scholarly journals 127 Quality of life in patients with connective tissue diseases: results from the Lupus Extended Autoimmune Phenotype (LEAP) study

Rheumatology ◽  
2018 ◽  
Vol 57 (suppl_3) ◽  
Author(s):  
John A Reynolds ◽  
Sarah Dyball ◽  
Sahena Haque ◽  
Hector Chinoy ◽  
Ariane Herrick ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Connective Tissue ◽  
Connective Tissue Diseases

scholarly journals Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

2017 ◽  
Vol Volume 8 ◽  
pp. 7-13 ◽  
Author(s):  
Michele Iudici ◽  
Rosaria Irace ◽  
Antonella Riccardi ◽  
Giovanna Cuomo ◽  
Serena Vettori ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Connective Tissue ◽  
Longitudinal Analysis ◽  
Connective Tissue Diseases ◽  
Undifferentiated Connective Tissue Diseases

scholarly journals Ekonomsko breme bolezni mišično-skeletnega sistema in vezivnega tkiva ter vpliv posledic na delo v organizacijah

2021 ◽  
Author(s):  
Sabina Sedlak ◽  
Sandra Simonović ◽  
Marjetka Jelenc
Keyword(s):  
Public Health ◽  
Quality Of Life ◽  
Connective Tissue ◽  
Economic Burden ◽  
Connective Tissue Diseases ◽  
Public Health Problem ◽  
Health Problems ◽  
Work Organizations ◽  
The Individual

Musculoskeletal and connective tissue diseases represent a growing public health problem and pose a major burden on health systems. Due to the increasing prevalence of musculoskeletal and connective tissue diseases, this area is becoming increasingly important in work organizations. An individual with health problems is less efficient and less productive at work, which results in poorer economic results. The health problems caused by these diseases also lead to premature retirement and a poorer quality of life for the individual. This increases the direct and indirect costs that burden employers and society as a whole. In cooperation with the Faculty of Economics, University of Ljubljana in 2000 the Slovenian National Institute of Public Health analyzed the economic burden of selected six diagnoses of the most common causes of musculoskeletal and connective tissue diseases for the period 2016 to 2018, on the basis of routine health databases. Based on the calculation of indirect and direct costs, the economic burden of musculoskeletal and connective tissue diseases accounted for about 5% of total health expenditure, which is 0.4% of gross domestic product in the study period. Risk factors associated with the development of diseases of the musculoskeletal system and connective tissue can be influenced by a healthy lifestyle, which is reflected in a better quality of life of the individual and higher productivity in work organizations.

scholarly journals Disorders of social functioning and quality of life in patients with gastroesophageal reflux disease while combined with undifferentiated connective tissue dysplasia

2020 ◽  
Vol 3 (1) ◽  
pp. 11-16
Author(s):  
Iryna Romash
Keyword(s):  
Quality Of Life ◽  
Gastroesophageal Reflux Disease ◽  
Connective Tissue ◽  
Gastroesophageal Reflux ◽  
Social Functioning ◽  
Reflux Disease ◽  
Control Group ◽  
Group I ◽  
Group Ii

Introduction. It has been scientifically confirmed that the risk of developing gastroesophageal reflux disease (GERD) increases especially with generalized or regional disruption of connective tissue structure, which is widespread among the population. Patients with such comorbid pathology may have a wide range of symptoms that may go beyond the general symptoms of heartburn and regurgitation. The symptoms and complications of GERD affect general health, daily and social functioning, physical and emotional activity. It also affects the quality of life (QoL) associated with health through frequent breaks during sleep, work and social activities. Purpose. study the dynamics of the level of quality of life and social functioning in patients with gastroesophageal reflux disease in combination with the syndrome of undifferentiated connective tissue dysplasia. Methodology. A total of 120 patients were included in the study: 65 men and 55 women: in 75 of them (Group II) GERD occurred on the background of UCTD, in 45 (Group I) as an independent disease. The control group consisted of 12 healthy individuals. The study was comprehensive. The Medical Outcomes Study 36-Item Short-Form Health Status (SF-36),the Gastrointestinal Symptom Rating Scale (GSRS) and the scale of "Personal and social performance" (PSP) -  were used to study patients in detail. Results and Discussion. Analyzing the results obtained on the basis of the GSRS questionnaire (Table 1), in patients with GERD on the background of UCTD, compared with patients of group I and the control group, there is a significant increase in three and four from the five scales. QoL in patients of Group II on the scale "Abdominal pain" were 14.3 ± 0.4 points, in Group I - 5.6 ± 1.3 points, in the Control Group - 2.4 ± 0.8 points, on the scale "Reflux syndrome": 13.7 ± 0.9, 10.5 ± 1.3 and 3.1 ± 0.9, respectively. "Dyspeptic syndrome" - 15.3 ± 0.4 points in Group II, 12.2 ± 0.6- in Group I and 6.1 ± 0.3- in the control group. "Constipation syndrome" 9.5 ± 0.8, 5.6 ± 1.03 and 5.7 ± 0.4, respectively (p <0,05). Conclusions: In this research we investigated the effect of comorbid pathology on QoL in patients with GERD, which developed against the background of UCTD. The results confirm that patients with such combined pathology have a lower level of quality of life and social functioning, and the tactics of treatment of such patients should take into account these changes

scholarly journals Periodontal Manifestation in a Patient with Kindler Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Aysegul Sari ◽  
Salih Celik
Keyword(s):  
Quality Of Life ◽  
Connective Tissue ◽  
Epidermolysis Bullosa ◽  
Hard Palate ◽  
Kindler Syndrome ◽  
Epidermal Tissue ◽  
Severe Periodontitis ◽  
Inherited Epidermolysis Bullosa ◽  
Oral Symptoms

Kindler syndrome is a rare subtype of inherited epidermolysis bullosa. A 42-year-old female patient was admitted to our clinic with a complaint of tooth mobility. Multiple hypo- and hyperpigmented macules dissipated all over her body, prominent poikilodermatous changes, xerosis of the skin, and atrophy were seen in the clinical extraoral examination. Intraoral examination showed atrophy of the buccal mucosa, limited oral opening, epidermal tissue easily separated from the connective tissue, painful ulcers of the hard palate, severe periodontitis, and keratosis of the lips. All of the teeth showed mobility. After dermatologist consultation, the diagnosis of the patient was clinically identified as “Kindler syndrome.” All of her teeth were extracted due to her progressive periodontal disease and late admission to our clinic. Periodontal treatment might be effective in treating and controlling oral symptoms related to the syndrome and in improving the patient’s quality of life.

scholarly journals Differentiated tactics of pregnancy in women with premature rupture of membranes

2020 ◽  
pp. 42-51
Author(s):  
Z.M. Dubossarska ◽  
◽  
Yu.O. Dubossarska ◽  
Ye.O. Puzii ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Connective Tissue ◽  
Pregnant Women ◽  
Well Being ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Positive Effects ◽  
Advanced Algorithm ◽  
Connective Tissue Dysplasia

The problem of premature rupture of membranes (PROM) is unfortunately still relevant in modern obstetrics and perinatology, especially in preterm pregnancy, and leads to 20% of all cases of perinatal loss. Among the possible causes, a lot of attention has recently been paid to disorders of connective tissue structure of genetic origin. The article provides an overview of current medical literature on the causes and diagnosis of PROM. Preliminary own data on the positive effect of the advanced algorithm for detecting undifferentiated connective tissue dysplasia (UCTD) on obstetric and perinatal outcomes are also given. The objective: to clarify the causes of PROM, the role of the severity of connective tissue dysplasia to predict risk factors for preterm birth, especially when combined in pregnant women with anemia. Materials and methods. A total of 60 pregnant women with IDF were examined. During the survey, laboratory and instrumental methods were used. Results. Quality of life in women with NDTT had an inverse mean relationship between the patients’ well-being and the number of PST phenotypic manifestations (r = 0.653; p> 94%). In addition, a high constitutionally determined level of personal anxiety was established. Quality of life depends on the number and severity of phenotypic abnormalities, ie the more signs of connective tissue dysplasia (joint hypermobility, scoliosis, nephroptosis, increased bleeding, myopia, pronounced varicose veins, etc.), the lower this indicator. As pregnancy progressed, worsening of health and decrease in quality of life in patients with NDST was observed. Conclusion. The advanced algorithm has demonstrated the positive effects in pregnant women with undifferentiated connective tissue dysplasia on obstetric and perinatal delivery, and the findings suggest that it is practiced in health care. Key words: premature rupture of membranes, preterm pregnancy, undifferentiated connective tissue dysplasia.

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