DNA methylation and the potential role of demethylating agents in prevention of progressive chronic kidney disease

2018 ◽  
Vol 32 (10) ◽  
pp. 5215-5226 ◽  
Author(s):  
Benjamin P. Larkin ◽  
Sarah J. Glastras ◽  
Hui Chen ◽  
Carol A. Pollock ◽  
Sonia Saad
Keyword(s):  
Chronic Kidney Disease ◽  
Dna Methylation ◽  
Kidney Disease ◽  
Potential Role ◽  
Demethylating Agents

scholarly journals Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling

2016 ◽  
Vol 9 (3) ◽  
pp. 444-453 ◽  
Author(s):  
Vibha Bhatnagar ◽  
Erin L. Richard ◽  
Wei Wu ◽  
Caroline M. Nievergelt ◽  
Michael S. Lipkowitz ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Potential Role

scholarly journals Improved nephrology referral of chronic kidney disease patients: potential role of smartphone apps

2019 ◽  
Vol 12 (6) ◽  
pp. 767-770
Author(s):  
Nestor Oliva-Damaso ◽  
Elena Oliva-Damaso ◽  
Jose C Rodriguez-Perez ◽  
Juan Payan
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Potential Role ◽  
Estimated Glomerular Filtration Rate ◽  
Young Patients ◽  
Rapid Decline ◽  
Smartphone Apps ◽  
Age Factor ◽  
Current Guidelines

Abstract In chronic kidney disease (CKD), referral to nephrology is based on Kidney Disease: Improving Global Outcomes 2012 guidelines and is generally indicated when the estimated glomerular filtration rate (eGFR) is <30 mL/min/1.73 m2 or when there is a rapid decline of eGFR, elevated urinary albumin:creatinine ratio (>300 mg/g) or other ‘alert’ signs such as the presence of urinary red blood cell casts. Since eGFR declines with ageing in otherwise healthy individuals, we propose that the eGFR threshold for nephrology referral should be adjusted according to age. According to current recommendations, young patients without rapidly progressing CKD are referred more often to nephrology when CKD is more severe, compared with age-matched controls with normal eGFRs, than elderly CKD patients. In this commentary, we discuss the age factor and other specific situations not considered in current guidelines for nephrology referral of CKD patients.

scholarly journals Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Christin Giordano ◽  
Olga Karasik ◽  
Kelli King-Morris ◽  
Abdo Asmar
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Uric Acid ◽  
Kidney Disease ◽  
Current Literature ◽  
Predictive Models ◽  
Potential Role ◽  
Poor Prognostic Factor

Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.

scholarly journals Potential role of active vitamin D in retarding the progression of chronic kidney disease

2006 ◽  
Vol 22 (2) ◽  
pp. 321-328 ◽  
Author(s):  
J. Tian ◽  
Y. Liu ◽  
L. A. Williams ◽  
D. de Zeeuw
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Kidney Disease ◽  
Potential Role ◽  
Active Vitamin ◽  
Active Vitamin D

scholarly journals Serum-to-urine renalase ratio and its differences between healthy adults and chronic kidney disease patients

2019 ◽  
Author(s):  
Natalia Maria Serwin ◽  
Magda Wiśniewska ◽  
Elżbieta Cecerska-Heryć ◽  
Krzysztof Safranow ◽  
Edyta Skwirczyńska ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Potential Role ◽  
Circulatory System ◽  
Healthy Adults ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Test Results ◽  
Serum And Urine

Abstract Background Renalase is a flavoprotein involved in pathomechanisms of chronic kidney disease and heart and circulatory system disorders. Secretion and way of action of this protein are still discussed. Aim of our study was to initially estimate the balance between serum and urine renalase in healthy adults and to compare obtained ratio to chronic kidney disease patients. Methods Our study involved 28 healthy volunteers and 62 patients with diagnosed chronic kidney disease in stages I to IV. Concentration of renalase in blood serum and urine was measured using enzyme-linked immunosorbent assay (ELISA) kit (Uscn Life Science, Wuhan, China). We analyzed serum-to-urine renalase proportion in both groups and evaluated the differences using Mann Whitney U-test. Results Renalase serum-to-urine ratio was significantly higher in chronic kidney disease patients in comparison with control group (1.146 and 0.177, respectively; p<0.05). Also renalase serum-to-urine/mg creatinine ratio was higher in CKD patients than in healthy subjects (0.863 and 0.176, respectively; p<0.05). In both groups, no correlation between renalase concentration or serum-to-urine ratio, and eGFR, was found. Conclusions Renalase is involved in chronic kidney disease pathomechanism and is highly secreted and cumulated in blood of subjects with chronic kidney disease, what is accompanied by reduction of urinary renalase excretion. This may occur due to the potential role of renalase as a cytokine, preventing further kidney, and probably heart, dysfunction or injury. Chronic kidney disease causes higher expression of renalase, but its balance between serum and urine depends on more factors and conditions, involved in CKD pathomechanism.

scholarly journals DNA Methylation Dysfunction in Chronic Kidney Disease

Genes ◽  
2020 ◽  
Vol 11 (7) ◽  
pp. 811
Author(s):  
Diego Ingrosso ◽  
Alessandra F. Perna
Keyword(s):  
Chronic Kidney Disease ◽  
Dna Methylation ◽  
Kidney Disease ◽  
Renal Disease ◽  
Disease Progression ◽  
Underlying Disease ◽  
Common Denominator ◽  
Control Of Gene Expression ◽  
End Stage

Renal disease is the common denominator of a number of underlying disease conditions, whose prevalence has been dramatically increasing over the last two decades. Two aspects are particularly relevant to the subject of this review: (I) most cases are gathered under the umbrella of chronic kidney disease since they require—predictably for several lustrums—continuous clinical monitoring and treatment to slow down disease progression and prevent complications; (II) cardiovascular disease is a terrible burden in this population of patients, in that it claims many lives yearly, while only a scant minority reach the renal disease end stage. Why indeed a review on DNA methylation and renal disease? As we hope to convince you, the present evidence supports the role of the existence of various derangements of the epigenetic control of gene expression in renal disease, which hold the potential to improve our ability, in the future, to more effectively act toward disease progression, predict outcomes and offer novel therapeutic approaches.

scholarly journals Chronic kidney disease delays VLDL-apoB-100 particle catabolism: potential role of apolipoprotein C-III

2009 ◽  
Vol 50 (12) ◽  
pp. 2524-2531 ◽  
Author(s):  
Doris T. Chan ◽  
Gursharan K. Dogra ◽  
Ashley B. Irish ◽  
Esther M. Ooi ◽  
P. Hugh Barrett ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Potential Role ◽  
Apolipoprotein C
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