CRITERIA FOR SELECTION OF DECEDENT VERSUS LIVING CONTROLS IN A MORTALITY CASE-CONTROL STUDY

1984 ◽  
Vol 120 (4) ◽  
pp. 635-642 ◽  
Author(s):  
EUGEMA E. CALLE
2012 ◽  
Vol 184 (17) ◽  
pp. E921-E923 ◽  
Author(s):  
N. Persaud ◽  
E. Coleman ◽  
D. Zwolakowski ◽  
B. Lauwers ◽  
D. Cass

Blood ◽  
2004 ◽  
Vol 104 (7) ◽  
pp. 2003-2006 ◽  
Author(s):  
Frank P. Mockenhaupt ◽  
Stephan Ehrhardt ◽  
Sabine Gellert ◽  
Rowland N. Otchwemah ◽  
Ekkehart Dietz ◽  
...  

Abstract The high frequency of α+-thalassemia in malaria-endemic regions may reflect natural selection due to protection from potentially fatal severe malaria. In Africa, bearing 90% of global malaria morbidity and mortality, this has not yet been observed. We tested this hypothesis in an unmatched case-control study among 301 Ghanaian children with severe malaria and 2107 controls (62% parasitemic). In control children, α+-thalassemia affected neither prevalence nor density of Plasmodium falciparum. However, heterozygous α+-thalassemia was observed in 32.6% of controls but in only 26.2% of cases (odds ratio [OR], 0.74; 95% confidence interval [CI], 0.56-0.98). Protection against severe malaria was found to be pronounced comparing severe malaria patients with parasitemic controls (adjusted OR in children < 5 years of age, 0.52; 95% CI, 0.34-0.78) and to wane with age. No protective effect was discernible for homozygous children. Our findings provide evidence for natural selection of α+-thalassemia in Africa due to protection from severe malaria.


2021 ◽  
Author(s):  
Wei LI ◽  
XUE Xiaodan ◽  
LI Dandan ◽  
Ying ZHANG ◽  
Wenda SHEN ◽  
...  

Abstract Background: Smoking is by far the most important cause of cancer that can be modified at the individual level. Asia has a high incidence of cancer incidence and death, while China has the highest incidence in Asia, and accounting for 27% of the world's cancer deaths. The purpose of the current study was to perform an evidence-based assessment of the burden of tobacco smoking-related cancers death in the Tianjin, China. Methods: A mortality case-control study to assess the risks of all-cause and major causes of cancer death attributable to smoking from 2010 to 2019. Results: Tobacco smoking was responsible for 23,709 (28.87%) cancer deaths among adult men and 8,648 (13.37%) among adult women in 2010 to 2019 in Tianjin. Lung cancer remains the largest cause of cancer death. In men, 49.06% of lung cancer, 27.55% of upper aerodigestive cancer, 10.11% of liver, 13.56% of kidney and other urinary cancer deaths were attributable to tobacco smoking. In women the proportion of ever-smoking-attributable lung cancer was 31.56%, 10.59% of upper aerodigestive and 10.56% of bladder cancer deaths. By year, smoking-attributable cancer deaths in men increased from 1817 in 2010 to 2695 in 2019; for women, the number remained stable at just over 800 per year. Conclusions: Approximately one in three cancer deaths in men and one in six cancer deaths in women would be potentially preventable through appropriate control of tobacco smoking in Tianjin. Effective control programs against tobacco smoking should be further implemented.


2008 ◽  
Vol 124 (3) ◽  
pp. 362-363
Author(s):  
Demosthenes B. Panagiotakos ◽  
Loukianos Rallidis ◽  
Christos Pitsavos ◽  
Christodoulos Stefanadis ◽  
Dimitrios Kremastinos

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