EP35 What do patients with lupus know about cardiovascular risk: could dietary modification be a promising therapeutic?

Abstract Background Cardiovascular disease is the leading cause of mortality for patients with lupus. Understanding increased cardiovascular risk (CVR) in autoimmune diseases could improve CVR management in patients. The objective of a patient-focused event was to explore patient opinions about CVR and potential treatment options. A secondary objective was to learn about lupus patient experiences with diet including their opinion on considering diet as a therapeutic. Methods We hosted a patient event promoted through social media, relevant charities, hospitals and research groups. 13 patients with lupus and/or Sjögren’s syndrome attended and were asked about CVR using a questionnaire and round table discussion with researchers, clinicians and dietitians. In addition, a 15-question diet-based online survey was made publicly available for 3 weeks promoted through the same methods as the patient event. Results Sixty percent of patients were aware of the increased CVR associated with autoimmune rheumatic disease and 60% stated that their doctor had spoken to them about CVR. 73% thought that it was important for them to be aware of this increased CVR. When asked about medication to reduce CVR; no patients wanted to take a statin (lipid-lowering drug), however, 70% of patients would take statins if advised by their doctor. Conversely, respondents were more positive about using diet or taking a dietary supplement to reduce CVR; 71% would change their diet and 57% would take a supplement either on their own accord or on advice from health professionals. Some patients had already made changes to their diet to reduce their CVR, including reducing fat and increasing fruit and vegetable consumption. All attendees were prepared to participate in a clinical study using diet modification strategies, having vascular scans to assess atherosclerosis and provide blood samples for CVR research in lupus. An online survey was used to further assess lupus patient opinion on modifying their diet depending on their CVR. 284 responses were received over 3 weeks. Patients reported there was a lack of clinical counselling regarding diet with only 24% of patients stating that their doctor had spoken to them about diet. Despite this, 100% of patients stated that they would change their diet if they knew it would help their symptoms and 83% would take part in a diet-based clinical trial, supporting the results from the face-to-face patient event. Text analysis of patient research suggestions identified an interest in using diet to manage fatigue and disease activity. Conclusion This multidisciplinary event and online survey successfully gathered patient information regarding CVR and diet. The opinions and comments provided evidence that patients support further research in cardiovascular studies, a demand for increased CVR and dietary clinical counselling and a preference to changing their diet, whilst avoiding medication, to reduce their CVR. Disclosures G.A. Robinson None. E. Chocano Navarro None. K. Waddington None. T. Mcdonnell None. C. Wincup None. L. Martin-Gutierrez None. A. Maggio None. E. McLoughlin None. L. Rosser None. M. Naja None. D.A. Isenberg None. A.Z. Kalea None. C. Ciurtin None. I. Pineda-Torra None. E.C. Jury None.

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Greenhouse and Nursery Water Management Characterization and Research Priorities in the USA

Water ◽

10.3390/w11112338 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2338 ◽

Cited By ~ 4

Author(s):

Sarah A. White ◽

James S. Owen ◽

John C. Majsztrik ◽

Lorence R. Oki ◽

Paul R. Fisher ◽

...

Keyword(s):

Water Management ◽

Crop Production ◽

Online Survey ◽

Research Priorities ◽

Round Table ◽

The United States ◽

Round Table Discussion ◽

Recycled Water ◽

Specialty Crops ◽

The Usa

Nursery, floriculture, and propagation production accounted for 79% ($13.3 Billion) of 2017 ornamental specialty crop production in the United States. Access to high quality water sources is increasingly limited for irrigating these economically significant crops. Given the production, environmental, and economic issues associated with the use of water—including recycled, reclaimed, surface, and ground water—it is critical to develop sustainable runoff, containment, and remediation technologies, and to identify alternative sources of water. To better understand current practices and future water-related needs as perceived by grower stakeholders, an online survey was distributed nationally and five in-depth round table discussion sessions were conducted at the Mid-Atlantic Nursery Trade Show, Gulf States Horticultural Expo, California Grown Show, AmericanHort’s Cultivate, and the Farwest Show with a total of 36 individual industry participants. A team of research and extension specialists facilitated by a Specialty Crops Research Initiative Planning Grant (NIFA Project # 2011-51181-30633) analyzed and concisely summarized the results from the survey and the round table discussions. Research priorities related to water management identified by stakeholders revolved around six themes: (1) recycled water infrastructure and management; (2) contaminants; (3) plant health and water quality; (4) water treatment technologies; (5) competing and complementary water uses; (6) societal perception of agricultural water use.

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Fashion blogs: too trendy for libraries or useful resources?

Art Libraries Journal ◽

10.1017/s0307472200016862 ◽

2011 ◽

Vol 36 (2) ◽

pp. 12-16 ◽

Cited By ~ 2

Author(s):

Vivienne Eades

Keyword(s):

Online Survey ◽

Information Sources ◽

Round Table ◽

Potential Usefulness ◽

Round Table Discussion ◽

Table Discussion ◽

Fashion Students

Do your students look at blogs? Do you see them as information sources? Are they part of your library’s resources? This article summarises some recent research on fashion blogs, both ‘amateur’ and ‘professional’, and their use in providing information to fashion students. It highlights the potential usefulness of subject blogs, based on points that arose from the data collected from fashion librarians and students in interviews, an online survey and a round-table discussion. Hopefully the results will encourage you to consider your own stance on blog information in the library, whichever subject you support.

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M.473 Use of lipid lowering drugs according to cholesterol value and absolute cardiovascular risk

Atherosclerosis ◽

10.1016/s0021-9150(04)90471-6 ◽

2004 ◽

Vol 5 (1) ◽

pp. 109-110

Author(s):

C BROTONS

Keyword(s):

Cardiovascular Risk ◽

Lipid Lowering ◽

Lipid Lowering Drugs ◽

Absolute Cardiovascular Risk

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European consensus on essential steps of Minimally Invasive Ivor Lewis and McKeown Esophagectomy through Delphi methodology

Surgical Endoscopy ◽

10.1007/s00464-021-08304-5 ◽

2021 ◽

Author(s):

Yassin Eddahchouri ◽

◽

Frans van Workum ◽

Frits J. H. van den Wildenberg ◽

Mark I. van Berge Henegouwen ◽

...

Keyword(s):

Minimally Invasive ◽

Expert Panel ◽

Minimally Invasive Esophagectomy ◽

Round Table ◽

Round Table Discussion ◽

Ivor Lewis ◽

Delphi Methodology ◽

Invasive Esophagectomy ◽

European Consensus ◽

Mckeown Esophagectomy

Abstract Background Minimally invasive esophagectomy (MIE) is a complex and technically demanding procedure with a long learning curve, which is associated with increased morbidity and mortality. To master MIE, training in essential steps is crucial. Yet, no consensus on essential steps of MIE is available. The aim of this study was to achieve expert consensus on essential steps in Ivor Lewis and McKeown MIE through Delphi methodology. Methods Based on expert opinion and peer-reviewed literature, essential steps were defined for Ivor Lewis (IL) and McKeown (McK) MIE. In a round table discussion, experts finalized the lists of steps and an online Delphi questionnaire was sent to an international expert panel (7 European countries) of minimally invasive upper GI surgeons. Based on replies and comments, steps were adjusted and rephrased and sent in iterative fashion until consensus was achieved. Results Two Delphi rounds were conducted and response rates were 74% (23 out of 31 experts) for the first and 81% (27 out of 33 experts) for the second round. Consensus was achieved on 106 essential steps for both the IL and McK approach. Cronbach’s alpha in the first round was 0.78 (IL) and 0.78 (McK) and in the second round 0.92 (IL) and 0.88 (McK). Conclusions Consensus among European experts was achieved on essential surgical steps for both Ivor Lewis and McKeown minimally invasive esophagectomy.

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Eye Health, COVID-19, and the Occupational Health Professional: Round Table

Workplace Health & Safety ◽

10.1177/21650799211022990 ◽

2021 ◽

Vol 69 (8) ◽

pp. 352-358

Author(s):

Susan Gallagher ◽

Jay Clasing ◽

Edward Hall ◽

Stephanie Hammond ◽

Gayle Howard ◽

...

Keyword(s):

Occupational Health ◽

Health Professional ◽

Screen Time ◽

Occupational Injury ◽

Clinical Care ◽

Round Table ◽

Round Table Discussion ◽

Eye Health ◽

The Impact ◽

Health Risk Management

Background: Eye health has garnered increased attention since the COVID-19 pandemic. This Round Table explored the impact mask wearing, delays in eye examinations, and increased screen time have on vision and ultimately the worker. Methods: Leading experts in the areas of occupational health, risk management, eye health, and communication were identified and invited to participate in a Round Table discussion. Questions posed to experts were based on literature that addressed eye health, such as mask wearing, communication and managing expectations when accessing professional eye health appointments, and increased screen time. Findings: Experts agreed that eye health considerations must be in place. These considerations should address not only clinical care of the patient but ways to protect workers from occupational injury associated with the eye. Conclusion/Application to practice: The occupational health professional is a key resource for assessment and training that pertains to eye health.

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Patterns of care for prostate cancer radiotherapy—results from a survey among German-speaking radiation oncologists

Strahlentherapie und Onkologie ◽

10.1007/s00066-020-01738-1 ◽

2021 ◽

Author(s):

Marco M. E. Vogel ◽

Sabrina Dewes ◽

Eva K. Sage ◽

Michal Devecka ◽

Jürgen E. Gschwend ◽

...

Keyword(s):

Prostate Cancer ◽

Online Survey ◽

Treatment Options ◽

Equivalent Dose ◽

Patterns Of Care ◽

Treatment Recommendation ◽

Published Data ◽

Prostate Bed ◽

Radiation Oncologists ◽

German Speaking

Abstract Background Emerging moderately hypofractionated and ultra-hypofractionated schemes for radiotherapy (RT) of prostate cancer (PC) have resulted in various treatment options. The aim of this survey was to evaluate recent patterns of care of German-speaking radiation oncologists for RT of PC. Methods We developed an online survey which we distributed via e‑mail to all registered members of the German Society of Radiation Oncology (DEGRO). The survey was completed by 109 participants between March 3 and April 3, 2020. For evaluation of radiation dose, we used the equivalent dose at fractionation of 2 Gy with α/β = 1.5 Gy, equivalent dose (EQD2 [1.5 Gy]). Results Median EQD2(1.5 Gy) for definitive RT of the prostate is 77.60 Gy (range: 64.49–84.00) with median single doses (SD) of 2.00 Gy (range: 1.80–3.00), while for postoperative RT of the prostate bed, median EQD2(1.5 Gy) is 66.00 Gy (range: 60.00–74.00) with median SD of 2.00 Gy (range: 1.80–2.00). For definitive RT, the pelvic lymph nodes (LNs) are treated in case of suspect findings in imaging (82.6%) and/or according to risk formulas/tables (78.0%). In the postoperative setting, 78.9% use imaging and 78.0% use the postoperative tumor stage for LN irradiation. In the definitive and postoperative situation, LNs are irradiated with a median EQD2(1.5 Gy) of 47.52 Gy with a range of 42.43–66.00 and 41.76–62.79, respectively. Conclusion German-speaking radiation oncologists’ patterns of care for patients with PC are mainly in line with the published data and treatment recommendation guidelines. However, dose prescription is highly heterogenous for RT of the prostate/prostate bed, while the dose to the pelvic LNs is mainly consistent.

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THU0652-HPR ONLINE EDUCATION YIELDS SIGNIFICANT GAINS IN RHEUMATOLOGISTS’ KNOWLEDGE OF BIOLOGICS AND BIOSIMILARS BUT A SUBSTANTIAL GAP REMAINS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6048 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 570.2-571

Author(s):

A. Stan ◽

E. Bell ◽

P. Schoonheim ◽

E. Mysler

Keyword(s):

Online Education ◽

Statistical Significance ◽

Treatment Options ◽

Educational Activity ◽

Round Table Discussion ◽

Knowledge Gain ◽

Regulatory Requirements ◽

Research Support ◽

Significance Level ◽

Post Assessment

Background:Biologics are complex proteins which have revolutionized the treatment of many serious diseases. Due to their complexity and manufacturing which involves living organisms, it is not possible to create identical versions of reference biologics, but it is possible to create biosimilar drugs. Biosimilars have the potential to yield high cost savings and expand treatment options to meet the growing demand for biological therapies.Objectives:This study assessed whether the online CME-accredited round-table-discussion titled “Understanding Biologics: from protein to clinical practice” improved physicians’ understanding of the inherent variability of biologics and what similarity means in the context of biologics as well as the analytical assessment of quality that applies to both biologics and biosimilars.Methods:Rheumatologists participated in an online CME activity (www.medscape.org/viewarticle/900121) consisting of a 30-minute video discussion between 4 experts with accompanying slides. Educational effect was assessed using a 4-question repeated pairs, pre-/post-assessment. A chi-square test was used to determine if a statistically significant improvement (P<.05 significance level) existed in the number of pre-/post-test correct responses. Cramer’s V was used to estimate the level of impact of the education. The CME activity launched on 22 Aug 2018, and the data were collected through 9 Oct 2018.Results:A total of 622 rheumatologists participated in the educational activity, and 87 completed the pre- and postassessment. Overall the activity had a signficiant impact (P<.001) on rheumatologists’ understanding of the inherent variability of biologics and the regulatory requirements for approval of a biosimilar. The Cramer’s V value of 0.186 indicates a considerable effect of the education. The average perecentage of correct responses rose from 33% pre-activity to 51% post-activity. A linked learning assessment (individual responses matched pre- and post-education) showed that 25% of learners improved their knowledge and 26% reinforced their knowledge. The change in percentage of correct responses from pre- to post-assessment achieved statistical significance (P<.05) in 2 of the 3 questions presented: (i) understanding the type of studies needed to demonstrate comparability of a biosimilar to an originator (11% at baseline; 45% post activity), (ii) understanding the type of variability considered acceptable for a biologic (46% at baseline; 63% post activity). However, no knowledge gain was observed regarding basic analytic attributes evaluated to ensure batch to batch consistency (37% at baseline; 38% post activity). Almost 45% of rheumatologists gained confidence in their ability to describe the regulatory requirements for approval of a biosimilar.Conclusion:This online CME activity significantly improved rheumatologists’ understanding of the inherent variability of complex biologic medicines and the role of analytical studies in the regulatory approval of biosimilars. However, there is room for further improving physicians’ knowledge, especially of basic analytics of biologics and biosimilars.Acknowledgments:This CME-certified activity was supported by independent funding from Sandoz.Disclosure of Interests:Adriana Stan Grant/research support from: The CME-certified activity was supported by anindependent educational grant from Sandoz., Elaine Bell: None declared, Peter Schoonheim Grant/research support from: This CME-certified activity was supported by independent funding from Sandoz., Eduardo Mysler Grant/research support from: AbbVie, Lilly, Pfizer, Roche, BMS, Sandoz, Amgen, and Janssen., Consultant of: AbbVie, Lilly, Pfizer, Roche, BMS, Sandoz, Amgen, and Janssen.

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