scholarly journals Application of a nonlinear regression function to evaluate the kinetics of antibody response to vaccines in chicken lines divergently selected for multitrait immune response

1997 ◽  
Vol 76 (9) ◽  
pp. 1248-1255 ◽  
Author(s):  
S Weigend ◽  
N Mielenz ◽  
SJ Lamont
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Nonlinear Regression ◽  
Regression Function ◽  
Kinetics Of

scholarly journals Immunophenotyping and machine learning identify distinct immunotypes that predict COVID-19 clinical severity

2021 ◽  
Author(s):  
Yvonne M Mueller ◽  
Thijs J Schrama ◽  
Rik Ruijten ◽  
Marco W.J. Schreurs ◽  
Dwin G.B. Grashof ◽  
...  
Keyword(s):  
Machine Learning ◽  
Immune Response ◽  
Antibody Response ◽  
Clinical Improvement ◽  
Hierarchical Clustering ◽  
Disease Duration ◽  
Tertiary Care ◽  
Low Risk ◽  
Clinical Severity ◽  
Kinetics Of

Quantitative or qualitative differences in immunity may drive and predict clinical severity in COVID-19. We therefore measured modules of serum pro-inflammatory, anti-inflammatory and anti-viral cytokines in combination with the anti-SARS-CoV-2 antibody response in COVID-19 patients admitted to tertiary care. Using machine learning and employing unsupervised hierarchical clustering, agnostic to severity, we identified three distinct immunotypes that were shown post-clustering to predict very different clinical courses such as clinical improvement or clinical deterioration. Immunotypes did not associate chronologically with disease duration but rather reflect variations in the nature and kinetics of individual patient's immune response. Here we demonstrate that immunophenotyping can stratify patients to high and low risk clinical subtypes, with distinct cytokine and antibody profiles, that can predict severity progression and guide personalized therapy.

scholarly journals The kinetic variations of anti-nucleocapsid antibody in SARS-CoV-2 infection

2021 ◽  
Author(s):  
Shoji Kawada ◽  
Atsushi Ogata ◽  
Yasuhiro Kato ◽  
Masashi Okamoto ◽  
Yuta Yamaguchi ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Antibody Response ◽  
Nucleocapsid Protein ◽  
Healthcare Workers ◽  
Humoral Immune ◽  
Antibody Persistence ◽  
Decay Pattern ◽  
Kinetics Of

AbstractThe humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a pivotal role in controlling coronavirus disease 2019 (COVID-19) infections. However, little is known about the persistence of the antibody response.We evaluated that the kinetics of anti-nucleocapsid protein antibody of SARS-CoV2 infected healthcare workers in COVID-19 cluster occurred hospital. The long-term kinetics of anti-N antibody was classified high and keep pattern, high and decay pattern, and low and keep pattern. COVID-19 contact and symptomaticity was not related to kinetic patterns.The reason of kinetic difference was still unclear. However natural anti-SARS-CoV-2 antibody persistence was not uniform, suggesting inter-individual difference of SARS-CoV2 vaccine efficacy.

scholarly journals Immunological imprinting of the antibody response in COVID-19 patients

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Teresa Aydillo ◽  
Alexander Rombauts ◽  
Daniel Stadlbauer ◽  
Sadaf Aslam ◽  
Gabriela Abelenda-Alonso ◽  
...  
Keyword(s):  
Immune Response ◽  
Severe Acute Respiratory Syndrome ◽  
Antibody Response ◽  
Humoral Immune Response ◽  
Nucleocapsid Protein ◽  
Spike Protein ◽  
Ongoing Research ◽  
Variable Regions ◽  
Humoral Immune ◽  
Human Coronaviruses

AbstractIn addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are also susceptible to six other coronaviruses, for which consecutive exposures to antigenically related and divergent seasonal coronaviruses are frequent. Despite the prevalence of COVID-19 pandemic and ongoing research, the nature of the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Here we longitudinally profile the early humoral immune response against SARS-CoV-2 in hospitalized coronavirus disease 2019 (COVID-19) patients and quantify levels of pre-existing immunity to OC43, HKU1 and 229E seasonal coronaviruses, and find a strong back-boosting effect to conserved but not variable regions of OC43 and HKU1 betacoronaviruses spike protein. However, such antibody memory boost to human coronaviruses negatively correlates with the induction of IgG and IgM against SARS-CoV-2 spike and nucleocapsid protein. Our findings thus provide evidence of immunological imprinting by previous seasonal coronavirus infections that can potentially modulate the antibody profile to SARS-CoV-2 infection.

Kinetics of circulating antibody response toTrichomonas vaginalis: clinical and diagnostic implications: Table 1

2015 ◽  
Vol 91 (8) ◽  
pp. 561-563 ◽  
Author(s):  
Phuong Anh Ton Nu ◽  
Paola Rappelli ◽  
Daniele Dessì ◽  
Vu Quoc Huy Nguyen ◽  
Pier Luigi Fiori
Keyword(s):  
Antibody Response ◽  
Kinetics Of ◽  
Circulating Antibody

Kinetics of the local and systemic antibody response to primary and secondary infection with S48 Toxoplasma gondii in sheep

1995 ◽  
Vol 112 (1) ◽  
pp. 53-62 ◽  
Author(s):  
J.M. Wastling ◽  
D. Harkins ◽  
S. Maley ◽  
E. Innes ◽  
W. Panton ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Antibody Response ◽  
Secondary Infection ◽  
Kinetics Of

The Estimation of Nonparametric Functions in a Hilbert Space

1985 ◽  
Vol 1 (1) ◽  
pp. 7-26 ◽  
Author(s):  
A. R. Bergstrom
Keyword(s):  
Hilbert Space ◽  
Nonlinear Regression ◽  
Theoretical Basis ◽  
Fourier Coefficients ◽  
Orthogonal Series ◽  
Regression Function ◽  
Stopping Rule ◽  
Parametric Family ◽  
Convergence Theorems

This paper is concerned with the estimation of a nonlinear regression function which is not assumed to belong to a prespecified parametric family of functions. An orthogonal series estimator is proposed, and Hilbert space methods are used in the derivation of its properties and the proof of several convergence theorems. One of the main objectives of the paper is to provide the theoretical basis for a practical stopping rule which can be used for determining the number of Fourier coefficients to be estimated from a given sample.

scholarly journals Antibody response to Salmonella typhi lw human Schistosomiasis mansoni

1996 ◽  
Vol 29 (5) ◽  
pp. 441-445 ◽  
Author(s):  
Maria Imaculada Muniz-Junqueira ◽  
José Tavares-Neto ◽  
Aluizio Prata ◽  
Carlos Eduardo Tosta
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Blood Stream ◽  
Salmonella Typhi ◽  
Healthy Individuals ◽  
Typhoid Vaccine ◽  
Schistosomiasis Mansoni ◽  
Positive Antibody ◽  
Before And After ◽  
Hepatosplenic Schistosomiasis

Antibody response to Salmonella typhi O and H antigens was evaluated in 24 individuals with either hepatointestinal or hepatosplenic schistosomiasis mansoni before and after typhoid vaccination, and compared with that of non-infected controls. Before vaccination, Schistosoma-infected patients showed a higher frequency of positive antibody to O antigen and the same frequency to H antigen when compared with that of healthy individuals. However, those with hepatosplenic schistosomiasis showed higher titres of antibody to H antigen than those with hepatointestinal disease or healthy individuals. Infected subjects, particularly those with hepatointestinal disease, showed a decreased response after typhoid vaccine. Tins diminished ability to mount an immune response towards typhoid antigens dining schistosomiasis may interfere ivith the clearance of the bacteria from blood stream and, therefore, play a role in the prolonged survival of salmonella as obsewed in some patients with chronic salmonellosis associated with schistosomiasis.

Sign in / Sign up

Export Citation Format

Share Document