Use of a New Ocular Insert versus Conventional Mydriasis in Cataract Surgery

Background. To compare the efficacy and safety of a new ocular insert versus conventional mydriasis in cataract surgery.Methods. We selected 70 patients undergoing cataract surgery. Thirty five patients (Group 1) received instillation of mydriatic drops (tropicamide 1%, phenylephrine 10%, and cyclopentolate 1%) prior to surgery, and 35 patients (Group 2) had a Mydriasert insert (Théa Pharma) (0.28 mg of tropicamide and 5.4 mg of phenylephrine hydrochloride) placed in the inferior fornix. Pupil size before and after surgery, blood pressure, and heart rate were measured.Results. Before surgery, pupil diameter was mm in Group 1 and in Group 2 (). Twenty four hours after surgery, pupil diameter was mm in Group 1 and in Group 2 (). There were no statistically significant differences in blood pressure or heart rate between groups.Conclusions. The effect of the Mydriasert insert was similar to conventional mydriatic agents. Pupil size was restored to normal faster when using the Mydriasert insert compared with conventional mydriatic agents for pupil dilation.

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Topical anesthesia versus peribulbar anesthesia in phacoemulsification cataract surgery and intraocular lens implantation

Journal of Clinical and Investigative Surgery ◽

10.25083/2559.5555/5.2/100.103 ◽

2020 ◽

Vol 5 (2) ◽

pp. 100-103

Author(s):

Incaf Elboukhani ◽

◽

Choaib Essadouni ◽

Adil Mchachi ◽

Leila Benhmidoune ◽

...

Keyword(s):

Blood Pressure ◽

Cataract Surgery ◽

Topical Anesthesia ◽

Advantages And Disadvantages ◽

Anesthesia Group ◽

Duration Of Surgery ◽

Peribulbar Anesthesia ◽

Group 2 ◽

Phacoemulsification Cataract Surgery ◽

Group 1

Topical anesthesia during phacoemulsification cataract surgery has become the best choice for ophthalmologists, which broadens the indications for surgery, and eliminates the risk of peribulbar injections. The aim of our study is to assess the advantages and disadvantages, the efficacy and the tolerance of this protocol. Prospective study extending from January 2018 to December 2019, including 116 patients operated for cataracts under topical anesthesia (group 1), and 179 patients under peribulbar anesthesia (group 2). All patients were operated by phacoemulsification. The patients evaluated their pain on a visual analog scale graduated from 1 to 10. The two groups were comparable in age, gender and history of high blood pressure. All patients received premedication before surgery (Atarax). It was the first eye operated for cataracts in 79 patients in group 1 and 75 patients in group 2. The two groups did not differ significantly in systolic blood pressure rate (p= 0,36), pain score (p=0.54), duration of surgery (p=0.52), anaesthesia-related intraoperative difficulties (p=0.17), or intraoperative surgical complication rate (p=0.49) or blood oxygen saturation (p=0.74). However, in the peribulbar groups, better patient and surgeon satisfaction scores were obtained (P < .005).

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Influence of Health Related Fitness on the Morphofunctional Condition of Second Mature Aged Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17228465 ◽

2020 ◽

Vol 17 (22) ◽

pp. 8465

Author(s):

Olha Podrihalo ◽

Svetlana Savina ◽

Leonid Podrigalo ◽

Sergii Iermakov ◽

Władysław Jagiełło ◽

...

Keyword(s):

Heart Rate ◽

Handgrip Strength ◽

The Body ◽

Related Effect ◽

Functional Capabilities ◽

Before And After ◽

Health Related ◽

Group 2 ◽

Group 1 ◽

Health Related Fitness

To analyze the influence of health-related fitness on the condition of second mature aged women. Participants: 65 women divided into two groups. Group 1–40 women, (43.33 ± 0.93) years old and group 2–25 women (44.40 ± 0.93) years old. The participants trained for 8 months, three times a week for 1 h. Group 1 trained dance aerobics (Monday), strength fitness (Wednesday) and stretching (Friday). Group 2 trained only stretching. The body length and mass, handgrip strength test, vital capacity, blood pressure, heart rate, Stange and Genchi tests, and motion amplitude in joints were evaluated before and after the program. The significance of the differences between the groups was evaluated by Student’s criterion (t) and Rosenbaum (Q). The different intensity of the health-related effect was confirmed at the end of the program. Physiometric indicators significantly increased in group 1. The complex physical activity led to a decrease in heart rate. The results of the Stange and Genchi tests significantly increased. Goniometric indicators of group 2 increased. The comparative analysis of the participants indicators confirms the generalized and higher health-related effect of the complex fitness program. The effect of such a program showed an increase of the adaptive potential, a significant increase in the functional capabilities of women, and the optimization of the studied indicators. With the same time expenditure for health-related fitness, the complex program has a more multifaceted effect in comparison with stretching.

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An evaluation of intracameral mydriasis for routine cataract surgery

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2017-310510 ◽

2017 ◽

Vol 102 (6) ◽

pp. 784-789 ◽

Cited By ~ 5

Author(s):

Christopher B Schulz ◽

Srini V Goverdhan ◽

Roger C Humphry

Keyword(s):

Cataract Surgery ◽

Patient Experience ◽

Pupil Size ◽

Cost Effective ◽

Turnaround Time ◽

Real World Evidence ◽

Intraoperative Floppy Iris Syndrome ◽

Group 2 ◽

Standard Regime ◽

Group 1

BackgroundIntracameral Mydrane might facilitate a more streamlined cataract service and improve the patient experience. There is limited ‘real-world’ evidence of its use in a UK setting.MethodsAs part of a local evaluation of cataract surgery using intracameral Mydrane (group 2; n=60), data were collected on intraoperative pupil size and postoperative visual acuity (VA), as well as the rate of mechanical pupil dilation, intraoperative floppy iris syndrome (IFIS) and complications. Preoperative and theatre turnaround time was recorded and patients completed a validated measure of satisfaction postoperatively. Data were compared with a previous cohort subjected to the existing standard regime of preoperative topical mydriatics (group 1; n=60).ResultsPostoperative VA was comparable between groups (0.09±0.16 vs 0.08±0.15; p=0.59). Pupil size in group 2 was 7.0±1.0 mm prior to capsulorhexis and 6.5±0.29 mm after cortical aspiration, with a smaller pupil in patients on alpha-antagonists (4.7±1.1 mm; p=0.004) at this later time point. Comparing group 2 with group 1, preoperative waiting was less (87 vs 146 min; p<0.0001) and satisfaction was higher (76.0±11.2 vs 66.3±8.6; p<0.0001), although theatre turnaround time was longer (25 min vs 22 min).ConclusionIntracameral mydriasis was clinically effective in most patients undergoing cataract surgery and might be associated with an improved patient experience and a more streamlined preoperative flow. Mydrane represents a licensed alternative to the off-label use of other intracameral mydriatic agents, but was not judged to be a cost-effective intervention for routine use in this particular setting.

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A Comparison of Endothelial Cell Loss in Combined Cataract and MIGS (Hydrus) Procedure to Phacoemulsification Alone: 6-Month Results

Journal of Ophthalmology ◽

10.1155/2015/769289 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Antonio M. Fea ◽

Giulia Consolandi ◽

Giulia Pignata ◽

Paola Maria Loredana Cannizzo ◽

Carlo Lavia ◽

...

Keyword(s):

Endothelial Cell ◽

Cataract Surgery ◽

Open Angle Glaucoma ◽

Glaucoma Surgery ◽

Cell Loss ◽

Endothelial Cell Loss ◽

Age Related ◽

Before And After ◽

Group 2 ◽

Group 1

Purpose. To compare the corneal endothelial cell loss after phacoemulsification, alone or combined with microinvasive glaucoma surgery (MIGS), in nonglaucomatous versus primary open angle glaucoma (POAG) eyes affected by age-related cataract.Methods. 62 eyes of 62 patients were divided into group 1 (n=25, affected by age-related cataract) and group 2 (n=37, affected by age-related cataract and POAG). All patients underwent cataract surgery. Group 2 was divided into subgroups A (n=19, cataract surgery alone) and B (n=18, cataract surgery and MIGS). Prior to and 6 months after surgery the patients’ endothelium was studied. Main outcomes were CD (cell density), SD (standard deviation), CV (coefficient of variation), and 6A (hexagonality coefficient) variations after surgeries.Results. There were no significant differences among the groups concerning preoperative endothelial parameters. The differences in CD before and after surgery were significant in all groups: 9.1% in group 1, 17.24% in group 2A, and 11.71% in group 2B. All endothelial parameters did not significantly change after surgery.Conclusions. Phacoemulsification determined a loss of endothelial cells in all groups. After surgery the change in endothelial parameters after MIGS was comparable to the ones of patients who underwent cataract surgery alone.

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Effects of electromagnetic radiation from 3G mobile phone on heart rate, blood pressure and ECG parameters in rats

Toxicology and Industrial Health ◽

10.1177/0748233711420468 ◽

2011 ◽

Vol 28 (7) ◽

pp. 629-638 ◽

Cited By ~ 4

Author(s):

Cengiz Colak ◽

Hakan Parlakpinar ◽

Necip Ermis ◽

Mehmet Emin Tagluk ◽

Cemil Colak ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Electromagnetic Radiation ◽

Close Contact ◽

Experimental Period ◽

Ecg Signals ◽

Group 4 ◽

Before And After ◽

Group 2 ◽

3G Mobile Phone

Effects of electromagnetic energy radiated from mobile phones (MPs) on heart is one of the research interests. The current study was designed to investigate the effects of electromagnetic radiation (EMR) from third-generation (3G) MP on the heart rate (HR), blood pressure (BP) and ECG parameters and also to investigate whether exogenous melatonin can exert any protective effect on these parameters. In this study 36 rats were randomized and evenly categorized into 4 groups: group 1 (3G-EMR exposed); group 2 (3G-EMR exposed + melatonin); group 3 (control) and group 4 (control + melatonin). The rats in groups 1 and 2 were exposed to 3G-specific MP’s EMR for 20 days (40 min/day; 20 min active (speech position) and 20 min passive (listening position)). Group 2 was also administered with melatonin for 20 days (5 mg/kg daily during the experimental period). ECG signals were recorded from cannulated carotid artery both before and after the experiment, and BP and HR were calculated on 1st, 3rd and 5th min of recordings. ECG signals were processed and statistically evaluated. In our experience, the obtained results did not show significant differences in the BP, HR and ECG parameters among the groups both before and after the experiment. Melatonin, also, did not exhibit any additional effects, neither beneficial nor hazardous, on the heart hemodynamics of rats. Therefore, the strategy (noncontact) of using a 3G MP could be the reason for ineffectiveness; and use of 3G MP, in this perspective, seems to be safer compared to the ones used in close contact with the head. However, further study is needed for standardization of such an assumption.

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Comparison of esmolol versus combination of esmolol and fentanyl in preventing cardiovascular stress response to intubation

International Journal of Clinical Trials ◽

10.18203/2349-3259.ijct20170309 ◽

2017 ◽

Vol 4 (1) ◽

pp. 49

Author(s):

Rahul Bhalke ◽

Maroti S. Karale ◽

Umesh Deshmukh

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Stress Response ◽

Mean Arterial Pressure ◽

Arterial Pressure ◽

Cardiovascular Responses ◽

Intravenous Fentanyl ◽

Group 2 ◽

Post Intubation ◽

Group 1

Background: A number of cardiovascular responses occur during laryngoscopy and intubation which can have serious consequences during anaesthesia.We planned to conduct a study to evaluate effectiveness of intravenous Esmolol and intravenous Fentanyl in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation.Methods: A prospective, observational, randomized, double blind comparative clinical study, conducted on 60 cases of ASA grade I/II patients undergoing elective abdominal surgery under general anesthesia. The data obtained was divided in the two groups based on drug used 5 min prior to induction, Group 1 (I.V. Esmolol 2 mg/kg) and Group 2 (I.V. Esmolol 2 mg/kg & I.V. Fentanyl 2 µg/kg). Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) were measured at various time intervals.Results: There was no significant difference in HR, SBP, DBP, MAP after premedication and induction in both the groups. However at intubation, both groups showed an increase in HR, SBP, DBP and MAP but the rise was attenuated in both groups. Increase in HR was more in group 1 as compared to group 2 and it was statistically significant at 01 and 02 minutes post intubation. The increase in SBP was statistically significant at 00, 01 and 02 minutes post intubation. The increase in MAP was statistically significant immediately after induction, at 00, 01, 02, 05 and 10 minutes post intubation. Conclusions: Combination of intravenous Esmolol and intravenous Fentanyl is more effective in attenuating heart rate, systolic, diastolic and mean arterial pressure response to intubation than intravenous Esmolol alone.

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The Impact of Obesity on Nighttime Blood Pressure Dipping

Medicina ◽

10.3390/medicina56120700 ◽

2020 ◽

Vol 56 (12) ◽

pp. 700

Author(s):

Beata Moczulska ◽

Maciej Zechowicz ◽

Sylwia Leśniewska ◽

Karolina Osowiecka ◽

Leszek Gromadziński

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Diastolic Pressure ◽

Blood Pressure Monitoring ◽

Blood Pressure Measurement ◽

Nighttime Blood Pressure ◽

Group 2 ◽

Cardiovascular Illness ◽

The Impact ◽

Group 1

Background and objectives: It is commonly known that obesity not only increases arterial hypertension (HT) risk but also impacts on the response to antihypertensives. This study aimed to assess blood pressure (BP) parameters based on Ambulatory Blood Pressure Measurement (ABPM) in obese patients. Materials and Methods: The study group consisted of 128 patients with obesity (BMI ≥ 30 kg/m2), with an average age of 43.25 years (±12.42), including 55 males and 73 females. They were divided into 2 groups: 1-with BMI ≥ 30 kg/m2 and <40 kg/m2, 2-with BMI ≥ 40 kg/m2. Each patient underwent 24-h blood pressure monitoring. The average 24-h, daytime and nighttime systolic and diastolic pressure, as well as 24-h mean heart rate and % of nocturnal dip, were assessed. Results: Mean BMI in group 1 was 34.73 kg/m2 (±2.96), and in group 2 it was 47.6 kg/m2 (±6.3). Group 1 was significantly older than group 2 (46.5 vs. 39 years old). The analysis of ABPM revealed significantly higher BP values in all measurements in group 2 (i.e., systolic blood pressure (SBP) 24 h median = 132 mmHg; diastolic blood pressure (DBP) 24 h median = 84 mmHg). The nocturnal dip was greater in group 1 (8.95%). Mean 24-h heart rate was also higher in group 2 (median = 76 beats/min) than group 1 (median = 67.5 beats/min). More than half of patients in group 2 had been previously treated for HT, and based on ABPM, new HT was diagnosed in 6 patients from group 1 and 14 patients from group 2. Three groups of patients were identified based on nighttime dip: dipper, non-dipper, and reverse-dipper. No patient of the extreme dipper type was found. Group 2 comprised of significantly more patients of the reverse-dipper type. Conclusions: Patients with extreme morbid obesity frequently exhibit HT of the reverse-dipping pattern. This type is often linked with a higher risk of more advanced cardiovascular illness.

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Effect of Low Dose Insulin Therapy on Normoglycemic Critically Ill Patients in Intensive Care Units

QJM ◽

10.1093/qjmed/hcaa039.009 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

A M Kamel ◽

M R Hosny ◽

M O Awad ◽

A M Eid

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Intensive Care ◽

Blood Glucose ◽

Body Temperature ◽

Insulin Therapy ◽

Low Dose ◽

Target Blood Glucose ◽

Group 2 ◽

Group 1

Abstract Background Insulin has anti-inflammatory effect and vasodilatory effect via endothelial NO release in arteries, veins and capillaries. Insulin inhibits release of inflammatory mediators like IL-6, TNF-α and enhances the immune function of monocytes. Stress-induced hyperglycemia is very common in the ICU, being detected in 50–85% of critically ill patients. It is defined as a blood glucose level >140 mg/dL or glycated hemoglobin (HbA1c) > 6.5 without a past history of pre-existing diabetes. Aim of the Work to evaluate the effect of low dose insulin therapy on the clinical progression of organ dysfunction and on the level of C-reactive protein (CRP), procalcitonin and lipid profile in patients known to be normoglycemic complaining of systemic inflammatory response syndrome (SIRS) or sepsis in intensive care unit. Patients and Methods The study was conducted on 60 patients which were randomized into 2 groups: 30 patients received moderate insulin therapy (group 1) and 30 patients received iv infusion of placebo (normal saline 0.9% NaCl) during the course of the study (group 2). Results There was an improvement in blood pressure, heart rate and body temperature in group 1 compared to group 2 and throughout the study period in group 1. CRP and lactate levels were declined in group 1 with better creatinine values. Triglycerides were decreased in group 1 and hypoxic index was higher in group 1 compared to group 2. Conclusion Insulin therapy with target blood glucose (120-140 mg/dL) has been found in our study that it reduces the complications of SIRS and organ failure, which was expressed by the gradual improvement in heart rate, means arterial blood pressure, body temperature, serum lactate level and urine output. These results support the hypothesis that insulin has a positive inotropic effect. Recommendations Future studies are required to compare between moderate insulin therapy with target blood glucose (120 – 140 mg/dL) and intensive insulin therapy with target blood glucose (80-110 mg/dL) as regard patients' mortality and morbidity.

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Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage

Neurology ◽

10.1212/wnl.0000000000006156 ◽

2018 ◽

Vol 91 (11) ◽

pp. e1058-e1066 ◽

Cited By ~ 14

Author(s):

Andrew B. Buletko ◽

Tapan Thacker ◽

Sung-Min Cho ◽

Jason Mathew ◽

Nicolas R. Thompson ◽

...

Keyword(s):

Blood Pressure ◽

Cerebral Ischemia ◽

Intracerebral Hemorrhage ◽

Blood Pressure Target ◽

Neurologic Deterioration ◽

Acute Cerebral Ischemia ◽

Before And After ◽

Group 2 ◽

Cerebral Ischemic ◽

Group 1

ObjectiveTo determine the incidence and predictors of acute cerebral ischemia and neurologic deterioration in intracerebral hemorrhage (ICH) patients after an institutional protocol change in systolic blood pressure (SBP) target from <160 to <140 mm Hg.MethodsWe retrospectively compared persons admitted with primary ICH before and after a protocol change in SBP target from <160 to <140 mm Hg. The primary outcomes were presence of acute cerebral ischemia on MRI completed within 2 weeks of ICH and acute neurologic deterioration.ResultsOf 286 persons with primary ICH, 119 underwent MRI and met inclusion criteria. Sixty-two had a target SBP <160 mm Hg (group 1) and 57 had a target SBP <140 mm Hg (group 2). There were no differences between the 2 groups in baseline clinical and radiographic characteristics, but over the first 24 hours of hospitalization, group 2 had lower mean SBP (134 vs 143 mm Hg, p < 0.001) and lower minimum SBP over 72 hours (106 vs 112 mm Hg, p = 0.02). Acute cerebral ischemia was more frequent in group 2 than in group 1 (32% vs 16%; p = 0.047) as was acute neurologic deterioration (19% vs 5%; p = 0.022). A minimum SBP ≤120 mm Hg over 72 hours was associated with cerebral ischemia, while no patient with a minimum SBP ≥130 mm Hg had cerebral ischemia. Acute cerebral ischemia was significantly associated with worse discharge NIH Stroke Scale score, while SBP target was not.ConclusionsIntensive lowering of SBP <140 mm Hg in acute ICH, particularly allowing SBP <120 mm Hg, is associated with increased remote cerebral ischemic lesions and acute neurologic deterioration.

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Evaluation of morpho-physiological characteristics of students living in northern conditions

Bulletin of Nizhnevartovsk State University ◽

10.36906/2311-4444/20-2/15 ◽

2020 ◽

pp. 116-123

Author(s):

M. V. Osin ◽

V. P. Maltsev

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cardiovascular System ◽

Physical Development ◽

Hemodynamic Parameters ◽

Development Indicators ◽

Spring Period ◽

Arterial Blood ◽

Group 2 ◽

Group 1

The study focused on the physical development indicators in younger teens aged 11–12 (Group 1) and 13–14 (Group 2) living in northern conditions (Surgut, Russia). The data was collected and processed in spring from February through March 2020. The physical development, the functional state of the cardiovascular system and the functional body reserves were assessed by anthropometric and hemodynamic indicators. It was found that the physical development was harmonious in the majority of examined teenagers. Among elder teenagers, more boys had good physical development, while more elder girls showed signs of asthenization. Hemodynamic parameters reflected the improved functioning of the cardiovascular system in relation to age. The integrative indicators of heart rate hemodynamics and arterial blood pressure were above the age-sex norm, which indicates stress on the vital systems. The adaptation reserves in teenagers of both groups were reduced during the spring period: 47–66 % of teenagers in Group 1 and 57–68 % of teenagers in Group 2 demonstrated unsatisfactory adaptation indicators.

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