The Role of Endothelin‐1 Receptor Subtypes in Limiting Insulin‐Stimulated Blood Flow in Middle‐Aged Adults

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ben E. Young ◽  
Jaume Padilla ◽  
Stine H. Finsen ◽  
Stefan P. Mortensen ◽  
Paul J. Fadel
2021 ◽  
Author(s):  
Yan Luo

BACKGROUND The depression level among US adults significantly increased during the Coronavirus Disease 2019 (COVID-19) pandemic and age disparity in depression during the pandemic were reported in recent studies. Delay or avoidance of medical care is one of the collateral damages caused by the COVID-19 pandemic and it can lead to increased morbidity and mortality. OBJECTIVE The present study aims to assess the prevalence of depression and delay of care among US middle-aged adults and older adults during the pandemic, as well as investigate the role of delay of care in depression among those two age groups. METHODS This cross-sectional study used the 2020 Health and Retirement Study (HRS) COVID-19 Project (Early, Version 1.0) data. Univariate analyses, bivariate analyses, and binary logistic regression were applied. US adults older than 46 years old were included. Depression was measured by Composite International Diagnostic Interview Short Form (CIDI-SF). Delay of care were measured by four items: delay of surgery, delay of seeing a doctor, delay of dental care, and delay of other care. Univariate analyses, bivariate analyses, and binary logistic regression were conducted. RESULTS More than half of participants were older than 65 years old (58.23%) and 274 participants (8.75%) had depression during the pandemic. Delay of dental care was positively associated with depression among both middle-aged adults (OR=2.05, 95%CI=1.04-4.03, P<0.05) and older adults (OR=3.08, 95%CI=1.07-8.87, P<0.05). Delay of surgery was positively associated with depression among older adults (OR=3.69, 95%CI=1.06-12.90, P<0.05). Self-reported pain was positively related to depression among both age groups. Middle-aged adults who reported higher education level (some college of above) or worse self-reported health had higher likelihood to have depression. While perceived more loneliness was positively associated with depression among older adults, financial difficulty was positively associated with depression among middle-aged adults. CONCLUSIONS This study found that depression among middle-aged and older adults during the pandemic was also prevalent. The study highlighted the collateral damage of the COVID-19 pandemic by identifying the effect of delay of surgery and dental care on depression during the pandemic. Although surgery and dental care cannot be delivered by telehealth, telehealth services can still be provided to address patients’ concern on delay of surgery and dental care. Moreover, the implementation of tele-mental health services is also needed to address mental health symptoms among US middle-aged and older adults during the pandemic. Future research that uses more comprehensive CLINICALTRIAL N/A


2013 ◽  
Vol 9 ◽  
pp. P671-P672
Author(s):  
Cynthia Carlsson ◽  
Benjamin Austin ◽  
Barbara Bendlin ◽  
Hanna Blazel ◽  
Jodi Barnet ◽  
...  

2001 ◽  
Vol 281 (6) ◽  
pp. F1132-F1140 ◽  
Author(s):  
R. Kramp ◽  
P. Fourmanoir ◽  
N. Caron

First published August 15, 2001; 10.1152/ajprenal.00078.2001.—Renal blood flow (RBF) autoregulatory efficiency may be enhanced during NO inhibition in the rat, as recently reported. Under these conditions, endothelin (ET) synthesis and release may be increased. Our purpose was therefore to determine the role of ET in RBF autoregulatory changes induced by NO inhibition. To address this point, ETA/B receptors were blocked in anesthetized rats with bosentan, or selectively with BQ-610 or BQ-788. NO synthesis was inhibited with N G-nitro-l-arginine methyl ester (l-NAME). Mean arterial pressure (MAP) was decreased after bosentan (−10 mmHg; P < 0.01) or increased after l-NAME (25 mmHg; P < 0.001). RBF measured with an electromagnetic flow probe was reduced byl-NAME (−50%) and by BQ-788 (−24%). The pressure limits of the autoregulatory plateau (PA ∼100 mmHg) and of no RBF autoregulation (Po ∼80 mmHg) were significantly lowered by 15 mmHg after l-NAME but were unchanged after bosentan, BQ-610, or BQ-788. During NO inhibition, autoregulatory resetting was completely hindered by bosentan (PA ∼100 mmHg) and by ETB receptor blockade with BQ-788 (PA ∼106 mmHg), but not by ETA receptor blockade with BQ-610 (PA ∼85 mmHg). These results suggest that the involvement of ET in the RBF autoregulatory resetting occurs during NO inhibition, possibly by preferential activation of the ETB receptor. However, the relative contribution of ET receptor subtypes remains to be further specified.


2003 ◽  
Vol 44 (2) ◽  
pp. 728 ◽  
Author(s):  
Gabriele Fuchsja¨ger-Mayrl ◽  
Alexandra Luksch ◽  
Magdalena Malec ◽  
Elzbieta Polska ◽  
Michael Wolzt ◽  
...  

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Katrina J. Carter ◽  
Aaron T. Ward ◽  
Shawn E. Bolin ◽  
Marlowe W. Eldridge ◽  
Scott A. Hagen ◽  
...  

2012 ◽  
Vol 9 (8) ◽  
pp. 990-997 ◽  
Author(s):  
Cynthia M. Carlsson ◽  
Guofan Xu ◽  
Zhifei Wen ◽  
Jodi H. Barnet ◽  
Hanna M. Blazel ◽  
...  

2018 ◽  
Vol 105 ◽  
pp. 101-108 ◽  
Author(s):  
Marieke van der Heiden ◽  
Mariette B. van Ravenhorst ◽  
Marjan Bogaard ◽  
Annemieke M.H. Boots ◽  
Guy A.M. Berbers ◽  
...  

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Jesse C Craig ◽  
Ryan M Broxterman ◽  
D Taylor La Salle ◽  
James Cerbie ◽  
Stephen M Ratchford ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document