scholarly journals Prevalence and Risk Factors of Excessive Daytime Sleepiness in a Community Sample of Young Children: The Role of Obesity, Asthma, Anxiety/Depression, and Sleep

SLEEP ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 503-507 ◽  
Author(s):  
Susan L. Calhoun ◽  
Alexandros N. Vgontzas ◽  
Julio Fernandez-Mendoza ◽  
Susan D. Mayes ◽  
Marina Tsaoussoglou ◽  
...  
2011 ◽  
pp. 41-45
Author(s):  
Mario Fernando Prieto Peres ◽  
Domingos Savio Vieira ◽  
Marcelo Rodrigues Masruha ◽  
André Leite Gonçalves ◽  
Juliane Prieto Peres Mercante ◽  
...  

Background: The hypothalamus is a key brain region in the control of energy metabolism, sleep and circadian rhythms, stress and anxiety, food intake, sexual and reproductive behaviors. Orexin-A (hypocretin-1) is a neuropeptide, synthesized in the hypothalamus extensively linked to sleep/wake states, particularly excessive daytime sleepiness. Chronic migraine is comorbid with several conditions but little is known about its mechanisms. We aimed to study the role of orexin-A in the mechanism of chronic migraine and comorbid conditions. Methods: We studied orexin-A levels in the CSF of 60 chronic migraine patients, comparing with age and sex matched controls, and comorbidity with anxiety, depression and excessive daytime sleepiness, using appropriate scales. Results: Orexin-A levels were inversively correlated with anxiety levels (r=-308, p=0,03), but not depression and excessive daytime sleepiness. Orexin levels in CM patients were not different than controls. Discussion/Conclusion: Anxiety in CM may be due to a decrease in orexin-A or may be the cause of its depletion. The orexinergic system may be implicated in anxiety comorbid with migraine.


SLEEP ◽  
2015 ◽  
Vol 38 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Julio Fernandez-Mendoza ◽  
Alexandros N. Vgontzas ◽  
Ilia Kritikou ◽  
Susan L. Calhoun ◽  
Duanping Liao ◽  
...  

2017 ◽  
Vol 8 (2) ◽  
pp. 76-80 ◽  
Author(s):  
Sung Min Kim ◽  
Yoo Hyun Um ◽  
Tae-Won Kim ◽  
Jong-Hyun Jeong ◽  
Ho-Jun Seo ◽  
...  

2017 ◽  
Vol 103 ◽  
pp. 63-69 ◽  
Author(s):  
Matthieu Hein ◽  
Jean-Pol Lanquart ◽  
Gwenolé Loas ◽  
Philippe Hubain ◽  
Paul Linkowski

2016 ◽  
Vol 62 (7) ◽  
pp. 628-634 ◽  
Author(s):  
Deborath Lucia de Oliveira Diniz ◽  
Pedro Rodrigues Barreto ◽  
Pedro Felipe Carvalhedo de Bruin ◽  
Veralice Meireles Sales de Bruin

Summary Objective: Wake-up stroke (WUS) is defined when the exact time of the beginning of the symptoms cannot be determined, for the deficits are perceived upon awakening. Sleep alterations are important risk factors for stroke and cardiovascular diseases. This study evaluates the characteristics of patients with and without WUS, the presence of daytime sleepiness, and associated risk factors. Method: Patients with ischemic stroke were investigated about the presence of WUS. Clinical and demographic characteristics were evaluated. Stroke severity was studied by the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (MRS), and daytime sleepiness severity was studied by the Epworth Sleepiness Scale (ESS). Results: Seventy patients (57.1% men) aged from 32 to 80 years (58.5±13.3) were studied. WUS was observed in 24.3%. Arterial hypertension (67.1%), type 2 diabetes (27.1%), and hyperlipidemia (22.8%) were frequent. Type 2 diabetes and sedentary lifestyle were more common in patients with WUS (p<0.05). Overall, mild, moderate or very few symptoms of stroke (NIHSS<5) were predominant (62.3%). Among all cases, 20% had excessive daytime sleepiness (ESS>10). No differences were found between patients with and without WUS as regards stroke severity or excessive daytime sleepiness. Patients with excessive daytime sleepiness were younger and had more sedentary lifestyle (p<0.05). Individuals with previous history of heavy drinking had more daytime sleepiness (p=0.03). Conclusion: Wake-up stroke occurs in approximately 25% of stroke cases. In this study, patients with WUS had more diabetes and sedentary lifestyle. Daytime sleepiness is frequent and is associated with sedentary lifestyle and heavy drinking.


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