scholarly journals Involvement of cGMP‐dependent protein kinase in colon cancer cells: analysis of cell proliferation, apoptosis and beta‐catenin expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Hassan Sellak ◽  
Songwei Wu ◽  
Thomas M. Lincoln
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Beta Catenin ◽  
Colon Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals Type II cGMP-dependent protein kinase inhibits ligand-induced activation of EGFR in gastric cancer cells

2014 ◽  
Vol 9 (4) ◽  
pp. 1405-1409 ◽  
Author(s):  
LU JIANG ◽  
YONGCHANG CHEN ◽  
YUEYING LI ◽  
TING LAN ◽  
MIN WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa

2012 ◽  
Vol 303 (2) ◽  
pp. G209-G219 ◽  
Author(s):  
Rui Wang ◽  
In-Kiu Kwon ◽  
Muthusamy Thangaraju ◽  
Nagendra Singh ◽  
Kebin Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Colon Cancer Cell ◽  
Tissue Homeostasis ◽  
Colon Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Colon Cancer Cell Lines ◽  
Proliferation And Differentiation ◽  
Dependent Protein

Signaling through cGMP has emerged as an important regulator of tissue homeostasis in the gastrointestinal tract, but the mechanism is not known. Type 2 cGMP-dependent protein kinase (PKG2) is a major cGMP effector in the gut epithelium, and the present studies have tested its importance in the regulation of proliferation and differentiation in the mouse colon and in colon cancer cell lines. Tissue homeostasis was examined in the proximal colon of Prkg2 −/− mice using histological markers of proliferation and differentiation. The effect of ectopic PKG2 on proliferation and differentiation was tested in vitro using inducible colon cancer cell lines. PCR and luciferase reporter assays were used to determine the importance of Sox9 downstream of PKG2. The colons of Prkg2 −/− mice exhibited crypt hyperplasia, increased epithelial apoptosis, and reduced numbers of differentiated goblet and enteroendocrine cells. Ectopic PKG2 was able to inhibit proliferation and induce Muc2 and CDX2 expression in colon cancer cells, but did not significantly affect cell death. PKG2 reduced Sox9 levels and signaling, suggesting possible involvement of this pathway downstream of cGMP in the colon. The work presented here demonstrates a novel antiproliferative and prodifferentiation role for PKG2 in the colon. These homeostatic functions of PKG2 were reproducible in colon cancer cells lines where downregulation of Sox9 is a possible mechanism. The similarities in phenotype between PKG2 and GCC knockout mice positions PKG2 as a likely mediator of the homeostatic effects of cGMP signaling in the colon.

scholarly journals Type II cGMP-dependent protein kinase inhibits activation of key members of the RTK family in gastric cancer cells

2013 ◽  
Vol 1 (3) ◽  
pp. 399-404 ◽  
Author(s):  
LU JIANG ◽  
YONGCHANG CHEN ◽  
JIANRONG SANG ◽  
YUEYING LI ◽  
TING LAN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

scholarly journals Type II cGMP-dependent protein kinase inhibits ERK/JNK-mediated activation of transcription factors in gastric cancer cells

2012 ◽  
Vol 6 (5) ◽  
pp. 1190-1194 ◽  
Author(s):  
JIANRONG SANG ◽  
YONGCHANG CHEN ◽  
LU JIANG ◽  
YAN TAO ◽  
YAN WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factors ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Activation Of Transcription ◽  
Dependent Protein

scholarly journals Type II cGMP-dependent protein kinase inhibits EGF-induced JAK/STAT signaling in gastric cancer cells

2016 ◽  
Vol 14 (2) ◽  
pp. 1849-1856 ◽  
Author(s):  
Min Wu ◽  
Yan Wu ◽  
Ting Lan ◽  
Lu Jiang ◽  
Hai Qian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Stat Signaling ◽  
Dependent Protein

scholarly journals Type II cGMP-dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells

2017 ◽  
Vol 16 (4) ◽  
pp. 5729-5737 ◽  
Author(s):  
Min Wu ◽  
Yan Wu ◽  
Hai Qian ◽  
Yan Tao ◽  
Ji Pang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Cells ◽  
Human Cancer ◽  
Type Ii ◽  
Dependent Protein Kinase ◽  
Human Cancer Cells ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein
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