scholarly journals 18. An unusual PET project: large vessel vasculitis presenting as lower limb claudication in the absence of aortitis

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Neil Morton ◽  
Yik Long Man ◽  
David D’Cruz

Abstract Introduction Rheumatologists are increasingly aware of extracranial giant cell arteritis (GCA), namely large vessel vasculitis (LVV) involving the aorta and its branches. It is uncommon for patients to present with claudication as their initial complaint. We present an unusual case of femoral arteritis presenting with lower limb claudication. PET-CT demonstrated increased uptake bilaterally in the femoral arteries with typical hypoechoic haloes on Doppler ultrasound. There was no evidence of aortitis. We also illustrate the diagnostic challenge differentiating between vasculitis and atherosclerosis on PET-CT and how steroid-therapy reduces the sensitivity PET imaging. Case description A 57-year-old lady with known hypertension presented to her local hospital with a 3-year history of worsening claudication in her lower limbs. Her exercise tolerance was limited to 50 metres over the past 2 months and she had rest pain. Other symptoms included widespread musculoskeletal pain, chest pain, headaches and jaw pain on mastication. Lower limb Doppler ultrasound demonstrated significant stenosis of the distal femoral arteries bilaterally with hypoechoic haloes typical for vasculitis. Immunology tests were all negative but inflammatory markers were raised (ESR 43 mm/h, CRP 14 mg/L). In view of the Doppler findings and GCA symptoms she was started on prednisolone 60mg. The prednisolone was held 2 days before a PET-CT which demonstrated mild uptake in both femoral arteries with no evidence of aortitis. Her CT angiogram showed significant diffuse atheromatous disease in the superficial femoral and popliteal arteries bilaterally. In view of this, the PET-CT uptake was thought to be in keeping with atherosclerosis rather than vasculitis. Her prednisolone was therefore stopped and she was transferred to a tertiary vascular centre for further management.  The vascular team at our hospital were still concerned about the possibility of vasculitis and a second rheumatology opinion was sought. Her inflammatory markers continued to rise (ESR 76 mm/h, CRP 29 mg/L). It was felt that the PET-CT results may have been affected by high-dose prednisolone which was temporarily held. The PET-CT was therefore repeated having been off steroids for 4 weeks. This demonstrated increased uptake in the superficial femoral and profunda arteries when compared to her previous scan. All her images were reviewed and the diagnosis was felt to be in keeping with LVV. Furthermore, she had a good clinical response to 40mg prednisolone and methotrexate was subsequently added. Discussion Classical GCA typically presents with cranial symptoms. Extracranial symptoms such claudication can occur although only 4% of patients fall into this category. In our patient, femoral arteritis presented with lower limb claudication. Peripheral limb ischaemia and/or aorta involvement is associated with a slightly younger demographic of LVV (<60 years).  Initially, there was diagnostic uncertainty given her raised inflammatory markers and hypoechoic femoral artery haloes on Doppler ultrasound, yet diffuse atherosclerosis on the CT angiogram. Hypoechoic haloes and multiple short segment occlusions are more typically seen in vasculitis rather than atherosclerotic disease. Accelerated atherosclerosis is common in primary vasculitides. Despite establishing the diagnosis of LVV by ultrasound in this case, the sensitivity for this in the common femoral artery is < 17%, and PET-CT is preferred. EULAR recommendations for LVV diagnosis include ultrasound and PET-CT. PET-CT was performed twice in this patient because the initial scan was performed following temporary cessation of high-dose steroids, which can decrease the sensitivity of PET-CT. The first PET-CT showed only mild uptake in the femoral arteries which could be consistent with atherosclerosis. Interestingly, PET-CT has been used to identify plaques vulnerable to rupture bed on FDG-avidity. Recent studies have utilised PET-CT to quantify the burden of atherosclerotic disease to help risk stratify patients accurately. This potential diagnostic ambiguity between vasculitis and atherosclerosis on PET-CT reinforces the importance of remaining off steroids around the time of PET imaging where possible. Key learning points This case sheds light on LVV through several interesting perspectives. Firstly, it is unusual for LVV to present with claudication in the lower limbs in the absence of aortitis, demonstrating the variety of ways in which the same pathophysiological mechanism can present clinically. We also highlight the initial diagnostic challenge, as mild uptake in the femoral arteries on PET-CT can be consistent with atherosclerosis. However, with typical findings of hypoechoic haloes on Doppler ultrasound and raised inflammatory markers, clinically this was in keeping with LVV. Interestingly, a repeat PET-CT off steroids demonstrated increased FDG-avidity in the affected areas. This is important as even holding steroids for 2 days before a PET-CT affected the results of the study. This case adds to the growing number of atypical extracranial presentations of LVV and provides useful insight for future possible cases. Conflict of interest The authors declare no conflicts of interest.

2015 ◽  
Vol 9 (11) ◽  
pp. 1289-1293 ◽  
Author(s):  
Kavitha Saravu ◽  
Rajagopal Kadavigere ◽  
Ananthakrishna Barkur Shastry ◽  
Rohit Pai ◽  
Chiranjay Mukhopadhyay

Two distinct and potentially deceitful cases of neurologic melioidosis are reported. Case 1: A 39-year-old alcoholic and uncontrolled diabetic male presented with cough, fever, and left focal seizures with secondary generalization. An magnetic resonance imaging (MRI) brain scan revealed a small peripherally enhancing subdural collection along the interhemispheric fissure suggestive of minimal subdural empyema. Blood culture grew Burkholderia pseudomallei. Patient was diagnosed with disseminated bacteraemic melioidosis with subdural empyema. He was successfully treated with ceftazidime-cotrimoxazole-doxycycline. Case 2: A 45-year-old male presented with left lower limb weakness, difficulty in passing urine and stool, and back pain radiating to lower limbs. Neurological examination revealed flaccid left lower limb with absent deep tendon reflexes and plantar reflex. Spinal MRI showed T2 hyperintensity from D9 to L1 suggestive of demyelination. Patient was treated with high dose methylprednisolone. By day 3 of steroid treatment, lower limb weakness progressed. Subsequent MRI showed extensive cord hyperintensity on T2 weighted sequence extending from C5 to conus medullaris consistent with demyelination. Cerebrospinal fluid (CSF) culture grew B. pseudomallei, and the patient was given meropenem-cotrimoxazole. After three weeks of parenteral treatment, the lower limbs remained paralyzed. Patient was discharged on oral cotrimoxazole-doxycycline. Conclusions: Melioidosis should be considered as a differential in focal suppurative central nervous system (CNS) lesions, meningoencephalitis, or encephalomyelitis in endemic areas. CNS infections must be ruled out prior to steroid administration. The role of corticosteroids in demyelinating CNS melioidosis has been refuted. This is a rare documentation of effect of unintentional corticosteroid treatment in melioidosis.


2021 ◽  
Vol 14 (2) ◽  
pp. e238580
Author(s):  
Amedra Basgaran ◽  
Sayani Khara ◽  
Aravinth Sivagnanaratnam

A 54 year-old man was admitted after being found on the floor of his home, thought to have been there for approximately 5 days. He was diagnosed with a non-ST elevation myocardial infarction and bilateral cerebral ischaemic infarcts, as well as an acute kidney injury driven by rhabdomyolysis. The following day, bilateral lower limb ischaemia was observed. A full body CT angiogram revealed a complete thromboembolic shower with bilateral arterial occlusion in the lower limbs, bilateral pulmonary emboli, a splenic infarct and mesenteric ischaemia. An echocardiogram revealed a large thrombus in the left ventricle as the likely thromboembolic source. Bilateral lower limb amputations were recommended, commencing a complex discussion regarding the best course of management for this patient. The discussion was multifaceted, owing to the patient’s lack of capacity, and input from multiple teams and the patient’s relatives was required. Both ethical and clinical challenges arise from this case of a thromboembolic shower.


2020 ◽  
Vol 13 (12) ◽  
pp. e237507
Author(s):  
Joshua M Inglis ◽  
Jia Tan

A 58-year-old woman presented with a 1-week history of lower limb bruising. She had a medical history of recurrent metastatic colon cancer with a sigmoid colectomy and complete pelvic exenteration leading to colostomy and urostomy formation. She had malignant sacral mass encroaching on the spinal cord. This caused a left-sided foot drop for which she used an ankle-foot orthosis. She was on cetuximab and had received radiotherapy to the sacral mass 1 month ago. On examination, there were macular ecchymoses with petechiae on the lower limbs. There was sparing of areas that had been compressed by the ankle-foot orthosis. Bloods showed mild thrombocytopaenia and anaemia with markedly raised inflammatory markers. Coagulation studies consistent with inflammation rather than disseminated intravascular coagulation. She was found to have Klebsiella bacteraemia secondary to urinary source. Skin biopsy showed dermal haemorrhage without vessel inflammation. Vitamin C levels were low confirming the diagnosis of scurvy.


2010 ◽  
Vol 9 (2) ◽  
pp. 15-23 ◽  
Author(s):  
Fanilda Souto Barros ◽  
José Maria Gomez Perez ◽  
Eliana Zandonade ◽  
Sérgio X. Salles-Cunha ◽  
Javier Leal Monedero ◽  
...  

Introduction: Pelvic varicose veins, one of the main causes of chronic pelvic pain and dyspareunia, are an important source of reflux for lower limb varicose veins, especially in recurrent cases. Color Doppler ultrasound of the lower limbs and transvaginal ultrasound are the noninvasive diagnostic methods most commonly used to assess pelvic venous insufficiency, whereas phlebography is still considered as the gold standard. Objectives: To determine the prevalence of lower limb varicose veins originating from the pelvis in a group of female patients and to determine the agreement between results obtained via color Doppler ultrasound of the lower limbs, transvaginal ultrasound, and phlebography. Methods: The sample comprised female patients referred to a vascular laboratory for lower limb screening. Patients diagnosed with deep venous thrombosis were excluded. Data analysis included kappa coefficient of agreement, McNemar's test, sensitivity and specificity values. Results: Of a total of 1,020 patients, 124 (12.2%) had findings compatible with reflux of pelvic origin. Among these patients, 51 (41.2%) were recurrent cases. A total of 249 were submitted to transvaginal ultrasound. There was significant agreement between lower limb ultrasonographic findings and transvaginal findings. Phlebography was performed in 54 patients. The comparison between transvaginal ultrasound and phlebography was associated with a 96.2% sensitivity and 100% specificity. Conclusions: The authors draw attention to the relatively high prevalence of lower limb varicose veins originating from the pelvis, suggesting an important but underdiagnosed cause of recurrent varicose veins.


2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Rima Nakrani ◽  
Ho-Man Yeung ◽  
Jin Sun Kim ◽  
Bhishak Kamat ◽  
Maruti Kumaran

Pulmonary artery intimal sarcoma (PAIS) is a rare tumor without clear syndromic presentation other than nonspecific symptoms of cough, dyspnea, and weight loss. This diagnosis is difficult due to challenging radiographic interpretations of multiple imaging modalities. We present a case of a 60-year-old male, who presented to his pulmonologist and underwent a CT chest with IV contrast that initially suggested primary lung carcinoma. CT angiogram showed significant vascular filling defects suspicious of an intravascular mass, rather than vascular invasion by lung lesions. The PET/CT scans further suggested a malignant process, but indistinguishable between an extravascular or intravascular etiology. Taking these results together, they suggested an intravascular malignancy, prompting a tissue biopsy, which ultimately led to a diagnosis of PAIS with metastases. Establishing a definitive diagnosis is essential as treatment and prognosis are different for sarcoma compared to carcinoma. There is no standard treatment to date, and management often includes a multidisciplinary approach involving surgery, radiation, chemotherapy, and targeted therapy. PAIS is a rare entity that cannot be diagnosed clinically and needs a multimodality approach for its diagnosis.


2019 ◽  
Vol 90 (e7) ◽  
pp. A18.1-A18
Author(s):  
Allycia MacDonald ◽  
Jason Dyke ◽  
Simon Khangure ◽  
Andrew Kelly

IntroductionApproximately 10% of amyotrophic lateral sclerosis (ALS) cases are inherited, of which 20% are due to mutations in the superoxide dismutase-1 gene (SOD1). MRI abnormalities are not uncommon in ALS, and there have been previous case reports of peripheral nerve enhancement in patients with SOD1 mutations, typically attributed to rapid neuronal degeneration.CaseA 31-year-old previously well Malaysian woman presented with a 3 month history of progressive lower limb weakness, initially involving the right lower limb but progressing to involve the left, requiring the use of a walking aid. Initial examination demonstrated asymmetric upper and lower motor neuron signs in bilateral upper and lower limbs. EMG findings were of a severe pure motor axonal process. CSF examination revealed elevated protein without significant elevation of white cells. MRI brain and spine demonstrated smooth cauda-equina ventral nerve root thickening and enhancement. Treatment with intravenous immunoglobulin and high dose corticosteroid was commenced for a presumed inflammatory process, with no clinical improvement. A cauda-equina nerve root biopsy was performed, demonstrating features consistent with an immune-mediated demyelinating neuropathy. The patient continued to deteriorate, developing flaccid upper limb weakness and facial involvement. Plasma exchange, azathioprine, cyclophosphamide, and rituximab were sequentially administered over the following two months without altering the rate of disease progression. Genetic testing returned a positive SOD1 heterozygous gene mutation, confirming the diagnosis of ALS.ConclusionsWe present a case of SOD1-ALS with atypical features on imaging and histopathology suggesting an underlying demyelinating process, expanding the known clinical spectrum of this mutation.


Author(s):  
Chia Daniel Msuega ◽  
Annongu Isaac Terkimbi ◽  
Hameed Mohammed ◽  
Kator Paul Iorpagher ◽  
Abdullahi Aliyu

Background: Doppler ultrasound scan (DUS) is a valuable, cost effective, and relatively rapid diagnostic technique that provides a non-invasive assessment of the vascular circulation in the lower limb. Aims: To determine the pattern of lower limbs Doppler requests in our environment and to evaluate the Doppler findings. Study Design: Retrospective study Place and Duration of Study: Radiology department of Benue state university Teaching Hospital over a one-year period from January 2018 to December 2018. Methods: We included 200 patients that had lower limb Doppler ultrasound for various indications. Data on age, gender, indications and findings was retrieved from departmental cards and case notes, then collated and analyzed using SPSS software version 23, with the P value taken as =.005. Results: Two hundred patients were scanned;106 males and 94 females with age range of 10-109 years. Their mean age was 34.2 ±13.5 years. Most patients 48(24.0%), who presented for Doppler sonography of the lower limb had diabetic foot ulcer (DFU), followed by left leg swelling in 42(21.0%) patients. DVT alone was indicated in 33(16.5%) patients. Both DFU and DVT were more in the male patients with a M:F ratio of 26:22 and 21:12 respectively. The indications for lower limb doppler ultrasound scan are seen to generally increase with increasing age, with the least among those less than 40years 32(16.0%) and highest among the greater than 60years age groups 89(44.5%). At doppler ultrasound, there are more patients with Deep vein thrombosis (DVT) 104(52.0%). Normal study and peripheral vascular disease (PVD) have equal incidence respectively in 48(24%) of the patients. DVT and PVD were more in the male group with a M: F ratio of 55:49 and 27:21 respectively while normal studies were seen equally in both sexes (M: F=24:24). Conclusion: Doppler ultrasound has been shown to be a cost-effective and valuable non-invasive tool for the diagnosis of lower limb vascular diseases.


Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Clare Tomlinson ◽  
Asim Khan ◽  
Debashish Mukerjee ◽  
Naveen Bhadauria

Abstract Background/Aims  Sarcoidosis is a rare multisystem disease characterised by the presence of noncaseating granulomas. It most commonly affects the lungs though can affect any other organ system. Rarely, it can manifest as an acute myopathy. We describe a case of a patient presenting with muscle weakness and constitutional symptoms who was eventually diagnosed with sarcoidosis. Methods  A 48-year-old male with a background of lumbar spondylosis and BPH, presented with a 6-week history of progressive upper and lower limb weakness, myalgia and reduced mobility. He also described an 18-month history of progressive fatigue, drenching night sweats and 10-kilogram weight loss. His symptoms meant he was unable to work as a firefighter. Examination demonstrated profound muscle wasting and reduced power in the proximal muscles of his upper and lower limbs. There was no evidence of rash, synovitis or lymphadenopathy. Blood tests showed a normocytic anaemia (Hb 100 g/L) and raised C-reactive peptide (180 mg/L) and erythrocyte sedimentation rate (100 mm/hour). The creatine kinase ranged between 20-42 units/litre. He had a weakly positive anti-nuclear antibody (1:80). The remaining autoantibody screen was negative including ENA, DSDNA, ANCA, rheumatoid factor and anti-CCP. Complement proteins were unremarkable. Furthermore, an extended myositis panel revealed no myositis-specific or myositis-associated antibodies. Serum calcium and angiotensin-converting enzyme (ACE) levels were normal. Blood cultures and virology screen including for HIV, hepatitis B, hepatitis C, CMV, EBV, COVID-19 and respiratory viruses were all negative. A chest radiograph was also unremarkable. Results  He subsequently underwent electromyography which revealed generalised myopathy. An MRI of the lower limb proximal musculature showed evidence of muscle oedema worse on the right-side but no definitive evidence of myositis. A PET-CT followed revealing FDG-avid generalised lymphadenopathy and polyarticular uptake, but little uptake in the skeletal muscles. He underwent an external iliac lymph node core biopsy which demonstrated multiple noncaseating granulomas and lymphadenitis. Cultures for Tuberculosis were negative and there was no evidence of a lymphoproliferative disorder. A muscle biopsy was desired but not possible due to lack of availability because of the COVID-19 pandemic. The patient was diagnosed with sarcoidosis and commenced on three pulses of intravenous methylprednisolone followed by a weaning regimen of high-dose oral prednisolone and subcutaneous methotrexate. This resulted in a sustained improvement in his symptoms and normalisation of inflammatory markers. Conclusion  Symptomatic myopathy is present in only 0.5-2.5% of sarcoidosis patients. This unique case highlights the heterogeneity of this disease and the vital role different diagnostic modalities play in achieving the correct diagnosis. It is also pertinent that the lymphadenopathy, found incidentally via imaging, led to the diagnosis. Although notoriously a diagnosis of exclusion, this case emphasises the importance of considering sarcoidosis even in the absence of respiratory symptoms, a raised ACE or hypercalcaemia. Disclosure  C. Tomlinson: None. A. Khan: None. D. Mukerjee: None. N. Bhadauria: None.


2016 ◽  
Vol 7 (6) ◽  
pp. 53-57 ◽  
Author(s):  
Shehu B Kakale ◽  
Sadisu M Maaji ◽  
Shamsudden A Aliyu

Background: There is a paucity of reports on the deep vein thrombosis in our environment.Aims and Objective: The aim of this study is to document the role of Doppler ultrasound in detecting deep vein thrombosis in our environment.Methods and Materials: Between Januarys to December 2014 forty six in patients with suspicion of DVT were evaluated prospectively. All patients presented with symptoms of single or bilateral disease, and a high probability of the disease. Two trained radiologists performed all duplex scan examinations. The patients were scanned using Mindray DC-3/DC-3T Diagnostic ultrasound scanner (Mindray Bio- Medical Electronics Co., LTD) linear (7-12MHz) transducers was used.Results: A total of 46 patients had duplex-Doppler scan examination carried out between January-December 2014. There were 30(65.2%) males and 16(38.8%) females subjects recruited for the study. The mean age was 48.9±SD17.3 with range of 18-85 years. A total of 21 patients (45.6%) were found to have deep vein thrombosis (DVTs) on duplex-Doppler examination. Proximal DVTs was seen in 6(12.9%) and 14(30.3%) for right and left lower limbs respectively. Distal DVTs was seen in 1(2.2%) in the right lower limb and 25(54.4%) show normal findings bilaterally. Diffused DVTs was seen in 2(4.3%) patients involving external, through popliteal veins on the right lower limb. In 3(6.5%) of the patients only the common femoral, superficial femoral and popliteal shows diffuse DVTs.Conclusion: With availability of Doppler ultrasound in our environment the diagnosis of DVT is now easier. Duplex scanning techniques are faster, safer, and less expensive. Because of its noninvasive nature, venous duplex is repeatable, allowing for continued follow up after the diagnosis. Asian Journal of Medical Sciences Vol.7(6) 2016 53-57


2021 ◽  
Vol 12 ◽  
Author(s):  
Sónia Mateus ◽  
Rui Paulo ◽  
Patrícia Coelho ◽  
Francisco Rodrigues ◽  
Vasco Marques ◽  
...  

The purpose of this study was to analyze the arterial and venous diameters of lower limbs in indoor soccer athletes and non-athletes using Doppler ultrasound to identify the differences in the variation of arterial and venous diameters between groups. Additionally, we intended to verify the differences of arterial and venous diameters between the skilled member (right member) and the not skilled member in each group. 74 male volunteers, aged between 19 and 30 years old, were divided in a group of athletes (n = 37, 24 ± 2.7 years, soccer players from national championship), and a group of non-athletes (n = 37, 26 ± 2.83 years). Vascular lower limb was assessed using Doppler ultrasound (Philips HD7 echograph with linear transducer 7–12 MHz). The athletes showed higher diameters of right common femoral artery (p = 0.009; moderate), left common femoral artery (p = 0.005; moderate), right deep femoral artery (p = 0.013; moderate), right popliteal artery (p = 0.003; moderate), and left popliteal artery (p = 0.017; small) than non-athletes. Veins’ diameters were also higher in athletes, specifically the right deep femoral vein (p ≤ 0.001; large), left deep femoral vein (p ≤ 0.001; large), right popliteal vein (p ≤ 0.001; large), and left popliteal vein (p ≤ 0.001; large). Differences were found between the skilled and non-skilled leg in athletes in the popliteal vein (7.68 ± 1.44 mm vs. 7.22 ± 1.09 mm, respectively, p &lt; 0.003). It seems that futsal athletes have superior mean diameters of lower limbs arteries and veins of the deep venous system to non-athletes. Moreover, the veins presented greater dilation, namely of the leg of the skilled lower limb.


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