Survival following lung transplantation for silicosis and other occupational lung diseases

BACKGROUND Occupational lung diseases are diseases affecting the respiratory system, including occupational asthma, black lung disease and many more. Workers exposed to marble dust stand an increased risk of suffering from asthma symptoms, chronic bronchitis, nasal inflammation and impairment of lung functions. The recognition of occupational causes can be made difficult by years of latency between exposure in the workplace and the occurrence of disease. Through this study, authors have established the importance of early identification of symptoms of occupational lung diseases and the importance of preventive measures that can be applied to reduce incidence of such diseases. METHODS This was a cross sectional community-based study conducted on 340 marble mining or cutting workers of Rajnagar [Morwar], Rajsamand district of Rajasthan, for a duration of three months. Workers were clinically examined and asked about environmental conditions and use of preventive measures through a questionnaire designed by the investigators and with the help of pamphlets and videos, educational interventions were provided. RESULTS Almost 90 % of the workers didn’t use protective measure like mask or shield. Among the 10 % workers who were using safety measures, 60 % were using face mask and 20 % were using apron at the work place. After the educational intervention given by investigators, around 63 % had started using various safety measures. CONCLUSIONS Early interventions after development of symptoms are important as they can decrease chances of further worsening of the condition. Health education, periodic health check-ups and use of protective measures are the essence in preventing occupational lung diseases. KEYWORDS Occupational Lung Disease, Cough, Marble Workers, Silicosis

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The state of the cardiovascular system in occupational bronchitis and chronic obstructive pulmonary disease, not associated with the impact of harmful industrial factors

Terapevt (General Physician) ◽

10.33920/med-12-2103-08 ◽

2021 ◽

pp. 55-68

Author(s):

Vyacheslav S. Lotkov ◽

Anton Vladimirovich Glazistov ◽

Antonina G. Baykova ◽

Marina Yuryevna Vostroknutova ◽

Natalia E. Lavrentieva

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Cardiovascular System ◽

Pulmonary Disease ◽

Lung Diseases ◽

Chronic Obstructive ◽

External Respiration ◽

Obstructive Pulmonary Disease ◽

Occupational Lung Diseases ◽

The Right ◽

The Impact

The formation and progression of chronic dust bronchitis and chronic bronchitis of toxic-chemical etiology, chronic obstructive pulmonary disease is accompanied by an increase in the degree of ventilation disorders, echocardiographic signs of hypertrophy and dilatation of the right ventricle are formed, typical for chronic pulmonary heart disease. The progression of disturbances in the function of external respiration in dusty lung diseases leads to a decrease in myocardial contractility. The detection of hemodynamic disturbances at the early stages of the development of occupational lung diseases indicates the need for individual monitoring of the functional state of the cardiovascular system in the process of contact with industrial aerosols, especially in groups of workers with long-term exposure.

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Cytology of Nonneoplastic Occupational and Environmental Diseases of the Lung and Pleura

Archives of Pathology & Laboratory Medicine ◽

10.5858/2007-131-1700-conoae ◽

2007 ◽

Vol 131 (11) ◽

pp. 1700-1708 ◽

Cited By ~ 1

Author(s):

Rodolfo Laucirica ◽

Mary L. Ostrowski

Keyword(s):

Respiratory Tract ◽

Lung Diseases ◽

Asbestos Exposure ◽

Cell Hyperplasia ◽

Cytologic Examination ◽

Diagnostic Categories ◽

Etiologic Agents ◽

Limited Experience ◽

Occupational Lung Diseases

Abstract Context.—Cytologic examination of the respiratory tract has been a useful diagnostic tool when evaluating neoplastic lesions of the respiratory tract. However, we have limited experience in the application of this technique in the management of nonneoplastic occupational and environmental diseases of the lung and pleura. This review focuses on the cytologic characteristics of a variety of occupational lung diseases, grouping them into 2 broad diagnostic categories: reactive cellular changes and noncellular elements. The former includes entities such as reactive mesothelial proliferation, goblet cell metaplasia, Creola bodies, and reserve cell hyperplasia, and the latter encompasses Curschmann spirals, Charcot-Leyden crystals, and asbestos bodies. Objective.—To illustrate the cytologic features of several nonneoplastic occupational and environmental diseases and correlate the cytology with various etiologic agents. Data Sources.—Case-derived material and literature review. Conclusions.—The role of cytology in the diagnosis of nonneoplastic occupational and environmental lung diseases is limited. This may be because more than one agent can elicit a similar host reaction and/or the offending agent can be associated with more than one pathologic process. However, in the appropriate clinical and radiographic setting, the cytology can render valuable diagnostic information. Examples include pulmonary alveolar proteinosis in patients with acute silicoproteinosis and asbestos bodies in bronchoalveolar lavage samples of patients with asbestos exposure.

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Evaluation of the efficacy of a novel perfusion solution for normothermic ex vivo lung perfusion compared with Steen solution™ (animal experimental study)

Russian Journal of Transplantology and Artificial Organs ◽

10.15825/1995-1191-2021-3-82-89 ◽

2021 ◽

Vol 23 (3) ◽

pp. 82-89

Author(s):

S. V. Gautier ◽

O. M. Tsirulnikova ◽

I. V. Pashkov ◽

N. V. Grudinin ◽

D. O. Oleshkevich ◽

...

Keyword(s):

Lung Transplantation ◽

Lung Diseases ◽

Ex Vivo ◽

Infectious Complications ◽

Lung Perfusion ◽

Ex Vivo Lung Perfusion ◽

Perfusion Solution ◽

Number Of Patients ◽

Donor Lung ◽

End Stage

Respiratory diseases, together with infectious complications and hereditary lung diseases, rank third in international mortality statistics. Today, lung transplantation is a recognized method of treating end-stage lung diseases. However, the number of transplant surgeries performed is not much. This is down to the high requirements on the condition of a potential lung donor and directly on the quality of the donor lung. This has significantly limited the number of optimal donors. Rehabilitation of donor lungs to optimal gas exchange indicators can be achieved and objectively assessed in the course of ex vivo lung perfusion (EVLP). The EVLP procedure is widespread in leading transplantation centers in Europe and North America. It allows to significantly expand the pool of donor lungs, thereby serving a greater number of patients in need of lung transplantation. The possibility of EVLP procedure using publicly available perfusion equipment was demonstrated. The optimized protocol fully demonstrated its reliability and efficiency. The developed perfusion solution had no statistically significant differences in comparison with the Steen SolutionTM, which in the future will serve as an alternative for EVLP procedure.

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Occupational and Environmental Lung Diseases Selected Pneumoconiosis

10.2310/im.1352 ◽

2017 ◽

Author(s):

Cora S Sack ◽

Sverre Vedal ◽

Joel D Kaufman

Keyword(s):

Lung Diseases ◽

Hypersensitivity Pneumonitis ◽

Clinical Care ◽

Hard Metal ◽

Chronic Beryllium Disease ◽

Pleural Plaque ◽

Computed Tomographic ◽

Occupational Lung Diseases ◽

Harmful Substances ◽

Beryllium Disease

Environmental and occupational lung diseases encompass a diverse group of lung diseases caused by the inhalation of potentially harmful substances. This review provides an in-depth discussion of the pneumoconioses, hypersensitivity pneumonitis, chronic beryllium disease, and other occupational lung diseases that affect the parenchyma. For each disease, the review presents the epidemiology, biologic mechanisms when known, diagnosis, and clinical care. The review includes tables with different pneumoconioses, occupations and industries associated with silicosis and asbestosis, and some selected causes of hypersensitivity pneumonitis, as well as chest radiographs, computed tomographic scans, and/or pathologic slides of some selected diseases. This review contains 9 figures, 4 tables, and 68 references. Key words: asbestosis, asbestos-related pleural plaque, coal worker’s pneumoconiosis, chronic beryllium disease, hard metal pneumoconiosis, hypersensitivity pneumonitis, pneumoconiosis, progressive massive fibrosis, silicosis

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