scholarly journals O022 Long-term cardiovascular risk in obstructive sleep apnoea: a sleep clinic cohort study

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A10-A10
Author(s):  
B Shenoy ◽  
B Singh ◽  
G Cadby ◽  
B McQuillan ◽  
J Hung ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Obstructive Sleep Apnoea ◽  
Cox Regression ◽  
Sleep Apnoea ◽  
Health Study ◽  
Periodic Limb Movements ◽  
Obstructive Sleep ◽  
The Impact

Abstract The relationship between obstructive sleep apnoea (OSA) and the development of long-term cardiovascular disease (CVD) is incompletely understood. We therefore investigated the impact of OSA severity, assessed by polysomnographic (PSG) metrics, on the development of long-term CVD in a sleep clinic cohort. Participants in the Western Australian Sleep Health Study, who attended a sleep clinic at a tertiary hospital between 2006 and 2010, were linked to state health administrative data from 1969 to 2016. Cox regression was used to investigate associations between standard PSG metrics of OSA severity (including the apnoea-hypopnoea index [AHI], time with oxygen saturation <90% [T90], and arousal index) and a CVD composite outcome (hospitalisation due to coronary heart disease, heart failure, stroke, or atrial fibrillation), controlling for baseline CVD risk factors such as age, sex, and body mass index (BMI). A total of 4067 participants were included: mean (SD) age of 50.6 (14.0) years, with 60.8% men. The mean BMI was 32.7 (7.7) kg/m². Over a median follow-up of 7.3 years, 584 (14.4%) participants developed the composite CVD outcome. Following adjustment for risk factors, independent predictors of incident CVD were an AHI ≥30 events/hour (hazard ratio [HR], 1.21; 95% CI, 1.02–1.45), log (T90 + 1) (HR, 1.16; 95% CI, 1.03–1.31), and the periodic limb movements of sleep index (PLMSI) (HR, 1.01; 95% CI, 1.00–1.01). We demonstrated independent effects of AHI, hypoxaemia, and PLMSI on incident CVD in this large sleep clinic cohort, suggesting multi-faceted aspects of disrupted sleep influence cardiovascular risk in OSA.

Relationship Between Obstructive Sleep Apnoea, Oxygen Desaturation and Cardiovascular Risk

2019 ◽  
Vol 70 (10) ◽  
pp. 3582-3586
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Obstructive Sleep Apnoea ◽  
Cardiovascular Events ◽  
Sleep Apnoea ◽  
Oxygen Desaturation ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Obstructive sleep apnoea syndrome (OSAS) increases the risk cardiovascular events regardless of the presence of previous cardiovascular disease. As both OSAS and coronary heart disease (CHD) have same risk factors it’s often difficult to quantify the proportion of each risk factor in developing cardiac events. The aim of this study was to evaluate the 10-year risk of developing a coronary heart disease (CHD) event or stroke in newly diagnosed OSAS patients. 65 patients diagnosed with OSAS over a period of four months in Oradea Sleep Laboratory were included. Demographic characteristics, anthropometric parameters, clinical and biochemical data, sleep disorder and daytime sleepiness assessment, results of polysomnography were collected in all patients. In 55 selected patients by age range from 34 to 74 years old, cardiovascular risk was assessed using Framingham score calculator. Statistical analysis was performed using SPSS-PC version 7.5 and Stata 10.The estimated 10-years risk of a CHD event was 18.97% (± 9.67) in all cases. It was higher in men (22.17% ± 9.24) compare to women (12.39% ± 6.92) and it was not significantly different by stages of OSAS severity (20.58% ±9.41 in patients with severe OSAS versus 15.4% in mild OSAS), suggesting that apnea hypopnea index is not a major confounding factor. Desaturation of oxygen is a better outcome to define the relation between OSAS and cardiovascular diseases. OSAS and cardiovascular risk factors increased risk for future adverse cardiovascular events related to the severity of oxygen desaturation. Keywords: obstructive sleep apnoea syndrome, cardiovascular events, risk factors, oxygen desaturation

scholarly journals Morbidity and mortality in patients with cardiovascular risk factors and obstructive sleep apnoea: results from the DIAST-CHF cohort

2019 ◽  
Vol 154 ◽  
pp. 127-132 ◽  
Author(s):  
Helge Haarmann ◽  
Jennifer Koch ◽  
Nina Bonsch ◽  
Meinhard Mende ◽  
Stefanie Maria Werhahn ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Morbidity And Mortality ◽  
Obstructive Sleep

scholarly journals Cardiovascular risk factors in men and women with obstructive sleep apnoea syndrome

2010 ◽  
Vol 104 (7) ◽  
pp. 1063-1068 ◽  
Author(s):  
Jean-Pierre Laaban ◽  
Line Mounier ◽  
Olivier Roque d'Orbcastel ◽  
Dan Veale ◽  
Jacques Blacher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Men And Women ◽  
Sleep Apnoea Syndrome ◽  
Obstructive Sleep

Obstructive Sleep Apnoea, Atrial Fibrillation and Erectile Dysfunction – The OSAFED Syndrome – Is there More than Meets the Eye?

2015 ◽  
Vol 01 (01) ◽  
pp. 19
Author(s):  
Filip M Szymanski ◽  
Anna E Platek ◽  
Krzysztof J Filipiak ◽  
◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Erectile Dysfunction ◽  
Clinical Practice ◽  
Cardiovascular Risk ◽  
General Population ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Clinical Syndromes ◽  
Obstructive Sleep

Obstructive sleep apnoea, atrial fibrillation and erectile dysfunction (OSAFED) syndrome is a new clinical entity recently introduced into clinical practice. The acronym consists of the first letters of the three clinical entities that comprise the disease, namely obstructive sleep apnoea (OSA), atrial fibrillation (AF) and erectile dysfunction (ED). As with many other clinical syndromes, OSAFED syndrome groups several clinical entities, which seemingly concern various organs and have different symptoms, but are closely associated by sharing risk factors and phenotype, and effecting cardiovascular risk in the same manner. OSA, AF and ED are also highly prevalent in the general population and tend to coexist. OSAFED syndrome was named as such to show how important diagnosis is of all these components in specific groups of patient. It is crucial for clinicians to improve the diagnosis and early treatment of all – OSA, AF and ED – and the incorporation of all these factors into one syndrome might help to facilitate this process.

Obstructive Sleep Apnoea and Vascular Disease in Patients with Type 2 Diabetes

2015 ◽  
Vol 11 (02) ◽  
pp. 110
Author(s):  
Abd A Tahrani ◽  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vascular Disease ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Obstructive Sleep ◽  
The Impact

Obstructive sleep apnoea (OSA) is common and is associated with many vascular risk factors, such as hypertension, insulin resistance, albuminuria, dyslipidaemia, increased inflammation and endothelial dysfunction. Epidemiological studies have shown that OSA is associated with increased cardiovascular disease (CVD) and that continuous positive airway pressure (CPAP) might reduce CVD events in patients with OSA. In addition, OSA has also been shown to be associated with albuminuria, chronic kidney disease, a wide range of ocular diseases and peripheral neuropathy. Considering that CVD and microvascular complications are major contributors to the morbidity, mortality and the economic burden of diabetes and that OSA is common in patients with type 2 diabetes (T2D), it is important to understand the role of OSA in the development and/or progression of vascular disease in patients with T2D and to explore the impact of CPAP on diabetes-related vascular outcomes. The purpose of this article is to review the evidence for the relationship and impact of OSA on vascular disease and vascular risk factors particularly in patients with T2D.

Obstructive sleep apnoea, type 2 diabetes and cardiovascular risk factors

2017 ◽  
Vol 39 ◽  
pp. e16-e17 ◽  
Author(s):  
B. De Vega Sánchez ◽  
S.A. Juarros Martínez ◽  
Milagros Del Olmo Chiches ◽  
C. Disdier Vicente ◽  
E. González Sarmiento
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep

scholarly journals Coexistence of cardiovascular risk factors and obstructive sleep apnoea in polysomnography

2021 ◽  
pp. 103782
Author(s):  
Paweł Gać ◽  
Dominika Urbanik ◽  
Piotr Macek ◽  
Helena Martynowicz ◽  
Grzegorz Mazur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Obstructive Sleep

scholarly journals Obesity and Non-Obesity Obstructive Sleep Apnoea Hypertension Syndromes (OOHS & NOOHS): New Clinical Discoveries

2021 ◽  
Author(s):  
Chunsong Hu ◽  
Qinghua Wu ◽  
Juxiang Li ◽  
Yanqing Wu ◽  
Menghong Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnoea ◽  
Clinical Characteristics ◽  
Sleep Apnoea ◽  
Major Adverse Cardiovascular Events ◽  
Related Risk ◽  
Obstructive Sleep ◽  
Long Term Follow Up

Abstract Obesity, obstructive sleep apnoea (OSA) and hypertension are common clinical risk factors. Their coexistence is termed Obesity and Non-Obesity OSA Hypertension Syndromes (OOHS & NOOHS) due to high linkage. This study reported the clinical characteristics of OOHS and NOOHS. A total of 163 patients, aged 23–74 years, were randomly enrolled at the outpatients department who were either obese or non-obese, suffered OSA and hypertension. Subjects with a Body Mass Index (BMI) of ≥25 (Chinese criteria), of ≥27 (criteria of this study), and of ≥30 (WHO criteria) were defined as obese or non-obese, respectively. Cases with snoring were classified as mild, moderate and severe OSA by using the Apnoea-Hypopnoea Index where mild is 5–15, moderate is 15–30, and severe is > 30. Daytime blood pressure (BP) was measured to assess any correlation. Data from those with isolated obesity, OSA, hypertension, and metabolic syndrome were compared. Long-term follow-up was carried out. 7 typical cases with OOHS and NOOHS were assessed and included general patient information, initial diagnosis, medical history, related risk factors, BMI, and BP. 163 cases with OOHS and NOOHS often have similar or different clinical characteristics. Both potentially suffer from major adverse cardiovascular events (MACEs) which are associated with increased BMI, OSA, and increased BP. Long-term follow-up showed the outcomes consistently linked to their lifestyle and adherence to treatment. Our new clinical discoveries suggest that both OOHS and NOOHS are high risk conditions in MACEs. There is an urgent need for early lifestyle interventions and related treatments.

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