scholarly journals Pomegranate ( Punica granatum ) fruit polyphenols, punicalagin, ellagic acid and gallic acid, inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species (975.10)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Weixi Liu ◽  
Hang Ma ◽  
Joel Dain ◽  
Navindra Seeram
Keyword(s):  
Gallic Acid ◽  
Ellagic Acid ◽  
Advanced Glycation Endproducts ◽  
Punica Granatum ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl

Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

2014 ◽  
Vol 5 (11) ◽  
pp. 2996-3004 ◽  
Author(s):  
Weixi Liu ◽  
Hang Ma ◽  
Leslie Frost ◽  
Tao Yuan ◽  
Joel A. Dain ◽  
...  
Keyword(s):  
Advanced Glycation Endproducts ◽  
Inhibitory Effects ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Reactive Carbonyl Species ◽  
First Time ◽  
Carbonyl Species ◽  
Reactive Carbonyl

The present study reported for the first time the inhibitory effects of pomegranate phenolics on the formation of advanced glycation endproducts and their carbonyl scavenger reactivity.

scholarly journals Reactive Metabolites and AGE-RAGE-Mediated Inflammation in Patients following Liver Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Thorsten Brenner ◽  
Thomas H. Fleming ◽  
David Spranz ◽  
Peter Schemmer ◽  
Thomas Bruckner ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Plasma Levels ◽  
Asymmetric Dimethylarginine ◽  
Advanced Glycation Endproducts ◽  
Reactive Metabolites ◽  
Minor Importance ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Reactive Carbonyl Species ◽  
Deceased Donors

Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased donors. The occurrence of short-term complications within 10 days of transplantation was documented. Blood samples were collected prior to transplantation, immediately after transplantation, and at consecutive time points, for a total of seven days after transplantation. Plasma levels of methylglyoxal were determined using HPLC, whereas plasma levels of L-arginine, asymmetric dimethylarginine, advanced glycation endproducts-carboxylmethyllysine, soluble receptor for advanced glycation endproducts, and total antioxidant capacity were measured by ELISA. Patients following liver transplantation were shown to suffer from increased RAGE-associated inflammation with an AGE load mainly dependent upon reactive carbonyl species-derived AGEs. In contrast, carboxylmethyllysine-derived AGEs were of a minor importance. As assessed by the ratio of L-arginine/asymmetric dimethylarginine, the bioavailability of nitric oxide was shown to be reduced in hepatic IRI, especially in those patients suffering from perfusion disorders following liver transplantation. For the early identification of patients at high risk of perfusion disorders, the implementation of asymmetric dimethylarginine measurements in routine diagnostics following liver transplantation from deceased donors should be taken into consideration.

Cinnamon Bark Proanthocyanidins as Reactive Carbonyl Scavengers To Prevent the Formation of Advanced Glycation Endproducts

2008 ◽  
Vol 56 (6) ◽  
pp. 1907-1911 ◽  
Author(s):  
Xiaofang Peng ◽  
Ka-Wing Cheng ◽  
Jinyu Ma ◽  
Bo Chen ◽  
Chi-Tang Ho ◽  
...  
Keyword(s):  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Cinnamon Bark ◽  
Glycation Endproducts ◽  
Reactive Carbonyl

scholarly journals The Immune Tolerance Role of the HMGB1-RAGE Axis

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 564
Author(s):  
Haruki Watanabe ◽  
Myoungsun Son
Keyword(s):  
Immune Responses ◽  
Immune Tolerance ◽  
Lupus Erythematosus ◽  
Advanced Glycation Endproducts ◽  
High Mobility ◽  
Chromatin Binding ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Extracellular Milieu

The disruption of the immune tolerance induces autoimmunity such as systemic lupus erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group box 1 (HMGB1), is released from the nucleus to the extracellular milieu in particular environments such as autoimmunity, sepsis and hypoxia. Extracellular HMGB1 engages pattern recognition receptors, including Toll-like receptors (TLRs) and the receptor for advanced glycation endproducts (RAGE). While the HMGB1-RAGE axis drives inflammation in various diseases, recent studies also focus on the anti-inflammatory effects of HMGB1 and RAGE. This review discusses current perspectives on HMGB1 and RAGE’s roles in controlling inflammation and immune tolerance. We also suggest how RAGE heterodimers responding microenvironments functions in immune responses.

scholarly journals Insoluble dietary fibre scavenges reactive carbonyl species under simulated physiological conditions: The key role of fibre-bound polyphenols

2021 ◽  
Vol 349 ◽  
pp. 129018
Author(s):  
Hao Zhang ◽  
Antonio Dario Troise ◽  
Yajing Qi ◽  
Gangcheng Wu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Dietary Fibre ◽  
Physiological Conditions ◽  
Reactive Carbonyl Species ◽  
Insoluble Dietary Fibre ◽  
Carbonyl Species ◽  
Reactive Carbonyl

scholarly journals Detoxification of Reactive Carbonyl Species by Glutathione Transferase Tau Isozymes

2019 ◽  
Vol 10 ◽  
Author(s):  
Jun’ichi Mano ◽  
Sayaka Kanameda ◽  
Rika Kuramitsu ◽  
Nagisa Matsuura ◽  
Yasuo Yamauchi
Keyword(s):  
Glutathione Transferase ◽  
Reactive Carbonyl Species ◽  
Carbonyl Species ◽  
Reactive Carbonyl
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