scholarly journals MO505IMPACT OF THE COVID-19 PANDEMIC ON SYMPTOMS OF ANXIETY AND DEPRESSION AND HEALTH-RELATED QUALITY OF LIFE IN OLDER PATIENTS WITH CHRONIC KIDNEY DISEASE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Carlijn Voorend ◽  
Mathijs Van Oevelen ◽  
Margot Nieberg ◽  
Yvette Meuleman ◽  
Casper Franssen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Kidney Disease ◽  
Older Patients ◽  
Mental Health Problems ◽  
Emotional Symptoms ◽  
Related Quality ◽  
Health Related ◽  
Physical Hrqol

Abstract Background and Aims Older patients with advanced chronic kidney disease (CKD) are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced CKD. Method An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR <20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally. Results The 82 included patients had a median age of 77.5 years (inter-quartile range 73.9-82.1), 77% was male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious for COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic (Figure 1). Higher COVID-19-related stress was associated with a lower education level (p=0.036), and patients who reported to feel more down due to COVID-19 were more often female (p=0.020). Anxiety scores were higher among females compared to males (median 4.0 [IQR 3.0-9.0] versus 2.0 [0.0-6.0], p=0.020), and weakly associated to a decline in eGFR (correlation coefficient 0.197, p=0.023). Compared to pre-COVID-19, presence of depressive symptoms had increased (11% to 22%; p=0.022) and physical HRQoL declined (40.4±10.1 to 36.1±10.4, p<0.001). Mental HRQoL (50.3±9.6 to 50.4±9.9; p=0.913) and emotional symptoms remained similar. Males showed a greater decline in physical HRQoL (mean -5.3, SD 8.5) compared to females (mean -0.9, SD 5.7; p=0.039). Conclusion Our findings show that older patients with advanced CKD suffered from disease-related anxiety for COVID-19, increased depressive symptoms, and reduced physical HRQOL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental health problems during the pandemic is essential. More in-depth investigation on disease-related COVID-19 concerns and its implications for the CKD population is needed.

scholarly journals Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
C. G. N. Voorend ◽  
M. van Oevelen ◽  
M. Nieberg ◽  
Y. Meuleman ◽  
C. F. M. Franssen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Depressive Symptoms ◽  
Kidney Disease ◽  
Older Patients ◽  
Mental Wellbeing ◽  
Emotional Symptoms ◽  
Advanced Chronic Kidney Disease ◽  
Related Quality

Abstract Background Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease. Methods An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR < 20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May–June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally. Results The 82 included patients had a median age of 77.5 years (interquartile range 73.9–82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar. Conclusions Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important. Trial registration The study is registered at the Netherlands Trial Register (NTR), trial number NL7104. Date of registration: 06-06-2018.

Systematic Nonpain Symptom Assessment and Management

2020 ◽  
pp. 167-177
Author(s):  
Hana Yu ◽  
Jennifer S. Scherer
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Sleep Disturbances ◽  
Future Research ◽  
Emotional Symptoms ◽  
Uremic Pruritus ◽  
Evidence Based Treatments ◽  
Related Quality ◽  
Health Related

Patients with advanced chronic kidney disease (CKD) suffer from a substantial burden of physical and emotional symptoms that adversely affect their health-related quality of life. Their number of symptoms when systematically evaluated is comparable to cancer patients. Overall symptom burden and severity are correlated directly with impaired quality of life and depression. Among the most frequent are fatigue, pain, pruritus, sleep disturbances and poor appetite. This chapter highlights one of the most common and troublesome of these symptoms affecting advanced CKD patients, particularly those with end-stage kidney disease: uremic pruritus. The epidemiology, pathophysiology, and current evidence-based treatments are discussed as a way to provide a practical guide for diagnosis and treatment. Lastly, areas for future research to improve symptom management in this growing, chronically ill population are identified.

scholarly journals Depression Levels Following Discharge Predict Quality of Life in Heart Disease Patients

2019 ◽  
Vol 35 ◽  
Author(s):  
Mariantonia Lemos ◽  
Juan Pablo Román- Calderón ◽  
Paula Cristina Rios ◽  
Susana Torres ◽  
Diana María Agudelo
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Linear Growth ◽  
Growth Models ◽  
Stress Measure ◽  
Related Quality ◽  
Health Related ◽  
Physical Hrqol

Abstract Depression and stress have been related with poor Health Related Quality of Life (HRQoL) prognosis. However, it is not clear when these depressive symptoms should be measured. A sample of 177 Coronary Heart Disease patients were followed for 15 months aimed to compare the effect of depression and stress measure at time of hospitalization and three months later on the physical HRQoL trajectory. Linear growth models’ results showed that depression and stress after discharge are negatively correlated with the physical HRQoL and depressive symptoms negatively affect the prognosis of these patients.

scholarly journals Depressive symptoms, mental health-related quality of life, and survival among older patients with multiple myeloma

2019 ◽  
Vol 28 (9) ◽  
pp. 4097-4106
Author(s):  
Ali Alobaidi ◽  
Nadia A. Nabulsi ◽  
Brian Talon ◽  
Alemseged A. Asfaw ◽  
Jifang Zhou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Myeloma ◽  
Depressive Symptoms ◽  
Older Patients ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Medication Adherence, Burden and Health-Related Quality of Life in Adults with Predialysis Chronic Kidney Disease: A Prospective Cohort Study

2020 ◽  
Vol 17 (1) ◽  
pp. 371 ◽  
Author(s):  
Wubshet H. Tesfaye ◽  
Charlotte McKercher ◽  
Gregory M. Peterson ◽  
Ronald L. Castelino ◽  
Matthew Jose ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Medication Adherence ◽  
Kidney Disease ◽  
Health Related Quality ◽  
Regimen Complexity ◽  
Related Quality ◽  
Health Related ◽  
Physical Hrqol ◽  
Over Time

This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m2. Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.

scholarly journals Health-Related Quality of Life, Depressive Symptoms, Anxiety, and Somatization Symptoms in Male and Female Patients with Chronic Tinnitus

2021 ◽  
Vol 10 (13) ◽  
pp. 2798
Author(s):  
Benjamin Boecking ◽  
Raphael Biehl ◽  
Petra Brueggemann ◽  
Birgit Mazurek
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Chronic Tinnitus ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Male Patients ◽  
Gender Specific ◽  
Physical Hrqol

Objective: To investigate the joint impact of tinnitus-related distress (TRD), anxiety, depressive symptoms, and other somatization symptoms on health-related quality of life (HRQoL) in female vs. male patients with chronic tinnitus. Method: Three-hundred-and-fifty-two patients with chronic tinnitus completed audiological testing and a psychological assessment battery that comprised—among other measures—German versions of the Tinnitus Questionnaire, Hospital Anxiety and Depression Scale, Somatic Symptom Scale-8, and Health-Related Quality of Life scale. Descriptive analyses examined associations as well as within- and between-gender differences of the measured variables. Gender-specific serial indirect effects analyses aimed to explain the impact of TRD on HRQoL through psychological processes, notably anxiety, depressive symptoms, and somatization symptoms. Results: Both female and male patients yielded lower mental than physical HRQoL and negative associations between the measured psychological variables and HRQoL. Compared to male patients, female patients reported higher levels of tinnitus-related- and wider psychological distress, other somatization symptoms (e.g., headaches), and impairments in mental and physical HRQoL. For each gender, depressive symptoms, anxiety, and somatization symptoms fully mediated the effect of TRD on mental and physical HRQoL. A double-dissociation revealed an interaction of somatization symptoms and depression on the TRD-HRQoL association in women, and of somatization symptoms and anxiety in men. Conclusions: In patients with chronic tinnitus, psychological constructs account for reported impairments in both mental and physical HRQoL. To improve patients’ HRQoL, treatment conceptualizations should consider gender-specific psychological expressions of low mood or anxiety.

scholarly journals Health-Related Quality of Life among Cancer Survivors Depending on the Occupational Status

2021 ◽  
Vol 18 (7) ◽  
pp. 3803
Author(s):  
Kisook Kim ◽  
Hyohyeon Yoon
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Cancer Survivors ◽  
Occupational Status ◽  
Influential Factors ◽  
Health Related Quality ◽  
Factors Affecting ◽  
Related Quality ◽  
Health Related

The study aimed to identify and compare the factors affecting health-related quality of life (HRQoL) depending on the occupational status of cancer survivors. This study was a secondary data analysis from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2014 to 2018. Hierarchical multivariate linear regression was used to investigate the factors affecting the HRQoL of each group. Non-working cancer survivors had significantly lower HRQoL than working cancer survivors (p < 0.001). A hierarchical multiple regression model showed that demographic, health-related, and psychological characteristics explained 62.0% of non-working cancer survivors’ HRQoL (F = 4.29, p < 0.001). Among the input variables, health-related characteristics were the most influential factors (ΔR2 = 0.274, F = 9.84, p < 0.001). For working cancer survivors, health-related characteristics were the only variable that was statistically associated with HRQoL (F = 5.556, p < 0.001). It is important to enhance physical activities and manage the chronic disease to improve the HRQoL of working cancer survivors. Further, managing health-related characteristics, including depressive symptoms and suicidal ideation, is necessary for non-working cancer survivors. Regarding working survivors, psychological factors such as depressive symptoms and suicidal tendencies did not affect HRQoL. Therefore, an early and effective return to work program should be developed for the improvement of their HRQoL.

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