scholarly journals GILL EVACUATION AND RELEASE OF GLOCHIDIA BY UNIO PICTORUM AND UNIO TUMIDUS (BIVALVIA: UNIONIDAE) UNDER THERMAL AND HYPOXIC STRESS

2003 ◽  
Vol 69 (1) ◽  
pp. 55-59 ◽  
Author(s):  
DAVID C. ALDRIDGE ◽  
ANNA L. McIVOR
Keyword(s):  
Hypoxic Stress ◽  
Unio Tumidus ◽  
Unio Pictorum

The impact of in vivo and in vitro exposure to base analogue 5-FU on the level of DNA damage in haemocytes of freshwater mussels Unio pictorum and Unio tumidus

2014 ◽  
Vol 191 ◽  
pp. 145-150 ◽  
Author(s):  
Zoran Gačić ◽  
Stoimir Kolarević ◽  
Karolina Sunjog ◽  
Margareta Kračun-Kolarević ◽  
Momir Paunović ◽  
...  
Keyword(s):  
Dna Damage ◽  
Freshwater Mussels ◽  
In Vitro Exposure ◽  
Unio Tumidus ◽  
The Impact ◽  
Unio Pictorum

scholarly journals Distribution and recent status of freshwater mussels of family Unionidae (Bivalvia) in the Czech Republic

2019 ◽  
pp. 45 ◽  
Author(s):  
Luboš Beran
Keyword(s):  
Czech Republic ◽  
Anodonta Cygnea ◽  
The Czech Republic ◽  
Restricted Area ◽  
Water Abstraction ◽  
Allochthonous Species ◽  
Unio Tumidus ◽  
Fish Hosts ◽  
Unio Pictorum ◽  
Sinanodonta Woodiana

This study is devoted mainly to the distribution and its changes, inhabited and preferable habitats of bivalves from family Unionidae in the territory of the Czech Republic and the discussion of major threats and conservation measures. Altogether 6 autochthonous (Unio crassus, Unio pictorum, Unio tumidus, Anodonta anatina, Anodonta cygnea, Pseudanodonta complanata) and 1 allochthonous species (Sinanodonta woodiana) has been known in the Czech Republic. All these species occurred in all three river basins (Labe, Odra, Danube) and watersheds (North, Baltic and Black seas). A. anatina is the most widespread and common unionid while P. complanata is an autochthonous bivalve with the most restricted area of distribution. U. crassus has been a significantly disappearing species. As in most European countries, pollution and habitat loss including fragmentation and degradation, together with other factors such as water abstraction, invasive species and loss of fish hosts are the main threats affecting their populations.

Comparative study of the genotoxic response of freshwater mussels Unio tumidus and Unio pictorum to environmental stress

Hydrobiologia ◽  
2013 ◽  
Vol 735 (1) ◽  
pp. 221-231 ◽  
Author(s):  
Branka Vuković-Gačić ◽  
Stoimir Kolarević ◽  
Karolina Sunjog ◽  
Jelena Tomović ◽  
Jelena Knežević-Vukčević ◽  
...  
Keyword(s):  
Comparative Study ◽  
Environmental Stress ◽  
Freshwater Mussels ◽  
Unio Tumidus ◽  
Unio Pictorum

Hypoxic stress responses and levetiracetam: Differential regulation of hypoxia-inducible neuroprotective factors in fetal mouse brain

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
R Trollmann ◽  
J Schneider ◽  
D Wenzel ◽  
W Rascher ◽  
O Ogunshola ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Stress Responses ◽  
Differential Regulation ◽  
Hypoxic Stress ◽  
Fetal Mouse

scholarly journals Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yanxia Zhan ◽  
Junxian Du ◽  
Zhihui Min ◽  
Li Ma ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Breast Cancer Cells ◽  
Hypoxic Stress ◽  
Cellular Functions ◽  
Breast Cancer Therapy ◽  
Array Analysis ◽  
Cancer Stroma ◽  
Carcinoma Associated Fibroblasts

AbstractHypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer. The circRNA array analysis was performed to screen differential expressed circRNAs between hypoxic and normoxic CAFs exosomes. Candidate circHIF1A (circ_0032138) was screened out and it was confirmed that circHIF1A was up-regulated in the exosomes from hypoxic CAFs and their exosomes. Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic CAFs exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression. In a summary, circHIF1A from hypoxic CAFs exosomes played an important role in stem cell properties of breast cancer. CircHIF1A may act as a target molecule of breast cancer therapy.

scholarly journals Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress

2021 ◽  
Vol 22 (4) ◽  
pp. 1520
Author(s):  
Marina A. Mikeladze ◽  
Elizaveta A. Dutysheva ◽  
Victor G. Kartsev ◽  
Boris A. Margulis ◽  
Irina V. Guzhova ◽  
...  
Keyword(s):  
Cell Death ◽  
Hypoxic Stress ◽  
C6 Cells ◽  
Tumor Resistance ◽  
Glioblastoma Cells ◽  
Enzyme Expression ◽  
Hsp70 Chaperone ◽  
Therapeutic Tools ◽  
Enzyme Molecules

Hypoxia, which commonly accompanies tumor growth, depending on its strength may cause the enhancement of tumorigenicity of cancer cells or their death. One of the proteins targeted by hypoxia is glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and we demonstrated here that hypoxia mimicked by treating C6 rat glioblastoma cells with cobalt chloride caused an up-regulation of the enzyme expression, while further elevation of hypoxic stress caused the enzyme aggregation concomitantly with cell death. Reduction or elevation of GAPDH performed with the aid of specific shRNAs resulted in the augmentation of the tumorigenicity of C6 cells or their sensitization to hypoxic stress. Another hypoxia-regulated protein, Hsp70 chaperone, was shown to prevent the aggregation of oxidized GAPDH and to reduce hypoxia-mediated cell death. In order to release the enzyme molecules from the chaperone, we employed its inhibitor, derivative of colchicine. The compound was found to substantially increase aggregation of GAPDH and to sensitize C6 cells to hypoxia both in vitro and in animals bearing tumors with distinct levels of the enzyme expression. In conclusion, blocking the chaperonic activity of Hsp70 and its interaction with GAPDH may become a promising strategy to overcome tumor resistance to multiple environmental stresses and enhance existing therapeutic tools.

scholarly journals High Plasma Cystine Levels Are Associated with Blood Pressure and Reversed by CPAP in Patients with Obstructive Sleep Apnea

2021 ◽  
Vol 10 (7) ◽  
pp. 1387
Author(s):  
Raphael Boneberg ◽  
Anita Pardun ◽  
Lena Hannemann ◽  
Olaf Hildebrandt ◽  
Ulrich Koehler ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Mononuclear Cells ◽  
Vascular Risk Factor ◽  
High Plasma ◽  
Apnea Hypopnea Index ◽  
Hypoxic Stress ◽  
Peripheral Blood Mononuclear ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) independent of obesity (OBS) imposes severe cardiovascular risk. To what extent plasma cystine concentration (CySS), a novel pro-oxidative vascular risk factor, is increased in OSA with or without OBS is presently unknown. We therefore studied CySS together with the redox state and precursor amino acids of glutathione (GSH) in peripheral blood mononuclear cells (PBMC) in untreated male patients with OSA (apnea-hypopnea-index (AHI) > 15 h−1, n = 28) compared to healthy male controls (n = 25) stratifying for BMI ≥ or < 30 kg m−2. Fifteen OSA patients were reassessed after 3–5-months CPAP. CySS correlated with cumulative time at an O2-saturation <90% (Tu90%) (r = 0.34, p < 0.05) beside BMI (r = 0.58, p < 0.001) and was higher in subjects with “hypoxic stress” (59.4 ± 2.0 vs. 50.1 ± 2.7 µM, p < 0.01) defined as Tu90% ≥ 15.2 min (corresponding to AHI ≥ 15 h−1). Moreover, CySS significantly correlated with systolic (r = 0.32, p < 0.05) and diastolic (r = 0.31, p < 0.05) blood pressure. CPAP significantly lowered CySS along with blood pressure at unchanged BMI. Unexpectedly, GSH antioxidant capacity in PBMC was increased with OSA and reversed with CPAP. Plasma CySS levels are increased with OSA-related hypoxic stress and associated with higher blood pressure. CPAP decreases both CySS and blood pressure. The role of CySS in OSA-related vascular endpoints and their prevention by CPAP warrants further studies.

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