Therapeutics

2014 ◽  
pp. 574-602
Author(s):  
David A. Mitchell ◽  
Laura Mitchell ◽  
Lorna McCaul
Keyword(s):  
Dental Treatment ◽  
Antiviral Drugs ◽  
Dental Practice ◽  
Hospital Practice ◽  
General Dental Practice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Contents. Prescribing. Analgesics in general dental practice. Analgesics in hospital practice. Anti-inflammatory drugs. Antidepressants. Antiemetics. Anxiolytics, sedatives, hypnotics, and tranquillizers. Antibiotics—1. Antibiotics—2. Antifungal and antiviral drugs. Antihistamines and decongestants. Drugs influencing dental treatment. Miscellaneous. Alarm bells.

scholarly journals Reinforcing the Supply Chain of Umifenovir and Other Antiviral Drugs with Retrosynthetic Software

2021 ◽  
Author(s):  
Yingfu Lin ◽  
Zirong Zhang ◽  
Babak Mahjour ◽  
Di Wang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Antiviral Drug ◽  
Drug Repurposing ◽  
Antiviral Drugs ◽  
Multiple Drug ◽  
General Strategy ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract The global disruption caused by the 2020 coronavirus pandemic stressed the supply chain of many products, including pharmaceuticals. Multiple drug repurposing studies for COVID-19 are now underway. If a winning therapeutic emerges, it is unlikely that the existing inventory of the medicine, or even the chemical raw materials needed to synthesize it, will be available in the quantities required. We used retrosynthetic software to arrive at alternate chemical supply chains for the antiviral drug umifenovir, as well as eleven other antiviral and anti-inflammatory drugs. We have experimentally validated four routes to umifenovir and one route to bromhexine. In several instances, the software utilizes C–H functionalization logic, and one route to umifenovir employs functionalization of six C–H bonds. The general strategy we apply can be used to identify distinct starting materials, and relieve stress on existing supply chains.

The Reduction of Broken Appointments in General Dental Practice

2000 ◽  
Vol os7 (4) ◽  
pp. 141-144 ◽  
Author(s):  
Piyush Patel ◽  
Michael Forbes ◽  
John Gibson
Keyword(s):  
Patient Information ◽  
Dental Treatment ◽  
Dental Practice ◽  
Target Groups ◽  
Simple Modification ◽  
New Methods ◽  
General Dental Practice ◽  
Practice Population ◽  
Financial Income

Purpose of study Accumulation of time lost because of broken appointments in general dental practice can lead to an inefficiently-run practice and may also lead to reduced financial income. This study assessed the reasons for patients failing to attend and analysed the effect of two simple interventions in reducing the numbers of broken appointments. Basic procedures This study audited the causes of broken appointments in a Glasgow dental practice over a four-month period and, in a second four-month period, analysed the effect of using two new methods of patient information in reducing the number of broken appointments in two target groups of the practice population. Main findings The majority of patients failing to attend for dental treatment were unemployed. Simple changes to recall letters and appointment cards significantly reduced the rates of failed appointments in patients attending the practice. Principal conclusions Simple modification to existing practice systems (recall letters and appointment cards) led to a statistically significant reduction in the number of broken appointments.

An Audit of Dental General Anaesthetic Referral from a General Dental Practice in South Wales

2009 ◽  
Vol os16 (4) ◽  
pp. 143-147 ◽  
Author(s):  
Wayne Richards ◽  
Kamran Razzaq ◽  
Gary Higgs
Keyword(s):  
Dental Treatment ◽  
Continuing Care ◽  
General Anaesthetic ◽  
Dental Practice ◽  
Treatment Pathways ◽  
Individual Level ◽  
General Dental Practice ◽  
Number Of Teeth ◽  
Number Of Patients ◽  
Deprived Areas

Aims The aim of this audit was to quantify the number of patients that received a dental general anaesthetic (DGA) between 1999 and 2007 following referral from a general dental practice. It also aimed to establish the deprivation status of those referred and to investigate further dental treatment pathways of these patients. Methods Data were collected from all patient records held by the practice. The information collected included: postcode, gender, age at the close of the study, age at time of DGA, reason for DGA, number of teeth extracted, and details of further ongoing care. In the absence of individual level socioeconomic data, a deprivation score (derived from the Welsh Index of Multiple Deprivation [WIMD]) was appended to each record in order to provide a measure of deprivation based on the postcode of the patient. Results Two hundred and eighty-seven patients were referred for DGA during the nine-year period. Their mean age was 9.4 years (95% confidence interval [CI] = 8.4, 10.4) and 30.7% were children aged five years or younger. The most common reason for DGA was dental caries. The mean number of teeth extracted was 4.5 (95% CI = 4.1, 4.9). Patients living in deprived areas were more likely to be referred for DGA. Of the 87 who did not subsequently attend for continuing care, 72 were from deprived areas compared with 15 from more affluent areas ( P=0.003). Conclusions In proportion to the number of patients registered at a practice, the number of referrals for DGAs was relatively low. Patients categorised as deprived (based on their residential postcode) received more referrals for DGAs than those from more affluent areas. Patients from deprived locations were significantly more likely not to attend for continuing care after their DGA than those from more affluent areas.

scholarly journals FEATURES OF USING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN DENTAL PRACTICE

2018 ◽  
Vol 25 (5) ◽  
pp. 48-52
Author(s):  
A. K. Iordanishvili ◽  
A. I. Dyagilev ◽  
O. N. Risovannaya ◽  
V. Yu. Skorikov ◽  
V. L. Popkov
Keyword(s):  
Pain Relief ◽  
Work Experience ◽  
Pain Syndrome ◽  
Cyclooxygenase Inhibitors ◽  
Dental Practice ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Dental Clinics ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

Aim. This study was conducted to assess the awareness of dentists about the questions of pharmacokinetics and pharmacodynamics of nonsteroidal anti-inflammatory drugs as well as to study the features of their use for the relief of pain syndrome in dental practice.Materials and methods. By means of the questionnaires were studied 107 dentists working in dental clinics and dental departments of General hospitals, especially their use of the nonsteroidal anti-inflammatory drugs for pain relief.Results. It was determined that 85% of doctors use non-selective and moderately selective cyclooxygenase inhibitors (COX), 15%-prefer Cox-2 inhibitor with the pronounced selectivity for pain relief. The highest number of correct answers was given by a group of doctors with work experience from 5 to 10 years (40.3%), the lowest – by doctors with work experience more than 20 years, respectively 40.3% and 36.1% of the total number of doctors from the studied groups.Conclusion. There was noted that it is necessary to pay attention to the peculiarities of pain relief for the improvement of dentists’ work as well as to involve clinical pharmacologists for these purposes. 

scholarly journals ANALYSIS OF THE USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN DOMESTIC DENTAL PRACTICE

2021 ◽  
Vol 1 (1) ◽  
pp. 307
Author(s):  
Т. А. Petrova ◽  
R. V. Lutsenko ◽  
Т. О. Devyatkina ◽  
G. Yu. Ostrovska ◽  
E. G. Kolot ◽  
...  
Keyword(s):  
Dental Practice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Study of the expression of functionally relative genes in the treatment of coronavirus infection in chickens

2021 ◽  
Vol 51 (5) ◽  
pp. 68-76
Author(s):  
A. S. Bobikova ◽  
V. S. Cherepushkina ◽  
T. E. Mironova ◽  
V. N. Afonyushkin ◽  
N. A. Donchenko ◽  
...  
Keyword(s):  
Integrated Approach ◽  
Antiviral Drugs ◽  
Inflammatory Activity ◽  
Control Group ◽  
Virus Particles ◽  
Infectious Bronchitis ◽  
System A ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Experimental Group

The level of expression of anti-inflammatory cytokines NF-kB, IL-6, IFN-y, Caspasa-3, FC in chickens in the lungs and intestines during the modeling of infectious bronchitis in chickens was studied. To simulate coronavirus pneumonia, the vaccine was administered individually, 10 doses per head orally. The chickens of the 1st experimental group were fed with the Lyumantse preparation at the rate of 3 kg / t of feed, the 2nd experimental group received the Glitsevir drug at the rate of 200 μg / 0.3 ml per head. The chickens of the control group did not receive the preparations. It was revealed that antiviral drugs in the experimental groups suppressed the destruction of epithelial cells in the intestine. This may not always be an indication of a positive character, as in the case of apoptosis, not only the intestinal cells affected by the virus particles but also healthy cells are destroyed. There was a decrease in the number of active macrophages in the intestines of the experimental groups relative to the control. The amount of interferon produced was also below the control, which indicates a decreased activity of the immune system. A higher pro-inflammatory activity in the respiratory system of chickens was detected when Glicevir was used. It consists of increased expression of IL-6, interferon-gamma, macrophage receptor to Fc antibody fragments and inflammatory regulatory factor NF-kB genes compared to Lumantse with anti-inflammatory activity, but also compared to untreated control group chickens. It is concluded that it is possible to predict the risk of an exacerbation of an infectious process in the lungs against the background of a local decrease in the viral load in the intestine. An integrated approach is needed in the treatment of coronavirus infections, including either systemic antiviral drugs or anti-inflammatory drugs.

scholarly journals Use of psychopharmaceuticals during COVID-19 treatment

2020 ◽  
Vol 52 (1-2) ◽  
pp. 89-97
Author(s):  
Maja Milosavljević ◽  
Olivera Vuković
Keyword(s):  
Drug Interactions ◽  
Enzyme Level ◽  
Antiviral Drugs ◽  
Qtc Interval ◽  
Number Of Patients ◽  
Inflammatory Drugs ◽  
Therapeutic Protocols ◽  
Anti Inflammatory ◽  
Treatment Of Infection

No specific cure has been found since the beginning of the COVID-19 pandemic. In the treatment of infection caused by SARS-CoV-2 virus, therapeutic protocols include drugs of different groups: antiviral drugs, antibodies, antibiotics, anti-inflammatory drugs, etc. It can be expected that a certain number of patients who are receiving therapy with psychopharmacotherapy will get sick from COVID-19, but we also know that the infection itself has certain psychological manifestations. Due to the above, the use of psychopharmacotherapy together with other drugs in the therapy of COVID-19 is sometimes unavoidable. Co-administering these drugs has to be with caution due to the potential prolongation of the QTc interval, drug interactions at the CYP enzyme level, and the associated potential for agranulocytosis.

scholarly journals Application of IARTI and Ameliorating Principles to Improve Compliance and Completion of Treatment in General Dental Practice

2021 ◽  
pp. 23-25
Author(s):  
Louis ZG Touyz ◽  
Leonardo M Nassani
Keyword(s):  
Practice Management ◽  
Initial Assessment ◽  
Dental Practice ◽  
Depression And Anxiety ◽  
Hospital Practice ◽  
Performance Loss ◽  
General Dental Practice ◽  
Dental Practitioners ◽  
Improve Compliance ◽  
Principles Of Practice

Introduction: Many General Dental Practitioners run single handedly a mini-hospital. Practice administration, delivery of treatment and financial stewardship are all demanding with consequent induction of uncertainty, distress, and diminished performance, loss of satisfaction and unwelcome depression and anxiety. Aim: This contribution describes moderation of stresses in general dental practice by applying amelioration policies. Discussion: This advisory is targeted at all dentists involved in extensive dental therapy. The stress and anxiety of practice management is improved by applying newly established principles of practice, namely the Initial Assessment and Ranking of Treatment Index (IARTI) and What arrangements Have you made to meet your Oligations (WAHUM TOMYO), Immediate Payment Therapy (IPP) and Big Toe Philosophy (BTP). Conclusion: By applying these fundamental principles into general dental practice, much anxiety is relieved, challenges and problems are avoided or resolved and successful practice of dentistry is realized. A much higher frequency of failures will occur if these principles are not applied. Success does depend on applying IARTI and WAHUM TOMYO, IPP and BTP.

Sign in / Sign up

Export Citation Format

Share Document