Evaluation of an Intervention to Improve Rectal Screening Rates for Neisseria gonorrhoeae and Chlamydia trachomatis Among Human Immunodeficiency Virus (HIV)-Positive Men Who Have Sex With Men

A genital ulcer can be associated with sexually transmitted infections, such as syphilis and herpes, and sexually transmitted organisms, such as Chlamydia trachomatis. We report a case of scrotal ulcer caused by Staphylococcus aureus clone USA300 in a 56-year-old man living with human immunodeficiency virus in Osaka, Japan. It is important to enhance the awareness and surveillance regarding the potential of spread of this organism in the community of men who have sex with men in this district.

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Persistent Chlamydia trachomatis, Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa

International Journal of STD & AIDS ◽

10.1177/0956462419898612 ◽

2020 ◽

Vol 31 (4) ◽

pp. 294-302 ◽

Cited By ~ 1

Author(s):

Andrew Medina-Marino ◽

Maanda Mudau ◽

Noah Kojima ◽

Remco PH Peters ◽

Ute D Feucht ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Antiretroviral Therapy ◽

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Antenatal Care ◽

Pregnant Women ◽

Trichomonas Vaginalis ◽

Repeat Testing ◽

Care Visit ◽

Immunodeficiency Virus

The objective of this study is to assess the predictors and frequency of persistent sexually transmitted infection (STI) positivity in human immunodeficiency virus (HIV)-infected pregnant women treated for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) or Trichomonas vaginalis (TV) infection. We enrolled HIV-infected pregnant women attending their first antenatal care visit and tested them for urogenital CT, NG and TV infection using Xpert® CT/NG and TV assays (Cepheid, Sunnyvale, CA). Those testing positive were treated. Participants either notified partners to seek treatment or were given extra medication to deliver to partners for treatment. Repeat testing was conducted approximately 21 days post-treatment or treatment initiation. Among 427 participants, 172 (40.3%) tested positive for any STI. Of the 136 (79.1%) that returned for repeat testing, 36 (26.5%) tested positive for the same organism: CT = 27 (26.5%), NG = 1 (6.3%), TV = 11 (16.7%). Persistent CT positivity was independently associated with having more than one sex partner in the preceding 12 months (adjusted-prevalence ratio [aPR] = 3.03, 95% CI: 1.44–6.37) and being newly diagnosed with HIV infection during the first antenatal care visit compared to those currently on antiretroviral therapy (aPR = 3.97, 95% CI: 1.09–14.43). Persistent TV positivity was associated with not knowing if a partner sought treatment following STI disclosure (aPR = 12.6, 95% CI: 2.16–73.5) and prior diagnosis of HIV but not currently on antiretroviral therapy. (aPR = 4.14; 95% CI: 1.25–13.79). We identified a high proportion of HIV-infected pregnant women with persistent CT or TV positivity after treatment. To decrease the risk of re-infection, enhanced strategies for partner treatment programmes are needed to improve the effectiveness of STI screening and treatment in pregnancy. The relationship between not being on antiretroviral therapy and persistent STI positivity needs further study.

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Cinsel Saldırı ve İstismar Olgularında Cinsel Yolla Bulaşan Hastalıkların Değerlendirilmesi

The Bulletin of Legal Medicine ◽

10.17986/blm.1346 ◽

2020 ◽

Vol 25 (2) ◽

pp. 139-147

Author(s):

Derya Çağlayan ◽

Ahsen Kaya ◽

Ekin Özgür Aktaş

Keyword(s):

Human Immunodeficiency Virus ◽

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Trichomonas Vaginalis ◽

Immunodeficiency Virus

Cinsel saldırı ve cinsel istismar olgularının fiziksel ve ruhsal travma ile birlikte cinsel yolla bulaşan hastalıklar (CYBH) açısından da değerlendirilmesi önemlidir. Bu olgularda muayene genellikle travma bulgularının tespiti ve saldırganın kimliğinin tespitine yönelik örnek alımı ile sınırlı olmaktadır. Cinsel yolla bulaşan Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Hepatit B virüsü, Human immunodeficiency virüs ve sifiliz gibi çok sayıda etken mevcut olmakla birlikte ülkemizde bu etkenlere yönelik tarama testleri ve profilaksi uygulamaları ile ilgili standardize edilmiş bir rehber bulunmamaktadır. Bu nedenle, tüm olgularda bulaş riski göz önünde bulundurulmalı, gereklilik halinde tedavi ve profilaksi uygulamaları açısından değerlendirme yapılmalıdır. Ayrıca saldırgana ulaşılabildiği durumlarda gerek mağdurun CYBH için tıbbi bakım ihtiyacının belirlenebilmesi gerekse saldırganın yargılanma süreci ve illiyet bağının kurulabilmesi için bu kişilerin de muayenesi ve tetkikleri yapılmalıdır. Bu derlemede, cinsel saldırı ve cinsel istismar mağdurlarında görülebilecek cinsel yolla bulaşan hastalıkların değerlendirilmesi ve saldırganın muayenesi hususlarının, literatür bilgileri eşliğinde, adli-tıbbi yönden incelenerek sağlık çalışanlarının bu konuya dikkatlerini çekmek amaçlandı.

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Lymphogranuloma venereum presenting as penile ulcer in two HIV-negative gay men

International Journal of STD & AIDS ◽

10.1177/0956462418821579 ◽

2019 ◽

Vol 30 (5) ◽

pp. 515-518 ◽

Cited By ~ 2

Author(s):

Stephen C Davies ◽

Jane Shapiro ◽

Nicholas B Comninos ◽

David J Templeton

Keyword(s):

Human Immunodeficiency Virus ◽

Chlamydia Trachomatis ◽

Gay Men ◽

Lymphogranuloma Venereum ◽

Immunodeficiency Virus ◽

Sex With Men ◽

Hiv Negative

An epidemic of lymphogranuloma venereum among men who have sex with men (MSM) has persisted in Australia for over a decade and virtually all diagnoses are made from rectal samples. We discuss two cases of human immunodeficiency virus-negative MSM who presented with a penile ulcer. The diagnosis can be made by ensuring a swab of any such ulcer is tested for Chlamydia trachomatis.

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Extragenital Gonorrhoea in Men Who Have Sex with Men: A Retrospective Study in a STI Clinic in Lisbon, Portugal

Acta Médica Portuguesa ◽

10.20344/amp.10146 ◽

2018 ◽

Vol 31 (5) ◽

pp. 247 ◽

Cited By ~ 3

Author(s):

Margarida Moura Valejo Coelho ◽

Eugénia Matos-Pires ◽

Vasco Serrão ◽

Ana Rodrigues ◽

Cândida Fernandes

Keyword(s):

Human Immunodeficiency Virus ◽

Retrospective Study ◽

Neisseria Gonorrhoeae ◽

Sexually Transmitted Infection ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Sexually Transmitted Infection Clinic ◽

Immunodeficiency Virus ◽

Sex With Men ◽

Infection Clinic

Introduction: Recent studies worldwide reveal a significant prevalence of extragenital infections by Neisseria gonorrhoeae among men who have sex with men. We aimed to analyse the frequency and characteristics of extragenital gonococcal infections diagnosed in men who have sex with men in a walk-in Sexually Transmitted Infection clinic in Lisbon, Portugal.Material and Methods: We conducted a cross-sectional, retrospective study of the anorectal and/or oropharyngeal Neisseria gonorrhoeae infections in men who have sex with men, diagnosed in our Sexually Transmitted Infection clinic between January 2014 and December 2016.Results: We found extragenital infection in 87 cases of gonorrhoea identified in men who have sex with men in this period, including: 49 cases of anorectal disease, 9 of oropharyngeal disease, 13 cases of infection at both extragenital sites, and 16 of simultaneous extragenital and urogenital gonorrhoea. Patients’ ages ranged from 17 to 64 years (median: 28 years). Forty-seven (54%) of the patients did not present with any extragenital symptoms. Thirty (35%) were human immunodeficiency virus-1-positive.Discussion: Since most extragenital Neisseria gonorrhoeae infections are asymptomatic, they may be missed and go untreated unless actively investigated. Current international guidelines recommend the screening of gonorrhoea at extragenital sites in men who have sex with men because anorectal and oropharyngeal infections constitute a potential disease reservoir, and may facilitate transmission and/or acquisition of human immunodeficiency virus infection.Conclusion: Our results highlight the relevance of testing men who have sex with men for Neisseria gonorrhoeae at extragenital sites, regardless of the existence of local complaints. The implementation of adequate screening programmes in Portugal should be considered. We also reinforce the need to raise awareness in the population regarding the adoption of prophylactic measures against transmission of sexually transmitted infections during anal and/or oral sexual exposure.

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Self-Screening for Neisseria gonorrhoeae and Chlamydia trachomatis in the Human Immunodeficiency Virus Clinic—High Yields and High Acceptability

Sexually Transmitted Diseases ◽

10.1097/olq.0b013e31822e6136 ◽

2011 ◽

Vol 38 (12) ◽

pp. 1107-1109 ◽

Cited By ~ 31

Author(s):

Suneeta Soni ◽

John A. White

Keyword(s):

Human Immunodeficiency Virus ◽

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Immunodeficiency Virus ◽

High Yields

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Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma spp. Coinfection in an HIV-Positive Homosexual Man

Journal of Laboratory Physicians ◽

10.1055/s-0041-1731119 ◽

2021 ◽

Author(s):

Swati Khullar ◽

Jyoti Rawre ◽

Deepika Yadav ◽

Neena Khanna ◽

Benu Dhawan

Keyword(s):

Chlamydia Trachomatis ◽

Mycoplasma Hominis ◽

Mycoplasma Genitalium ◽

Hiv Positive ◽

Sexually Transmitted ◽

Immunodeficiency Virus ◽

Oropharyngeal Swab ◽

Sex With Men ◽

Multiple Male ◽

Ureaplasma Spp

AbstractA 21-year-old human immunodeficiency virus-positive male patient presented with complaints of multiple hyperpigmented verrucous papules over his perianal area. He reported having unprotected anal and oral sex with multiple male partners. On examination, superficial ill-defined perianal erosions were present. A first void urine sample and clinician-collected rectal and oropharyngeal swabs were sent for the detection of Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma spp. Rectal swab tested positive for all the four pathogens. Oropharyngeal swab and urine samples tested positive for C. trachomatis. The patient was treated with doxycycline and moxifloxacin. This case underscores the importance of screening of men who have sex with men for possible coinfections with multiple sexually transmitted pathogens.

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PERAN MIKROBIOM PADA INFEKSI MENULAR SEKSUAL

Media Dermato Venereologica Indonesiana ◽

10.33820/mdvi.v46i3.74 ◽

2019 ◽

Vol 46 (3) ◽

Author(s):

Wresti Indriatmi

Keyword(s):

Human Immunodeficiency Virus ◽

Human Papillomavirus ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Trichomonas Vaginalis ◽

Immunodeficiency Virus ◽

Simplex Virus

Komposisi mikrobiota saluran reproduksi berkaitan dengan kesehatan reproduksi dan ketahanannya terhadap infeksi menular seksual, terutama pada perempuan. Saluran reproduksi perempuan dan laki-laki dapat terpajan dengan komunitas mikroba asing selama aktivitas seksual. Proteksi oleh mikrobiota vagina sehat terhadap infeksi virus dapat diperankan oleh efek virusidal langsung atau oleh faktor pertahanan alamiah yang terdapat di dalam lingkungan vagina. Flora vagina abnormal yang kekurangan lactobacilli dihubungkan dengan kemudahan terinfeksi Neisseria gonorrhoeae, Chlamydia trachomatis, serta Trichomonas vaginalis. Pada laki-laki, mikrobiota dapat ditemukan pada genitalia bagian bawah, terutama penis, yang dapat dipengaruhi oleh sirkumsisi. Sirkumsisi dapat mengurangi risiko beberapa infeksi menular seksual (IMS), yaitu herpes simplex virus (HSV), human papillomavirus (HPV), dan human immunodeficiency virus (HIV) dengan cara mengubah mikrobiota penis dan lingkungan imunitas lokal. Mikrobiota pada rektum juga berperan bila hubungan seksual dilakukan secara anogenital reseptif. Dengan demikian, penularan patogen infeksi menular seksual akan dipengaruhi oleh komposisi mikrobiota genital atau pun rektum.Kata kunci: mikrobiom, mikrobiota, infeksi menular seksual

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The Characteristics of Patients Frequently Tested and Repeatedly Infected with Neisseria gonorrhoeae

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17051495 ◽

2020 ◽

Vol 17 (5) ◽

pp. 1495 ◽

Cited By ~ 1

Author(s):

Juliën Wijers ◽

Christian Hoebe ◽

Nicole Dukers-Muijrers ◽

Petra Wolffs ◽

Geneviève van Liere

Keyword(s):

Logistic Regression ◽

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Sexually Transmitted Infections ◽

Hiv Positive ◽

Regression Analyses ◽

Sexually Transmitted ◽

Number Of Patients ◽

Sex With Men ◽

Insight Into

We assessed whether patients repeatedly infected with Neisseria gonorrhoeae (NG) were different compared to patients repeatedly tested negative, to obtain insight into the characteristics of patients frequently tested and infected with NG. All patients tested for NG (n = 16,662) between January 2011 and July 2018 were included. Multivariable logistic regression analyses were performed for the outcomes “repeat NG infections” and “once NG positive and not retested” versus patients “repeatedly tested NG negative”. Of the individuals tested for NG, 0.2% (40/16,662) had repeat (≥2) NG infections, and accounted for 23% of all diagnosed NG infections. STI clinic patients, men (mostly men who have sex with men (MSM)), patients aged ≥25 years, and patients co-infected with HIV or Chlamydia trachomatis (CT) more often had repeat NG infections. The number of patients not retested after their initial NG diagnosis was 29.9% (92/308). Men (mostly MSM), HIV positive patients, and patients notified for sexually transmitted infections (STIs) were more often NG positive and not retested. Concluding, only 40 patients tested for NG accounted for one in four diagnosed NG infections. However, re-infections are likely to be missed among MSM and HIV positive patients, as they were mainly not retested after NG infection. It remains important to test and re-test for NG, especially in MSM, in order to halt transmission.

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