scholarly journals Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

2019 ◽  
Vol 241 (2) ◽  
pp. R65-R80 ◽  
Author(s):  
Folami Y Ideraabdullah ◽  
Anthony M Belenchia ◽  
Cheryl S Rosenfeld ◽  
Seth W Kullman ◽  
Megan Knuth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Later Life ◽  
The Body ◽  
Fetal Life ◽  
Developmental Origins ◽  
Long Term Effects ◽  
Cardiometabolic Disorders ◽  
Health And Disease

Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.

Long-term effects of vitamin D deficiency on gait and balance in the older adults

2020 ◽  
Vol 39 (12) ◽  
pp. 3756-3762
Author(s):  
Zehra Yagmur Sahin Alak ◽  
Esra Ates Bulut ◽  
Ozge Dokuzlar ◽  
Idil Yavuz ◽  
Pinar Soysal ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Long Term Effects

Gestational vitamin D deficiency: long-term effects on the brain

2008 ◽  
Vol 66 (12) ◽  
pp. 726-729 ◽  
Author(s):  
Cathy W Levenson ◽  
Silvia M Figueirôa
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Long Term Effects ◽  
The Brain

Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates

2020 ◽  
Vol 13 (4) ◽  
pp. e233853 ◽  
Author(s):  
Chase C Houghton ◽  
Susie Q Lew
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Additional Treatment ◽  
Long Term Effects ◽  
Over The Counter ◽  
Hypervitaminosis D ◽  
Vitamin D Intoxication ◽  
Common Diagnosis ◽  
Vitamin D Supplement

Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50 000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment with glucocorticoids and bisphosphonates was warranted during his second admission. The pathophysiology of hypercalcaemia from vitamin D intoxication results from the long-term effects of vitamin D storage in adipose tissue. In the present case, we discuss this pathophysiology and treatment approaches in the context of increasing awareness of and testing for vitamin D deficiency, and growing access to over-the-counter supplements.

scholarly journals COVID-19 pandemic leading to unidentified, silent-pandemic of vitamin D deficiency in young children: a case report

2021 ◽  
Vol 8 (12) ◽  
pp. 6068
Author(s):  
Manasvee Dewan ◽  
Neha Sharma ◽  
Pragyan Swagatika Panda ◽  
Priyanka Banerjee
Keyword(s):  
Vitamin D ◽  
Case Report ◽  
Vitamin D Deficiency ◽  
Communicable Disease ◽  
The Body ◽  
Infants And Toddlers ◽  
Cellular Functions ◽  
Outdoor Activities ◽  
Non Communicable Disease

Vitamin D is a pro hormone needed for the homeostasis of calcium and phosphorus in the body. This state is crucial for maintaining metabolism, nerve conduction and general cellular functions in the body. Coronavirus disease 2019 (COVID-19) pandemic has led to long-term lockdowns. Schools are closed, people are confined to their homes and outdoor activities are at a halt. This has led to rise in cases of vitamin D deficiency (particularly in infants and toddlers) which is going un-noticed and can further lead us to another pandemic of non-communicable disease - vitamin D deficiency. We have presented a case report of healing rickets in a 19-month-old toddler. We aim to highlight this under-diagnosed and ignored vitamin deficiency that can affect the overall health of our younger generation in this COVID-19 era.

scholarly journals A Study of “Osteoporosis due to lack of Vitamin - D deficiency” through a small Survey in Kolkata, (West Bengal)

2021 ◽  
Vol 9 (4) ◽  
pp. 101-110
Author(s):  
S Rehan Ahmed ◽  
Keyword(s):  
Vitamin D ◽  
Bone Loss ◽  
Health Care Providers ◽  
Bone Health ◽  
Healthy Lifestyle ◽  
The Body ◽  
Care Providers ◽  
Long Term Effects ◽  
Resultant Increase

Bone loss and osteoporosis with the resultant increase in fracture risk should be major concerns for patients and health care providers. As the population ages, the long-term effects of osteoporosis including pain, loss of independence and institutionalized care will become more prevalent. Efforts to prevent bone loss and osteoporosis should start with proper education about a healthy lifestyle, including optimal calcium and vitamin D and exercise in adolescence. This education should continue throughout life, with emphasis during times of increased bone loss such as the menopause transition. This paper reviews the cornerstone of bone health; calcium and vitamin D. Although dietary sources of both nutrients are available, most people do not receive adequate amounts for proper bone health. In addition, the heightened awareness of damaging effects of sunlight has limited vitamin D synthesis from the skin. Fortunately, supplements are available that can supply the body with amounts necessary for bone health.

scholarly journals Animal Models for DOHaD Research: Focus on Hypertension of Developmental Origins

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 623
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain
Keyword(s):  
Animal Models ◽  
Early Life ◽  
Later Life ◽  
Convincing Evidence ◽  
Environmental Chemicals ◽  
Developmental Origins ◽  
Critical Window ◽  
Health And Disease ◽  
Underlying Mechanisms

Increasing evidence suggests that fetal programming through environmental exposure during a critical window of early life leads to long-term detrimental outcomes, by so-called developmental origins of health and disease (DOHaD). Hypertension can originate in early life. Animal models are essential for providing convincing evidence of a causal relationship between diverse early-life insults and the developmental programming of hypertension in later life. These insults include nutritional imbalances, maternal illnesses, exposure to environmental chemicals, and medication use. In addition to reviewing the various insults that contribute to hypertension of developmental origins, this review focuses on the benefits of animal models in addressing the underlying mechanisms by which early-life interventions can reprogram disease processes and prevent the development of hypertension. Our understanding of hypertension of developmental origins has been enhanced by each of these animal models, narrowing the knowledge gap between animal models and future clinical translation.

scholarly journals The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110069
Author(s):  
Rebecca J. Moon ◽  
Elizabeth M. Curtis ◽  
Stephen J. Woolford ◽  
Shanze Ashai ◽  
Cyrus Cooper ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Development ◽  
Controlled Trial ◽  
Clinical Care ◽  
Later Life ◽  
Vitamin D Supplementation ◽  
Public Health Policies ◽  
Positive Effects

Optimisation of skeletal mineralisation in childhood is important to reduce childhood fracture and the long-term risk of osteoporosis and fracture in later life. One approach to achieving this is antenatal vitamin D supplementation. The Maternal Vitamin D Osteoporosis Study is a randomised placebo-controlled trial, the aim of which was to assess the effect of antenatal vitamin D supplementation (1000 IU/day cholecalciferol) on offspring bone mass at birth. The study has since extended the follow up into childhood and diversified to assess demographic, lifestyle and genetic factors that determine the biochemical response to antenatal vitamin D supplementation, and to understand the mechanisms underpinning the effects of vitamin D supplementation on offspring bone development, including epigenetics. The demonstration of positive effects of maternal pregnancy vitamin D supplementation on offspring bone development and the delineation of underlying biological mechanisms inform clinical care and future public-health policies.

scholarly journals Vitamin D Deficiency in Testicular Cancer Survivors: A Systematic Review

2021 ◽  
Vol 22 (10) ◽  
pp. 5145
Author(s):  
Giuseppe Schepisi ◽  
Caterina Gianni ◽  
Sara Bleve ◽  
Silvia De Padova ◽  
Cecilia Menna ◽  
...  
Keyword(s):  
Vitamin D ◽  
Testicular Cancer ◽  
Vitamin D Deficiency ◽  
Molecular Mechanisms ◽  
Hypovitaminosis D ◽  
Young Males ◽  
Report Data ◽  
Testicular Cancer Survivors ◽  
Patients Experience

Testicular cancer (TC) is the most frequent tumor in young males. In the vast majority of cases, it is a curable disease; therefore, very often patients experience a long survival, also due to their young age at diagnosis. In the last decades, the role of the vitamin D deficiency related to orchiectomy has become an increasingly debated topic. Indeed, vitamin D is essential in bone metabolism and many other metabolic pathways, so its deficiency could lead to various metabolic disorders especially in long-term TC survivors. In our article, we report data from studies that evaluated the incidence of hypovitaminosis D in TC survivors compared with cohorts of healthy peers and we discuss molecular mechanisms and clinical implications.

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