scholarly journals Inflammatory Circulating Mononuclear Cell Phenotype in Healthy Older Adults with Low‐Grade Systemic Inflammation and Endothelial Dysfunction

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Lindsey B Gano ◽  
Katie A. Magerko ◽  
Cassandra Roeca ◽  
Brooke R. Lawson ◽  
Kristen L. Jablonski ◽  
...  
Keyword(s):  
Older Adults ◽  
Endothelial Dysfunction ◽  
Mononuclear Cell ◽  
Systemic Inflammation ◽  
Cell Phenotype ◽  
Low Grade ◽  
Healthy Older Adults

scholarly journals Low-Grade Systemic Inflammation Interferes with Anabolic and Catabolic Characteristics of the Aged Human Skeletal Muscle

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Dimitrios Draganidis ◽  
Athanasios Z. Jamurtas ◽  
Niki Chondrogianni ◽  
George Mastorakos ◽  
Tobias Jung ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Systemic Inflammation ◽  
Human Skeletal Muscle ◽  
Acute Phase Proteins ◽  
Proteasome Activity ◽  
Low Grade ◽  
Age Related ◽  
Hs Crp

Aging is associated with the development of chronic low-grade systemic inflammation (LGSI) characterized by increased circulating levels of proinflammatory cytokines and acute phase proteins such as C-reactive protein (CRP). Collective evidence suggests that elevated levels of inflammatory mediators such as CRP, interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) are correlated with deteriorated skeletal muscle mass and function, though the molecular footprint of this observation in the aged human skeletal muscle remains obscure. Based on animal models showing impaired protein synthesis and enhanced degradation in response to LGSI, we compared here the response of proteolysis- and protein synthesis-related signaling proteins as well as the satellite cell and amino acid transporter protein content between healthy older adults with increased versus physiological blood hs-CRP levels in the fasted (basal) state and after an anabolic stimulus comprised of acute resistance exercise (RE) and protein feeding. Our main findings indicate that older adults with increased hs-CRP levels demonstrate (i) increased proteasome activity, accompanied by increased protein carbonylation and IKKα/β phosphorylation; (ii) reduced Pax7+ satellite cells; (iii) increased insulin resistance, at the basal state; and (iv) impaired S6 ribosomal protein phosphorylation accompanied by hyperinsulinemia following an acute RE bout combined with protein ingestion. Collectively, these data provide support to the concept that age-related chronic LGSI may upregulate proteasome activity via induction of the NF-κB signaling and protein oxidation and impair the insulin-dependent anabolic potential of human skeletal muscle.

Is poor self-rated sleep quality associated with elevated systemic inflammation in healthy older adults?

2020 ◽  
Vol 192 ◽  
pp. 111388
Author(s):  
Kimberley Kira Petrov ◽  
Amie Hayley ◽  
Sarah Catchlove ◽  
Karen Savage ◽  
Con Stough
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Systemic Inflammation ◽  
Healthy Older Adults

scholarly journals Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto’s Thyroiditis

2006 ◽  
Vol 91 (12) ◽  
pp. 5076-5082 ◽  
Author(s):  
Stefano Taddei ◽  
Nadia Caraccio ◽  
Agostino Virdis ◽  
Angela Dardano ◽  
Daniele Versari ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Vitamin C ◽  
Systemic Inflammation ◽  
Antioxidant Vitamin ◽  
Low Grade ◽  
Reactive Protein ◽  
Cox 2 ◽  
Oxide Synthase ◽  
Low Grade Inflammation

Abstract Objective: The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis. Background: sHT patients are characterized by peripheral endothelial dysfunction and low-grade inflammation. Methods: In 53 sHT and 45 healthy subjects, we studied the forearm blood flow (strain-gauge plethysmography) response to intrabrachial acetylcholine (Ach) (0.15–15 μg/min·dl) with and without local vascular COX inhibition by intrabrachial indomethacin (50 μg/min·dl) or nitric oxide synthase blockade by N-mono methyl arginine (l-NMMA) (100 μg/min·dl) or the antioxidant vitamin C (8 mg/min·dl). The protocol was repeated 2 h after systemic nonselective COX inhibition (100 mg indomethacin) or selective COX-2 blockade (200 mg celecoxib) oral administrations. Results: sHT patients showed higher C-reactive protein and IL-6 values. In controls, vasodilation to Ach was blunted by l-NMMA and unchanged by vitamin C. In contrast, in sHT, the response to Ach, reduced in comparison with controls, was resistant to l-NMMA and normalized by vitamin C. In these patients, systemic but not local indomethacin normalized vasodilation to Ach and the inhibition of l-NMMA on Ach. Similar results were obtained with celecoxib. When retested after indomethacin administration, vitamin C no longer succeeded in improving vasodilation to Ach in sHT patients. Response to sodium nitroprusside was unchanged by indomethacin or celecoxib. Conclusions: In sHT patients, low-grade chronic inflammation causes endothelial dysfunction and impaired nitric oxide availability by a COX-2-dependent pathway leading to increased production of oxidative stress.

scholarly journals Leukocyte count, systemic inflammation, and health status in older adults: a narrative review

2018 ◽  
Vol 81 (1) ◽  
pp. 81-101 ◽  
Author(s):  
Piotr Chmielewski
Keyword(s):  
Older Adults ◽  
Systemic Inflammation ◽  
Molecular Mechanisms ◽  
Leukocyte Count ◽  
The Elderly ◽  
Low Grade ◽  
Associated Diseases ◽  
Increased Risk ◽  
Leukocyte Counts ◽  
Normal Leukocyte

Abstract Epidemiological and clinical studies suggest that elevated leukocyte count within the normal range can predict cardiovascular and total mortality in older adults. These findings are remarkable because this simple and common laboratory test is included in routine medical check-ups. It is well known that chronic systemic inflammation (inflammaging) is one of the hallmarks of aging and an important component of obesity-associated insulin resistance that can lead to type 2 diabetes and other health problems in both overweight individuals and elderly people. To understand the molecular mechanisms linking increased systemic inflammation with aging-associated diseases and elevated leukocyte counts in the elderly is to unravel the multiplicity of molecular factors and mechanisms involved in chronic low-grade systemic inflammation, the gradual accumulation of random molecular damage, age-related diseases, and the process of leukopoiesis. There are several possible mechanisms through which chronic low-grade systemic inflammation is associated with both higher leukocyte count and a greater risk of aging-associated conditions in older adults. For example, the IL-6 centric model predicts that this biomediator is involved in chronic systemic inflammation and leukopoiesis, thereby suggesting that elevated leukocyte count is a signal of poor health in older adults. Alternatively, an increase in neutrophil and monocyte counts can be a direct cause of cardiovascular events in the elderly. Interestingly, some authors assert that the predictive ability of elevated leukocyte counts with regard to cardiovascular and allcause mortality among older adults surpass the predictive value of total cholesterol. This review reports the recent findings on the links between elevated but normal leukocyte counts and the increased risks of all-cause, cardiovascular, and cancer mortality. The possible molecular mechanisms linking higher but normal leukocyte counts with increased risk of aging-associated diseases in the elderly are discussed here.

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