scholarly journals Vascular Endothelial Function Is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-Aged and Older Adults

Hypertension ◽  
2010 ◽  
Vol 55 (2) ◽  
pp. 363-369 ◽  
Author(s):  
Ashley E. Walker ◽  
Sara Marian Seibert ◽  
Anthony J. Donato ◽  
Gary L. Pierce ◽  
Douglas R. Seals
Keyword(s):  
Older Adults ◽  
Blood Cell ◽  
Endothelial Function ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Blood Cell Count ◽  
Middle Aged

scholarly journals White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults

2012 ◽  
Vol 6 (2) ◽  
pp. 65 ◽  
Author(s):  
Kyle J. Diehl ◽  
Brian R. Weil ◽  
Jared J. Greiner ◽  
Brian L. Stauffer ◽  
Christopher A. DeSouza
Keyword(s):  
Older Adults ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cell Count ◽  
Middle Aged ◽  
Endothelin 1

Testosterone, SHBG and differential white blood cell count in middle-aged and older men

Maturitas ◽  
2012 ◽  
Vol 71 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Judith S. Brand ◽  
Yvonne T. van der Schouw ◽  
Mitch Dowsett ◽  
Elizabeth Folkerd ◽  
Robert N. Luben ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Older Men ◽  
Blood Cell Count ◽  
Middle Aged ◽  
Differential White Blood Cell

Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women

2005 ◽  
Vol 21 (5) ◽  
pp. 441-447 ◽  
Author(s):  
Tomoko Mabuchi ◽  
Hiroshi Yatsuya ◽  
Koji Tamakoshi ◽  
Rei Otsuka ◽  
Nobue Nagasawa ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cell Count ◽  
Middle Aged ◽  
Japanese Men ◽  
Men And Women ◽  
Serum Leptin

scholarly journals White Blood Cells and Severe COVID-19: A Mendelian Randomization Study

2021 ◽  
Vol 11 (3) ◽  
pp. 195
Author(s):  
Yitang Sun ◽  
Jingqi Zhou ◽  
Kaixiong Ye
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
White Blood Cell ◽  
Blood Cells ◽  
Mendelian Randomization ◽  
Association Studies ◽  
White Blood Cells ◽  
Genome Wide Association Studies ◽  
Blood Cell Count

Increasing evidence shows that white blood cells are associated with the risk of coronavirus disease 2019 (COVID-19), but the direction and causality of this association are not clear. To evaluate the causal associations between various white blood cell traits and the COVID-19 susceptibility and severity, we conducted two-sample bidirectional Mendelian Randomization (MR) analyses with summary statistics from the largest and most recent genome-wide association studies. Our MR results indicated causal protective effects of higher basophil count, basophil percentage of white blood cells, and myeloid white blood cell count on severe COVID-19, with odds ratios (OR) per standard deviation increment of 0.75 (95% CI: 0.60–0.95), 0.70 (95% CI: 0.54–0.92), and 0.85 (95% CI: 0.73–0.98), respectively. Neither COVID-19 severity nor susceptibility was associated with white blood cell traits in our reverse MR results. Genetically predicted high basophil count, basophil percentage of white blood cells, and myeloid white blood cell count are associated with a lower risk of developing severe COVID-19. Individuals with a lower genetic capacity for basophils are likely at risk, while enhancing the production of basophils may be an effective therapeutic strategy.

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