knowledge about Covid-19, besides that it is not possible to convey information to the elderly people online. The purpose of this activity is to provide education about COVID-19 to the community, especially to the elderly who are in RW 05 Jaticempaka Pondokgede Bekasi Village. The steps taken in this service activity are 1) Outreach to partners 2) recording the number of elderly people in Jaticempaka Village RW 05, 3) Preparing educational media using x banners, 4) Providing covid-19 education by means of door to door to avoid crowds, 5) Providing food assistance to elderly residents and residents affected by Covid-19. The results of the activities of the elderly can understand what the Covid-19 virus is, how it spreads, and how to implement health protocols to avoid Covid-19 virus infection. Keywords: education; elderly people; covid-19


2021 ◽  
Author(s):  
Tina J Dafoe ◽  
Theodore dos Santos ◽  
Aliya F Spigelman ◽  
James Lyon ◽  
Nancy Smith ◽  
...  

Designated a pandemic in March 2020, the spread of severe acute respiratory syndrome virus 2 (SARS-CoV2), the virus responsible for coronavirus disease 2019 (COVID-19), led to new guidelines and restrictions being implemented for individuals, businesses, and societies in efforts to limit the impacts of COVID-19 on personal health and healthcare systems. Here we report the impacts of the COVID-19 pandemic on pancreas processing and islet isolation/distribution outcomes at the Alberta Diabetes Institute IsletCore, a facility specialising in the processing and distribution of human pancreatic islets for research. While the number of organs processed was significantly reduced, organ quality and the function of cellular outputs were minimally impacted during the pandemic when compared to an equivalent period immediately prior. Despite the maintained quality of isolated islets, recipient groups reported poorer feedback regarding the samples. Our findings suggest this is likely due to disrupted distribution which led to increased transit times to recipient labs, particularly those overseas. Thus, to improve overall outcomes in a climate of limited research islet supply, prioritization of tissue recipients based on likely tissue transit times may be needed.


Author(s):  
Dr. Ahmed Al-Shukaili ◽  

In December 2019 a new type of coronaviruses appeared in China and named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the disease associated with this virus is called Coronavirus Disease 2019 or COVID-19. Currently, COVID19 is the main global health threat. In this review, we focus in the current knowledge of immune response to SARS-CoV-2. Dysregulation of immune system, such as elevation levels of proinflammatory mediators and their roles in disease progression and pathogenesis as well as imbalance between innate and adaptive immune cells, are discussed in this review.


2009 ◽  
Vol 364 (1530) ◽  
pp. 2725-2737 ◽  
Author(s):  
Ying Ma ◽  
Youjun Feng ◽  
Di Liu ◽  
George F. Gao

The outbreak and spread of severe acute respiratory syndrome-associated coronavirus and the subsequent identification of its animal origin study have heightened the world's awareness of animal-borne or zoonotic pathogens. In addition to SARS, the highly pathogenic avian influenza virus (AIV), H5N1, and the lower pathogenicity H9N2 AIV have expanded their host ranges to infect human beings and other mammalian species as well as birds. Even the ‘well-known’ reservoir animals for influenza virus, migratory birds, became victims of the highly pathogenic H5N1 virus. Not only the viruses, but bacteria can also expand their host range: a new disease, streptococcal toxic shock syndrome, caused by human Streptococcus suis serotype 2 infection, has been observed in China with 52 human fatalities in two separate outbreaks (1998 and 2005, respectively). Additionally, enterohaemorrhagic Escherichia coli O157:H7 infection has increased worldwide with severe disease. Several outbreaks and sporadic isolations of this pathogen in China have made it an important target for disease control. A new highly pathogenic variant of porcine reproductive and respiratory syndrome virus (PRRSV) has been isolated in both China and Vietnam recently; although PRRSV is not a zoonotic human pathogen, its severe outbreaks have implications for food safety. All of these pathogens occur in Southeast Asia, including China, with severe consequences; therefore, we discuss the issues in this article by addressing the situation of the zoonotic threat in China.


2020 ◽  
Vol 11 (SPL1) ◽  
pp. 455-461
Author(s):  
Ashish B. Budhrani

The virus can multiply itself and their genetic code mostly includes either RNA or DNA. In many different ways, the various types of viral species are spread. For examples, Human immunodeficiency virus is transferred through body fluids, plant viruses are transferred from plant to plant by insects and other organisms, Severe Acute Respiratory Syndrome virus transmitted by humans and animals, COVID-19 is a respiratory virus that transmitted mainly through direct contact with an infected individual by respiratory droplets when the infected person coughs or sneezes, or by saliva droplets or nose discharge. are the viruses that belong to the class and subclass , order . Some human infections are mild, but Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS) human transmission from animals to humans, have caused more than ten thousand cumulative cases in the past two decades. And now a novel namely known as COVID-19 is a unique strain which has notbeen previously recognized in humans emerged as the most important global health threats. this study aims to assess the awareness of this COVID-19 among the general public and to provide basic information such as signs and symptoms, origin, diagnostic method, treatment, prevention recommended by WHO and impact of COVID-19 on global wealth. Global stock exchange has a drop-down rapidly as stock investors continue to worry about the broader economic effects of the COVID-19.


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