Efficacy of a Novel Fenugreek Seed Extract (Furocyst) in Polycystic Ovary Syndrome in Female Subjects

Background: Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine conditions affecting women of reproductive age Group with prevalence of approximately 7- 10% worldwide. Objective: The objectives of the study were to find out the effect of Standardized Fenugreek Seed extract as Furostenolic Saponins (Furocyst) on reduction in ovarian volume and the number of ovarian cysts. Method: An open labelled, Multicentre, single-arm, and non-comparative study was planned on 50 female patients suffering from PCOS. Patients were enrolled as per inclusion i.e. premenopausal women between 18-45 years of age, BMI less than 42, diagnosed with PCOS, with adequate hepatic, renal and haematological functions. Patients willing to give informed consent in writing Patients with Hysterectomy/ Congenital adrenal Hyperplasia/ Cushing’s syndrome / Androgen secreting tumour/ Thyroid-dysfunction/ Hypo-gonadism were excluded. Women were allocated to receive Furocyst and were assessed on parameters of USG & hormonal on second day of cycle before and every 4 weeks within treatment period of 12 weeks. Result: After treatment for 3 months with Furocyst caused significant reduction in ovary Volume (p 0.000), 46% of study population showed reduction in cyst size who had bigger cyst, 36% study population showed complete dissolution of cyst who had small cyst, 12% study population got pregnant and 71% patients reported regular menstrual cycle on completion of treatment and LH: FSH ratio was also reduced to normal. Overall 94% of patients reported positively or got benefitted from Standardized Fenugreek seed extract dosing. No changes were observed in liver function test (LFT), kidney function test (KFT) and haemogram level. Conclusions: Present Study indicates that Standardized Fenugreek seed extract as Furostenolic Saponins (Furocyst) is very effective and safe in the management of Poly Cystic Ovary Syndrome in women of reproductive age Group.

Download Full-text

Protective Role of Seed Extract of Tephrosia purpurea in Letrozole Induced Polycystic Ovary Syndrome in Wistar Rats

Journal of Biological Sciences ◽

10.3923/jbs.2018.458.467 ◽

2018 ◽

Vol 18 (8) ◽

pp. 458-467 ◽

Cited By ~ 1

Author(s):

Muddasir Basheer ◽

Seema Rai ◽

Hindole Ghosh ◽

Younis Ahmad Haja

Keyword(s):

Polycystic Ovary Syndrome ◽

Wistar Rats ◽

Polycystic Ovary ◽

Protective Role ◽

Seed Extract ◽

Ovary Syndrome ◽

Tephrosia Purpurea

Download Full-text

Single Nucleotide Polymorphism of Insulin Receptor Gene rs2059806 in Polycystic Ovary Syndrome- A Case-control Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/49653.15395 ◽

2021 ◽

Author(s):

Satwika Sinha ◽

Kaushik Kar ◽

Partha Pratim Chowdhury ◽

Anindya Dasgupta

Keyword(s):

Polycystic Ovary Syndrome ◽

Insulin Receptor ◽

Odds Ratio ◽

Polycystic Ovary ◽

Receptor Gene ◽

Case Control ◽

Ovary Syndrome ◽

Insulin Receptor Gene ◽

Control Female ◽

Female Subjects

Introduction: One of the most common endocrinopathies faced in clinical practice is Polycystic Ovary Syndrome (PCOS). Furthermore, it is one of the major causative factors of anovulatory infertility affecting a large number of female population worldwide. They are also at a greater risk for developing impaired glucose tolerance, type 2 diabetes mellitus and cardiovascular disease. Decreased sensitivity to insulin is a common feature observed in women with this syndrome. Aim: To assess whether polymorphism of insulin receptor gene has a significant role to develop the PCOS. Materials and Methods: This was a case-control, observational, hospital-based study, conducted at Department of Biochemistry, Calcutta National Medical College, Kolkata from January 2018 to September 2018. Total 123 patients with PCOS cases and 111 normo-ovulatory normal control female subjects were selected. Blood samples were collected for estimation of serum testosterone and Deoxyribonucleic Acid (DNA) extraction. Polymerase Chain Reaction (PCR) followed by Restriction Fragment Length Polymorphism (RFLP) pattern of PCR fragments of DNA samples were determined. The study analysed and compared the genotyping and allele frequencies of rs2059806 polymorphism in control and case group. For comparison, chi-square test was performed (Odds ratio, p<0.05). Results: Amongst the 123 PCOS cases and 111 normal female subjects of the study, mean age of PCOS patients were 22.59±4.7 years and that of control subjects was 21.9±5.1 years. The present study observed an increase in mutant G allele in PCOS subjects (Odds ratio-2.18, p=0.0035). Conclusion: The polymorphism of insulin receptor gene rs2059806 may have a probable role in the development of PCOS.

Download Full-text