scholarly journals Adipose Stem Cells attenuates Bleomycin induced Pulmonary Fibrosis

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Anandharajan Rathinasabapathy ◽  
Vinayak Shenoy ◽  
Alana Horowitz ◽  
Dominic Guzzo ◽  
Sina Jaekel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pulmonary Fibrosis ◽  
Adipose Stem Cells

Airway transplantation of adipose stem cells protects against bleomycin-induced pulmonary fibrosis

2017 ◽  
Vol 66 (4) ◽  
pp. 739-746 ◽  
Author(s):  
Pedro Llontop ◽  
Daniel Lopez-Fernandez ◽  
Bernardino Clavo ◽  
Juan Luis Afonso Martín ◽  
María D Fiuza-Pérez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pulmonary Fibrosis ◽  
Poor Prognosis ◽  
Adipose Stem Cells ◽  
Adipose Derived Stem Cells ◽  
Sprague Dawley ◽  
Real Time Quantitative Pcr ◽  
Sprague Dawley Rats ◽  
Mrna Gene ◽  
Mrna Gene Expression

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis. Adipose-derived stem cells (ADSC) have demonstrated regenerative properties in several tissues. The hypothesis of this study was that airway transplantation of ADSC could protect against bleomycin (BLM)-induced pulmonary fibrosis (PF). Fifty-eight lungs from 29 male Sprague-Dawley rats were analyzed. Animals were randomly divided into five groups: a) control (n=3); b) sham (n=6); c) BLM (n=6); d) BLM+ADSC-2d (n=6); and e) BLM+ADSC-14d (n=8). Animals received 500 µL saline (sham), 2.5 UI/kg BLM in 500 µL saline (BLM), and 2×106 ADSC in 100 µL saline intratracheally at 2 (BLM+ADSC-2d) and 14 days (BLM+ADSC-14d) after BLM. Animals were sacrificed at 28 days. Blinded Ashcroft score was used to determine pulmonary fibrosis extent on histology. Hsp27, Vegf, Nfkβ, IL-1, IL-6, Col4, and Tgfβ1 mRNA gene expression were determined using real-time quantitative-PCR. Ashcroft index was: control=0; sham=0.37±0.07; BLM=6.55±0.34 vs sham (P=0.006). BLM vs BLM+ADSC-2d=4.63±0.38 (P=0.005) and BLM+ADSC-14d=3.77±0.46 (P=0.005). BLM vs sham significantly increased Hsp27 (P=0.018), Nfkβ (P=0.009), Col4 (P=0.004), Tgfβ1 (P=0.006) and decreased IL-1 (P=0.006). BLM+ADSC-2d vs BLM significantly decreased Hsp27 (P=0.009) and increased Vegf (P=0.006), Nfkβ (P=0.009). BLM+ADSC-14d vs BLM significantly decreased Hsp27 (P=0.028), IL-6 (P=0.013), Col4 (P=0.002), and increased Nfkβ (P=0.040) and Tgfβ1 (P=0.002). Airway transplantation of ADSC significantly decreased the fibrosis rate in both early and established pulmonary fibrosis, modulating the expression of Hsp27, Vegfa, Nfkβ, IL-6, Col4, and Tgfβ1. From a translational perspective, this technique could become a new adjuvant treatment for patients with IPF.

scholarly journals Recent Findings on Cell-Based Therapies for COVID19-Related Pulmonary Fibrosis

2021 ◽  
Vol 30 ◽  
pp. 096368972199621
Author(s):  
Hong-Meng Chuang ◽  
Li-Ing Ho ◽  
Horng-Jyh Harn ◽  
Ching-Ann Liu
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Pulmonary Fibrosis ◽  
Tissue Repair ◽  
Immune Modulation ◽  
Distress Syndrome ◽  
Clinical Symptoms ◽  
The United States ◽  
Past Experiences ◽  
Respiratory Tract Inflammation

COVID-19 has spread worldwide, including the United States, United Kingdom, and Italy, along with its site of origin in China, since 2020. The virus was first found in the Wuhan seafood market at the end of 2019, with a controversial source. The clinical symptoms of COVID-19 include fever, cough, and respiratory tract inflammation, with some severe patients developing an acute and chronic lung injury, such as acute respiratory distress syndrome (ARDS) and pulmonary fibrosis (PF). It has already claimed approximately 300 thousand human lives and the number is still on the rise; the only way to prevent the infection is to be safe till vaccines and reliable treatments develop. In previous studies, the use of mesenchymal stem cells (MSCs) in clinical trials had been proven to be effective in immune modulation and tissue repair promotion; however, their efficacy in treating COVID-19 remains underestimated. Here, we report the findings from past experiences of SARS and MSCs, and how SARS could also induce PF. Such studies may help to understand the rationale for the recent cell-based therapies for COVID-19.

scholarly journals Water-jet assisted lipoaspiration and Sepax Cell Separation System For Isolation of adipose stem cells with high adipogenic potential

2021 ◽  
Author(s):  
Anne Therese Lauvrud ◽  
Rojda Gümüscü ◽  
Rebecca Wiberg ◽  
Maria Brohlin ◽  
Peyman Kelk ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Separation ◽  
Water Jet ◽  
Adipose Stem Cells ◽  
Separation System

scholarly journals Hybrid Adipogenic Implants from Adipose Stem Cells for Soft Tissue Reconstruction In Vivo

2010 ◽  
Vol 16 (11) ◽  
pp. 3299-3307 ◽  
Author(s):  
Eduardo K. Moioli ◽  
Mo Chen ◽  
Rujing Yang ◽  
Bhranti Shah ◽  
June Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Adipose Stem Cells ◽  
Soft Tissue Reconstruction ◽  
Tissue Reconstruction

Plasticity of human adipose stem cells to perform adipogenic and endothelial differentiation

2007 ◽  
Vol 60 (4) ◽  
pp. S11
Author(s):  
K. Hemmrich ◽  
M. Wosnitza ◽  
A. Groger ◽  
S. Gräber ◽  
N. Pallua
Keyword(s):  
Stem Cells ◽  
Adipose Stem Cells ◽  
Endothelial Differentiation ◽  
Human Adipose Stem Cells

scholarly journals 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy

2018 ◽  
Vol 23 (1) ◽  
pp. 237-259 ◽  
Author(s):  
Katarzyna Kornicka ◽  
Jolanta Szłapka-Kosarzewska ◽  
Agnieszka Śmieszek ◽  
Krzysztof Marycz
Keyword(s):  
Stem Cells ◽  
Mitochondrial Dynamics ◽  
Adipose Stem Cells
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