scholarly journals Ketamine decreases immune gene expression in ovine fetal frontal cortex exposed to acute hypoxic hypoxia (887.5)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Eileen Chang ◽  
Maria Rabaglino ◽  
Elaine Richards ◽  
Charles Wood
Keyword(s):  
Gene Expression ◽  
Frontal Cortex ◽  
Hypoxic Hypoxia ◽  
Immune Gene ◽  
Immune Gene Expression ◽  
Acute Hypoxic Hypoxia ◽  
Ovine Fetal

scholarly journals Ketamine (KET) decreases inflammatory and apoptotic gene expression in ovine fetal frontal cortex exposed to global acute hypoxic hypoxia (HH)

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Eileen I‐Ling Chang ◽  
Maria Belen Rabaglino ◽  
Elaine M. Richards ◽  
Charles E. Wood
Keyword(s):  
Gene Expression ◽  
Frontal Cortex ◽  
Hypoxic Hypoxia ◽  
Apoptotic Gene ◽  
Acute Hypoxic Hypoxia ◽  
Ovine Fetal

Impact of cinnamaldehyde on innate immunity and immune gene expression in Channa striatus against Aphanomyces invadans

2021 ◽  
Author(s):  
Ramasamy Harikrishnan ◽  
Gunapathy Devi ◽  
Chellam Balasundaram ◽  
Hien Van Doan ◽  
Sanchai Jaturasitha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Innate Immunity ◽  
Immune Gene ◽  
Channa Striatus ◽  
Immune Gene Expression

scholarly journals Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Ling Cai ◽  
Hongyu Liu ◽  
Fang Huang ◽  
Junya Fujimoto ◽  
Luc Girard ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Neuroendocrine Cells ◽  
Immune Gene ◽  
Small Cell Lung ◽  
Immune Gene Expression ◽  
Pulmonary Neuroendocrine Cells

AbstractSmall cell lung cancer (SCLC) is classified as a high-grade neuroendocrine (NE) tumor, but a subset of SCLC has been termed “variant” due to the loss of NE characteristics. In this study, we computed NE scores for patient-derived SCLC cell lines and xenografts, as well as human tumors. We aligned NE properties with transcription factor-defined molecular subtypes. Then we investigated the different immune phenotypes associated with high and low NE scores. We found repression of immune response genes as a shared feature between classic SCLC and pulmonary neuroendocrine cells of the healthy lung. With loss of NE fate, variant SCLC tumors regain cell-autonomous immune gene expression and exhibit higher tumor-immune interactions. Pan-cancer analysis revealed this NE lineage-specific immune phenotype in other cancers. Additionally, we observed MHC I re-expression in SCLC upon development of chemoresistance. These findings may help guide the design of treatment regimens in SCLC.

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