A191 EFFECT OF CORE TEMPERATURE MANIPULATION DURING CONTROLLED HEMORRHAGE IN RATS

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 191A
Author(s):  
K Nagao ◽  
V Komanduri ◽  
M Kumar ◽  
JC Liao ◽  
KG Belani
Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Jon C Rittenberger ◽  
Katharyn Flickinger ◽  
David Hopkins ◽  
Jonathan Elmer ◽  
Frank Guyette ◽  
...  

Introduction: Temperature manipulation to decrease metabolism is commonly after acute brain injury. Preclinical data suggest metabolism decreases 7-8% for each degree C drop in core temperature. We hypothesized similar results would be found in healthy individuals. Methods: Following informed consent and physical screening, we administered a 1mcg/kg bolus of dexmedetomidine followed by 20cc/kg of cold (4C) saline bolus. We cooled subjects using surface pads (emcools (Austria)). Dexmedetomidine infusion was titrated to effect (max dose <1.5mcg/kg/hr). We recorded vital signs, Richmond Agitation Sedation Scale, Bedside Shivering Assessment Scale and sensation of cold every 15 minutes. We measured resting metabolism at baseline and after each 1 C decrease in temperature thereafter using indirect calorimetry and a ventilated canopy system. We analyzed data using analysis of variance. Results: Median age in the 9 enrolled subjects was 30 (SD 10) years and most (78%) were male. Median height was 173 (IQR 168, 180) cm and median weight was 77 (IQR 72, 83) kg. Baseline VO2 was 3.4 (IQR 3.0, 3.8) ml/kg/min and baseline energy expenditure was 1692 (IQR 1579, 1845) kcal/day. Both VO2 and energy expenditure decreased with core temperature (p=0.017 and p=0.027) (Table). Conclusion: Metabolic rate decreases with core temperature manipulation. The largest change occurs between 37C and 36C with smaller changes thereafter.


1995 ◽  
Vol 82 (5) ◽  
pp. 1169-1180 ◽  
Author(s):  
Takashi Matsukawa ◽  
Andrea Kurz ◽  
Daniel I. Sessler ◽  
Andrew R. Bjorksten ◽  
Benjamin Merrifield ◽  
...  

Background Skin temperature is best kept constant when determining response thresholds because both skin and core temperatures contribute to thermoregulatory control. In practice, however, it is difficult to evaluate both warm and cold thresholds while maintaining constant cutaneous temperature. A recent study shows that vasoconstriction and shivering thresholds are a linear function of skin and core temperatures, with skin contributing 20 +/- 6% and 19 +/- 8%, respectively. (Skin temperature has long been known to contribute approximately 10% to the control of sweating). Using these relations, we were able to experimentally manipulate both skin and core temperatures, subsequently compensate for the changes in skin temperature, and finally report the results in terms of calculated core-temperature thresholds at a single-designated skin temperature. Methods Five volunteers were each studied on 4 days: (1) control; (2) a target blood propofol concentration of 2 micrograms/ml; (3) a target concentration of 4 micrograms/ml; and (4) a target concentration of 8 micrograms/ml. On each day, we increased skin and core temperatures sufficiently to provoke sweating. Skin and core temperatures were subsequently reduced to elicit peripheral vasoconstriction and shivering. We mathematically compensated for changes in skin temperature by using the established linear cutaneous contributions to the control of sweating (10%) and to vasoconstriction and shivering (20%). From these calculated core-temperature thresholds (at a designated skin temperature of 35.7 degrees C), the propofol concentration-response curves for the sweating, vasoconstriction, and shivering thresholds were analyzed using linear regression. We validated this new method by comparing the concentration-dependent effects of propofol with those obtained previously with an established model. Results The concentration-response slopes for sweating and vasoconstriction were virtually identical to those reported previously. Propofol significantly decreased the core temperature triggering vasoconstriction (slope = -0.6 +/- 0.1 degrees C.micrograms-1.ml-1; r2 = 0.98 +/- 0.02) and shivering (slope = -0.7 +/- 0.1 degrees C.micrograms -1.ml-1; r2 = 0.95 +/- 0.05). In contrast, increasing the blood propofol concentration increased the sweating threshold only slightly (slope = 0.1 +/- 0.1 degrees C.micrograms -1.ml-1; r2 = 0.46 +/- 0.39). Conclusions Advantages of this new model include its being nearly noninvasive and requiring relatively little core-temperature manipulation. Propofol only slightly alters the sweating threshold, but markedly reduces the vasoconstriction and shivering thresholds. Reductions in the shivering and vasoconstriction thresholds are similar; that is, the vasoconstriction-to-shivering range increases only slightly during anesthesia.


2015 ◽  
Vol 135 (8) ◽  
pp. 343-348
Author(s):  
Shinya Nakagawa ◽  
Masao Shimizu ◽  
Tsuyoshi Hamaguchi

2020 ◽  
Vol 15 ◽  
Author(s):  
Fahad Layth Malallah ◽  
Baraa T. Shareef ◽  
Mustafah Ghanem Saeed ◽  
Khaled N. Yasen

Aims: Normally, the temperature increase of individuals leads to the possibility of getting a type of disease, which might be risky to other people such as coronavirus. Traditional techniques for tracking core-temperature require body contact either by oral, rectum, axillary, or tympanic, which are unfortunately considered intrusive in nature as well as causes of contagion. Therefore, sensing human core-temperature non-intrusively and remotely is the objective of this research. Background: Nowadays, increasing level of medical sectors is a necessary targets for the research operations, especially with the development of the integrated circuit, sensors and cameras that made the normal life easier. Methods: The solution is by proposing an embedded system consisting of the Arduino microcontroller, which is trained with a model of Mean Absolute Error (MAE) analysis for predicting Contactless Core-Temperature (CCT), which is the real body temperature. Results: The Arduino is connected to an Infrared-Thermal sensor named MLX90614 as input signal, and connected to the LCD to display the CCT. To evaluate the proposed system, experiments are conducted by participating 31-subject sensing contactless temperature from the three face sub-regions: forehead, nose, and cheek. Conclusion: Experimental results approved that CCT can be measured remotely depending on the human face, in which the forehead region is better to be dependent, rather than nose and cheek regions for CCT measurement due to the smallest


2021 ◽  
Author(s):  
Toshiomi Tanaka ◽  
Shinji Adachi ◽  
Kazuharu Nomura ◽  
Hideki Tanaka ◽  
Tatsuya Unuma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicola M. Kerschbaumer ◽  
Stefan Niedermaier ◽  
Theobald Lohmüller ◽  
Jochen Feldmann

AbstractIn recent years, radiative cooling has become a topic of considerable interest for applications in the context of thermal building management and energy saving. The idea to direct thermal radiation in a controlled way to achieve contactless sample cooling for laboratory applications, however, is scarcely explored. Here, we present an approach to obtain spatially structured radiative cooling. By using an elliptical mirror, we are able to enhance the view factor of radiative heat transfer between a room temperature substrate and a cold temperature landscape by a factor of 92. A temperature pattern and confined thermal gradients with a slope of ~ 0.2 °C/mm are created. The experimental applicability of this spatially structured cooling approach is demonstrated by contactless supercooling of hexadecane in a home-built microfluidic sample. This novel concept for structured cooling yields numerous applications in science and engineering as it provides a means of controlled temperature manipulation with minimal physical disturbance.


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