scholarly journals Clinical Evaluation of Standardized Fenugreek Seed Extract as Furostanolic Saponins (Furocyst) In Polycystic Ovary Syndrome Patients

Background: Polycystic Ovarian Syndrome (PCOS) is one of the most common endocrine conditions affecting women of reproductive age Group with prevalence of approximately 7- 10% worldwide. Objective: The objectives of the study were to find out the effect of Standardized Fenugreek Seed extract as Furostenolic Saponins (Furocyst) on reduction in ovarian volume and the number of ovarian cysts. Method: An open labelled, Multicentre, single-arm, and non-comparative study was planned on 50 female patients suffering from PCOS. Patients were enrolled as per inclusion i.e. premenopausal women between 18-45 years of age, BMI less than 42, diagnosed with PCOS, with adequate hepatic, renal and haematological functions. Patients willing to give informed consent in writing Patients with Hysterectomy/ Congenital adrenal Hyperplasia/ Cushing’s syndrome / Androgen secreting tumour/ Thyroid-dysfunction/ Hypo-gonadism were excluded. Women were allocated to receive Furocyst and were assessed on parameters of USG & hormonal on second day of cycle before and every 4 weeks within treatment period of 12 weeks. Result: After treatment for 3 months with Furocyst caused significant reduction in ovary Volume (p 0.000), 46% of study population showed reduction in cyst size who had bigger cyst, 36% study population showed complete dissolution of cyst who had small cyst, 12% study population got pregnant and 71% patients reported regular menstrual cycle on completion of treatment and LH: FSH ratio was also reduced to normal. Overall 94% of patients reported positively or got benefitted from Standardized Fenugreek seed extract dosing. No changes were observed in liver function test (LFT), kidney function test (KFT) and haemogram level. Conclusions: Present Study indicates that Standardized Fenugreek seed extract as Furostenolic Saponins (Furocyst) is very effective and safe in the management of Poly Cystic Ovary Syndrome in women of reproductive age Group.

Author(s):  
Khushboo Suresh Shinde ◽  
Sunil Somnath Patil

Background: Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting women of reproductive age group. Though its incidence is markedly increasing, the awareness is still low; as a result it remains undiagnosed. Aim of this study was to find the incidence and risk factors of PCOS among women in reproductive age group, so as to encourage young women to seek timely treatment and prevent its long term complications.Methods: A study was conducted over a period of 1 year amongst 100 women attending the Gynecology OPD using a paper based questionnaire. General examination and the required laboratory tests were done to confirm the diagnosis.Results: It was found that the incidence of PCOS among the study population was 21%. Risk factors include lack of physical activity, irregular menstrual cycle, body mass index more than 25, and Waist-hip ratio above 0.86.Conclusions: It is seen that there is a need to educate women at an early stage to prevent the development of this syndrome and its early detection by them. This will facilitate the health professionals to start the treatment at a stage where the complications have not yet set in.


Author(s):  
Zhongwei Huang ◽  
Eu Leong Yong

Polycystic ovary syndrome (PCOS) is an enigmatic condition and its pathophysiology remains to be determined but it is likely to involve the androgen, insulin, and anti-Mullerian hormone pathways. PCOS is diagnosed in women in the reproductive age group based on the Rotterdam criteria. The spectrum of disease involves various phenotypes based on the current diagnostic criteria and this may have reproductive, metabolic, and endocrine consequences. Reproductive issues include that of irregular menstrual cycles and anovulation. Metabolic disorders such as insulin resistance, obesity, dyslipidaemia, and hypertension must be screened for in all women who are diagnosed with PCOS. Long-term risks of metabolic and endocrine disorders in women with PCOS still need further confirmation with more robust data. Reproductive ageing appears to be increased in women with PCOS and they seem to menopause at a later age. Thus far, PCOS appears to be associated with endometrial hyperplasia and cancer.


2021 ◽  
Vol 3 (1) ◽  
pp. 85-89
Author(s):  
Sadia Saber ◽  
Naz Yasmin ◽  
Mohammed Tarek Alam ◽  
Mohammad Monower Hossain ◽  
Rafa Faaria Alam

Introduction: Among all the bacterial infections encounter in primary care, urinary tract infection (UTI) has considered as one of the most frequent bacterial infection. UTI can be defined as the presence of an infection in any part of our urinary system-kidneys, ureters, urinary bladder and urethra. Majority of the infections involve the lower urinary tract – the urinary bladder and the urethra. Women of reproductive age group (15-44 years) are the most vulnerable of developing UTI than men. The objective of this study is to determine the prevalence rate of UTI among females of reproductive age group and to ascertain the association between socio demographic factors among study population. Material and Methods: This is a cross sectional observational study executed in a tertiary care teaching hospital, Dhanmondi, Dhaka. 250 women of reproductive age group were encountered as the study group here. Data collection was done by using a structured interview schedule followed by collection of urine sample for microscopic examination and culture. Analysis of data was done by using SPSS 15 software. Prevalence of UTI among study population was calculated by using percentage and the strength of association between socio demographic factors were evaluated in our study. Results: Prevalence of UTI among study population was found to be 41.20%. A strong association of statistical significance was observed among marital status (p values <0.05), the level of education of the study population (p value <0.05) and the urine culture reports among UTI patients (p value 0.001) Conclusion: Now a days UTI can be considered as one the most serious public health problem if it is remaining untreated. To prevent the possibilities of evolving further complexity of UTI early detection and prompt treatment is very much crucial. We should promote more educational programming about UTI prevention not only to reduce the sufferings of the patients and their hospital stay but also to compensate for the economical loss.


2018 ◽  
Vol 18 (2) ◽  
pp. 117-120
Author(s):  
Fatima Jesmin ◽  
Fatima Begum ◽  
CAHM Enamullah ◽  
Faridul Alam

Objective: The objective of this study was to assess the relationship between Bone Mineral Density (BMD) and parity in women of reproductive age group.Materials and methods: A cross sectional analytical study was carried out where the study population was women of reproductive age group (15 to 49 years of age). A total of 180 women were included as study subjects and the sampling technique was non random sampling. The study population was selected from healthy women of reproductive age group. Data about age, height, weight and history of parity were taken. BMD was measured by DEXA. Then relationship between BMD and parity were analysed.Results: In this study, a large number, 79 (43.9%) of participants were in age group of 29-38 years with mean± SD 35.46±6.75 years. Association between BMD and age of the study subjects represented that values of BMD decreased with increasing age (P<0.05). Bivariate analysis between BMD and parity revealed that values of BMD at lumbar spine and femur were associated with parity and it was also showed that the BMD of nulliparous women and one-to-two parity groups were significantly higher than multiparous (≥3 parity) women (P<0.05).Conclusion: From overall analysis of this study it can be concluded that BMD at lumbar spine and femur in women of reproductive age group was negatively associated with number of parity.Bangladesh J. Nuclear Med. 18(2): 117-120, July 2015


2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Thozhukat Sathyapalan ◽  
Stephen L. Atkin

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age group and is associated with a higher cardiovascular risk. Obesity, mainly visceral adiposity, is prevalent in patients with PCOS. Obesity is associated with low-grade inflammation and raised inflammatory cytokines, both of which are also described in patients with PCOS. In this paper, the potential relationships between fat distribution, adipocyte dysfunction and, altered inflammatory markers in patients with PCOS have been discussed.


Author(s):  
Anurag Kesarwani ◽  
Darshna Jain

Background: Aims of this study was found the association of PCOS with Lipid profile of patients. Methods: Cross sectional Hospital based study conducted on Women at reproductive age (15-45 years) and who presented with Rotterdam Criteria. Results: Mean triglyceride of patients was 113.68±19.25 mg/dl, mean LDL of patients was 95.24±14.94 mg/dl, mean cholesterol of patients was 159.98±18.26 mg/dl and mean HDL of patients was 52.16±6.32 mg/dl Conclusion: PCOS, being a common condition prevailing in women with reproductive age group, is the cause of problem for one in four patients attending a gynecologist. Despite treating the infertility and menstrual complaints of the PCOS patients, it is a treating doctor’s duty to take it as an opportunity to screen for metabolic syndrome and advice for healthy diet, physical activity and weight reduction. Healthy life style modification not only improves their menstrual and ovulatory symptoms, but also prevents the future cardiovascular and other morbid ailments. Keywords: PCOS, LDL, FBS, HDL


Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
A Swaroop ◽  
A Sarkari Jaipuriar ◽  
P Kumar ◽  
D Bagchi

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Befikaduwa Zekarias ◽  
Frehiwot Mesfin ◽  
Bezatu Mengiste ◽  
Adane Tesfaye ◽  
Lemma Getacher

Background. Iodine deficiency disorder is a major public health problem in Ethiopia that is more common in women of reproductive age. However, it is not well addressed and there is a lack of information on its prevalence and associated factors in women of reproductive age group. Therefore, the objective of this study was to assess goiter prevalence and associated factors among women of reproductive age in the Demba Gofa woreda, Gamo Gofa Zone, Southwest Ethiopia. Methods. A community-based cross-sectional study was used among 584 randomly selected women in the reproductive age group from February 05 to April 20, 2016. A simple random sampling technique was used to select the study kebeles, and a systematic random sampling technique was used to select the study samples. Data were collected through a pretested questionnaire, and the goiter examination was done clinically for each participant. The collected data were coded and entered into a computer for statistical analysis using EpiData version 3.2 and analyzed using SPSS version 20. Variables with a P value ≤0.25 in bivariate logistic regression analysis were entered into multivariate logistic regression analysis, and finally, variables with a P value <0.05 in multivariate logistic regression were considered significantly associated with the dependent variable. Results. The total goiter rate was 43%, 95% CI = 39.2–46.9. Cassava consumption (AOR: 2.02, 95% CI: 1.03–4), salt wash before use (AOR: 3.14, 95% CI: 1.1–11.3), salt use after >2 months of purchase (AOR: 11, 95% CI: 5–26), family history of goiter (AOR: 4.6, 95% CI: 1.4–15.8), and poor knowledge of iodized salt (AOR: 2.7, 95% CI: 1.4–5.5) were significant factors associated with goiter. Conclusion. Iodine deficiency was found to be severe in women of reproductive age in the study area. This showed that women of reproductive age, especially during pregnancy, are exposed to iodine deficiency and its adverse effects at delivery. Thus, they need urgent supplementation with iodine, improved access to foods rich in iodine, and intake of iodized salt. Additionally, health education should focus on the importance of iodized salt, the proper method of use, and the prevention of iodine deficiency, which are highly recommended to minimize the problem.


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