Nucleoside diphosphate kinase Nm23-M1 involves in oligodendroglial versus neuronal cell fate decision in vitro

2012 ◽  
Vol 84 (4) ◽  
pp. 281-293 ◽  
Author(s):  
Hamed Owlanj ◽  
Hai Jie Yang ◽  
Zhi Wei Feng
Keyword(s):  
Cell Fate ◽  
Neuronal Cell ◽  
Nucleoside Diphosphate Kinase ◽  
Cell Fate Decision ◽  
Fate Decision

scholarly journals Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by cell condensed condition in spheroid culture

2020 ◽  
Author(s):  
Jeonghyun Kim ◽  
Taiji Adachi
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Fate ◽  
Actin Polymerization ◽  
Cell Fate Decision ◽  
Spheroid Culture ◽  
Self Organized ◽  
Culture Model ◽  
Fate Decision

AbstractOsteocytes are mechanosensory commander cells to regulate bone remodeling throughout the lifespan. While the osteocyte is known as a terminally differentiated cell derived from mesenchymal stem cell, the detailed mechanisms of cell-fate decision toward osteocyte differentiation still remain unclear. In this study, we fabricated three-dimensional (3D) self-organized spheroids using human mesenchymal stem cells (hMSCs). Under the osteogenesis induction medium, the spheroid culture model exerted the osteocyte-likeness within 2 days compared to a conventional 2D monolayer model. By using an inhibitor of actin polymerization, we showed an involvement of actin balancing in the osteocyte differentiation in the spheroid. Notably, we represented that the cell condensed condition acquired in the 3D spheroid culture model determined a differentiation fate of MSCs to osteocytes via actin balancing. Taken together, we suggest that our self-organized spheroid model can be utilized as a new in vitro model to represent the osteocyte differentiation process and further to recapitulate an in vitro ossification process.

scholarly journals Maintaining a stochastic neuronal cell fate decision

2009 ◽  
Vol 23 (4) ◽  
pp. 385-390 ◽  
Author(s):  
D. Vasiliauskas ◽  
R. Johnston ◽  
C. Desplan
Keyword(s):  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Decision ◽  
Fate Decision

scholarly journals MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision

2005 ◽  
Vol 102 (35) ◽  
pp. 12449-12454 ◽  
Author(s):  
R. J. Johnston ◽  
S. Chang ◽  
J. F. Etchberger ◽  
C. O. Ortiz ◽  
O. Hobert
Keyword(s):  
Cell Fate ◽  
Negative Feedback ◽  
Feedback Loop ◽  
Neuronal Cell ◽  
Negative Feedback Loop ◽  
Double Negative ◽  
Cell Fate Decision ◽  
Fate Decision

scholarly journals Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tim Liebisch ◽  
Armin Drusko ◽  
Biena Mathew ◽  
Ernst H. K. Stelzer ◽  
Sabine C. Fischer ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Division ◽  
Cell Fate ◽  
Inner Cell Mass ◽  
Cell Mass ◽  
Cell Lineage ◽  
Cell Fate Decision ◽  
Cell Fate Decisions ◽  
Chemical Signalling ◽  
Fate Decision

AbstractDuring the mammalian preimplantation phase, cells undergo two subsequent cell fate decisions. During the first decision, the trophectoderm and the inner cell mass are formed. Subsequently, the inner cell mass segregates into the epiblast and the primitive endoderm. Inner cell mass organoids represent an experimental model system, mimicking the second cell fate decision. It has been shown that cells of the same fate tend to cluster stronger than expected for random cell fate decisions. Three major processes are hypothesised to contribute to the cell fate arrangements: (1) chemical signalling; (2) cell sorting; and (3) cell proliferation. In order to quantify the influence of cell proliferation on the observed cell lineage type clustering, we developed an agent-based model accounting for mechanical cell–cell interaction, i.e. adhesion and repulsion, cell division, stochastic cell fate decision and cell fate heredity. The model supports the hypothesis that initial cell fate acquisition is a stochastically driven process, taking place in the early development of inner cell mass organoids. Further, we show that the observed neighbourhood structures can emerge solely due to cell fate heredity during cell division.

scholarly journals Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Xudong Zhu ◽  
Zhiyang Chen ◽  
Weiyan Shen ◽  
Gang Huang ◽  
John M. Sedivy ◽  
...  
Keyword(s):  
Cell Fate ◽  
Cellular Response ◽  
State Of The Art ◽  
Cell Senescence ◽  
Therapeutic Interventions ◽  
Cell Fate Decision ◽  
The Past ◽  
Fate Decision ◽  
The Individual ◽  
Remarkable Progress

AbstractRemarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the decline of physical function often initiates by cell senescence and organ ageing. Epigenetic dynamics and immunometabolic reprogramming link to the alterations of cellular response to intrinsic and extrinsic stimuli, representing current hotspots as they not only (re-)shape the individual cell identity, but also involve in cell fate decision. This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Potential therapeutic interventions targeting cell senescence and regulatory mechanisms, using state-of-the-art techniques are also discussed.

Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF

Science ◽  
2000 ◽  
Vol 287 (5457) ◽  
pp. 1489-1493 ◽  
Author(s):  
X. Meng
Keyword(s):  
Cell Fate ◽  
Cell Fate Decision ◽  
Fate Decision
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