scholarly journals Acute mineralocorticoid receptor blockade leads to decreased vascular endothelial function in healthy older adults

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Han Kyul Kim ◽  
Moon‐Hyon Hwang ◽  
Jeung‐Ki Yoo ◽  
Meredith J. Luttrell ◽  
Thomas H. Meade ◽  
...  
Keyword(s):  
Older Adults ◽  
Endothelial Function ◽  
Mineralocorticoid Receptor ◽  
Receptor Blockade ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Healthy Older Adults ◽  
Mineralocorticoid Receptor Blockade

scholarly journals The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials

2020 ◽  
Vol 17 (16) ◽  
pp. 5643 ◽  
Author(s):  
Michitaka Kato ◽  
Fumi Nihei Green ◽  
Kazuki Hotta ◽  
Toshiya Tsukamoto ◽  
Yasunari Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Stretching Exercises

Background: Aerobic exercise is known to reduce arterial stiffness; however, high-intensity resistance exercise is associated with increased arterial stiffness. Stretching exercises are another exercise modality, and their effect on arterial stiffness remains unclear. The purpose of this study was to determine whether stretching exercises reduce arterial stiffness in middle-aged and older adults, performing the first meta-analysis of currently available studies. Methods: We searched the literature for randomized controlled trials (RCTs) and non-RCTs published up to January 2020 describing middle-aged and older adults who participated in a stretching intervention vs. controls without exercise training. The primary and secondary outcomes were changes in arterial stiffness and vascular endothelial function and hemodynamic status. Pooled mean differences (MDs) and standard MDs (SMDs) with 95% confidence intervals (CIs) between the intervention and control groups were calculated using a random effects model. Results: We identified 69 trials and, after an assessment of relevance, eight trials, including a combined total of 213 subjects, were analyzed. Muscle stretching exercises were shown to significantly reduce arterial stiffness and improve vascular endothelial function (SMD: −1.00, 95% CI: −1.57 to −0.44, p = 0.0004; SMD: 1.15, 95% CI: 0.26 to 2.03, p = 0.01, respectively). Resting heart rate (HR) and diastolic blood pressure (DBP) decreased significantly after stretching exercise intervention (MD: −0.95 beats/min, 95% CI: −1.67 to −0.23 beats/min, p = 0.009; MD: −2.72 mm Hg, 95% CI: −4.01 to −1.43 mm Hg, p < 0.0001, respectively) Conclusions: Our analyses suggest that stretching exercises reduce arterial stiffness, HR, and DBP, and improve vascular endothelial function in middle-aged and older adults.

scholarly journals Absence of Inhibitor of Nuclear Factor κ B Kinase‐Mediated Suppression of Vascular Endothelial Function in Middle‐Aged/Older Adults Who Exercise

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Ashley E Walker ◽  
Gary L Pierce ◽  
Lisa A Lesniewski ◽  
Brooke R Lawson ◽  
Katherine A Magerko ◽  
...  
Keyword(s):  
Older Adults ◽  
Endothelial Function ◽  
Vascular Endothelial ◽  
Nuclear Factor ◽  
Vascular Endothelial Function ◽  
Middle Aged ◽  
Nuclear Factor Κ B

Mineralocorticoid Receptor Blockade does not Reduce Pulse Wave Velocity in Older Adults with Metabolic Syndrome

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 744-745
Author(s):  
Jeung-Ki Yoo ◽  
Moon-Hyon Hwang ◽  
Meredith Luttrell ◽  
Molly Cernosek ◽  
Thomas H. Meade ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Mineralocorticoid Receptor ◽  
Pulse Wave ◽  
Receptor Blockade ◽  
Mineralocorticoid Receptor Blockade

scholarly journals Vascular Endothelial Function Is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-Aged and Older Adults

Hypertension ◽  
2010 ◽  
Vol 55 (2) ◽  
pp. 363-369 ◽  
Author(s):  
Ashley E. Walker ◽  
Sara Marian Seibert ◽  
Anthony J. Donato ◽  
Gary L. Pierce ◽  
Douglas R. Seals
Keyword(s):  
Older Adults ◽  
Blood Cell ◽  
Endothelial Function ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Blood Cell Count ◽  
Middle Aged
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