Long-Term Effects of 1, 25-Dihydroxy Vitamin D3 and 24, 25-Dihydroxy Vitamin D3 in Renal Osteodystrophy

QJM ◽  
1982 ◽  
Keyword(s):  
Vitamin D ◽  
Renal Osteodystrophy ◽  
Long Term Effects

LONG-TERM EFFECTS OF SMALL DOSES OF 1,25-DIHYDROXYCHOLECALCIFEROL IN RENAL OSTEODYSTROPHY

The Lancet ◽  
1978 ◽  
Vol 311 (8065) ◽  
pp. 629-632 ◽  
Author(s):  
K.Y. Ahmed ◽  
M.R. Wills ◽  
Z. Varghese ◽  
E.A. Meinhard ◽  
J.F. Moorhead
Keyword(s):  
Renal Osteodystrophy ◽  
Long Term Effects ◽  
Small Doses

Metabolic Bone Disease in the CAPD Patient

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 24-26 ◽  
Author(s):  
Francisco Llach
Keyword(s):  
Vitamin D ◽  
Renal Osteodystrophy ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Osteitis Fibrosa ◽  
Prospective Evaluation ◽  
Metabolic Bone ◽  
Capd Patient

It seems that CAPD may improve some patients with osteomalacia but may be similar to hemodialysis in regard to osteitis fibrosa. However, long-term prospective evaluation of the incidence of bone disease in CAPD patients is necessary before we can determine how CAPD may alter the incidence and expression of renal osteodystrophy. We need more information before we can conclude that CAPD may improve pure osteomalacia. Finally, the data available are insufficient to clarify the role of vitamin D analogues in these patients.

Long-term effects of vitamin D deficiency on gait and balance in the older adults

2020 ◽  
Vol 39 (12) ◽  
pp. 3756-3762
Author(s):  
Zehra Yagmur Sahin Alak ◽  
Esra Ates Bulut ◽  
Ozge Dokuzlar ◽  
Idil Yavuz ◽  
Pinar Soysal ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Long Term Effects

Vitamin D in pregnancy and breastfeeding

2015 ◽  
Author(s):  
Sir Peter Gluckman ◽  
Mark Hanson ◽  
Chong Yap Seng ◽  
Anne Bardsley
Keyword(s):  
Vitamin D ◽  
Uv Light ◽  
Sun Exposure ◽  
Food Sources ◽  
Long Term Effects ◽  
Blood Glucose Homeostasis ◽  
Skeletal Effects ◽  
Adverse Pregnancy ◽  
In Pregnancy

Vitamin D, which is synthesized in skin exposed to UV light, or is consumed in the diet, plays a key role in maintaining bone integrity via the regulation of calcium and phosphorus homeostasis. It also influences a number of extra-skeletal processes, including immune function and blood glucose homeostasis. Maternal vitamin D deficiency in pregnancy leads to poor fetal skeletal mineralization in utero that can manifest as rickets in newborns. In addition to skeletal effects, women with very low vitamin D status face increased risks of other adverse pregnancy outcomes and possible long-term effects on their own health and that of their offspring. However, controversy remains over definitions of vitamin D sufficiency and deficiency, complicating recommendations on maternal intakes. At a minimum, all pregnant women should take a supplement of 400 IU/day, in addition to sensible sun exposure and increasing their intake of food sources.

Gestational vitamin D deficiency: long-term effects on the brain

2008 ◽  
Vol 66 (12) ◽  
pp. 726-729 ◽  
Author(s):  
Cathy W Levenson ◽  
Silvia M Figueirôa
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Long Term Effects ◽  
The Brain

scholarly journals Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

2019 ◽  
Vol 241 (2) ◽  
pp. R65-R80 ◽  
Author(s):  
Folami Y Ideraabdullah ◽  
Anthony M Belenchia ◽  
Cheryl S Rosenfeld ◽  
Seth W Kullman ◽  
Megan Knuth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Later Life ◽  
The Body ◽  
Fetal Life ◽  
Developmental Origins ◽  
Long Term Effects ◽  
Cardiometabolic Disorders ◽  
Health And Disease

Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.

scholarly journals The Long-term Effects of Gastric Bypass on Vitamin D Metabolism

2006 ◽  
Vol 243 (5) ◽  
pp. 701-705 ◽  
Author(s):  
Jason M. Johnson ◽  
James W. Maher ◽  
Eric J. DeMaria ◽  
Robert W. Downs ◽  
Luke G. Wolfe ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gastric Bypass ◽  
Long Term Effects ◽  
Vitamin D Metabolism

Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates

2020 ◽  
Vol 13 (4) ◽  
pp. e233853 ◽  
Author(s):  
Chase C Houghton ◽  
Susie Q Lew
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Additional Treatment ◽  
Long Term Effects ◽  
Over The Counter ◽  
Hypervitaminosis D ◽  
Vitamin D Intoxication ◽  
Common Diagnosis ◽  
Vitamin D Supplement

Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50 000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment with glucocorticoids and bisphosphonates was warranted during his second admission. The pathophysiology of hypercalcaemia from vitamin D intoxication results from the long-term effects of vitamin D storage in adipose tissue. In the present case, we discuss this pathophysiology and treatment approaches in the context of increasing awareness of and testing for vitamin D deficiency, and growing access to over-the-counter supplements.

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