scholarly journals MEMBRANE LIPID COMPOSITION INFLUENCES A NEURONAL CELL FATE DECISION IN C. ELEGANS

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Kalyann Kauv ◽  
Jill C. Bettinger ◽  
Andrew G. Davies
Keyword(s):  
Cell Fate ◽  
Lipid Composition ◽  
Neuronal Cell ◽  
Membrane Lipid ◽  
Cell Fate Decision ◽  
Membrane Lipid Composition ◽  
C Elegans ◽  
Fate Decision

scholarly journals HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis

2019 ◽  
Vol 29 (18) ◽  
pp. 3094-3100.e4 ◽  
Author(s):  
Michelle A. Attner ◽  
Wolfgang Keil ◽  
Justin M. Benavidez ◽  
Iva Greenwald
Keyword(s):  
Cell Fate ◽  
Cell Fate Decision ◽  
C Elegans ◽  
A Cell ◽  
Fate Decision

scholarly journals A hydraulic instability drives the cell death decision in the nematode germline

2020 ◽  
Author(s):  
N. T. Chartier ◽  
A. Mukherjee ◽  
J. Pfanzelter ◽  
S. Fürthauer ◽  
B. T. Larson ◽  
...  
Keyword(s):  
Decision Making ◽  
Cell Death ◽  
Cell Fate ◽  
Germ Cells ◽  
Cell Fate Decision ◽  
Homogeneous Population ◽  
C Elegans ◽  
The Common ◽  
Fate Decision ◽  
Cell Volumes

AbstractOocytes are large and resourceful. During oogenesis some germ cells grow, typically at the expense of others that undergo apoptosis. How germ cells are selected to live or die out of a homogeneous population remains unclear. Here we show that this cell fate decision in C. elegans is mechanical and related to tissue hydraulics. Germ cells become inflated when the pressure inside them is lower than in the common cytoplasmic pool. This condition triggers a hydraulic instability which amplifies volume differences and causes some germ cells to grow and others to shrink. Shrinking germ cells are extruded and die, as we demonstrate by reducing germ cell volumes via thermoviscous pumping. Together, this reveals a robust mechanism of mechanochemical cell fate decision making in the germline.

Cell autonomy of lin-12 function in a cell fate decision in C. elegans

Cell ◽  
1989 ◽  
Vol 57 (7) ◽  
pp. 1237-1245 ◽  
Author(s):  
Geraldine Seydoux ◽  
Iva Greenwald
Keyword(s):  
Cell Fate ◽  
Cell Fate Decision ◽  
C Elegans ◽  
A Cell ◽  
Cell Autonomy ◽  
Fate Decision

scholarly journals Maintaining a stochastic neuronal cell fate decision

2009 ◽  
Vol 23 (4) ◽  
pp. 385-390 ◽  
Author(s):  
D. Vasiliauskas ◽  
R. Johnston ◽  
C. Desplan
Keyword(s):  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Decision ◽  
Fate Decision

scholarly journals MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

2005 ◽  
Vol 102 (35) ◽  
pp. 12449-12454 ◽  
Author(s):  
R. J. Johnston ◽  
S. Chang ◽  
J. F. Etchberger ◽  
C. O. Ortiz ◽  
O. Hobert
Keyword(s):  
Cell Fate ◽  
Negative Feedback ◽  
Feedback Loop ◽  
Neuronal Cell ◽  
Negative Feedback Loop ◽  
Double Negative ◽  
Cell Fate Decision ◽  
Fate Decision

scholarly journals Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans

2020 ◽  
Vol 461 (2) ◽  
pp. 110-123 ◽  
Author(s):  
Jason R. Kroll ◽  
Jasonas Tsiaxiras ◽  
Jeroen S. van Zon
Keyword(s):  
Cell Fate ◽  
Cell Fate Decision ◽  
Pulse Dynamics ◽  
C Elegans ◽  
Fate Decision

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

Cell ◽  
1994 ◽  
Vol 79 (7) ◽  
pp. 1187-1198 ◽  
Author(s):  
Hilary A. Wilkinson ◽  
Kevin Fitzgerald ◽  
Iva Greenwald
Keyword(s):  
Cell Fate ◽  
Cell Fate Decision ◽  
C Elegans ◽  
Fate Decision

scholarly journals Morphogenesis of the C. elegans hermaphrodite uterus

Development ◽  
1996 ◽  
Vol 122 (11) ◽  
pp. 3617-3626 ◽  
Author(s):  
A.P. Newman ◽  
J.G. White ◽  
P.W. Sternberg
Keyword(s):  
Cell Fate ◽  
Cell Lineage ◽  
Cell Types ◽  
Cell Interaction ◽  
Cell Fate Decision ◽  
Cell Fates ◽  
C Elegans ◽  
A Cell ◽  
Anchor Cell ◽  
Fate Decision

We have undertaken electron micrographic reconstruction of the Caenorhabditis elegans hermaphrodite uterus and determined the correspondence between cells defined by their lineage history and differentiated cell types. In this organ, many cells do not move during morphogenesis and the cell lineage may function to put cells where they are needed. Differentiated uterine cell types include the toroidal ut cells that make structural epithelium, and specialized utse and uv cells that make the connection between the uterus and the vulva. A cell fate decision in which the anchor cell (AC) induces adjacent ventral uterine intermediate precursor cells to adopt the pi fate, rather than the ground state rho, has profound consequences for terminal differentiation: all pi progeny are directly involved in making the uterine-vulval connection whereas all rho progeny contribute to ut toroids or the uterine-spermathecal valve. In addition to specifying certain uterine cell fates, the AC also induces the vulva. Its multiple inductions thereby function to coordinate the connection of an internal to an external epithelium. The AC induces the pi cells and ultimately fuses with a subset of their progeny. This is an example of reciprocal cell-cell interaction that can be studied at single cell resolution. The AC is thus a transitory cell type that plays a pivotal role in organizing the morphogenesis of the uterine-vulval connection.

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