Lymphogranuloma venereum presenting as penile ulcer in two HIV-negative gay men

2019 ◽  
Vol 30 (5) ◽  
pp. 515-518 ◽  
Author(s):  
Stephen C Davies ◽  
Jane Shapiro ◽  
Nicholas B Comninos ◽  
David J Templeton
Keyword(s):  
Human Immunodeficiency Virus ◽  
Chlamydia Trachomatis ◽  
Gay Men ◽  
Lymphogranuloma Venereum ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Hiv Negative

An epidemic of lymphogranuloma venereum among men who have sex with men (MSM) has persisted in Australia for over a decade and virtually all diagnoses are made from rectal samples. We discuss two cases of human immunodeficiency virus-negative MSM who presented with a penile ulcer. The diagnosis can be made by ensuring a swab of any such ulcer is tested for Chlamydia trachomatis.

scholarly journals Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015

2016 ◽  
Vol 21 (5) ◽  
Author(s):  
Mojca Matičič ◽  
Irena Klavs ◽  
Jerneja Videčnik Zorman ◽  
Darja Vidmar Vovko ◽  
Rok Kogoj ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Anal Intercourse ◽  
Lymphogranuloma Venereum ◽  
Clinical Samples ◽  
Recommended Treatment ◽  
Insertive Anal Intercourse ◽  
Immunodeficiency Virus ◽  
Inguinal Lymphadenopathy ◽  
Sex With Men ◽  
Hiv Negative

A laboratory-confirmed lymphogranuloma venereum (LGV) case in Slovenia was reported in 2015, in a human immunodeficiency virus (HIV)-negative man presenting with inguinal lymphadenopathy. He reported unprotected insertive anal intercourse with two male partners in Croatia. Variant L2c of Chlamydia trachomatis was detected in clinical samples. Although the patient was eventually cured, the recommended treatment regimen with doxycycline had to be prolonged.

Scrotal ulcer due to community-acquired methicillin-resistant Staphylococcus aureus USA300 clone in an HIV-positive man who has sex with men in Japan: a case report

2019 ◽  
Vol 30 (12) ◽  
pp. 1229-1231 ◽  
Author(s):  
Yoshihiko Ogawa ◽  
Kei Kasahara ◽  
Tomoko Asada ◽  
Shingo Yoshihara ◽  
Nobuyasu Hirai ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Chlamydia Trachomatis ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Hiv Positive ◽  
Sexually Transmitted ◽  
Immunodeficiency Virus ◽  
Usa300 Clone ◽  
Sex With Men

A genital ulcer can be associated with sexually transmitted infections, such as syphilis and herpes, and sexually transmitted organisms, such as Chlamydia trachomatis. We report a case of scrotal ulcer caused by Staphylococcus aureus clone USA300 in a 56-year-old man living with human immunodeficiency virus in Osaka, Japan. It is important to enhance the awareness and surveillance regarding the potential of spread of this organism in the community of men who have sex with men in this district.

scholarly journals Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men

2020 ◽  
Author(s):  
Sebastiaan O Verboeket ◽  
Ferdinand W Wit ◽  
Eveline Verheij ◽  
Rosan A van Zoest ◽  
Neeltje A Kootstra ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Cd8 T Cell ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Cell Counts ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Use Behavior ◽  
Hiv Negative

Abstract Background We previously reported T-cell senescence to be similar in people with human immunodeficiency virus (PWH) with suppressed viremia (predominantly men who have sex with men [MSM]) and human immunodeficiency virus (HIV)-negative otherwise comparable controls but greater than in healthy blood donors. This led us to compare CD4+ and CD8+ T-cell counts and CD4+/CD8+ ratios between HIV-negative MSM and men who only have sex with women (MSW) and relate observed differences in behavioral factors and infectious exposures, including cytomegalovirus (CMV) infection. Methods In 368 HIV-negative MSM and 72 HIV-negative MSW, T lymphocyte phenotyping was performed 3 times biennially. Baseline CMV serology and sexually transmitted infection (STI) incidence and/or STI seroprevalence, sexual, and substance-use behavior data were collected during study visits. Results Men who have sex with men, compared with MSW, had higher CD8+ counts (551 vs 437 cells/mm3, P < .001), similar CD4+ counts (864 vs 880 cells/mm3, P = .5), and lower CD4+/CD8+ ratios (1.84 vs 2.47, P < .001). Differences were most pronounced for MSM with >10 recent sex partners and partly explained by higher CMV seroprevalence in MSM. Conclusions These findings suggest that factors other than HIV may, in both PWH and certain HIV-negative MSM, contribute to a low CD4+/CD8+ ratio. Whether this, like in PWH, contributes to comorbidity risk in HIV-negative MSM requires further study.

Patterns of Hepatitis C Virus Transmission in Human Immunodeficiency Virus (HIV)–infected and HIV-negative Men Who Have Sex With Men

2019 ◽  
Vol 69 (12) ◽  
pp. 2127-2135 ◽  
Author(s):  
Christophe Ramière ◽  
Caroline Charre ◽  
Patrick Miailhes ◽  
François Bailly ◽  
Sylvie Radenne ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Phylogenetic Trees ◽  
University Hospital ◽  
Sexual Practices ◽  
Acute Hepatitis C ◽  
Immunodeficiency Virus ◽  
Sex With Men ◽  
Hiv Negative

Abstract Background Sexually transmitted acute hepatitis C virus (HCV) infections (AHIs) have been mainly described in human immunodeficiency virus (HIV)–infected men who have sex with men (MSM). Cases in HIV-negative MSM are scarce. We describe the epidemic of AHI in HIV-infected and HIV-negative MSM in Lyon, France. Methods All cases of AHI diagnosed in MSM in Lyon University Hospital from 2014 to 2017 were included. AHI incidence was determined in HIV-infected and in preexposure prophylaxis (PrEP)–using MSM. Transmission clusters were identified by construction of phylogenetic trees based on HCV NS5B (genotype 1a/4d) or NS5A (genotype 3a) Sanger sequencing. Results From 2014 to 2017, 108 AHIs (80 first infections, 28 reinfections) were reported in 96 MSM (HIV-infected, 72; HIV-negative, 24). AHI incidence rose from 1.1/100 person-years (95 confidence interval [CI], 0.7–1.7) in 2014 to 2.4/100 person-years (95 CI, 1.1–2.6) in 2017 in HIV-infected MSM (P = .05) and from 0.3/100 person-years (95 CI, 0.06–1.0) in 2016 to 3.4/100 person-years (95 CI, 2.0–5.5) in 2017 in PrEP users (P < .001). Eleven clusters were identified. All clusters included HIV-infected MSM; 6 also included HIV-negative MSM. All clusters started with ≥1 HIV-infected MSM. Risk factor distribution varied among clusters. Conclusions AHI incidence increased in both HIV-infected and HIV-negative MSM. Cluster analysis suggests initial transmission from HIV-infected to HIV-negative MSM through chemsex and traumatic sexual practices, leading to mixed patterns of transmission regardless of HIV status and no overlap with the general population.

Observational study of anorectal Chlamydia trachomatis infections in France through the lymphogranuloma venereum surveillance network, 2010–2015

2018 ◽  
Vol 29 (12) ◽  
pp. 1215-1224 ◽  
Author(s):  
B de Barbeyrac ◽  
C Laurier-Nadalié ◽  
A Touati ◽  
C Le Roy ◽  
L Imounga ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Patient Characteristics ◽  
Lymphogranuloma Venereum ◽  
Surveillance Network ◽  
Immunodeficiency Virus ◽  
Anal Discharge ◽  
Sex With Men ◽  
Exposure Prophylaxis ◽  
National Reference Center ◽  
Sentinel Surveillance System

The objective of this article is to describe the epidemiology of lymphogranuloma venereum (LGV) and non-LGV Chlamydia trachomatis anorectal infections in France and to examine the characteristics of the affected populations via a voluntary sentinel surveillance system for LGV between 2010 and 2015. Anorectal samples positive for C. trachomatis (CT) were sent by the participating laboratories to the National Reference Center for CT for LGV identification. Biological and clinical data were collected by biologists and clinicians. There were 1740 LGV episodes and 2248 non-LGV episodes. Continuous monitoring highlighted a sharp increase in the number of LGV and non-LGV anorectal infections, which were 2.3-fold and 6.5-fold, respectively. Most of the infections occurred in men who have sex with men. LGV patients were older than non-LGV patients and were more frequently human immunodeficiency virus (HIV)-positive compared to non-LGV patients. Anorectal LGV was significantly associated with residence in Paris, HIV co-infection, concurrent syphilis and bloody anal discharge. Undocumented patient characteristics were strongly associated with anorectal LGV. The anorectal LGV epidemic is poorly controlled in France. Early detection and prompt treatment of patients and their sexual partners are required to prevent transmission in the context of pre-exposure prophylaxis (PrEP) for HIV infection.

scholarly journals Lymphogranuloma venereum – the first Hungarian cases

2015 ◽  
Vol 156 (1) ◽  
pp. 36-40
Author(s):  
András Bánvölgyi ◽  
Eszter Balla ◽  
Péter Bognár ◽  
Béla Tóth ◽  
Eszter Ostorházi ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Nucleic Acid Amplification ◽  
Diagnostic Challenge ◽  
Transmitted Infection ◽  
Rectal Pain ◽  
Urethral Discharge ◽  
Immunodeficiency Virus ◽  
Sex With Men

Lymphogranuloma venereum is a sexually transmitted infection caused by the Chlamydia trachomatis serovars L1–3. It has been found to be endemic in tropical countries. In the last decades several cases have been reported in Western Europe, particularly in men who have sex with men population infected with human immunodeficiency virus. The authors present three cases of lymphogranuloma venereum infections, observed at their department in 2013 and 2014. The three human immunodeficiency virus infected patients who belonged to men who have sex with men population had casual sexual contacts in Western Europe. The symptoms included urethral discharge, discomfort and inguinal lymphadenomegaly in two patients, and rectal pain, discharge and perianal ulceration in one patient. The diagnosis was confirmed by nucleic acid amplification test performed in samples obtained from urethral discharge and exudate of perianal ulcer; lymphogranuloma venereum 2b serovars were demonstrated in two patients and serovar 2 in one patient. Doxycyclin (daily dose of two times 100 mg for 21 days) resolved the symptoms in all cases. The authors conclude that lymphogranuloma venereum is a diagnostic challenge in Hungary, too. It is important to be aware of the altered clinical features of this disease to prevent complications and spreading. Orv. Hetil., 2015, 156(1), 36–40.

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