scholarly journals 1185. Association Between Blood Product Transfusion and Development of Hospital Acquired Infections or Mortality in Patients Admitted to the Hospital Wards. A Retrospective Case-Control Study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S617-S617
Author(s):  
Arunmozhi S Aravagiri ◽  
Ayutyanont Napatkamon ◽  
Sabhyata Sharma ◽  
Timothy Collins ◽  
Chimezie Ubbaonu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Secondary Outcome ◽  
Blood Products ◽  
Multivariable Model ◽  
Retrospective Case ◽  
Hospital Acquired Infections ◽  
Hospital Acquired ◽  
Hospital Wards ◽  
Control Study

Abstract Background Transfusion of blood products has been shown to be associated with increased mortality and risk of infections in critically ill patients and following cardiac surgery [1-2]. However, there is scarce data evaluating this association in patients admitted to hospital wards. Here we seek to see if transfusion of blood products carries the same risk of infection and mortality in more stable patients. Methods This was a retrospective case-control study of patients admitted to the internal medicine wards who received packed red blood cells (PRBC), fresh frozen plasma (FFP) or platelet transfusions, using data from the HCA Healthcare administrative database from 2016 to 2019. Patients admitted with an infection, on steroids or other immunosuppressant medications were excluded. ICD-10 codes at discharge were used to determine hospital acquired infections (HAI). The presence of HAI was the dependent variable. A multivariable logistic regression was used to determine the effects of the independent variables on development of HAI after adjusting for age and Carlson’s Comorbidity Index. Odds ratios and 95% confidence intervals were calculated. Primary outcome of study was presence of HAI, while secondary outcome was mortality in transfused vs. non-transfused patients. Results A total of 1952 subjects were included in the study analysis. Of these, 653 or 33.4% had a HAI during their admission. Adjusted multivariable model showed transfusion of PRBC (OR 1.14, 95%CI 0.85-1.52), platelets (OR 1.41, 95% CI 0.93-2.10) or FFP (OR 1.27 95%CI 0.90-1.75) was not associated with increased odds of having a HAI. The multivariable model however, did show an increase in odds of mortality in patients who were transfused with PRBC (OR 2.51, 95%CI 1.78-3.54), platelets (OR 3.17, 95%CI 2.01-5.0) or FFP (OR 2.78, 95% CI 1.89-4.08) compared to non-transfused. Conclusion Our data failed to show association between transfusion of blood products and HAI. However, it showed there was significant increase in mortality in patients that had received blood products during their admission. Disclosures All Authors: No reported disclosures

scholarly journals Hospital acquired Clostridium difficile infection in pediatric wards: a retrospective case–control study

SpringerPlus ◽  
2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Ayse Karaaslan ◽  
Ahmet Soysal ◽  
Nurhayat Yakut ◽  
Gulsen Akkoç ◽  
Sevliya Ocal Demir ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Case Control Study ◽  
Case Control ◽  
Retrospective Case ◽  
Hospital Acquired ◽  
Control Study

scholarly journals Association between intrahospital transfer and hospital-acquired infection in the elderly: a retrospective case–control study in a UK hospital network

2021 ◽  
pp. bmjqs-2020-012124 ◽  
Author(s):  
Emanuela Estera Boncea ◽  
Paul Expert ◽  
Kate Honeyford ◽  
Anne Kinderlerer ◽  
Colin Mitchell ◽  
...  
Keyword(s):  
Case Control Study ◽  
Multivariable Analysis ◽  
Case Control ◽  
Pathogen Transmission ◽  
Hospital Environment ◽  
High Risk Population ◽  
Retrospective Case ◽  
Hospital Acquired Infection ◽  
Hospital Acquired ◽  
Control Study

BackgroundIntrahospital transfers have become more common as hospital staff balance patient needs with bed availability. However, this may leave patients more vulnerable to potential pathogen transmission routes via increased exposure to contaminated surfaces and contacts with individuals.ObjectiveThis study aimed to quantify the association between the number of intrahospital transfers undergone during a hospital spell and the development of a hospital-acquired infection (HAI).MethodsA retrospective case–control study was conducted using data extracted from electronic health records and microbiology cultures of non-elective, medical admissions to a large urban hospital network which consists of three hospital sites between 2015 and 2018 (n=24 240). As elderly patients comprise a large proportion of hospital users and are a high-risk population for HAIs, the analysis focused on those aged 65 years or over. Logistic regression was conducted to obtain the OR for developing an HAI as a function of intrahospital transfers until onset of HAI for cases, or hospital discharge for controls, while controlling for age, gender, time at risk, Elixhauser comorbidities, hospital site of admission, specialty of the dominant healthcare professional providing care, intensive care admission, total number of procedures and discharge destination.ResultsOf the 24 240 spells, 2877 cases were included in the analysis. 72.2% of spells contained at least one intrahospital transfer. On multivariable analysis, each additional intrahospital transfer increased the odds of acquiring an HAI by 9% (OR=1.09; 95% CI 1.05 to 1.13).ConclusionIntrahospital transfers are associated with increased odds of developing an HAI. Strategies for minimising intrahospital transfers should be considered, and further research is needed to identify unnecessary transfers. Their reduction may diminish spread of contagious pathogens in the hospital environment.

scholarly journals Association between intrahospital transfers and hospital-acquired infection among elderly patients: A retrospective case-control study in one urban UK hospital trust

2020 ◽  
Author(s):  
Estera Boncea ◽  
Paul Expert ◽  
Kate Honeyford ◽  
Anne Kinderlerer ◽  
Colin Mitchell ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Case Control Study ◽  
Case Control ◽  
Pathogen Transmission ◽  
Hospital Environment ◽  
Retrospective Case ◽  
Hospital Acquired Infection ◽  
Hospital Trust ◽  
Hospital Acquired ◽  
Control Study

AbstractBackgroundIntrahospital transfers have become more common as hospital staff balance patient needs with bed availability. However, this may leave patients more vulnerable to potential pathogen transmission routes via increased exposure to contaminated surfaces and contacts with individuals.ObjectiveThis study aimed to quantify the association between the number of intrahospital transfers undergone during a hospital spell and the development of a hospital-acquired infection (HAI).MethodsA retrospective case-control study was conducted using data extracted from electronic health records and microbiology cultures of non-elective, medical admissions to a large urban hospital trust comprising 3 hospital sites between 2016 and 2018 (n=24,239). As elderly patients comprise a large proportion of hospital users and are a high-risk population for HAIs, the analysis focused on those over 65-years old. Logistic regression was conducted to obtain the odds ratio (OR) for developing a HAI as a function of intrahospital transfers until onset of HAI for cases, or hospital discharge for controls, while controlling for age, gender, time-at-risk, Elixhauser comorbidities, hospital site of admission, dominant treatment function code, intensive care admission, total number of procedures, and discharge destination.ResultsOf the 24,239 spells, 2879 cases were included in the analysis. 72.2% of spells contained at least one intrahospital transfer. On multivariable analysis, each additional intrahospital transfer increased the odds of acquiring a HAI by 9% (OR 1.09; 95%CI 1.05 to 1.13).ConclusionIntrahospital transfers are associated with increased odds of developing a HAI. Strategies for minimising intrahospital transfers should be considered, and further research is needed to identify unnecessary transfers. Their reduction may diminish spread of contagious pathogens in the hospital environment.

Reusable Needles — A Major Risk Factor for Acute Virus B Hepatitis

1993 ◽  
Vol 23 (2) ◽  
pp. 64-66 ◽  
Author(s):  
M Narendranathan ◽  
Mathew Philip
Keyword(s):  
Case Control Study ◽  
Single Injection ◽  
Diagnostic Procedures ◽  
Case Control ◽  
Sexual Practices ◽  
Response Relationship ◽  
Blood Products ◽  
Dose Response Relationship ◽  
Hospital Acquired ◽  
Control Study

We conducted a case control study to find the extent to which acute virus B hepatitis was hospital acquired. One hundred and sixty consecutive cases of acute virus B hepatitis were compared with age (±3 years) and sex matched healthy hospital visitors. Exposure to reusable needles, blood or blood products, therapeutic and diagnostic procedures, common razors and sexual practices were elicited by means of a questionnaire. Only exposures in the incubation period (6 weeks to 6 months before the onset of symptoms) were included in the analysis. The odds ratio (OR) for injections for reusable needles was 6.3 [95% confidence interval (CI) = 3.8–10.6]. The OR for single injection (OR = 3.9; 95% CI = 2.0–7.3) was less than that for multiple injections (OR = 9.8; 95% CI = 3.8–26.3), showing a dose response relationship. The proportion of cases of acute virus B hepatitis attributable to hospital related exposures was 67%. Proper aseptic techniques and sterilization practices can substantially reduce the incidence of acute hepatitis B in the population.

Assessment of Craniofacial Morphology in Mouth Breathing Children. A retrospective case-control study

2019 ◽  
Vol 70 (10) ◽  
pp. 3649-3653
Author(s):  
David Angelescu ◽  
Teodora Angelescu ◽  
Meda Romana Simu ◽  
Alexandrina Muntean ◽  
Anca Stefania Mesaros ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Craniofacial Morphology ◽  
Respiratory Pattern ◽  
Control Group ◽  
Upper Lip ◽  
Retrospective Case ◽  
Oral Breathing ◽  
Facial Height ◽  
Control Study

The aim of this retrospective case-control study is to determine a possible correlation between breathing mode and craniofacial morphology. The study was carried out in the Department of Pedodontics,Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. The sample comprised 80 patients, age between 6 and 13 years, which were divided in two groups based on respiratory pattern: control group composed of 38 nasal breathing children and case group composed of 42 oral breathing children. Three quantitative craniofacial parameters were measured from the frontal and lateral photos: facial index, lower facial height ratio and upper lip ratio. The statistical analysis showed a significant higher facial index (p=0.006*) and an increase lower facial height (p=0.033*) for the oral breathers group. No differences in facial morphology were found between genders and age groups, when comparing the data between the same type of respiratory pattern children. Spearman�s rho Correlation show a significant positive correlation (p=0.002*) between facial index and lower facial height and a significant negative correlation between facial index and upper lip (p=0,005*). Long faces children are more likely to develop oral breathing in certain conditions, which subsequently have a negative effect on increasing the lower facial height by altering the postural behavior of mandible and tongue.

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