scholarly journals 323. Distribution of Pathogens in Coinfections of Patients Admitted with COVID-19

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S267-S267
Author(s):  
Srilatha Neshangi ◽  
Budder Siddiqui ◽  
Sarah Tran ◽  
Phillip Zhang
Keyword(s):  
Staphylococcus Aureus ◽  
Respiratory Tract ◽  
Retrospective Review ◽  
Patient Population ◽  
Fungal Growth ◽  
Time Frame ◽  
Blood Cultures ◽  
Medical Facility ◽  
Separate Event

Abstract Background Patients who are admitted to the hospital with Coronavirus Disease 2019 (COVID-19) often have protracted hospitalizations complicated by bacterial or fungal co-infections. This also raises the question whether there is some feature of COVID-19 that predisposes to development of specific co-infections. To begin answering that question, we sought to review the distribution of microorganisms identified in bacterial and respiratory cultures in patients admitted with COVID-19. Methods In a retrospective review of all patients admitted with COVID-19 in the year 2020 at a single academic tertiary medical facility, all positive blood and respiratory cultures were reviewed. Common contaminants were removed. Duplicate growth of the same organism within the same patient was not counted as a separate event. Results 787 patients were admitted with COVID-19 for the specified time frame. There were 131 and 147 unique events of documented bacterial or fungal growth seen in blood cultures and respiratory tract cultures, respectively. The most commonly identified organism in blood cultures was Staphylococcus aureus (3.94% of patients with COVID-19), followed closely by Enterococcus (2.41%), Klebsiella (1.65%), and Escherichia (1.27%). Staphylococcus aureus was also the most frequently isolated organism in respiratory cultures (7.24% of patients with COVID-19), followed by Pseudomonas (3.43%), Klebsiella (1.78%), Serratia (0.89%), and Stenotrophomonas (0.89%). Conclusion This suggests that the distribution of pathogens implicated in coinfections in this patient population may not be substantially different from what might be expected in patients admitted for reasons outside of COVID-19. Further investigation with a larger patient population would provide more generalizable data, including patients admitted for reasons outside of COVID-19. Disclosures All Authors: No reported disclosures

scholarly journals 309. The Impact of Addiction Medicine Consultation on Discharges Against Medical Advice in Patients with Opioid Use Disorder and Staphylococcus Aureus Bacteremia

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S152-S152
Author(s):  
Stephanie Spivack ◽  
Daniel Mueller ◽  
Peter Axelrod ◽  
Joseph D’Orazio
Keyword(s):  
Staphylococcus Aureus ◽  
Patient Population ◽  
Medical Advice ◽  
Index Admission ◽  
Opioid Use ◽  
Urban Hospital ◽  
Addiction Medicine ◽  
Against Medical Advice ◽  
Number Of Patients ◽  
The Impact

Abstract Background People who inject drugs (PWID) are at risk for infectious complications of their injection practices, including Staphylococcus aureus (SA) bacteremia. Prolonged hospitalization is sometimes required; however, rates of discharges against medical advice (AMA) are elevated in this patient population. Inadequate control of pain and opioid withdrawal are commonly cited. Our aim was to assess the effectiveness of addiction medicine consultation for preventing AMA discharges. Methods We performed a retrospective chart review of adult PWID admitted to an urban hospital with SA bacteremia between August 2016 and May 2018. Demographics, HIV and HCV status, and presence or absence of addiction medicine consultation were recorded. We assessed whether discharges were planned or AMA; the number of hospitalizations at 30 days, 90 days, and 1 year from index admission; and death within one year. EpiInfo6 was used for data analysis. Results A total of 360 patients with SA bacteremia were reviewed. Of these, 101 reported intravenous opioid use at admission. Average age was 37 years, and 64% were male. HIV and HCV were present in 13% and 82% of patients, respectively. Addiction medicine was consulted on 29 patients. Of these, 4/29 (13.8%) left AMA, compared to 27/72 (37.5%) of patients without an addiction consult (RR = 0.3678 [95% CI = 0.1412 - 0.9583], p = 0.02). Patients receiving addiction medicine consultation averaged 0.17 readmissions within 30 days of their index admission, compared to 0.39 readmissions in the group without addiction medicine consult (p = 0.27). Readmissions at 90 days and 1 year were also lower but not statistically significant. At 1 year, 6 deaths were observed; 2 who had addiction medicine consultation and 4 who did not. Conclusion Consultation with an addiction medicine specialist significantly reduced the number of patients discharged AMA in a high-risk cohort of PWID presenting with SA bacteremia. Numerically fewer readmissions occurred after consultation, though this difference was not statistically significant. Mortality in both groups was low. There were high rates of HIV and HCV in this patient population, suggesting a particularly vulnerable patient population, which warrants further study. Disclosures All Authors: No reported disclosures

scholarly journals Controlled Multicenter Evaluation of a Bacteriophage-Based Method for Rapid Detection of Staphylococcus aureus in Positive Blood Cultures

2013 ◽  
Vol 51 (4) ◽  
pp. 1226-1230 ◽  
Author(s):  
T. Bhowmick ◽  
S. Mirrett ◽  
L. B. Reller ◽  
C. Price ◽  
C. Qi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Rapid Detection ◽  
Blood Cultures

Bacteremia With Otitis Media

PEDIATRICS ◽  
1991 ◽  
Vol 87 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Sara A. Schutzman ◽  
Stephen Petrycki ◽  
Gary R. Fleisher
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Blood Culture ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Potential Benefit ◽  
Blood Cultures ◽  
Children At Risk ◽  
Focus Of Infection ◽  
Persistent Bacteremia

To investigate the occurrence and outcome of bacteremia associated with otitis media, charts were reviewed from patients who were 3 to 36 months of age, had temperatures ≥39°C, and were diagnosed with isolated clinical otitis media. A total of 2982 patients were identified. Blood cultures were obtained from 1666 (56%). Of the 1666 patients, who had blood drawn for cultures, 50 (3.0%) had bacteremia. These included 39 with Streptococcus pneumoniae, 4 with Haemophilus influenzae, 2 with Neisseria meningitidis, 3 with Salmonella species, and 2 with Staphylococcus aureus. The incidence of bacteremia increased at higher temperatures, being 1.9% at temperatures ≤40°C and 5.0% at temperatures >40°C. Younger children were more likely to have bacteremia; 3.7% ≤12 months of age, 2.4% 13 to 24 months of age, and 1.9% 25 to 36 months of age had blood culture results that were positive (not significant). Reevaluation of the 50 bacteremic patients showed that 9 patients had continued fever, 3 patients had persistent bacteremia, pneumonia developed in 1 patient, and meningitis developed in 1 patient. It was concluded that (1) 3% of young febrile children with otitis media have bacteremia at the time of evaluation, a rate comparable to that previously reported in children with no focus of infection; (2) the incidence of bacteremia increases at higher temperatures; and (3) most febrile children with otitis media do well. The clinician must therefore weigh the potential benefit of drawing a blood culture to identify children at risk for complications against the inherent cost, inconvenience, and discomfort.

scholarly journals Prevalence of Methicillin Resistant Staphylococcus Aureus In Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 673-677
Author(s):  
Abdullah Akhtar Ahmed ◽  
Shakhaowat Hossain ◽  
Babul Aktar ◽  
Nusrat Akhtar Juyee ◽  
SM Ali Hasan
Keyword(s):  
Staphylococcus Aureus ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infection Control ◽  
Respiratory Tract Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Throat Swab ◽  
College Hospital ◽  
Methicillin Resistant ◽  
Medical College

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections. To combat the challenge of life threatening MRSA remains a primary focus of most hospital infection control programs6. This study is undertaken in Khwaja Yunus Ali Medical College Hospital to identify the MRSA for determination of its prevalence and is considered a component of an infection control program in many countries5.Methods: Three hundred seventy hospitalized patients of surgery and medicine departments were studied during 2015. Clinical information of the patients and their pus, wound swab, sputum, throat swab and CSF were cultured.Results: Out of 370 patients, pus and wound swab of 217 (59%) had wound infection, sputum and throat swab of 141 had respiratory tract infection (38%) and CSF of 12 (3.2%) had meningitis were aseptically collected and cultured. Staphylococcus aureus were isolated in 51% cases and out of them MRSA was identified in 72 (73%) cases. MRSA isolated in 50% cases of meningitis, 49% cases of respiratory tract infection and 29% cases of wound infection.Conclusion: Methicillin-resistant Staphylococcus aureus appeared as a common cause of major illness and death and impose serious economic costs on patients and hospitals of our area like other developing countries. Detection of MRSA was associated with more severe clinical presentation.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 673-677

Sign in / Sign up

Export Citation Format

Share Document