scholarly journals MO074RENAL FUNCTION DECLINE IN OLDER MEN AND WOMEN WITH ADVANCED CKD - RESULTS FROM THE EQUAL STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nicholas Chesnaye ◽  
Friedo W Dekker ◽  
Marie Evans ◽  
Fergus Caskey ◽  
Claudia Torino ◽  
...  
Keyword(s):  
Renal Function ◽  
Negative Impact ◽  
Patient Characteristics ◽  
Older Men ◽  
Informative Censoring ◽  
Dialysis Initiation ◽  
Joint Models ◽  
Men And Women ◽  
Observational Prospective Cohort Study ◽  
Older Men And Women

Abstract Background and Aims Understanding the mechanisms underlying the differences in renal decline between men and women may improve sex-specific clinical monitoring and management. To this end, we aimed to compare the slope of renal function decline in older men and women in CKD 4-5, taking into account informative censoring related to the sex-specific risks of mortality and dialysis initiation. Method The EQUAL study is an observational prospective cohort study in stage 4-5 CKD patients ≥65 years not on dialysis. Data on clinical and demographic patient characteristics were collected between April 2012 to December 2018. eGFR was calculated using the CKD-EPI equation. Linear mixed models were used to model the eGFR trajectory by sex, and joint models were applied to deal with informative censoring. Results We included 7801 eGFR measurements in 1682 patients over 2911 years of follow-up. Renal function declined 14.0% (95% CI 12.9%-15.1%) on average each year. Renal function declined faster in men (16.2% per year, 95% CI 15.9%-17.1%) compared with women (9.6% per year, 95% CI 6.3%-12.1%), which remained largely unchanged after accounting for various mediators, and for informative censoring due to mortality and dialysis initiation. We identified effect modification by diabetes, with faster declines in renal function found especially in women with diabetes. Conclusion In conclusion, renal function declines faster in men compared with women, which remained similar after adjustment for mediators, and despite a higher risk of informative censoring in men. We demonstrate a disproportional negative impact of diabetes specifically in women.

scholarly journals Renal function decline in older men and women with advanced chronic kidney disease—results from the EQUAL study

2020 ◽  
Author(s):  
Nicholas C Chesnaye ◽  
Friedo W Dekker ◽  
Marie Evans ◽  
Fergus J Caskey ◽  
Claudia Torino ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Negative Impact ◽  
Older Men ◽  
Informative Censoring ◽  
Dialysis Initiation ◽  
Men And Women ◽  
Renal Function Decline ◽  
Older Men And Women

Abstract Introduction Understanding the mechanisms underlying the differences in renal decline between men and women may improve sex-specific clinical monitoring and management. To this end, we aimed to compare the slope of renal function decline in older men and women in chronic kidney disease (CKD) Stages 4 and 5, taking into account informative censoring related to the sex-specific risks of mortality and dialysis initiation. Methods The European QUALity Study on treatment in advanced CKD (EQUAL) study is an observational prospective cohort study in Stages 4 and 5 CKD patients ≥65 years not on dialysis. Data on clinical and demographic patient characteristics were collected between April 2012 and December 2018. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. eGFR trajectory by sex was modelled using linear mixed models, and joint models were applied to deal with informative censoring. Results We included 7801 eGFR measurements in 1682 patients over a total of 2911 years of follow-up. Renal function declined by 14.0% [95% confidence interval (CI) 12.9–15.1%] on average each year. Renal function declined faster in men (16.2%/year, 95% CI 15.9–17.1%) compared with women (9.6%/year, 95% CI 6.3–12.1%), which remained largely unchanged after accounting for various mediators and for informative censoring due to mortality and dialysis initiation. Diabetes was identified as an important determinant of renal decline specifically in women. Conclusion In conclusion, renal function declines faster in men compared with women, which remained similar after adjustment for mediators and despite a higher risk of informative censoring in men. We demonstrate a disproportional negative impact of diabetes specifically in women.

Exercise training in older men and women: Effects on cardiovascular and renal function

1996 ◽  
Vol 6 (1) ◽  
pp. 27-34 ◽  
Author(s):  
James V. Jessup ◽  
David T. Lowenthal ◽  
Michael L. Pollock ◽  
Kathleen A. Smyth ◽  
Leonard Williams ◽  
...  
Keyword(s):  
Renal Function ◽  
Exercise Training ◽  
Older Men ◽  
Men And Women ◽  
Older Men And Women

The Case of Thematic Tests Adapted to Older Adults

2011 ◽  
Vol 32 (1) ◽  
pp. 46-71 ◽  
Author(s):  
Benoît Verdon
Keyword(s):  
Older Adults ◽  
Older Persons ◽  
Older Men ◽  
Elderly Persons ◽  
Mental Processes ◽  
Men And Women ◽  
Projective Tests ◽  
New Material ◽  
Older Men And Women ◽  
Latent Content

Since the 1950s, the growing interest of clinicians in using projective tests to study normal or pathological aging processes has led to the creation of several thematic tests for older adults. This development reflects their authors’ belief that the TAT is not suitable to the concerns and anxieties of elderly persons. The new material thus refers explicitly to situations related to age; it aims to enable older persons to express needs they cannot verbalize during consultations. The psychodynamic approach to thematic testing is based on the differentiation between the pictures’ manifest and latent content, eliciting responses linked to mental processes and issues the respondent is unaware of. The cards do not necessarily have to show aging characters to elicit identification: The situations shown in the pictures are linked to loss, rivalry, helplessness, and renunciation, all issues elderly respondents can identify with and that lead them to express their mental fragilities and resources. The article first explains the principles underlying four of these thematic tests, then develops several examples of stories told for card 3BM of the TAT, thus showing the effectiveness of this tool for the understanding and differentiation of loss-related issues facing older men and women.

Clyde Warrior, 1939–1968

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Tiffany Hale
Keyword(s):  
Native Americans ◽  
Older Men ◽  
The United States ◽  
Men And Women ◽  
Student Nonviolent Coordinating Committee ◽  
Political Struggles ◽  
Poor People's Campaign ◽  
Organizational Leader ◽  
Martin Luther King ◽  
Older Men And Women

To identify Clyde Warrior as an intellectual subverts prevailing notions of intellectualism. We often think of intellectuals as older men and women whose major contributions are revealed late in life, once the passions of youth have been tempered by experience. Warrior was not this. People frequently imagine intellectuals as existing in isolation, insulated from the demands of regular folk. Warrior was not this either. He was a Ponca, born on the reservation and raised with the influence of his grandparents and community. He was also a renowned singer and powwow fancy dancer, as well as a college student, an organizational leader, a husband, and father of two daughters. Warrior’s political consciousness grew out of the deep connections he maintained to his rural Ponca roots, but he took care to educate himself about the problems affecting Native Americans across the United States as well as colonized peoples globally. As an Oklahoman, he was attuned to race relations in the South and empathized with the struggles of Africans and African Americans. His approach to indigenous political struggles was shaped and informed, for example, by his early and active participation with the Student Nonviolent Coordinating Committee (SNCC) and Martin Luther King Jr.’s Poor People’s Campaign.

scholarly journals Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study

2021 ◽  
Author(s):  
Estella Musacchio ◽  
Pierluigi Binotto ◽  
Fatima Silva-Netto ◽  
Egle Perissinotto ◽  
Leonardo Sartori
Keyword(s):  
Older Men ◽  
Dental Status ◽  
Men And Women ◽  
Older Men And Women

scholarly journals Determinants of Bone Mineral Density in Older Men and Women: Body Composition as Mediator

2001 ◽  
Vol 16 (11) ◽  
pp. 2142-2151 ◽  
Author(s):  
S. M. F. Pluijm ◽  
M. Visser ◽  
J. H. Smit ◽  
C. Popp-Snijders ◽  
J. C. Roos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Older Men ◽  
Mineral Density ◽  
Men And Women ◽  
Older Men And Women

Medical Need and Use of Services Among Older Men and Women

1988 ◽  
Vol 43 (5) ◽  
pp. S162-S171 ◽  
Author(s):  
E. Mutran ◽  
K. F. Ferraro
Keyword(s):  
Older Men ◽  
Men And Women ◽  
Medical Need ◽  
Use Of Services ◽  
Older Men And Women

P-174: Type 2 diabetes and cognitive decline in a large sample of community-dwelling older men and women

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S154-S154
Author(s):  
Olivia I. Okereke ◽  
Jae H. Kang ◽  
Nancy R. Cook ◽  
J. Michael Gaziano ◽  
JoAnn E. Manson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Decline ◽  
Older Men ◽  
Community Dwelling ◽  
Men And Women ◽  
Large Sample ◽  
Older Men And Women
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