A NEW TL-DOS NEUTRON DOSEMETER FOR MEASUREMENTS OF THE PERSONAL DOSE EQUIVALENT HP(10)

2019 ◽  
Vol 188 (1) ◽  
pp. 8-12
Author(s):  
M Heiny ◽  
F Busch ◽  
K Kröninger ◽  
R Theinert ◽  
J Walbersloh
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Field Measurements ◽  
Whole Body ◽  
Dose Equivalent ◽  
Detector Sensitivity ◽  
Radiation Workers ◽  
High Linear Energy Transfer

Abstract A new thermoluminescence albedo dosemeter with improved properties is developed as part of the TL-DOS project. The dosemeter measures the neutron and photon whole-body dose of radiation workers. The TL-DOS neutron dosemeter is presented and its results of well-known field measurements as well as field calibrations are shown. Its advantages, such as its potential to measure the high-linear energy transfer peaks, its improved detector sensitivity and long detector lifetime, are explained. The new dosemeter is compared to a thermoluminescence albedo dosemeter already used in routine dosimetry in Germany.

Total-body irradiation with high-LET particles: acute and chronic effects on the immune system

2002 ◽  
Vol 282 (3) ◽  
pp. R677-R688 ◽  
Author(s):  
Daila S. Gridley ◽  
Michael J. Pecaut ◽  
Gregory A. Nelson
Keyword(s):  
Energy Transfer ◽  
Immune System ◽  
Dna Synthesis ◽  
Nk Cells ◽  
Linear Energy Transfer ◽  
Interleukin 2 ◽  
Lymphoid Cells ◽  
Whole Body ◽  
Simultaneous Exposure ◽  
High Linear Energy Transfer

Although the immune system is highly susceptible to radiation-induced damage, consequences of high linear energy transfer (LET) radiation remain unclear. This study evaluated the effects of 0.1 gray (Gy), 0.5 Gy, and 2.0 Gy iron ion (56Fe26) radiation on lymphoid cells and organs of C57BL/6 mice on days 4 and 113 after whole body exposure; a group irradiated with 2.0 Gy silicon ions (28Si) was euthanized on day 113. On day 4 after 56Fe irradiation, dose-dependent decreases were noted in spleen and thymus masses and all major leukocyte populations in blood and spleen. The CD19+ B lymphocytes were most radiosensitive and NK1.1+ natural killer (NK) cells were most resistant. CD3+ T cells were moderately radiosensitive and a greater loss of CD3+/CD8+TC cells than CD3+/CD4+TH cells was noted. Basal DNA synthesis was elevated on day 4, but response to mitogens and secretion of interleukin-2 and tumor necrosis factor-α were unaffected. Signs of anemia were noted. By day 113, high B cell numbers and low TC cell and monocyte percents were found in the 2.0 Gy56Fe group; the 2.0 Gy 28Si mice had low NK cells, decreased basal DNA synthesis, and a somewhat increased response to two mitogens. Collectively, the data show that lymphoid cells and tissues are markedly affected by high linear energy transfer (LET) radiation at relatively low doses, that some aberrations persist long after exposure, and that different consequences may be induced by various densely ionizing particles. Thus simultaneous exposure to multiple radiation sources could lead to a broader spectrum of immune dysfunction than currently anticipated.

The cytotoxicity of high-linear energy transfer radiation is reinforced by oxaliplatin in human glioblastoma cells

2007 ◽  
Vol 254 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Sami Benzina ◽  
Frederic Debomy ◽  
Jean-Pierre Bergerat ◽  
Jean-Marc Denis ◽  
John Gueulette ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Linear Energy Transfer Radiation ◽  
High Linear Energy Transfer

DOSE-RATE AND CELL-KILLING SENSITIVITY OF HIGH-LINEAR ENERGY TRANSFER ION BEAM

2018 ◽  
Vol 183 (1-2) ◽  
pp. 219-222
Author(s):  
Y Furusawa ◽  
Y Matsumoto ◽  
R Hirayama ◽  
D Ohsawa ◽  
T Konishi
Keyword(s):  
Energy Transfer ◽  
Dose Rate ◽  
Linear Energy Transfer ◽  
Ion Beam ◽  
Cell Killing ◽  
High Linear Energy Transfer
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