scholarly journals Impact of evening alcohol consumption on nocturnal autonomic and cardiovascular function in adult men and women: a dose–response laboratory investigation

SLEEP ◽  
2020 ◽  
Author(s):  
Massimiliano de Zambotti ◽  
Mohamad Forouzanfar ◽  
Harold Javitz ◽  
Aimee Goldstone ◽  
Stephanie Claudatos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Alcohol Consumption ◽  
Blood Pressure Monitoring ◽  
Alcohol Ingestion ◽  
High Dose ◽  
Standard Drink ◽  
Men And Women ◽  
Adult Men ◽  
Alcohol Dose ◽  
Moderate Alcohol Intake

Abstract Study Objectives To investigate the dose-dependent impact of moderate alcohol intake on sleep-related cardiovascular (CV) function, in adult men and women. Methods A total of 26 healthy adults (30–60 years; 11 women) underwent 3 nights of laboratory polysomnographic (PSG) recordings in which different doses of alcohol (low: 1 standard drink for women and 2 drinks for men; high: 3 standard drinks for women and 4 drinks for men; placebo: no alcohol) were administered in counterbalanced order before bedtime. These led to bedtime average breath alcohol levels of up to 0.02% for the low doses and around 0.05% for the high doses. Autonomic and CV function were evaluated using electrocardiography, impedance cardiography, and beat-to-beat blood pressure monitoring. Results Presleep alcohol ingestion resulted in an overall increase in nocturnal heart rate (HR), suppressed total and high-frequency (vagal) HR variability, reduced baroreflex sensitivity, and increased sympathetic activity, with effects pronounced after high-dose alcohol ingestion (p’s < 0.05); these changes followed different dose- and measure-dependent nocturnal patterns in men and women. Systolic blood pressure showed greater increases during the morning hours of the high-alcohol dose night compared to the low-alcohol dose night and placebo, in women only (p’s < 0.05). Conclusions Acute evening alcohol consumption, even at moderate doses, has marked dose- and time-dependent effects on sleep CV regulation in adult men and women. Further studies are needed to evaluate the potential CV risk of repeated alcohol-related alterations in nighttime CV restoration in healthy individuals and in those at high risk for CV diseases, considering sex and alcohol dose and time effects.

High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Natércia Neves Marques de Queiroz ◽  
Franciane Trindade Cunha de Melo ◽  
Fabrício de Souza Resende ◽  
Luísa Corrêa Janaú ◽  
Norberto Jorge Kzan de Souza Neto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Blood Pressure Monitoring ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Before And After ◽  
Patients With Diabetes ◽  
Morning Blood Pressure ◽  
Cholecalciferol Supplementation ◽  
Lipids Profile

Background: Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. Effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial. Objective: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive type 1 diabetes mellitus (T1DM) patients by 24-hour ambulatory blood pressure monitoring (ABPM). Methods: We performed a clinical trial including 35 T1DM normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation. Results and discussion: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relation between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). Conclusion: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive T1DM patients.

Alcohol Consumption and Risk of First-Time Venous Thromboembolism in Men and Women

2019 ◽  
Vol 119 (06) ◽  
pp. 962-970 ◽  
Author(s):  
Magdalena Johansson ◽  
Lars Johansson ◽  
Maria Wennberg ◽  
Marcus Lind
Keyword(s):  
Venous Thromboembolism ◽  
Alcohol Consumption ◽  
Alcohol Dependence ◽  
Population Based ◽  
Health Examination ◽  
Standard Drink ◽  
Men And Women ◽  
Increased Risk ◽  
The Mean ◽  
First Time

Background The relationship between alcohol intake and risk of venous thromboembolism (VTE) is unclear. Men and women differ in their drinking habits, which may affect a possible association. Objective This article investigates the association between alcohol consumption, alcohol dependence and VTE in the total population as well as in men and women separately. Methods We performed a prospective, population-based cohort study in northern Sweden. Study participants were 108,025 (51% women) persons aged 30 to 60 years who underwent a health examination between 1985 and 2014. We assessed alcohol consumption and defined alcohol dependence using a questionnaire. The outcome was a validated first-time VTE. Results The mean follow-up time was 13.9 years, and 2,054 participants had a first-time VTE. The mean alcohol consumption was 3.5 standard drinks weekly in men and 1.5 in women. Alcohol dependence was found in 10% of men and 3% of women. There was an association between alcohol consumption (hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.00–1.03 per standard drink weekly) as well as alcohol dependence (HR, 1.27; 95% CI, 1.06–1.52) and VTE after adjustments. In men, the risk of VTE increased over quartiles of weekly alcohol consumption (p for trend 0.02), with a HR of 1.22 (95% CI, 1.01–1.47) for the highest quartile. Alcohol dependence was associated with VTE in men (HR, 1.30; 95% CI, 1.07–1.59). In women, there were no significant associations. Conclusion High alcohol consumption and alcohol dependence were associated with increased risk of first-time VTE in men, but not in women.

Effects of ambulatory blood pressure monitoring on sleep in healthy, normotensive men and women

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Allison E. Gaffey ◽  
Joseph E. Schwartz ◽  
Kristie M. Harris ◽  
Martica H. Hall ◽  
Matthew M. Burg
Keyword(s):  
Blood Pressure ◽  
Ambulatory Blood Pressure Monitoring ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
Men And Women

Heart Rate and Blood Pressure Response in Adult Men and Women During Exercise and Sexual Activity

2007 ◽  
Vol 100 (12) ◽  
pp. 1795-1801 ◽  
Author(s):  
Sebastian T. Palmeri ◽  
John B. Kostis ◽  
Laurie Casazza ◽  
Lynn A. Sleeper ◽  
Minmin Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sexual Activity ◽  
Blood Pressure Response ◽  
Pressure Response ◽  
Men And Women ◽  
Adult Men

062 Sex Differences in Slow Wave Sleep Following Evening Binge Alcohol Consumption

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A26-A26
Author(s):  
Ian Greenlund ◽  
Jeremy Bigalke ◽  
Anne Tikkanen ◽  
Jennifer Nicevski ◽  
Carl Smoot ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Slow Wave ◽  
Repeated Measures ◽  
Slow Wave Sleep ◽  
Pearson Correlation ◽  
Sleep Architecture ◽  
Alcohol Content ◽  
Men And Women ◽  
Percent Change ◽  
Alcohol Dose

Abstract Introduction Binge alcohol consumption alters normal sleep architecture, often via increased slow wave sleep (SWS) and decreased rapid eye movement (REM) sleep. Women may be more susceptible to the sedative effects of alcohol during blood alcohol content (BAC) decrease as they report higher subjective sleepiness scores prior to bedtime. The purpose of the present study was to examine changes in SWS between men and women following binge alcohol consumption and determine the relation between BAC change at lights out and subsequent sleep architecture. Methods Twenty-three participants (11 men, 12 women) between the ages of 21–45 years were tested twice, once after evening binge alcohol consumption and once after fluid control (randomized, cross-over design). The alcohol dose was based on body weight and sex (1g/kg in men, 0.85g/kg in women) and served as a 4–5 drink equivalent consumed over two hours. Breath alcohol content (BrAC) was monitored in 15-minute increments from first drink consumption to lights out. Overnight polysomnography (PSG) was recorded in each individual and scored by a board-certified sleep physician. Statistical analysis consisted of repeated measures ANOVA and Pearson correlation (p&gt;0.05). Results Age (24±4 vs. 26±6 years) and BMI (27±4 vs. 27±4 kg/m2) were similar between men and women. Peak BrAC (0.10±0.02% vs. 0.10±0.02%) and percent change (-19±11% vs. -19±11%) in BrAC from peak to lights out were also similar between the sexes. Peak BrAC was significantly correlated to the percentage of SWS in women (r=-0.71; p=0.01), but not men (r=-0.25; p=0.45). Similarly, the percent change in BrAC from peak to lights out was significantly correlated to the percentage of SWS in women (r=-0.66; p=0.02), but not men (r=-0.40; p=0.22). The SWS and REM latencies were not associated with either peak or lights out BrAC in both men and women. Conclusion Peak BrAC, and the rate of BrAC clearance prior to lights out, appear to impact SWS differently in men and women. Specifically, women appear to have more SWS in response to high BrAC than their male counterparts, suggesting a stronger depressor impact with regards to SWS in women. Support (if any) National Institutes of Health (AA-024892; U54GM115371; P20GM103474).

Effect of High-Dose Ibuprofen on 24-Hour Blood Pressure in Healthy Women

1987 ◽  
Vol 21 (6) ◽  
pp. 517-521 ◽  
Author(s):  
James M. Mckenney ◽  
Jackson T. Wright ◽  
Robert P. Goodman ◽  
Laverne Cooper ◽  
Nancy Yunker ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Prostaglandin E ◽  
High Dose ◽  
Pressure Monitoring ◽  
Percent Reduction ◽  
Double Blind ◽  
Salt Diet ◽  
Double Blind Design ◽  
Added Salt

The nonsteroidal anti-inflammatory drug (NSAID) indomethacin has been shown to increase blood pressure in normotensive individuals. The effect of other NSAID on blood pressure has not been as well studied. We evaluated the effects of ibuprofen, an NSAID currently available without a prescription, on 24-hour ambulatory blood pressure in ten young, healthy, normotensive women. Using a randomized, crossover, double-blind design, subjects received ibuprofen 800 mg and a placebo identical in appearance to ibuprofen three times a day for eight days with a washout period between regimens. Subjects were instructed to follow a no-added salt diet during the study. Twenty-four-hour blood pressure monitoring and 24-hour urine collection for prostaglandin E2, creatinine, and sodium were performed on days 1 and 8 of each study week. Tablet counts and a 40 percent reduction in urinary prostaglandin E2 documented compliance with ibuprofen. Ibuprofen had no significant effect on systolic or diastolic blood pressure at any hour during the 24-hour period. Mean blood pressure for the 24-hour period was 112/73 and 111/73 mm Hg on day 1 and 111/73 and 112/73 mm Hg on day 8 for placebo and ibuprofen, respectively. We conclude that ibuprofen at doses as high as 2400 mg/d for up to seven days has no effect on blood pressure in normotensive women. Further studies are needed in hypertensive subjects.

scholarly journals Attitudes and Recommendations of Physicians towards Alcohol Consumption and Cardiovascular Health: A Perspective from Argentina

2018 ◽  
Author(s):  
Ricardo Lopez Santi ◽  
Sohaib Haseeb ◽  
Bryce Alexander ◽  
Adrian D’Ovidio ◽  
Sergio Gimenez ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Intake ◽  
Cardiovascular Health ◽  
Physician Attitudes ◽  
Standard Drink ◽  
Sources Of Knowledge ◽  
Safe Limits ◽  
To Come ◽  
Moderate Alcohol Intake ◽  
Study Participants

Despite epidemiological findings of improvements in cardiovascular risk factors with a light-to-moderate intake of alcohol, many misconceptions remain regarding alcohol intake and the risks and benefits of consumption. We sought to examine physician attitudes and recommendations regarding alcohol intake in a cohort of Argentine physicians and to establish their sources of knowledge. An online national survey was distributed through the Argentine Federation of Cardiology (FAC) to cardiologists, internal medicine specialists, general and other subspecialty physicians in Argentina. The survey was completed by 745 physicians, of whom 671 (90%) were cardiologists. In total, 35% of physicians viewed moderate alcohol intake to be beneficial for cardiovascular health, 36% believed only wine offered such benefits, 24% viewed any intake to be harmful, and 5% had other opinions. More than half (57%) self-reported their knowledge to come from academic sources. Regarding knowledge of drinking guidelines, only 41% of physicians were aware of the concept of &lsquo;standard drink&rsquo;. Physicians were generally not comfortable converting &lsquo;standard drinks&rsquo; into other metric units, however men tended to be more comfortable than women (p=0.052). Physicians were not satisfied with their knowledge of drinking guidelines (3.01 &plusmn; 2.73, on a 0-10 scale). Physicians were generally comfortable in counselling patients regarding safe-limits of consumption (6.22 &plusmn; 3.20, on a 0-10 scale). Argentine physicians were not satisfied with their knowledge of alcohol consumption guidelines or their understanding of the reported metrics. Only one-third of study participants viewed moderate alcohol intake as beneficial for cardiovascular health. This study shows the necessity to optimize the sources of knowledge.

Effect of Previous-Day Alcohol Ingestion on Muscle Function and Performance of Severe-Intensity Exercise

2021 ◽  
pp. 1-6
Author(s):  
Alex G. Shaw ◽  
Sungwon Chae ◽  
Danielle E. Levitt ◽  
Jonathan L. Nicholson ◽  
Jakob L. Vingren ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Vertical Jump ◽  
Anaerobic Capacity ◽  
Cycle Ergometer ◽  
Alcohol Ingestion ◽  
Time To Exhaustion ◽  
Cycle Ergometer Test ◽  
Severe Intensity ◽  
Alcohol Dose ◽  
The Impact

Purpose: Many athletes report consuming alcohol the day before their event, which might negatively affect their performance. However, the effects of previous-day alcohol ingestion on performance are equivocal, in part, due to no standardization of alcohol dose in previous studies. The purpose of this study was to examine the impact of a standardized previous-day alcohol dose and its corresponding impact on morning-after muscular strength, muscular power, and muscular fatigue in a short-duration test and on performance of severe-intensity exercise. Methods: On 2 occasions, 12 recreationally active individuals reported to the Applied Physiology Laboratory in the evening and ingested a beverage containing either 1.09 g ethanol·kg−1 fat-free body mass (ALC condition) or water (PLA condition). The following morning, they completed a hangover symptom questionnaire, vertical jumps, isometric midthigh pulls, biceps curls, and a constant-power cycle ergometer test to exhaustion. The responses from ALC and PLA were compared using paired-means t tests. Results: Time to exhaustion in the cycle ergometer tests was less (P = .03) in the ALC condition (181 [39] s vs 203 [34] s; –11%, Cohen d = 0.61). There was no difference in performance in vertical jump test, isometric midthigh pulls, and biceps curls tests between the ALC and PLA conditions. Conclusions: Previous-day alcohol consumption significantly reduces morning-after performance of severe-intensity exercise. Practitioners should educate their athletes, especially those whose events rely on anaerobic capacity and/or a rapid response of the aerobic pathways, of the adverse effect of previous-day alcohol consumption on performance.

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