scholarly journals 0138 Behaviorally Assessed Sleep Duration and Oxidative Stress

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A54-A54
Author(s):  
A Decker ◽  
M Cribbet
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Alcohol Use ◽  
Sleep Duration ◽  
Demographic Data ◽  
Antioxidant Defenses ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cvd Risk ◽  
Short Sleep Duration ◽  
Short Sleep

Abstract Introduction Sleep may promote health by acting as an antioxidant, thereby increasing the body’s resistance to oxidative stress. Lipid peroxidation, a marker of oxidative stress, is one of the key early events in the development of atherosclerosis, the pathologic condition that underlies cardiovascular disease (CVD). Short sleep duration is prevalent in the general population and associated with CVD risk. However, the mechanisms linking short sleep to CVD are not well understood. Methods To test the hypothesis that short sleep duration would be associated with higher levels of oxidative stress, we conducted secondary data analysis on a diverse sample of participants (N= 81; Mage = 30.1(SD=10.9); 57% Male; 27% African American) from Pittsburgh, Pennsylvania. Participants wore actigraphs on their non-dominant wrists for 7 days to collect rest and activity data, which were used to derive average sleep duration. Participants provided urine samples and self-reported demographic data, along with daily mood, alcohol use, and physical activity. Oxidative stress was quantified as urinary concentrations of 15-F2t-isoprostane (15-F2-IsoP). Levels of 15-F2-IsoP were measured with a competitive enzyme linked-immunosorbent assay (ELISA) in duplicate. Urinary 15-F2-IsoP was adjusted by urinary creatinine to create an index of oxidative stress that took into account a measure of antioxidant defenses. Results Sleep duration was inversely correlated with oxidative stress (b= -.24, p=.03). In multiple regression analyses that controlled for age, sex, race, body mass index, alcohol use, physical activity, and depressed mood, sleep duration remained significantly negatively associated with oxidative stress, β = -.16, t = -2.33, p = .02, R2= .20. Conclusion These findings are important because they suggest that a relationship exists between short sleep and increased oxidative damage to lipids. Increasing our understanding of this relationship could motivate new CVD prevention strategies that target the inhibition of oxidative stress through sleep interventions. Support This study was supported by a grant from the National Center for Complementary and Integrative Health (AT006694); a grant from the National Institute of Allergy and Infectious Diseases (R01 AI066367); grants from the National Institutes of Health (UL1 RR024153 and UL1 RT000005); and by the John D. and Catherine T. MacArthur Foundation.

scholarly journals Sleep Duration and Sleep Quality Are Associated with Physical Activity in Elderly People Living in Nursing Homes

2018 ◽  
Vol 15 (11) ◽  
pp. 2512 ◽  
Author(s):  
Lovro Štefan ◽  
Goran Vrgoč ◽  
Tomislav Rupčić ◽  
Goran Sporiš ◽  
Damir Sekulić
Keyword(s):  
Physical Activity ◽  
Nursing Homes ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Elderly Individuals ◽  
Short Sleep ◽  
Long Sleep ◽  
Good Sleep

The main purpose of the study was to explore the associations of sleep duration and sleep quality with physical activity (PA). In this cross-sectional study, participants were 894 elderly individuals (mean age 80 ± 3 years; 56.0% women) living in nursing homes. PA, sleep duration, and sleep quality (based on the Pittsburgh Sleep Quality Index (PSQI)) were self-reported. The associations of sleep duration and sleep quality with PA at the nursing home level were analyzed using generalized estimating equations with clustering. Participants reporting short sleep duration (<6 h; OR = 0.45; 95% CI 0.25–0.80) were less likely to report sufficient PA, yet those reporting long sleep duration (>9 h; OR = 2.61; 95% CI 1.35–5.02) and good sleep quality (<5 points; OR = 1.59; 95% CI 1.19–2.12) were more likely to report sufficient PA. When sleep duration and sleep quality were entered into the same model, the same associations remained. This study shows that elderly individuals who report short sleep duration are less likely to meet PA guidelines, while those who report long sleep duration and good sleep quality are more likely to meet PA guidelines. Strategies aiming to improve sleep duration and sleep quality are warranted.

Abstract P545: Insufficient Sleep and Nitric Oxide-Mediated Endothelium-Dependent Vasodilation in Adults With Elevated Blood Pressure

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Kelly A Stockelman ◽  
Anthony R Bain ◽  
Dana M Withrow ◽  
Tracey A Larson ◽  
Elizabeth M Boland ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
Sleep Duration ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Short Sleep Duration ◽  
Insufficient Sleep ◽  
Short Sleep ◽  
Normal Sleep

Elevated blood pressure (BP ≥130/80 mmHg) is associated with increased risk for myocardial infarction, heart failure, stroke and vascular disease. Insufficient nightly sleep (<7 h/night) has been linked not only to the etiology of elevated blood pressure but is a prevalent, often ignored, comorbidity. Indeed, short sleep duration is now considered to be a plausible risk factor for elevated blood pressure and a harbinger of increased cardiovascular risk. A high prevalence of insufficient nightly sleep has been reported in adults with elevated blood pressure. The influence of insufficient sleep on endothelial vasodilator function in adults with elevated blood pressure is unknown. We tested the hypotheses that chronic insufficient sleep is associated with diminished nitric oxide (NO)-mediated endothelium-dependent vasodilation in adults with elevated blood pressure. Moreover, the insufficient sleep-related reduction in endothelial vasodilator function is due, at least in part to increased oxidative stress. Thirty-five middle-aged and older adults with elevated blood pressure were studied: 15 with normal nightly sleep duration (11M/4F; age: 58±2 yr; BP: 136/82±1/2 mmHg; sleep: 7.6±0.2 h/night) and 20 with short nightly sleep duration (14M/6F; 58±1 yr; BP: 138/84±1/1 mmHg; sleep: 6.0±0.1 h/night). Forearm blood flow (FBF) responses to intra-arterial infusion of acetylcholine (ACh), in the absence and presence of the endothelial NO synthase inhibitor N G -monomethyl-L-arginine (L-NMMA) and the antioxidant vitamin C were determined by venous occlusion plethysmography. The FBF response to ACh was significantly lower (~20%) in the short sleep (from 3.8±0.2 to 11.0±0.6 ml/100 ml tissue/min) compared with the normal sleep duration group (from 4.2±0.2 to 13.6±0.6 ml/100 ml tissue/min). L-NMMA significantly reduced (~25%) the FBF response to ACh in the normal sleep but not the short sleep group. Vitamin C markedly increased (~35%; P<0.05) the vasodilator response to ACh in short sleepers only. In summary, habitual short sleep duration worsens NO-mediated endothelium-dependent vasodilation in adults with elevated blood pressure. Furthermore, the sleep-related diminishment in endothelial vasodilator function is due, in part, to increased oxidative stress.

scholarly journals Contribution of short sleep duration to ethnic differences in cardiovascular disease: results from a cohort study in the Netherlands

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017645 ◽  
Author(s):  
Kenneth Anujuo ◽  
Charles Agyemang ◽  
Marieke B Snijder ◽  
Girardin Jean-Louis ◽  
Bert-Jan van den Born ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
The Netherlands ◽  
Sleep Duration ◽  
Ethnic Differences ◽  
Urban Setting ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Short Sleep Duration ◽  
Short Sleep

ObjectivesWe analysed association between short sleep duration and prevalence of cardiovascular disease (CVD) in a multiethnic population living in the Netherlands, and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD, independent of CVD risk factors.Methods20 730 participants (aged 18–71 years) of the HELIUS (Healthy Life in an Urban Setting) Study were investigated. Self-reported sleep duration was classified as: short (<7 hours/night) and healthy (7–9 hours/night). Prevalence of CVD was assessed using the Rose Questionnaire on angina pectoris, intermittent claudication and possible myocardial infarction. Association of short sleep duration with prevalent CVD and the contribution of short sleep to the observed ethnic differences in the prevalence of CVD were analysed using adjusted prevalence ratio(s) (PRs) with 95% CI.ResultsResults indicate that short sleep was associated with CVD among all ethnic groups with PRs ranging from 1.41 (95% CI 1.21 to 1.65) in Moroccans to 1.62 (95% CI 1.20 to 2.18) in Dutch after adjustment for age, sex and conventional CVD risk factors. The independent contributions of short sleep (in percentage) to ethnic differences in CVD compared with Dutch were 10%, 15%, 15%, 5% and 5% in South-Asian Surinamese, African-Surinamese, Ghanaian, Turkish and Moroccan, respectively.ConclusionShort sleep contributed to ethnic differences in CVD independent of well-known CVD risk factors particularly in Surinamese and Ghanaian groups. Reducing sleep deprivation may be a relevant entry point for reducing increased CVD risks among the various ethnic minority groups.

scholarly journals Sleep Duration and Excessive Daytime Sleepiness Are Associated with Obesity Independent of Diet and Physical Activity

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1219 ◽  
Author(s):  
Andrea Maugeri ◽  
Jose Medina-Inojosa ◽  
Sarka Kunzova ◽  
Antonella Agodi ◽  
Martina Barchitta ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sleep Duration ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Central Obesity ◽  
Sleep Disturbances ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Short Sleep ◽  
Diet And Physical Activity

In the European Union, Czech Republic ranks 3rd and 6th for the incidence of obesity and cardiovascular diseases, respectively. Worldwide, short sleep duration and excessive daytime sleepiness (EDS) characterize obese subjects, which in turn exhibit scarce physical activity and unhealthy diet. We aimed to understand the relationship between irregular sleep patterns, obesity and lifestyle factors, such as diet and physical activity, in a vulnerable Czech population. 1482 members of the Kardiovize cohort, a random sample of the Czech urban population, were included in a cross-sectional study. Exposure variables included self-reported sleep duration and EDS, assessed by the Epworth Sleepiness Scale. Primary outcomes were BMI and waist-to-hip ratio or prevalence of obesity and central obesity. Covariates included physical activity and diet. Associations and interactions between variables were evaluated using logistic regression analyses. After adjustment for covariates, short sleep duration (<7 h) was associated with greater odds of overweight (BMI > 25; OR = 1.42; 95%CI = 1.06–1.90; p = 0.020) and obesity (BMI > 30; OR = 1.40; 95%CI = 1.02–1.94; p = 0.047), while EDS was associated with greater odds of central obesity (OR = 1.72; 95%CI = 1.06–2.79; p = 0.030), independent of diet and physical activity. However, due to the cross-sectional nature of our study, further prospective, large-scale studies are needed to evaluate the etiological link and causality between sleep disturbances and obesity.

Abstract 2455: Short Sleep Duration is an Independent Predictor of Cardiovascular Events in Hypertensive Patients

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Kazuo Eguchi ◽  
Thomas G Pickering ◽  
Joseph E Schwartz ◽  
Satoshi Hoshide ◽  
Joji Ishikawa ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Short Duration ◽  
Cardiovascular Events ◽  
Sleep Time ◽  
Cvd Risk ◽  
Short Sleep Duration ◽  
Hypertensive Patients ◽  
Short Sleep ◽  
Multivariable Analyses ◽  
Normal Sleep

We aimed this study to test the hypothesis that short duration of sleep is independently associated with incident cardiovascular diseases (CVD) in hypertensive patients. We performed ambulatory BP monitoring (ABPM) in 1255 subjects with hypertension (mean age: 70.4 ± 9.9 years) and they were followed for an average of 50 ± 23 months. Short sleep duration was defined as <7.5 hrs (20 th percentile). Multivariable Cox hazard models predicting CVD events were used to estimate the adjusted hazard ratio (HR) and 95% CI for short sleep duration. A riser pattern was defined when average nighttime SBP exceeded daytime SBP. The end point was cardiovascular events: stroke, fatal or non-fatal myocardial infarction (MI), and sudden cardiac death. In multivariable analyses, short duration of sleep (<7.5 hrs) was associated with incident CVD (HR=1.68; 1.06 –2.66, P=.03). A synergistic interaction was observed between short sleep duration and the riser pattern (P=.089). When subjects were categorized on the basis of their sleep time and riser/non-riser patterns, the shorter sleep+riser group had a highest incidence of CVD among the 4 groups ( Figure ), and substantially and significantly higher incidence of CVD than the predominant normal sleep+non-riser group (HR=4.43; 2.09 –9.39, P<0.001), independent of covariates. Short duration of sleep is associated with incident CVD risk, and the combination of riser pattern and short duration of sleep that is most strongly predictive of future CVD, independent of ambulatory BP levels. Physicians should inquire about sleep duration in the risk assessment of hypertensive patients.

scholarly journals 1137 Sleep Duration, Physical Activity And Cognitive Decline In Chinese Older Adults: Findings From The CHARLS

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A433-A433
Author(s):  
J Li ◽  
A J Alfini ◽  
F Yu ◽  
J A Schrack ◽  
V Cotter ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Cognitive Decline ◽  
Sleep Duration ◽  
Community Dwelling ◽  
Cognitive Outcomes ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Long Sleep

Abstract Introduction Lack of physical activity and disturbed sleep have been linked to older adult’s poor cognitive outcomes; however, little is unknown how they interact to affect cognition long-term. The purpose of this study was to examine the association of baseline sleep duration and physical activity (PA) with change in cognition independently and interactively over four years. Methods The sample included 1126 community-dwelling older adults aged 60+ (mean age 67.1±5.9 years, 51% female) from the 2011 baseline and 2015 follow-up data of the China Health and Retirement Longitudinal Study (CHARLS). All variables were assessed through interviews. Sleep duration was measured with hours per 30-minute interval and categorized as very-short (&lt;5h), short (5-6.5h), normal (7-8.5h), and long (≥9h). PA was calculated based on PA intensity, duration, and number of days. Cognition was a composite score of mental capacity, episodic memory, and visuospatial abilities. Data were analyzed using multiple regression (primary outcome: change in cognition; main independent variables: baseline sleep, PA, and sleep PA interaction). Results At baseline, 19% of participants had very-short sleep duration, 34.4% had short sleep, 39.2% had normal sleep, and 7.2% had long sleep. At follow-up, 57.5% of participants experienced cognitive decline (-3.5±2.5). After controlling for age, gender, education, region, body mass index, smoking, drinking, number of chronic conditions, pain, depression, and cognition at baseline, compared to participants reporting 7-8.5h sleep, those with ≥9h sleep had significantly greater decline in cognition [β=-1.4, 95% CI=2.4, -0.4], while those with &lt;5h sleep [β=-0.5, 95% CI=-1.2, 0.2] and 5-6.5h sleep did not [β=-0.1, 95% CI=-0.7, 0.5]. PA was neither associated with cognitive decline, nor moderated the relationship between sleep duration and cognitive decline. Conclusion Long sleep might be a marker of cognitive decline in older adults. Prospective analysis, using objectively measured PA and sleep should be conducted to further examine these associations. Support National Institute of Nursing Research R00NR016484

scholarly journals How do adolescents with short sleep duration spend their extra waking hours? A device-based analysis of physical activity and sedentary behaviour in a Brazilian sample

Sleep Science ◽  
2021 ◽  
Vol 14 (nspe2) ◽  
Author(s):  
Bruno Gonçalves Galdino da Costa ◽  
Jean-Philippe Chaput ◽  
Marcus Vinicius Veber Lopes ◽  
Luís Eduardo Argenta Malheiros ◽  
Kelly Samara Silva
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Brazilian Sample ◽  
Short Sleep

scholarly journals Low Physical Activity Level and Short Sleep Duration Are Associated with an Increased Cardio-Metabolic Risk Profile: A Longitudinal Study in 8-11 Year Old Danish Children

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104677 ◽  
Author(s):  
Mads F. Hjorth ◽  
Jean-Philippe Chaput ◽  
Camilla T. Damsgaard ◽  
Stine-Mathilde Dalskov ◽  
Rikke Andersen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Longitudinal Study ◽  
Sleep Duration ◽  
Physical Activity Level ◽  
Risk Profile ◽  
Activity Level ◽  
Metabolic Risk ◽  
Short Sleep Duration ◽  
Short Sleep

scholarly journals Energy drink consumption among Australian adolescents associated with a cluster of unhealthy dietary behaviours and short sleep duration

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Tegan Nuss ◽  
Belinda Morley ◽  
Maree Scully ◽  
Melanie Wakefield
Keyword(s):  
Physical Activity ◽  
Sleep Duration ◽  
Energy Drinks ◽  
Energy Drink ◽  
Activity Level ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Dietary Behaviours ◽  
Regular Consumption ◽  
Energy Drink Consumption

Abstract Background Non-alcoholic energy drinks (‘energy drinks’) are high in sugar, as well as caffeine, leading to concerns regarding their suitability for children and adolescents. Despite this, marketing of energy drinks is often directed at adolescents, and there are no age restrictions on the sale of these products in Australia. The current study aimed to examine patterns in consumption of energy drinks among Australian secondary school students and identify sociodemographic and behavioural correlates associated with regular consumption. Methods Participants were 8942 students in Years 8 to 11 (aged 12 to 17 years) who participated in the 2018 National Secondary Students’ Diet and Activity (NaSSDA) cross-sectional survey. A multistage stratified random sampling procedure was used. Within the school setting, students self-completed an online questionnaire assessing their dietary, physical activity and sedentary behaviours. A multilevel logistic regression model was used to examine associations between energy drink consumption and sociodemographic and behavioural factors. Results Overall, 8% of students reported consuming energy drinks on a weekly basis (‘regular consumers’). A further 16% indicated they consume less than one cup per week of these types of drinks, while around three-quarters (76%) reported they do not consume energy drinks. Regular consumption of energy drinks was independently associated with being male, having greater weekly spending money, high intakes of snack foods, fast food, other sugar-sweetened beverages and fruit juice, as well as short sleep duration. There was no independent association with other sociodemographic characteristics (i.e., year level, level of disadvantage, geographic location), consumption of vegetables and fruit, physical activity level, or sedentary recreational screen time. Conclusions While most Australian adolescents do not consume energy drinks, regular consumption is more prevalent among males, and consumption appears to cluster with other unhealthy dietary behaviours and short sleep duration. Findings support the need for policies that will reach identified at-risk groups (e.g., increased regulation of the marketing and sale of energy drinks), as well as suggest opportunities for interventions targeting energy drink consumption alongside other unhealthy dietary behaviours.

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