scholarly journals Impact of Body Mass Index and Metabolic Health Status on All‐Cause Mortality Risk among Older Adults

2016 ◽  
Vol 30 (S1) ◽  
Author(s):  
Feon W. Cheng ◽  
Xiang Gao ◽  
Diane C. Mitchell ◽  
Craig Wood ◽  
Christopher Still ◽  
...  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Woong-pyo Hong ◽  
Yu-Ji Lee

Abstract Background Although hemodialysis (HD) adequacy, single-pool Kt/Vurea (spKt/V), is inversely correlated with body size, each is known to affect patient survival in the same direction. Therefore, we sought to examine the relationship between HD adequacy and mortality according to body mass index (BMI) in HD patients and explore a combination effect of BMI and HD adequacy on mortality risk. Methods We retrospectively reviewed patient data from the Korean Society of Nephrology registry, a nationwide database of medical records of HD patients, from January 2001 to June 2017. We included patients ≥18 years old who were receiving maintenance HD. Patients were categorized into three groups according to baseline BMI (< 20 (low), 20 to < 23 (normal), and ≥ 23 (high) kg/m2). Baseline spKt/V was divided into six categories. Results Among 18,242 patients on HD, the median follow-up duration was 5.2 (IQR, 1.9–8.9) years. Cox regression analysis showed that, compared to the reference (spKt/V 1.2–1.4), lower and higher baseline spKt/V were associated with greater and lower risks for all-cause mortality, respectively. However, among patients with high BMI (n = 5588), the association between higher spKt/V and lower all-cause mortality was attenuated in all adjusted models (Pinteraction < 0.001). Compared to patients with normal BMI and spKt/V within the target range (1.2–1.4), those with low BMI had a higher risk for all-cause mortality at all spKt/V levels. However, the gap in mortality risk became narrower for higher values of spKt/V. Compared to patients with normal BMI and spKt/V in the target range, those with high BMI and spKt/V < 1.2 were not at increased risk for mortality despite low dialysis adequacy. Conclusions The association between spKt/V and mortality in HD patients may be modified by BMI.


2020 ◽  
Vol 21 (8) ◽  
Author(s):  
Ayesha A. Javed ◽  
Rumaisa Aljied ◽  
David J. Allison ◽  
Laura N. Anderson ◽  
Jinhui Ma ◽  
...  

2004 ◽  
Vol 52 (6) ◽  
pp. 886-891 ◽  
Author(s):  
Stefano Volpato ◽  
Franco Romagnoni ◽  
Lucia Soattin ◽  
Alessandro Blè ◽  
Vincenzo Leoci ◽  
...  

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Saeka Takabayashi ◽  
Takumi Hirata ◽  
Wenjing Zhao ◽  
Takashi Kimura ◽  
Shigekazu Ukawa ◽  
...  

Abstract Background Dietary diversity is thought to reduce risk of malnutrition although it is also linked to obesity. We examined whether dietary diversity is associated with all-cause mortality in Japanese elderly by body mass index (BMI). Methods The current study included 2,944 people aged 64-65 years who participated in the NISSIN project in 1996-2005. Dietary diversity was measured by the Food Variety Score (FVS) which calculates frequency of all food items consumed daily using a self-administered food frequency questionnaire. Participants were divided into tertiles according to their FVS (1st: low, 2nd: middle, 3rd: high). Multivariate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using the Cox proportional hazard regression model. In stratified analysis, BMI was used to divide the participants into 3 groups: lean (BMI &lt;20), normal (BMI 20–24.9), and overweight/obese (BMI ≥ 25). Results Overall, 454 (30.7%) men and 222 (15.2%) women died over the median follow-up period of 16.6 years. No significant association between FVS and all-cause mortality was observed overall. However, when grouped by BMI, in the lean, multivariate adjusted HRs were 0.32 (CI: 0.17-0.59) in the middle FVS and 0.41 (CI: 0.19 -0.91) in the high FVS, compared with the low FVS. No significant association was found for normal and overweight/obese. Conclusions These findings indicate dietary diversity should be promoted for lean older adults. Key messages BMI should be considered when promoting dietary diversity.


VASA ◽  
2017 ◽  
Vol 46 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Henrik Rudolf ◽  
Naemi Wall ◽  
Renate Klaassen-Mielke ◽  
Ulrich Thiem ◽  
Curt Diehm ◽  
...  

Abstract. Background: Elevated levels of C-reactive protein (CRP) are known to be associated with cardiovascular (CV) morbidity and mortality in older adults, however, there seems to be heterogeneity of this association across subsets of individuals. We aim to assess the effects of interactions between CRP and one of the following traditional CV risk factors regarding all-cause mortality in unselected elderly men and women: age, sex, body mass index, diabetes, and hypertension. Patients and methods: Three hundred and forty-four general practitioners all over Germany enrolled 6,817 unselected participants, aged 65 years or older, and performed thorough examinations, including CRP measurement at baseline (getABI study). All-cause mortality was determined in the following seven years. Cox regression analyses were done using uni- and multivariable models. Results: At baseline 4,172 participants of this cohort had a CRP value of ≤ 3 mg/L (low level CRP group), 2,645 participants had a CRP value of > 3 mg/L (high level CRP group). The unadjusted hazard ratio for all-cause death of the high level CRP group compared to the low level CRP group was 1.49 (95 % confidence interval [95 %CI] 1.34 to 1.66). After adjustment for sex, age, education, peripheral artery disease/media sclerosis, other prior vascular events, smoking status, diabetes, systolic blood pressure, antihypertensive medication, body mass index, cholesterol, and statin use, the hazard ratio was 1.34 (95 %CI 1.20 to 1.50). Significant interactions with CRP were found for sex (adjusted hazard ratio 1.38, 95 %CI 1.11 to 1.72), age (0.75, 95 %CI 0.60 to 0.94), and baseline systolic blood pressure (0.64, 95 % CI 0.51 to 0.81). The interactions of CRP with body mass index and of CRP with diabetes were not significant. Conclusions: In older German adults, there seem to be effect modifications by age, sex, and arterial hypertension regarding the effect of CRP in the prediction of all-cause mortality.


2018 ◽  
Vol 37 (6) ◽  
pp. 2252-2259 ◽  
Author(s):  
Laura A. Schaap ◽  
Tara Quirke ◽  
Hanneke A.H. Wijnhoven ◽  
Marjolein Visser

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