scholarly journals Hematopoietic Cell Renewal as the Limiting Factor in Low-Level Radiation Exposure: Diagnostic Implications and Therapeutic Options

2002 ◽  
Vol 167 (suppl_1) ◽  
pp. 46-48 ◽  
Author(s):  
Theodor M. Fliedner ◽  
Iris Friesecke ◽  
Dieter Graessle ◽  
Carola Paulsen ◽  
Melanie Weiss
Keyword(s):  
Radiation Exposure ◽  
Hematopoietic Cell ◽  
Therapeutic Options ◽  
Limiting Factor ◽  
Cell Renewal ◽  
Low Level

scholarly journals Vodnyi: a Long-term, Low-level Radiation Exposure Field Site in Russia

2003 ◽  
Vol 38 (4) ◽  
pp. 332-343 ◽  
Author(s):  
Anatoly I. TASKAEV ◽  
Edward R. LANDA ◽  
Denis V. GURYEV ◽  
Natalia GOLOVKO BUTLER ◽  
Thomas F. KRAEMER
Keyword(s):  
Radiation Exposure ◽  
Field Site ◽  
Low Level ◽  
Exposure Field

Mapping of urban geoheritage in city of Liberec using participatory research

2020 ◽  
Author(s):  
Emil Drápela
Keyword(s):  
Participatory Research ◽  
Research Methodology ◽  
City Centre ◽  
Limiting Factor ◽  
Practical Application ◽  
Technical Parameters ◽  
Low Level ◽  
The Future ◽  
Professional Value

Urban geoheritage is a phenomenon that is present in almost every city, but so far, only some cities use it as a tourist product. In May and June 2019, in order to create an urban geoheritage trail in Liberec, it was mapped in the wider city centre. Considering the vastness of the area, mapping was carried out by volunteers who were interested in the topic of popularization of geology but did not have the expertise of geological knowledge. This lack of expertise may seem to be a significant limiting factor, but in fact, it is a positive thing, as the knowledge of the mapping volunteer is at a similar (low) level to the future user of the educational trail. Thus, in the evaluation of geosites, the expert-layman barrier is eliminated and the benefit is the feedback of the future user. However, participatory research has its own specifics, which must be adapted to the methodology used. First, it is to ensure the homogeneity of the data that is collected by a large number of volunteers and which can be influenced by subjective influences. Furthermore, it is their professional value and practical application. Finally, yet importantly, the technical parameters of data that will be further processed in GIS. This paper describes the research methodology used and summarizes the experience with the use of participatory research for the purpose of mapping urban geoheritage in Liberec.

Phase III trial of low-level laser therapy to prevent induced oral mucositis in head and neck cancer patients submitted to concurrent chemoradiation.

2011 ◽  
Vol 29 (18_suppl) ◽  
pp. LBA5524-LBA5524 ◽  
Author(s):  
H. S. Antunes ◽  
D. Herchenhorn ◽  
C. M. Araujo ◽  
E. Cabral ◽  
E. M. d. S. Ferreira ◽  
...  
Keyword(s):  
Head And Neck ◽  
Laser Therapy ◽  
Oral Mucositis ◽  
Phase Iii ◽  
Low Level Laser Therapy ◽  
Limiting Factor ◽  
Phase Iii Trial ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

LBA5524 Background: Oral mucositis (OM) remains a limiting factor in in head and neck squamous cell carcinomas (HNSCC) patients (pts) treated with chemoradiation (CRT) leading to pain, dysphagia, and weight loss. Low-level laser therapy (LLLT) emerges as a promising, preventive therapy of CRT-induced OM. Yet, a definitive randomized trial supporting its use is lacking. This study was designed to assess the efficacy of LLLT in reducing the incidence and/or severity of OM. Methods: Assuming OM grade (G3) for placebo 0.4 (P0); LLLT 0.15 (P1) ; β=0.2; α=0.05, sample size was 94 pts. From Jun 2007 to Dec 2010, 47 LLLT and 47 placebo pts bearer of HNSCC of nasopharynx, oropharynx and hipopharynx entered a prospective, randomized, double blind, placebo-controlled, phase III trial. CRT consisted of conventional RT 70.2 Gy (1.8Gy/d, 5 times/wk) + concurrent cisplatin 100 mg/m2 every 3 wks. Main endpoints were OM incidence and severity, RT interruptions due to OM and pain intensity. The LLLT used daily was a diode InGaAlP (660nm-100mW-4J/cm²). OM evaluation was done by WHO and OMAS scale. Results: Mean age was 54.6 and 87.2% of pts were male. Primary site: oropharynx (74 pts), nasopharynx (9 pts), hypopharynx (11 pts). In the LLLT arm the incidence of OM G 3/4 was only 6.4% versus 48% in the placebo arm; HR of 0.13 (IC 95%, p<0.001). Besides in the LLLT arm 51% of pts did not have ulcers versus 17% in placebo arm (p<0.001). LLLT pts had less severe pain (p=0.012), used less narcotic analgesic, HR 0.33 (IC 95%, p<0.001) and required less gastrostomia, HR 0.037 (IC 95%, p= 0.005). No LLLT pts had RT interrupted due to OM. EORTC QLQ-C30 and its specific head and neck module QLQ-H&N35 were applied. Results clearly favored the LLLT arm. In QLQ-C30 benefit was seen in both physical and emotional functioning (p=0.037), fatigue (p=0.011), pain (p=0.043); and in QLQ-H&N35, pain (p=0.007), swallowing (p=0.001) and trouble with social eating (p=0.026). Conclusions: Our results indicate that upfront LLLT in HNSCC pts submitted to CRT is an effective tool in reducing G 3/4 OM, oral pain, use of narcotic and gastrostomia. QoL data supports the efficacy findings. Thereby LLLT should be the new standard of care in this setting.

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