scholarly journals Effect of Low Dose Insulin Therapy on Normoglycemic Critically Ill Patients in Intensive Care Units

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Kamel ◽  
M R Hosny ◽  
M O Awad ◽  
A M Eid
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Intensive Care ◽  
Blood Glucose ◽  
Body Temperature ◽  
Insulin Therapy ◽  
Low Dose ◽  
Target Blood Glucose ◽  
Group 2 ◽  
Group 1

Abstract Background Insulin has anti-inflammatory effect and vasodilatory effect via endothelial NO release in arteries, veins and capillaries. Insulin inhibits release of inflammatory mediators like IL-6, TNF-α and enhances the immune function of monocytes. Stress-induced hyperglycemia is very common in the ICU, being detected in 50–85% of critically ill patients. It is defined as a blood glucose level >140 mg/dL or glycated hemoglobin (HbA1c) > 6.5 without a past history of pre-existing diabetes. Aim of the Work to evaluate the effect of low dose insulin therapy on the clinical progression of organ dysfunction and on the level of C-reactive protein (CRP), procalcitonin and lipid profile in patients known to be normoglycemic complaining of systemic inflammatory response syndrome (SIRS) or sepsis in intensive care unit. Patients and Methods The study was conducted on 60 patients which were randomized into 2 groups: 30 patients received moderate insulin therapy (group 1) and 30 patients received iv infusion of placebo (normal saline 0.9% NaCl) during the course of the study (group 2). Results There was an improvement in blood pressure, heart rate and body temperature in group 1 compared to group 2 and throughout the study period in group 1. CRP and lactate levels were declined in group 1 with better creatinine values. Triglycerides were decreased in group 1 and hypoxic index was higher in group 1 compared to group 2. Conclusion Insulin therapy with target blood glucose (120-140 mg/dL) has been found in our study that it reduces the complications of SIRS and organ failure, which was expressed by the gradual improvement in heart rate, means arterial blood pressure, body temperature, serum lactate level and urine output. These results support the hypothesis that insulin has a positive inotropic effect. Recommendations Future studies are required to compare between moderate insulin therapy with target blood glucose (120 – 140 mg/dL) and intensive insulin therapy with target blood glucose (80-110 mg/dL) as regard patients' mortality and morbidity.

scholarly journals Comparison of esmolol versus combination of esmolol and fentanyl in preventing cardiovascular stress response to intubation

2017 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Rahul Bhalke ◽  
Maroti S. Karale ◽  
Umesh Deshmukh
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Stress Response ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Cardiovascular Responses ◽  
Intravenous Fentanyl ◽  
Group 2 ◽  
Post Intubation ◽  
Group 1

<p><strong> </strong></p><p class="abstract"><strong>Background:</strong> A number of cardiovascular responses occur during laryngoscopy and intubation which can have serious consequences during anaesthesia.We planned to conduct a study to evaluate effectiveness of intravenous Esmolol and intravenous Fentanyl in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation.</p><p class="abstract"><strong>Methods:</strong> A prospective, observational, randomized, double blind comparative clinical study, conducted on 60 cases of ASA grade I/II patients undergoing elective abdominal surgery under general anesthesia. The data obtained was divided in the two groups based on drug used 5 min prior to induction, Group 1 (I.V. Esmolol 2 mg/kg) and Group 2 (I.V. Esmolol 2 mg/kg &amp; I.V. Fentanyl 2 µg/kg). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were measured at various time intervals.</p><p class="abstract"><strong>Results:</strong> There was no significant difference in HR, SBP, DBP, MAP after premedication and induction in both the groups. However at intubation, both groups showed an increase in HR, SBP, DBP and MAP but the rise was attenuated in both groups. Increase in HR was more in group 1 as compared to group 2 and it was statistically significant at 01 and 02 minutes post intubation. The increase in SBP was statistically significant at 00, 01 and 02 minutes post intubation. The increase in MAP was statistically significant immediately after induction, at 00, 01, 02, 05 and 10 minutes post intubation.  </p><p class="abstract"><strong>Conclusions:</strong> Combination of intravenous Esmolol and intravenous Fentanyl is more effective in attenuating heart rate, systolic, diastolic and mean arterial pressure response to intubation than intravenous Esmolol alone.</p>

scholarly journals The Impact of Obesity on Nighttime Blood Pressure Dipping

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 700
Author(s):  
Beata Moczulska ◽  
Maciej Zechowicz ◽  
Sylwia Leśniewska ◽  
Karolina Osowiecka ◽  
Leszek Gromadziński
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Diastolic Pressure ◽  
Blood Pressure Monitoring ◽  
Blood Pressure Measurement ◽  
Nighttime Blood Pressure ◽  
Group 2 ◽  
Cardiovascular Illness ◽  
The Impact ◽  
Group 1

Background and objectives: It is commonly known that obesity not only increases arterial hypertension (HT) risk but also impacts on the response to antihypertensives. This study aimed to assess blood pressure (BP) parameters based on Ambulatory Blood Pressure Measurement (ABPM) in obese patients. Materials and Methods: The study group consisted of 128 patients with obesity (BMI ≥ 30 kg/m2), with an average age of 43.25 years (±12.42), including 55 males and 73 females. They were divided into 2 groups: 1-with BMI ≥ 30 kg/m2 and <40 kg/m2, 2-with BMI ≥ 40 kg/m2. Each patient underwent 24-h blood pressure monitoring. The average 24-h, daytime and nighttime systolic and diastolic pressure, as well as 24-h mean heart rate and % of nocturnal dip, were assessed. Results: Mean BMI in group 1 was 34.73 kg/m2 (±2.96), and in group 2 it was 47.6 kg/m2 (±6.3). Group 1 was significantly older than group 2 (46.5 vs. 39 years old). The analysis of ABPM revealed significantly higher BP values in all measurements in group 2 (i.e., systolic blood pressure (SBP) 24 h median = 132 mmHg; diastolic blood pressure (DBP) 24 h median = 84 mmHg). The nocturnal dip was greater in group 1 (8.95%). Mean 24-h heart rate was also higher in group 2 (median = 76 beats/min) than group 1 (median = 67.5 beats/min). More than half of patients in group 2 had been previously treated for HT, and based on ABPM, new HT was diagnosed in 6 patients from group 1 and 14 patients from group 2. Three groups of patients were identified based on nighttime dip: dipper, non-dipper, and reverse-dipper. No patient of the extreme dipper type was found. Group 2 comprised of significantly more patients of the reverse-dipper type. Conclusions: Patients with extreme morbid obesity frequently exhibit HT of the reverse-dipping pattern. This type is often linked with a higher risk of more advanced cardiovascular illness.

scholarly journals Use of a New Ocular Insert versus Conventional Mydriasis in Cataract Surgery

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
C. Torrón ◽  
P. Calvo ◽  
O. Ruiz-Moreno ◽  
J. Leciñena ◽  
A. Pérez-Iñigo
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cataract Surgery ◽  
Pupil Size ◽  
Pupil Diameter ◽  
Phenylephrine Hydrochloride ◽  
Before And After ◽  
Group 2 ◽  
Ocular Insert ◽  
Group 1

Background. To compare the efficacy and safety of a new ocular insert versus conventional mydriasis in cataract surgery.Methods. We selected 70 patients undergoing cataract surgery. Thirty five patients (Group 1) received instillation of mydriatic drops (tropicamide 1%, phenylephrine 10%, and cyclopentolate 1%) prior to surgery, and 35 patients (Group 2) had a Mydriasert insert (Théa Pharma) (0.28 mg of tropicamide and 5.4 mg of phenylephrine hydrochloride) placed in the inferior fornix. Pupil size before and after surgery, blood pressure, and heart rate were measured.Results. Before surgery, pupil diameter was  mm in Group 1 and in Group 2 (). Twenty four hours after surgery, pupil diameter was  mm in Group 1 and in Group 2 (). There were no statistically significant differences in blood pressure or heart rate between groups.Conclusions. The effect of the Mydriasert insert was similar to conventional mydriatic agents. Pupil size was restored to normal faster when using the Mydriasert insert compared with conventional mydriatic agents for pupil dilation.

scholarly journals Evaluation of morpho-physiological characteristics of students living in northern conditions

2020 ◽  
pp. 116-123
Author(s):  
M. V. Osin ◽  
V. P. Maltsev
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Cardiovascular System ◽  
Physical Development ◽  
Hemodynamic Parameters ◽  
Development Indicators ◽  
Spring Period ◽  
Arterial Blood ◽  
Group 2 ◽  
Group 1

The study focused on the physical development indicators in younger teens aged 11–12 (Group 1) and 13–14 (Group 2) living in northern conditions (Surgut, Russia). The data was collected and processed in spring from February through March 2020. The physical development, the functional state of the cardiovascular system and the functional body reserves were assessed by anthropometric and hemodynamic indicators. It was found that the physical development was harmonious in the majority of examined teenagers. Among elder teenagers, more boys had good physical development, while more elder girls showed signs of asthenization. Hemodynamic parameters reflected the improved functioning of the cardiovascular system in relation to age. The integrative indicators of heart rate hemodynamics and arterial blood pressure were above the age-sex norm, which indicates stress on the vital systems. The adaptation reserves in teenagers of both groups were reduced during the spring period: 47–66 % of teenagers in Group 1 and 57–68 % of teenagers in Group 2 demonstrated unsatisfactory adaptation indicators.

To compare the haemodynamic stress response of direct laryngoscopy and oro-tracheal intubation using McCoy and Macintosh blade in general anaesthesia

2021 ◽  
Vol 12 (3) ◽  
pp. 28-32
Author(s):  
Arupratan Maiti ◽  
Sreya Moitro
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Stress Response ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Direct Laryngoscopy ◽  
Mean Blood Pressure ◽  
Macintosh Blade ◽  
Group 2 ◽  
Group 1

Background: Direct Laryngoscopy and intubation lead to extensive stress response and sympathetic stimulation in the body which can be critical for some patient subsets like cardiac ischemia, raised intracranial tension, cerebral aneurysm, open globe injury, glaucoma etc. Hence reduction of the intense stress response is of utmost importance for a stable and safe hemodynamics in those patients. Aims and Objectives: 1. To find out the hemodynamic stress response exerted by the Macintosh blade and McCoy blade. 2. To compare the hemodynamic stress responses between the two blades. Materials and Methods: In this study we had selected 60(male and female in equal number) ASA grade-1 and grade- 2 patients posted for elective general surgery. They were randomly divided into two groups - group 1(laryngoscopy done by McCoy blade)and group 2(laryngoscopy done by Macintosh blade). Systolic Blood Pressure, Diastolic Blood Pressure , Mean Blood Pressure and Heart Rate were recorded before and after anaesthesia induction, just after intubation and one, three and six minutes after orotracheal intubation. Results: The results were compared over time between the two groups. Mean values of Systolic Blood Pressure, Diastolic Blood Pressure, Mean Blood Pressure and heart rate were significantly higher in group 2 as compared to group 1(with p values as 0.009, 0.008, 00.004 and 0.000 respectively). Conclusion: Thus we conclude that the stress response was significantly higher when laryngoscopy was done with Macintosh blade as compared with McCoy blade. We would also like to stress that the art of laryngoscopy should just not be mastered but all anaesthesiologists should think of and practise techniques which would make laryngoscopy smooth and less stressful for our patients. Intubation with McCoy laryngoscope blade is one such technique.

scholarly journals Differentiated approach to the use of optimal medical therapy in patients with various clinical forms of stable ischemic heart disease

2019 ◽  
pp. 22-27 ◽  
Author(s):  
I. I. Shaposhnik ◽  
V. I. Karnot ◽  
T. M. Karandasova ◽  
O. F. Bannikova ◽  
O. G. Bocharova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Medical Therapy ◽  
Ischemic Heart ◽  
Elevated Blood ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

A total of 137 male patients with stable ischemic heart disease (SIHD), average age 62.3 ± 7.46 years, were divided into 3 groups depending on the initial measurements of blood pressure (BP) and heart rate (HR). Group 1 included patients with elevated blood pressure and/or heart rate (44.5% of patients); Group 2 included patients with normal blood pressure and/or heart rate (38.7%); Group 3 included patients with lowered blood pressure and/or heart rate (16.8%). Patients of Group 1 received beta-adrenergic blockers (BABs) or non-dihydropyridine calcium channel blockers (NDCCBs), in some cases ivabradine-containing BABs (Raenom®, Gedeon Richter) at doses required to achieve target blood pressure and heart rate. The patients of Group 2 received a limited range of drugs above listed due to their blood pressure and heart rate measurements, and the patients of Group 3 did not receive any due to the low levels of such measurements. Effectiveness of the therapy in patients of Group I was the highest. The use of trimetazidine MB (Predizin MB®, Gedeon Richter) has significantly improved the results of treatment in patients of Groups 2 and 3. Trimetazidine MB added to the therapy in patients of Group 1 improved the effectiveness of treatment. Prolongation of trimetazidine MB therapy contributed to improvement of its anti-ischemic effect. Thus, BABs, NDCCBs and ivabradine entered into the foreground, as an optimal medical therapy (OMT) in patients with elevated blood pressure and heart rate measurements. Trimetazidine MB, and ivabradine in some cases prevail in patients with normal and low blood pressure and/or heart rate. It should be stated that patients with various hemodynamic variants of SIHDa require a differentiated approach to the choice of OMT.

Acute severe carbon monoxide exposure in the rat: effects of hyperglycemia and hypoglycemia on mortality, recovery, and neurologic deficit

1991 ◽  
Vol 69 (8) ◽  
pp. 1168-1177 ◽  
Author(s):  
David G. Penney ◽  
C. Clough Helfman ◽  
Joseph C. Dunbar Jr. ◽  
Lowell E. McCoy
Keyword(s):  
Carbon Monoxide ◽  
Blood Glucose ◽  
Body Temperature ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Neurologic Deficit ◽  
Impaired Ability ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Human and animal studies suggest a poorer outcome in the presence of abnormal blood glucose concentration during cerebral hypoxia–ischemia. It is unknown whether this is also the case in acute severe carbon monoxide poisoning. Using Levine-prepared rats, three groups were established and exposed to CO to answer this question: (1) hyperglycemics resulting from the administration of a 50% glucose solution, (2) hypoglycemics resulting from the administration of normal saline, and (3) untreated controls. The rats inhaled 2400 ppm CO for 90 min in the absence of anesthesia. Blood glucose was raised to a mean value of 402 mg/dL just prior to CO exposure in group 1. This resulted in an increased mortality rate (i.e., 54%), and during 4 h of room air recovery an impaired ability to regain body temperature, an increased plasma lactate dehydrogenase activity, and an increased neurologic deficit as compared with group 3. Hypoglycemia, which developed during CO exposure in group 2 (mean minimum glucose after 90 min, 44 mg/dL), resulted in an increased mortality rate (i.e., 46%), and during 4 h of room air recovery an impaired ability to regain body temperature and an increased neurologic deficit as compared with group 3. Blood glucose concentration in the rats in groups 2 and 3 that died during or shortly after CO exposure was significantly depressed relative to the survivors of those groups. Plasma insulin activity was elevated during CO exposure in group 1 as compared with group 3, but fell during recovery; insulin remained low throughout CO exposure and recovery in group 2. The results demonstrate the deleterious effects of both a very high and a very low blood glucose concentration during acute CO exposure.Key words: blood pressure, body temperature, carbon monoxide, glucose, heart rate, hematocrit, hyperglycemia, hypoglycemia, insulin, lactate dehydrogenase, mortality, morbidity, neurologic deficit.

Abnormal Haemostasis and Blood Viscosity in Malignant Hypertension

1984 ◽  
Vol 52 (03) ◽  
pp. 253-255 ◽  
Author(s):  
C Isles ◽  
G D O Lowe ◽  
B M Rankin ◽  
C D Forbes ◽  
N Lucie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Viscosity ◽  
Renal Damage ◽  
Antithrombin Iii ◽  
Plasma Viscosity ◽  
Malignant Hypertension ◽  
Fibrin Deposition ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

SummaryWe have previously shown abnormalities of haemostasis suggestive of intravascular coagulation in patients with malignant hypertension, a condition associated with retinopathy and renal fibrin deposition. To determine whether such abnormalities are specific to malignant hypertension, we have measured several haemostatic and haemorheological variables in 18 patients with malignant hypertension (Group 1), 18 matched healthy controls (Group 2), and 18 patients with non-malignant hypertension (Group 3) matched for renal pathology, blood pressure and serum creatinine with Group 1. Both Groups 1 and 3 had increased mean levels of fibrinogen, factor VIIIc, beta-thrombo- globulin, plasma viscosity and blood viscosity (corrected for haematocrit); and decreased mean levels of haematocrit, antithrombin III and platelet count. Mean levels of fast antiplasmin and alpha2-macroglobulin were elevated in Group 1 but not in Group 3. We conclude that most blood abnormalities are not specific to malignant hypertension; are also present in patients with non-malignant hypertension who have similar levels of blood pressure and renal damage; and might result from renal damage as well as promoting further renal damage by enhancing fibrin deposition. However increased levels of fibrinolytic inhibitors in malignant hypertension merit further investigation in relation to removal of renal fibrin.

Analysis of the quality of early diagnostics of cardiovascular diseases in students of educational institutions of Khabarovsk (according to the data of preventive examinations)

2020 ◽  
pp. 13-16
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Diseases ◽  
Sinus Tachycardia ◽  
Blood Pressure Level ◽  
Educational Institutions ◽  
Conduction Disturbances ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

To identify the prevalence of early pathology of cardiovascular diseases, a survey of 400 200 girls) in the age group 15 and 17 years old was conducted as a part of routine medical of the level of blood pressure (BP) was carried out, with the calculation of the average level pressure on the basis of three separate measurements estimated by percentile tables for a registration of a standard resting ECG in 12 leads. According to the results of the survey, into 3 groups: with an increase in blood pressure above 95 ‰ (group 1 – 16 people), which recorded in males (p<0,05); Group 2 (67 people) – adolescents with a normal blood pressure level and group 3 of adolescents with a decrease in blood pressure below 5 ‰ changes in the form of rhythm and conduction disturbances were noted in almost every a predominance of sinus tachycardia in the first group. In the third group of adolescents, form of ectopic rhythm and pacemaker migration were significantly more frequently only 78 % of adolescents were referred for consultation and in-depth examination by a pediatric cardiologist.

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