scholarly journals Moral Information

2020 ◽  
pp. 197-210
Author(s):  
William MacAskill ◽  
Krister Bykvist ◽  
Toby Ord
Keyword(s):  
Expected Utility ◽  
Imperfect Information ◽  
Empirical Information ◽  
Shed Light

In this chapter, we show how the theory we’ve given can shed light on the question of how to value gaining new moral information. We explain how we should assess the expected utility of new empirical information, and how we could use an analogous framework to work out the expected choice worthiness of new moral information. We apply this framework to two examples: the choice of how a large foundation should spend its resources, and the choice of career for an individual. Finally, we consider to what extent the lessons from this framework change when we consider ‘imperfect’ information.

Deontological Decision Theory and the Grounds of Subjective Permissibility

2019 ◽  
pp. 204-222
Author(s):  
Seth Lazar
Keyword(s):  
Decision Making ◽  
Decision Theory ◽  
Expected Utility ◽  
Imperfect Information ◽  
Perfect Information ◽  
Risk And Uncertainty

If we had perfect information, then we could say, for any given objectively permissible act, what makes it objectively permissible. But when we have imperfect information, when we must decide under risk and uncertainty, what then makes an act subjectively permissible or impermissible? There are two salient possibilities. The first is the “verdicts” approach. It grounds judgments of subjective permissibility in probabilistically discounted judgments of objective permissibility. The principle “minimize expected objective wrongness” takes this approach. The second is the “reasons” approach. It grounds subjective permissibility in probabilistically discounted objective reasons. “Maximize expected utility” is one example. Chapter 10 considers whether the verdicts approach or the reasons approach to grounding judgments of subjective permissibility is better suited for deontological decision-making with imperfect information. Perhaps surprisingly, the reasons approach comes out on top.

scholarly journals Expected Utility Based Decision Making underZ-Information and Its Application

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Rashad R. Aliev ◽  
Derar Atallah Talal Mraiziq ◽  
Oleg H. Huseynov
Keyword(s):  
Decision Making ◽  
Expected Utility ◽  
Real World ◽  
Imperfect Information ◽  
Human Perception ◽  
Relevant Information ◽  
Point Of View ◽  
General Representation ◽  
Direct Computation ◽  
Source Of Information

Real-world decision relevant information is often partially reliable. The reasons are partial reliability of the source of information, misperceptions, psychological biases, incompetence, and so forth.Z-numbers based formalization of information (Z-information) represents a natural language (NL) based value of a variable of interest in line with the related NL based reliability. What is important is thatZ-information not only is the most general representation of real-world imperfect information but also has the highest descriptive power from human perception point of view as compared to fuzzy number. In this study, we present an approach to decision making underZ-information based on direct computation overZ-numbers. This approach utilizes expected utility paradigm and is applied to a benchmark decision problem in the field of economics.

BEHAVIORAL DECISION MAKING WITH COMBINED STATES UNDER IMPERFECT INFORMATION

2013 ◽  
Vol 12 (03) ◽  
pp. 619-645 ◽  
Author(s):  
RAFIK A. ALIEV ◽  
WITOLD PEDRYCZ ◽  
OLEG H. HUSEYNOV
Keyword(s):  
Decision Making ◽  
Prospect Theory ◽  
Expected Utility ◽  
Imperfect Information ◽  
Wide Spectrum ◽  
Real Life ◽  
Suggested Approach ◽  
Behavioral Decision Making ◽  
Behavioral Decision ◽  
Special Cases

Behavioral decision making is an area of multidisciplinary research attracting growing interest of scientists and practitioners, economists, and business people. A wide spectrum of successful theories is present now, including Prospect theory, multiple priors models, studies on altruism, trust and fairness. However, these theories are developed for precise and complete information, whereas real information concerning a decision maker's (DM) behavior and environment is imperfect, qualitative, and, as a result, often described in natural language (NL). We suggest an approach based on modeling a DM's behavior by a set of states. Each state represents a certain principal behavior. In our approach, states of nature and DM's states constitute a single space of combined states. For formalizing relevant information described in NL, we use fuzzy set theory. The utility model is based on Choquet-like integration over combined states. The investigations show that Expected Utility, Choquet Expected Utility and Cumulative Prospect Theory are special cases of the suggested approach. We apply the suggested approach to solving a benchmark and a real-life decision problem. The obtained results show validity of the suggested approach.

D. The Line Spectrum of Pulsating Variable Stars

1967 ◽  
Vol 28 ◽  
pp. 207-244
Author(s):  
R. P. Kraft
Keyword(s):  
Variable Stars ◽  
The Other ◽  
Line Spectrum ◽  
Afternoon Session ◽  
Empirical Information ◽  
Pulsating Variable Stars ◽  
Almost Continuous ◽  
Informal Approach

(Ed. note:Encouraged by the success of the more informal approach in Christy's presentation, we tried an even more extreme experiment in this session, I-D. In essence, Kraft held the floor continuously all morning, and for the hour and a half afternoon session, serving as a combined Summary-Introductory speaker and a marathon-moderator of a running discussion on the line spectrum of cepheids. There was almost continuous interruption of his presentation; and most points raised from the floor were followed through in detail, no matter how digressive to the main presentation. This approach turned out to be much too extreme. It is wearing on the speaker, and the other members of the symposium feel more like an audience and less like participants in a dissective discussion. Because Kraft presented a compendious collection of empirical information, and, based on it, an exceedingly novel series of suggestions on the cepheid problem, these defects were probably aggravated by the first and alleviated by the second. I am much indebted to Kraft for working with me on a preliminary editing, to try to delete the side-excursions and to retain coherence about the main points. As usual, however, all responsibility for defects in final editing is wholly my own.)

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

2019 ◽  
Vol 47 (6) ◽  
pp. 1733-1747 ◽  
Author(s):  
Christina Klausen ◽  
Fabian Kaiser ◽  
Birthe Stüven ◽  
Jan N. Hansen ◽  
Dagmar Wachten
Keyword(s):  
Cyclic Amp ◽  
Adenosine Monophosphate ◽  
Adenylyl Cyclases ◽  
Temporal Precision ◽  
Fluorescent Biosensors ◽  
Subcellular Domains ◽  
Spatio Temporal ◽  
Hydrolysis Of ◽  
Shed Light ◽  
Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

Sentence-Based Experience Logging in New Hearing Aid Users

2020 ◽  
Vol 29 (3S) ◽  
pp. 631-637
Author(s):  
Katja Lund ◽  
Rodrigo Ordoñez ◽  
Jens Bo Nielsen ◽  
Dorte Hammershøi
Keyword(s):  
Hearing Aid ◽  
Patient Experiences ◽  
Online Tool ◽  
Rehabilitation Process ◽  
Hearing Rehabilitation ◽  
Clinical Observations ◽  
Hearing Aid Use ◽  
Wide Range ◽  
Insight Into ◽  
Shed Light

Purpose The aim of this study was to develop a tool to gain insight into the daily experiences of new hearing aid users and to shed light on aspects of aided performance that may not be unveiled through standard questionnaires. Method The tool is developed based on clinical observations, patient experiences, expert involvement, and existing validated hearing rehabilitation questionnaires. Results An online tool for collecting data related to hearing aid use was developed. The tool is based on 453 prefabricated sentences representing experiences within 13 categories related to hearing aid use. Conclusions The tool has the potential to reflect a wide range of individual experiences with hearing aid use, including auditory and nonauditory aspects. These experiences may hold important knowledge for both the patient and the professional in the hearing rehabilitation process.

Pearls Shed Light on Tx for Dark-Skinned Children

2006 ◽  
Vol 37 (4) ◽  
pp. 42
Author(s):  
HEIDI SPLETE
Keyword(s):  
Shed Light

The Role of Zinc in Thyroid Hormones Metabolism

2019 ◽  
Vol 89 (1-2) ◽  
pp. 80-88 ◽  
Author(s):  
Juliana Soares Severo ◽  
Jennifer Beatriz Silva Morais ◽  
Taynáh Emannuelle Coelho de Freitas ◽  
Ana Letícia Pereira Andrade ◽  
Mayara Monte Feitosa ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Scientific Evidence ◽  
Thyroid Stimulating Hormone ◽  
Zinc Transporters ◽  
Serum Concentrations ◽  
Metabolic Adaptations ◽  
Serum T3 ◽  
Regulatory Effects ◽  
Shed Light

Abstract. Thyroid hormones play an important role in body homeostasis by facilitating metabolism of lipids and glucose, regulating metabolic adaptations, responding to changes in energy intake, and controlling thermogenesis. Proper metabolism and action of these hormones requires the participation of various nutrients. Among them is zinc, whose interaction with thyroid hormones is complex. It is known to regulate both the synthesis and mechanism of action of these hormones. In the present review, we aim to shed light on the regulatory effects of zinc on thyroid hormones. Scientific evidence shows that zinc plays a key role in the metabolism of thyroid hormones, specifically by regulating deiodinases enzymes activity, thyrotropin releasing hormone (TRH) and thyroid stimulating hormone (TSH) synthesis, as well as by modulating the structures of essential transcription factors involved in the synthesis of thyroid hormones. Serum concentrations of zinc also appear to influence the levels of serum T3, T4 and TSH. In addition, studies have shown that Zinc transporters (ZnTs) are present in the hypothalamus, pituitary and thyroid, but their functions remain unknown. Therefore, it is important to further investigate the roles of zinc in regulation of thyroid hormones metabolism, and their importance in the treatment of several diseases associated with thyroid gland dysfunction.

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