scholarly journals Low level of Lemon Balm (Melissa officinalis) essential oils showed hypoglycemic effects by altering the expression of glucose metabolism genes in db/db mice

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Mi Ja Chung ◽  
Sung‐Yun Cho ◽  
Sung‐Joon Lee
Keyword(s):  
Glucose Metabolism ◽  
Essential Oils ◽  
Melissa Officinalis ◽  
Lemon Balm ◽  
Low Level

scholarly journals Antibacterial and Cytotoxic Activity of Nepeta Cataria L., N. Cataria Var. Citriodora (Beck.) Balb. and Melissa Officinalis L. Essential Oils

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Ulrike Suschke ◽  
Frank Sporer ◽  
Jürgen Schneele ◽  
Heinrich Konrad Geiss ◽  
Jürgen Reichling
Keyword(s):  
Respiratory Tract ◽  
Essential Oils ◽  
Cytotoxic Activity ◽  
Clinical Isolates ◽  
Melissa Officinalis ◽  
Bronchial Epithelial ◽  
Lemon Balm ◽  
Nepeta Cataria ◽  
Tract Infections ◽  
Reference Strains

The aim of the present study was to investigate the susceptibility of bacteria that play a role in respiratory tract and skin infections to the essential oils of catnip (Nepeta cataria), lemon catnip (N. cataria var. citriodora) and lemon balm (Melissa officinalis) with regard to their chemical composition. In addition, we wanted to assess whether antibiotic-resistant and -sensitive strains differ in their susceptibility to the oils and if there are cross resistances between standard antibiotics and essential oils. To evaluate the safety of topical application, cytotoxicity of the oils was studied in human keratinocyte and bronchial epithelial cell lines and irritation threshold concentrations were determined in ovo using the HET-CAM-test. The composition of the essential oils was analyzed by GC and GC-MS. Their MICs and MBCs were determined by a broth microdilution method against both reference strains from culture collections and clinical isolates with different susceptibility to standard antibiotics. Cytotoxicity was assessed by the MTT assay. Except for P. aeruginosa (MIC ≥2%), all reference strains tested were susceptible to catnip and lemon balm oils with MIC values ranging from 0.016 % to 0.25% (v/v). The clinical isolates were as susceptible to the oils (± 1 serial dilution) as the corresponding reference strains, regardless of their origin and resistance to standard antibiotics. The oils were cytotoxic to both keratinocytes and bronchial epithelial cells at CC50 values from 0.0012% to 0.015% (v/v). Lemon balm oil, whose main components were monoterpene aldehydes, exhibited the highest antibacterial and cytotoxic activity, followed by lemon catnip oil, which contained mainly monoterpene alcohols, and catnip oil, which was characterized by nepetalactones. Our results provide a rationale for the use of catnip, lemon catnip and lemon balm oils in the complementary topical treatment of respiratory tract infections, as the oils show a high antibacterial activity against respiratory tract pathogens, including clinical isolates with reduced susceptibility to standard antibiotics. However, cytotoxicity must be considered in topical therapy.

Influence of Cutting and Harvest Day Time on the Essential Oils of Lemon Balm (Melissa officinalis L.)

2009 ◽  
Vol 12 (3) ◽  
pp. 348-357 ◽  
Author(s):  
Khalid A. Khalid ◽  
Wenli Hu ◽  
Weiming Cai ◽  
Mohammed S. Hussien
Keyword(s):  
Essential Oils ◽  
Melissa Officinalis ◽  
Lemon Balm

Toxic essential oils, part VI: Acute oral toxicity of lemon balm (Melissa officinalis L.) essential oil in BALB/c mice

2019 ◽  
Vol 133 ◽  
pp. 110794 ◽  
Author(s):  
Nikola M. Stojanović ◽  
Pavle J. Randjelović ◽  
Marko Z. Mladenović ◽  
Ivan R. Ilić ◽  
Vladimir Petrović ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Acute Oral Toxicity ◽  
Melissa Officinalis ◽  
Oral Toxicity ◽  
Lemon Balm

scholarly journals HEAVY METAL ACCUMULATION AND CHEMICAL COMPOSITION OF ESSENTIAL OILS OF LEMON BALM (MELISSA OFFICINALIS L.) CULTIVATED ON HEAVY METAL CONTAMINATED SOILS

2020 ◽  
Author(s):  
Violina Angelova ◽  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Chemical Composition ◽  
Essential Oils ◽  
Contaminated Soils ◽  
Ferrous Metal ◽  
Heavy Metal Accumulation ◽  
Geranyl Acetate ◽  
Melissa Officinalis ◽  
Lemon Balm

Comparative research has been conducted to allow us to determine the content of heavy metals and chemical composition of lemon balm oils, as well as to identify the possibility of lemon balm growth on soils contaminated by heavy metals. The experimental plots were situated at different distances of 0.5 km, and 15 km, respectively, from the source of pollution the Non-Ferrous-Metal Works (MFMW) near Plovdiv, Bulgaria. On reaching the flowering stage the lemon balm plants were gathered. The content of heavy metals in leaves of lemon balm was determined by ICP. The essential oils of the lemon balm were obtained by steam distillation in laboratory conditions which were analyzed for heavy metals and chemical composition was determined. Lemon balm is a plant that is tolerant to heavy metals and can be grown on contaminated soils. Heavy metals do not affect the development of lemon balm and the quality and quantity of oil obtained from it. Forty components were identified in the oils. The quantity of identified compounds corresponds to 98.82-98.83% of the total oil content. Among the detected compounds, beta-citral (neral) (19.31-20.78%), alfa-citral (geranial) (18,65-19,12%), β-caryophyllene (14.76-16.28%), α-cadinol (3.88-4.74%), geranyl acetate (3.49-3.59%), trans-geraniol (3.40-3.51%), germacrene (3.18-3.28%), citronellal (2.94-3.03%), nerol (2.63-2.71%), neryl acetate (2.42 -2.49%) were the major compounds. The essential oil of Melissa officinalis L. can be a valuable product for farmers from polluted regions.

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