Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry

Rheumatology ◽  
2019 ◽  
Author(s):  
Martina Bonifazi ◽  
Nicola Sverzellati ◽  
Eva Negri ◽  
Giovanni Pomponio ◽  
Valeria Seletti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Low Frequency ◽  
Small Airways ◽  
Impulse Oscillometry ◽  
Therapeutic Implications ◽  
Radiological Features ◽  
Related Quality ◽  
St George's Respiratory Questionnaire ◽  
The Difference

Abstract Objectives The prevalence and clinical implications of small airways involvement in SSc are still to be fully elucidated. The goal of the present work is to assess the prevalence of small airways dysfunction by impulse oscillometry and to determine whether it correlates with selected disease-related features and respiratory-related quality of life. Methods Ninety-four SSc patients and 93 healthy controls were studied by impulse oscillometry measurements. Small airways dysfunction was defined as the difference between resistance at low frequency, i.e. 5 Hz, and resistance at high frequency, i.e. 20 Hz, termed ‘R5-R20’, ⩾0.07 kPa/l/s. The St George’s Respiratory Questionnaire was used to measure health impairment in SSc patients. Radiological features of small airways disease and parenchymal abnormalities on high resolution CT chest scans were jointly assessed by two thoracic radiologists. Results Small airways dysfunction was present in 21.5% of the SSc patient cohort, with a prevalence almost 5-fold higher compared with controls, and it was significantly associated with worse respiratory-related quality of life. Radiological features consistent with small airways abnormalities were detected in 25% of SSc patients, mostly in the absence of interstitial lung changes. Combining functional and radiological evaluations, one-third of the SSc cohort showed at least one feature of small airways involvement, which was associated with the lcSSc phenotype and with longer disease duration. Conclusion The current study strengthens the hypothesis that small airway dysfunction might be a feature of SSc-related lung involvement, providing the first data on its significant impact on respiratory-related quality of life. A full assessment of lung function in SSc patients should include impulse oscillometry as a complementary technique, due to potential clinical and therapeutic implications.

Abstract 279: The Impact of Heart Failure on Depression and Quality of Life is Greater in Men than Women

2012 ◽  
Vol 5 (suppl_1) ◽  
Author(s):  
Rory Hachamovitch ◽  
Brian Griffin ◽  
Alan Klein ◽  
Benjamin Nutter ◽  
Irene Katzan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Demographic Data ◽  
Cardiovascular Assessment ◽  
Related Quality ◽  
Health Related ◽  
The Difference ◽  
The Impact ◽  
The Relationship

Background. Patients (pts) diagnosed with congestive heart failure (HF) have been reported to have more frequent depression and worsened health related quality of life (HRQOL). Although depression is more common in women than men in this condition, the impact of HF on depression and HRQOL in men versus women is unclear. We sought to examine the relationship between pt sex, HF diagnosis, and pt-perceived depression and HRQOL. Methods. Depression (PHQ-9) and HRQOL (EQ5D) data were collected using tablet computers from pts presenting for routine outpatient cardiovascular assessment at our institution between November, 2010 and December, 2011. Demographic, clinical, and historical data was collected as per routine. We examined the association of pt sex and clinical diagnosis of HF with instrument results after adjusting for potential confounding information using mutliple linear regression. Results. Of 3046 pts (age 61±15), 39% were female and 8.7% were diagnosed with HF. Overall, PHQ-9 was greater, and minor or major depression (PHQ-9≥10) was more frequent, in women than men (4.6±4.6 vs. 3.3±4.4; 14.0% vs. 8.9%, both p<0.05) and in HF pts than pts without HF (5.9±5.6 vs. 3.6±4.3, 22.0% versus 9.6%; both p<0.05). Similarly, HRQOL was worse in women than men (EQ-5D 0.80±0.18 vs. 0.87±0.16; p<0.01) and in HF pts than no HF (EQ-5D 0.76±0.18 vs. 0.85±0.17; p<0.01). However, the difference in PHQ-9 between pts with versus without HF was greater in men (6.23±6.06 vs. 3.02±4.06, p<0.01) than women (5.43±4.85 vs. 4.55±4.58, p=0.09). After adjusting for cardiovascular diagnoses, comorbidities, clinical and demographic data, multivariable modeling of PHQ-9 revealed a significant interaction between pt sex and HF diagnosis (p=0.001; see Figure) such that women had greater PHQ-9 scores compared to men without HF, but in the setting of HF, mens' PHQ-9 scores were greater. Modeling of EQ-5D also revealed that after risk-adjustment an interaction between HF diagnosis and sex was present with a similar pattern of findings. Conclusion. Although depression is more frequent and severe in women compared to men, and in pts with versus without HF, HF appears to impact depression severity more in men compared to women.

scholarly journals Health-Related Quality of Life Difference between Early Diagnosed and Finished Therapy of Nephrotic Syndrome in Children

2021 ◽  
Vol 9 (B) ◽  
pp. 801-805
Author(s):  
Riska Habriel Ruslie ◽  
Darmadi Darmadi ◽  
Cennikon Pakpahan
Keyword(s):  
Quality Of Life ◽  
Nephrotic Syndrome ◽  
Therapy Group ◽  
Steroid Resistance ◽  
Health Related Quality ◽  
Female Ratio ◽  
Related Quality ◽  
Health Related ◽  
The Difference

BACKGROUND: Nephrotic syndrome is the most common glomerular disease in children with high economic burden. The management of nephrotic syndrome at present is not only focusing in outcomes of disease but also the burden related to health-related quality of life (HRQOL). HRQOL of children with nephrotic syndrome is influenced by steroid dependence, steroid resistance, cytotoxic therapy, frequency of relapse, disease severity, socioeconomic status, and duration of illness. AIM: The objective of the study is to determine the difference of HRQOL in children between early diagnosed nephrotic syndrome and finished therapy of nephrotic syndrome. METHODS: A cross-sectional study was conducted between January and December 2018. Subjects were children aged 1–18 years with nephrotic syndrome and then divided into 2 groups based on either in the 1st week of full dose corticosteroid treatment or in the 1st week after finishing therapy equally. Demographical data, nutritional status, and laboratory results were obtained. HRQOL was measured using PedsQL 4.0 questionnaire in the Indonesian language. The difference of HRQOL was analyzed using independent T-test. RESULTS: A total of 100 subjects enrolled in this study and divided into two groups. Male-to-female ratio was 4:1 in early diagnosed group and 7.3:1 in finished therapy group. Mean age of subjects for the early diagnosed group was 4.6 years and finished therapy group was 5.3 years. Total HRQOL was improved after treatment administration in children with nephrotic syndrome (p < 0.001). The improvement was most significant in physical domain (p = 0.002). CONCLUSION: HRQOL in children with early diagnosed nephrotic syndrome was lower compared to children with finished therapy of nephrotic syndrome.

scholarly journals Adolescent-parent disagreement on health-related quality of life in food allergic adolescents; who makes the difference?

2011 ◽  
Vol 1 (S1) ◽  
Author(s):  
Jantina L van der Velde ◽  
Bertine MJ Flokstra-de Blok ◽  
Ann Hamp ◽  
Rebecca C Knibb ◽  
Eric J Duiverman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Adolescent Parent ◽  
The Difference

Reversal of anorexia with megestrol acetate (MA): Impact on quality of life (QoL) in non-metastasic lung cancer patients (pts) undergoing radiation therapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18613-18613 ◽  
Author(s):  
J. Pardo ◽  
A. Mena ◽  
A. Monleon ◽  
V. Macias ◽  
J. Sole ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Life Questionnaire ◽  
Negative Effects ◽  
Lung Cancer Patients ◽  
Related Quality ◽  
The Difference

18613 Background: Anorexia is a common and major problem in cancer patients. Its ethiology is multifactorial and has negative effects on pts QoL. Up to 30% of non-metastasic lung cancer pts receiving radiotherapy will develop anorexia during treatment. We conducted a randomized trial comparing the efficacy of two different doses of MA. The results of the first 130 pts included, presented at ASCO 2003, indicated that MA at doses of 600 mg/day is significantly more effective in the treatment of anorexia in these pts than low doses (320 mg/day) of MA. Here we present the results of the quality of life sub-study which purpose is to evaluate the effect of reversing anorexia in pts health related quality of life (HRQOL). Methods: From February 1999 to April 2003, 160 non-mestastatic lung cancer pts who developed anorexia during radiotherapy were randomized to receive either 320 mg/day or 600 mg/day of MA. All pts who developed anorexia filled up the EuroQuol (EQ-5D) quality of life questionnaire before treated with MA and the responders did it again when appetite was regained. The endpoint was improvement in pts HRQOL (defined as an increase > 5 mm in the EQVAS score between the second and first questionnaires). Results: The analysis of the EuroQuol (EQ-5D) questionnaires of the 131 pts who responded to treatment with MA shows that 106 pts (81%) had an improvement > 5 mm in the EQVAS score while 19 % did not. The difference is statistically significant (Binomial test: p < 0.0001). Regarding differences between the two series, 42 pts improved in the 320 mg arm versus 64 in the 600 mg arm which is not statistically significant (Fisher test: p = 0.501). Conclusions: Our results indicate that reversal of anorexia with MA has a clinically significant improvement in HRQOL in non-metastatic lung cancer pts undergoing radiation therapy. The absence of statistically significant differences between the two series may be due to the sample size. [Table: see text] No significant financial relationships to disclose.

Effect of High- Versus Low-Frequency Exercise Training in Multidisciplinary Cardiac Rehabilitation on Health-Related Quality of Life

1999 ◽  
Vol 19 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Marike A. Berkhuysen ◽  
Wybe Nieuwland ◽  
Bram P. Buunk ◽  
Robbert Sanderman ◽  
JanWillem Viersma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Exercise Training ◽  
Cardiac Rehabilitation ◽  
Low Frequency ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Longitudinal association between physical activity and health-related quality of life among community-dwelling older adults: a longitudinal study of Urban Health Centres Europe (UHCE)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xuxi Zhang ◽  
Siok Swan Tan ◽  
Carmen Betsy Franse ◽  
Tamara Alhambra-Borrás ◽  
Arpana Verma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Low Frequency ◽  
Health Related Quality ◽  
Longitudinal Association ◽  
Related Quality ◽  
Health Related ◽  
Mental Hrqol

Abstract Background Physical activity (PA) may play a key role in healthy aging and thus in promoting health-related quality of life (HRQoL). However, longitudinal studies on the association between PA and HRQoL are still scarce and have shown inconsistent results. In this study, we aimed to examine the longitudinal association between frequency of moderate PA and physical and mental HRQoL. Secondly, to assess the association between a 12-month change in frequency of moderate PA and HRQoL. Methods A 12-month longitudinal study was conducted in Spain, Greece, Croatia, the Netherlands, and the United Kingdom with 1614 participants (61.0% female; mean age = 79.8; SD = 5.2) included in the analyses. Two categories of the self-reported frequency of moderate PA including 1) ‘regular frequency’ and 2) ‘low frequency’ were classified, and four categories of the change in frequency of moderate PA between baseline and follow-up including 1) ‘continued regular frequency’, 2) ‘decreased frequency’, 3) ‘continued low frequency’ and 4) ‘increased frequency’ were identified. Physical and mental HRQoL were assessed by the 12-Item Short-Form Health Survey (SF-12). Results The frequency of moderate PA at baseline was positively associated with HRQoL at follow-up. Participants with a continued regular frequency had the highest HRQoL at baseline and follow-up. Participants who increased the frequency of moderate PA from low to regular had better physical and mental HRQoL at follow-up than themselves at baseline. After controlling for baseline HRQoL and covariates, compared with participants who continued a regular frequency, participants who decreased their frequency had significantly lower physical (B = -4.42; P < .001) and mental (B = -3.95; P < .001) HRQoL at follow-up; participants who continued a low frequency also had significantly lower physical (B = -5.45; P < .001) and mental (B = -4.10; P < .001) HRQoL at follow-up. The follow-up HRQoL of participants who increased their frequency was similar to those who continued a regular frequency. Conclusions Maintaining or increasing to a regular frequency of PA are associated with maintaining or improving physical and mental HRQoL. Our findings support the development of health promotion and long-term care strategies to encourage older adults to maintain a regular frequency of PA to promote their HRQoL.

scholarly journals Social gradient in health-related quality of life among urban residents in Limassol, Cyprus: Research article

2020 ◽  
Author(s):  
Panagiota Ellina ◽  
Nicos Middleton ◽  
Ekaterini Lambrinou ◽  
Christiana Kouta
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Social Inequalities ◽  
Social Gradient ◽  
Health Related Quality ◽  
Social Inequalities In Health ◽  
Related Quality ◽  
Health Related ◽  
The Difference

Abstract Background: Social inequalities in health threaten social cohesion and, therefore, their investigation is an important research field. Monitoring the health of the population is necessary to identify health needs, design programs focused in people’s needs and to evaluate the effectiveness of health policies.Methods: A cross-sectional survey using primary data was applied. The study investigates the size and the extent of social inequalities in quality of life and health behaviours in Limassol, Cyprus. Data collection was done by door-to-door survey, in the form of interviews. The sample consisted of 450 residents aged 45-64 across 45 randomly selected neighbourhoods, that met the selection criteria. The tools used were: Demographic questionnaire, SF 36 Questionnaire, IPAQ- International Physical Activity Questionnaire short form.Results: The social gradient appears in all social indicators. As for the physical dimension of health has a strong relationship between health-related quality of life with the education index. Specifically, the difference between the two poles is 12 points for men and 14 points for women (p = 0.16). Profession systematically appears to have a stronger relationship with men than with women, and is present in both physical and mental dimensions. Specifically, the difference between the two poles is 13 points for men and 10 points for women (p = 0.31).Conclusions: Exploring social inequalities in health-related quality of life, is a complex situation influencing social, physical and psychological health state. It seems that young male individuals, who are highly educated, employed full time, earning high incomes and engaging in mild physical activity, have significantly higher level of health-related life quality, compared to other middle age adult groups, living in Limassol. This finding is in agreement with other studies that show correlations between gender and the patterns of risk factors.

scholarly journals Social gradient in health-related quality of life among urban residents in Limassol, Cyprus: Research article

2020 ◽  
Author(s):  
Panagiota Ellina ◽  
Nicos Middleton ◽  
Ekaterini Lambrinou ◽  
Christiana Kouta
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Social Inequalities ◽  
Social Gradient ◽  
Health Related Quality ◽  
Social Inequalities In Health ◽  
Related Quality ◽  
Health Related ◽  
The Difference

Abstract Background: Social inequalities in health threaten social cohesion and, therefore, their investigation is an important research field. Monitoring the health of the population is necessary to identify health needs, design programs focused in people’s needs and to evaluate the effectiveness of health policies.Methods: A cross-sectional survey using primary data was applied. The study investigates the size and the extent of social inequalities in quality of life and health behaviours in Limassol, Cyprus. Data collection was done by door-to-door survey, in the form of interviews. The sample consisted of 450 residents aged 45-64 across 45 randomly selected neighbourhoods, that met the selection criteria. The tools used were: Demographic questionnaire, SF 36 Questionnaire, IPAQ- International Physical Activity Questionnaire short form.Results: The social gradient appears in all social indicators. As for the physical dimension of health has a strong relationship between health-related quality of life with the education index. Specifically, the difference between the two poles is 12 points for men and 14 points for women (p = 0.16). Profession systematically appears to have a stronger relationship with men than with women, and is present in both physical and mental dimensions. Specifically, the difference between the two poles is 13 points for men and 10 points for women (p = 0.31).Conclusions: Exploring social inequalities in health-related quality of life, is a complex situation influencing social, physical and psychological health state. It seems that young male individuals, who are highly educated, employed full time, earning high incomes and engaging in mild physical activity, have significantly higher level of health-related life quality, compared to other middle age adult groups, living in Limassol. This finding is in agreement with other studies that show correlations between gender and the patterns of risk factors.

scholarly journals Health-related quality of life of patients diagnosed with COPD in Extremadura, Spain: results from an observational study

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
María Merino ◽  
◽  
Renata Villoro ◽  
Álvaro Hidalgo-Vega ◽  
Concepción Carmona
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Education Level ◽  
Stepwise Multiple Regression ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
St George's Respiratory Questionnaire

Abstract Background COPD is a high prevalence chronic disease that involves large reductions of health-related quality of life (HRQL) of patients. This study aims to describe the HRQL of patients with COPD in Extremadura (Spain). Methods This is a cross-sectional observational study carried out using a representative sample of patients diagnosed with COPD in Extremadura. The inclusion criteria were patients of legal age, diagnosed with COPD at least 12 months prior to the visit, residing in Extremadura, with electronic medical records available for the 12 months prior to the visit and providing informed consent. The intervention aimed to elicit HRQL indicators obtained from two validated questionnaires: EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L), and St. George’s Respiratory Questionnaire-COPD (SGRQ-C). The main outcome measures were general HRQL (utility and visual analogue scale) and specific quality of life of COPD patients (total score and three component scores: Symptoms, Activity, and Impacts). Stepwise multiple regression analysis was applied to evaluate the association of EQ-5D-5L and SGRQ-C with respect to clinical and sociodemographic characteristics of the patients. Results We recruited 386 patients (mean age 71.8 ± 10.3 years, 76.2% males). In the EQ-5D-5L, participants reported greater problems with respect to mobility (56.5%) and pain/discomfort (48.2%). The mean utility was 0.72 ± 0.31, and the SGRQ-C total score was 40.9 ± 25.0. The results of both questionnaires were associated with number of exacerbations in the last 12 months, level of COPD severity, gender, and education level of the patient (p < 0.05). Conclusions The results for both utility and total SGRQ-C score indicate that having suffered exacerbations in the last year, presenting a higher level of severity, being a woman, and having a low education level are related to worse HRQL in patients with COPD.

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