Difficult Intubation in Acromegalic Patients

2000 ◽  
Vol 93 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Hubert Schmitt ◽  
Michael Buchfelder ◽  
Martin Radespiel-Tröger ◽  
Rudolf Fahlbusch
Keyword(s):  
Difficult Intubation ◽  
Preoperative Assessment ◽  
Difficult Laryngoscopy ◽  
Fisher Exact Test ◽  
Muscle Paralysis ◽  
Exact Test ◽  
Number Of Patients ◽  
Lehane Grade ◽  
Grade Ii ◽  
Grade Iii

Background Previous studies have suggested that the incidence of difficult intubation in acromegalic patients is higher than in normal patients. However, these studies were retrospective and did not include preoperative assessment of the airways. The aims of this study were to determine the incidence of difficult intubation and to assess the usefulness of preoperative tests in predicting difficult laryngoscopy. Methods One hundred twenty-eight consenting acromegalic patients requiring general anesthesia and tracheal intubation were studied. Preoperatively, Mallampati classification, thyromental distance, and head and neck movement were determined in each patient. After induction of anesthesia and muscle paralysis, laryngoscopic grade was assessed during direct laryngoscopy; Cormack and Lehane grade III or IV were classified as difficult. The association of individual airway assessment with laryngeal view was evaluated using the Fisher exact test. Predictors of difficult laryngoscopy were evaluated by calculating their sensitivity and specificity. Results Laryngoscopy was difficult (grade III) in 33 of 128 patients (26%). Application of external laryngeal pressure improved laryngeal visualization to grade II in 20 of these 33 patients. In the remaining 13 patients (10%), intubation was difficult (more than two attempts, blade change, use of gum-elastic bougie). Mallampati classes 3 and 4 were significantly related to laryngoscopy grade III (Fisher exact test, P = 0.001). Conclusions The incidence of difficult laryngoscopy and intubation in acromegalic patients is higher than in normal patients. Preoperative Mallampati scores of 3 and 4 were of value in predicting difficult laryngoscopy. Nevertheless, even this test will miss a significant number of patients with a difficult airway.

Electronic cigarettes: How confident and effective are allergists, pulmonologists, and primary care physicians in their practice behavior?

2020 ◽  
Vol 41 (3) ◽  
pp. 192-197
Author(s):  
Sherry S. Zhou ◽  
Alan P. Baptist
Keyword(s):  
Primary Care ◽  
Primary Care Physicians ◽  
Electronic Cigarettes ◽  
The United States ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Knowledge And Beliefs ◽  
Tobacco Cigarette ◽  
Number Of Patients ◽  
Personal Use

Background: There has been a striking increase in electronic cigarette (EC) use in the United States. The beliefs and practices toward ECs among physicians are unknown. Objective: The purpose of this study was to investigate EC practice patterns among allergists, pulmonologists, and primary care physicians. Methods: An anonymous survey was sent to physicians. The survey contained 32 questions and addressed issues related to demographics, cessation counseling behaviors, personal use, and knowledge and beliefs about ECs. Statistical analysis was performed by using analysis of variance, the Pearson χ2 test, Fisher exact test, and logistic regression. Results: A total of 291 physicians completed the survey (222 primary care physicians, 33 pulmonologists, and 36 allergists) for a response rate of 46%. The allergists asked about tobacco cigarette use as frequently as did the pulmonologists and more than the primary care physicians (p < 0.001), but they rarely asked about EC use. The pulmonologists scored highest on self-reported knowledge on ECs, although all the groups answered <40% of the questions correctly. The allergists did not feel as comfortable about providing EC cessation counseling as did the pulmonologists and primary care physicians (p < 0.001). All three groups were equally unlikely to recommend ECs as a cessation tool for tobacco cigarette users. Conclusion: Allergists lacked knowledge and confidence in providing education and cessation counseling for EC users. As the number of patients who use these products continues to increase, there is an urgent need for all physicians to be comfortable and knowledgeable with counseling about ECs.

scholarly journals McGrath Video Laryngoscope May Take a Longer Intubation Time Than Macintosh Laryngoscope

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Prerana N. Shah ◽  
Kaveri Das
Keyword(s):  
Randomized Study ◽  
Macintosh Laryngoscope ◽  
Total Duration ◽  
Video Laryngoscope ◽  
Intubation Time ◽  
Laryngoscopic View ◽  
Lehane Grade ◽  
Secondary Endpoints ◽  
Grade Ii ◽  
Grade Iii

Background. Video laryngoscopes provide better view and can improve ease of intubation compared with standard laryngoscopes. Methods. A prospective randomized study was done on 60 patients, 18 to 65 years old, comparing McGrath video laryngoscope and Macintosh laryngoscope. The aim was to compare the ease, efficacy, and usability of them during routine airway management. The primary endpoint was duration of intubation and the secondary endpoints were Cormack and Lehane grade of laryngoscopic view, number of intubation attempts, and incidence of complications. Results. There was an increase in total duration of intubation with McGrath video laryngoscope with 42.9 ± 19.5 seconds compared to Macintosh laryngoscope with 17.9 ± 4.6 seconds. In Macintosh group, 73.3% had grade I, 20% had grade II, and 6.7% had grade III Cormack Lehane view, while in McGrath group, 83.3% had grade I, 13.3% had grade II, and 3.3% had grade III. In McGrath group, 6 patients (20%) required more than 120 seconds to get intubated and only 73.3% were intubated in 1 attempt, while patients in Macintosh group had 100% successful intubation in 1 attempt. Pharyngeal trauma was seen with McGrath videolaryngoscopy. Conclusion. Duration of laryngoscopy, intubation, and total duration of intubation were significantly higher in McGrath group than in Macintosh group. McGrath group required a higher number of intubation attempts.

The Fragility of Statistically Significant Findings From Randomized Trials in Sports Surgery: A Systematic Survey

2016 ◽  
Vol 45 (9) ◽  
pp. 2164-2170 ◽  
Author(s):  
Moin Khan ◽  
Nathan Evaniew ◽  
Mark Gichuru ◽  
Anthony Habib ◽  
Olufemi R. Ayeni ◽  
...  
Keyword(s):  
Sports Medicine ◽  
Data Extraction ◽  
Statistical Significance ◽  
Arthroscopic Surgery ◽  
Fisher Exact Test ◽  
Fragility Index ◽  
Exact Test ◽  
Orthopaedic Care ◽  
Bivariate Correlation ◽  
Number Of Patients

Background: High-quality, evidence-based orthopaedic care relies on the generation and translation of robust research evidence. The Fragility Index is a novel method for evaluating the robustness of statistically significant findings from randomized controlled trials (RCTs). It is defined as the minimum number of patients in 1 arm of a trial that would have to change status from a nonevent to an event to alter the results of the trial from statistically significant to nonsignificant. Purpose: To calculate the Fragility Index of statistically significant results from clinical trials in sports medicine and arthroscopic surgery to characterize the robustness of the RCTs in these fields. Methods: A search was conducted in Medline, EMBASE, and PubMed for RCTs related to sports medicine and arthroscopic surgery from January 1, 2005, to October 30, 2015. Two reviewers independently assessed titles and abstracts for study eligibility, performed data extraction, and assessed risk of bias. The Fragility Index was calculated using the Fisher exact test for all statistically significant dichotomous outcomes from parallel-group RCTs. Bivariate correlation was performed to evaluate associations between the Fragility Index and trial characteristics. Results: A total of 48 RCTs were included. The median sample size was 64 (interquartile range [IQR], 48.5-89.5), and the median total number of outcome events was 19 (IQR, 10-27). The median Fragility Index was 2 (IQR, 1-2.8), meaning that changing 2 patients from a nonevent to an event in the treatment arm changed the result to a statistically nonsignificant result, or P ≥ .05. Conclusion: Most statistically significant RCTs in sports medicine and arthroscopic surgery are not robust because their statistical significance can be reversed by changing the outcome status on only a few patients in 1 treatment group. Future work is required to determine whether routine reporting of the Fragility Index enhances clinicians’ ability to detect trial results that should be viewed cautiously.

scholarly journals EXPERIENCE OF VIDEO LARYNGOSCOPY DURING TRACHEAL INTUBATION FOR EMERGENCY INDICATIONS IN THE PRACTICE OF AN ANESTHESIOLOGIST AND RESUSCITATOR

2020 ◽  
Vol 21 (3) ◽  
pp. 33-38
Author(s):  
V. V. Vasilev
Keyword(s):  
Tracheal Intubation ◽  
Difficult Intubation ◽  
Direct Laryngoscopy ◽  
Successful Intubation ◽  
Failed Intubation ◽  
Advantages And Disadvantages ◽  
Lehane Grade ◽  
Grade Ii ◽  
The Mean ◽  
Technical Solutions

Objectives. To assess the advantages and disadvantages of videolaryngoscopy as one of methods of tracheal intubation which is being widely used as an alternative to direct laryngoscopy in anesthesiologist’s practice.Material and methods. Over 100 of tracheal intubations were conducted with the use of videolaryngoscope, along with a routine use of the direct laryngoscopy. The results of 48 intubations are discussed. 4 clinical cases are presented in this article.Results. Cormack-Lehane grade I view was obtained in 39 cases (81,3%), Cormack-Lehane grade II - in 9 patients (18,8%). First attempt intubation was performed in 43 cases (89,6%), in 4 cases intubation was successful after second attempt (8,3%), failed intubation was in 1 case (2,1%). The mean duration of successful intubation was 36,9 sec. Certain difficulties occured during intubation related with the advancement of the endotracheal tube. Technical solutions are given for some of intraprocedural conditions.Conclusions. Videolaryngoscopy is a safe and effective method of tracheal intubation. Although this method is not lacking in disadvantages it has a number of advantages, main of which is the improved larynx visualization. In our opinion, this method can not completely replace direct laryngoscopy in anesthesiolodist’s practice, but may serve as an adjuvant in case of difficult intubation.

Disparity of reported risk of hypersensitivity reactions (HSR) for platinum chemotherapeutic agents

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20662-e20662
Author(s):  
P. DeMoor ◽  
L. Barnachea ◽  
L. Bazhenova
Keyword(s):  
Single Agent ◽  
Chemotherapeutic Agents ◽  
Free Interval ◽  
Time Period ◽  
Number Of Patients ◽  
Increased Risk ◽  
Grade Ii ◽  
Modern Era ◽  
Platinum Agents ◽  
Grade Iii

e20662 Background: HSR are observed with multiple chemotherapeutic agents and patients should be counseled regarding risk. A wide variation in frequency of platinum HSR is reported in the literature. We sought to confirm the frequency of HSR in the modern era and examine the cause for disparity in reported versus observed risk. Methods: We conducted a retrospective analysis of Quality Variance Reports from 06/2006 to 02/2008 to investigate incidence of HSR to platinum-based therapy at Moores UCSD Infusion Center (IC) and compared data to those historically reported. HSR were graded according to CTCAE v. 3.0. Results: 1,753 doses of platinum agents were administered over this time period. Our IC assumes 0% risk of HSR to cisplatin (0 events in 701 doses), 0.7 % risk to carboplatin (5 events in 689 doses: 2 grade II, 2 grade III, 1 grade V), and 1.4 % risk to oxaliplatin (5 events in 363 doses: 2 grade II, 1 grade III, 2 grade IV). Review of the literature showed a 1 - 20% risk of HSR to cisplatin, provisional to whether it is administered as single agent or in combination. Carboplatin infers a 0.8 - 50% risk of HSR with increased risk after 6 cycles and with longer platinum-free interval. Finally, oxaliplatin bears a 0.5 - 19% risk of HSR with increased risk after 6 infusions. Conclusions: Our own experience is not entirely consistent with the reported frequency of platinum reactions because of the 62-fold disparity of reported percent risk. We found several factors that may explain the disparity: use of emesis prophylaxis may circumvent HSR, authors’ misinterpretation of data or citation errors, under-reporting of adverse events, and differences in defining percent risk of HSR. Some publications document risk of HSR based on the number of patients that react versus documenting risk based on the number of reactions per number of doses. The table below, using our IC data, underscores this point. This data reveals the necessity of standardizing the way in which we report percent risk, since treatment decisions are often based on percent risk. [Table: see text] No significant financial relationships to disclose.

Outcome and evaluation of 1p and 19q deletion by chromogenic in situ hybridization (CISH) in patients with diagnosis of oligodendroglioma (OD) and oligoastrocitoma (OA).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e21025-e21025
Author(s):  
Santiago Rafael Bella ◽  
Jose Roberto Llugdar ◽  
Alejo Lingua ◽  
Ricardo Alejandro Theaux ◽  
Francisco Papalini ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Tumor Tissue ◽  
Complete Response ◽  
Number Of Patients ◽  
Response To Chemotherapy ◽  
Pathological Evaluation ◽  
Grade Ii ◽  
Grade Iii

e21025 Background: In OD and OA, the 1p and 19q deletion has prognostic value in survival. It is also a predictive factor for response to chemotherapy. Fluorescence in situ hybridization (FISH) is the standard method for its evaluation. CISH could be an alternative that has already been validated in other neoplasias. In OD and OA, this combined deletion is present in about 50% of patients when analyzed with FISH. Methods: Patients resected at Clinica Reina Fabiola from january 2006 to january 2010 and diagnosed of OD and OA were propectivelly included. Paraffin-embebed tumor tissue was analyzed for 1p19q deletions by CISH. The results were correlated to the histology (OD and OA) and grade (II and III) of the tumors. Results: The demographic features of the patients from the present study coincide with literature. The 1p and 19q deletion was found in 3 of the 24 patients analyzed (13%). The combined deletion was only found in those with grade II OD. No combined deletion was found in patients diagnosed of grade III OD and grade II and III OA. In the subgroup of patients with grade II OD, the combined deletion was observed in 3 of 11 patients (27%). The 3 patients in which the deletion in both chromosomes was observed, received treatment with chemotherapy and radiotherapy, all of them with complete response. 5 years DFS was 90%-median follow up 36,8 (CI: 30,5-42,98) Conclusions: The detection of the combined deletion with CISH technique was inferior (13%) than the literature. We cannot demonstrate that CISH is a reliable method for the detection of the 1p and 19q deletion. The possible reasons of this difference could be attributed to the number of patients of the study, to deviations in the procedures of the test or to the fact that the CISH method is not coincident with FISH. This prospectivelly monoinstitutional results are also different to our previous report, and may be due to different pathological evaluation.

scholarly journals Comparison of modified mallampati test between sitting and supine positions for prediction of difficult intubation

1970 ◽  
Vol 10 (1) ◽  
pp. 12-15 ◽  
Author(s):  
S Khatiwada ◽  
B Bhattarai ◽  
K Pokharel ◽  
R Acharya ◽  
A Ghirnire ◽  
...  
Keyword(s):  
Difficult Intubation ◽  
Supine Position ◽  
Difficult Laryngoscopy ◽  
Sitting Position ◽  
Predictive Values ◽  
Statistical Measures ◽  
Position Specificity ◽  
Grading Scale ◽  
Sensitivity Specificity ◽  
Grade Iii

Background: Modified Mallampati test is a standard method of assessing the airway for predicting potentially difficult laryngoscopy and intubation. This test requires the patient to be in sitting position for airway evaluation. Although applicable to the majority of patients, airway evaluation in sitting position may not always be convenient or advisable. Objectives: To compare modified Mallampati grades between sitting and supine position and to find out their corelation to Cormack and Lehane laryngoscopy grade. Materials: This prospective study was conducted in 215, ASA I and II patients undergoing various routine surgical procedures under general anaesthesia, in BPKIHS, Dharan over a period of 3 months. The airway assessment was done using modified Mallampati grade in sitting and supine positions. Mallampati grade of III or IV was defined as the predictor of difficult airway. The laryngoscopy grade was assessed using the Cormack and Lehane grading scale. Grade III or IV of Cormack and Lehane grades was defined as the difficult laryngoscopy and assumed as the predictor of difficult intubation. Statistical measures including sensitivity, specificity, positive and negative predictive values and accuracy were used for comparing the two positions for predicting difficult or ease of intubation. Results: Out of 215 patients, majority 146(68%) were females. Mallampati grade III or IV was observed in more patients in supine position compared to sitting position (48.3% vs. 35.8%, p = 0.008). Difficult laryngoscopy was observed in 13(6%) patients. Sensitivity of modified Mallampati test was 77% in both the positions. Predictive value of Mallampati grading for difficult intubation were 13% and 10% and for easy intubation were 96% and 97% respectively in sitting and supine position. Specificity and accuracy of modified Mallampati test were both 67% in sitting position, where as they were 54% and 55% respectively in supine position. Conclusion: Modified Mallampati grade significantly worsens in supine position compared to sitting. However, airway evaluation in both the positions almost equally predicts for difficult intubation. DOI: http://dx.doi.org/10.3126/hren.v10i1.6000 HREN 2012; 10(1): 12-15

scholarly journals Prediction of Difficult Airway Among Patients Requiring Endotracheal Intubation in a Tertiary Care Hospital in Eastern Nepal

2017 ◽  
Vol 56 (207) ◽  
pp. 314-318 ◽  
Author(s):  
Sindhu Khatiwada ◽  
Balkrishna Bhattarai ◽  
Krishna Pokharel ◽  
Roshan Acharya
Keyword(s):  
Difficult Airway ◽  
Endotracheal Intubation ◽  
Difficult Intubation ◽  
Tertiary Care ◽  
Difficult Laryngoscopy ◽  
Screening Tests ◽  
Care Hospital ◽  
Laryngoscopic View ◽  
Predictive Values ◽  
Lehane Grade

Introduction: Unanticipated difficult intubation is an undesirable situation. Various bedside screening tests are routinely performed for predicting difficult airway. Although considered a surrogate indicator, difficult laryngoscopy is not the exact measure of intubation difficulty. We aimed to determine the best screening test for predicting difficult laryngoscopy and the association between difficult laryngoscopic view and difficult intubation. Methods: This prospective, observational study involved 314, ASA I/II adult patients requiring endotracheal intubation for various routine surgical procedures. Sternomental distance < 12 cm, thyromental distance < 6.5cm, inter-incisor distance < 3.5 cm, mandibular protrusion grade 3 and modified Mallampati class III/IV were the predictors of difficult laryngoscopy. Laryngoscopic view was defined as ‘difficult’ when the Cormack and Lehane grade was III/ IV. The sensitivity, specificity, positive and negative predictive values and accuracy of these predictors were compared to find out the best predictor. Requirement of >3 attempts for insertion of the tracheal tube was defined as ‘difficult intubation’. The association between difficult laryngoscopic view and difficult intubation was determined. Results: The sensitivity of the modified Mallampati class for predicting difficult laryngoscopy was highest (83%). Twelve (3.8%) patients had grade III laryngoscopic view and none had a grade of IV. Intubation was difficult in seven (2.2%) patients. Majority of patients (4 of 7) with difficult intubation had difficult laryngoscopic view (p<0.001). Conclusions: Modified Mallampati test was better for predicting difficult laryngoscopy compared to other bedside screeing tests. Difficult laryngoscopy could significantly predict difficult intubation in our patients.   Keywords: Airway evaluation; difficult intubation; difficult laryngoscopy; modified Mallampati class; Nepalese patients; sensitivity.

scholarly journals Effect of Head Elevation to Different Heights in Laryngeal Exposure with Direct Laryngoscopy

2019 ◽  
Vol 17 (2) ◽  
pp. 168-172
Author(s):  
Pragya Acharya ◽  
Anil Shrestha ◽  
Arjun Gurung ◽  
Megha Koirala ◽  
Gentle Sundar Shrestha ◽  
...  
Keyword(s):  
Direct Laryngoscopy ◽  
Elective Surgery ◽  
Difficult Laryngoscopy ◽  
Adult Patients ◽  
Laryngoscopic View ◽  
Head Elevation ◽  
Laryngeal Exposure ◽  
Lehane Grade ◽  
Induction Of Anaesthesia ◽  
Grade Iii

Background: The purpose of this study was to determine the optimal pillow height for the best laryngoscopic view in adult patients scheduled for elective surgery under general anaesthesia.Methods: 150 adult patients undergoing surgery under general anaesthesia with endotracheal intubation with no features suggestive of difficult airway were enrolled for the study. After induction of anaesthesia the assessment of direct laryngoscopic views was done at head positions without a pillow and with non-compressible pillows of heights 5cm and 10cm.Results: The laryngoscopic view with the 5cm pillow was significantly superior to other head position (p<0.01). The incidence of difficult laryngoscopy (Cormack and Lehane grade III) was 32.7% without a pillow which improved to (Cormack and Lehane grade III) 4% with 10cm pillow and there were no cases of difficult laryngoscopy with 5cm pillow.Conclusions: The use of 5cm pillow in the ‘sniffing’ position obtains the best laryngoscopic view during direct laryngoscopy.Keywords: Direct laryngoscopy; head elevation; laryngoscopicview; pillow height.

scholarly journals Assessment of Airway Parameters for Predicting Difficult Laryngoscopy and Intubation in a Tertiary Center in Western Nepal

2020 ◽  
Vol 17 (4) ◽  
pp. 516-520
Author(s):  
Gajal Lakhe ◽  
Hari Poudel ◽  
Krishna Murari Adhikari
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Difficult Intubation ◽  
Predictive Value ◽  
Area Under Curve ◽  
Difficult Laryngoscopy ◽  
Screening Tests ◽  
Upper Lip ◽  
Tertiary Center ◽  
Lehane Grade

Background: The screening tests used for pre-operative evaluation of airway to predict difficult laryngoscopy and intubation have variable diagnostic accuracy. The unanticipated poor laryngeal view is gold standard for defining difficult intubation. We aimed to find out the prevalence of difficult laryngoscopy and intubation, which airway parameter better predicts difficult intubation and whether difficult laryngoscopy is associated with difficult intubation or not.Methods: This analytic cross sectional study was conducted in 665 ASA I/II adult patients, aged 18-65, without obvious airway pathology undergoing elective surgery under general anesthesia. The pre-operative screening tests included mouth opening, modified mallampatti, ratio of height to thyromental distance, sternomentaldistance and upper lip bite test. Cormack-Lehane grade III/ IV was defined as difficult laryngoscopy and potentially difficult intubation. Sensitivity, specificity, positive predictive value, negative predictive value, accuracy and area under curve at 95% confidence interval was calculated for all five screening tests. Results: The prevalence of difficult laryngoscopy and intubation was 6.6% (44 cases). The upper lip bite test because of its highest specificity, positive predictive value, negative predictive value, accuracy and area under curve (99.7%; 93.9%; 99.7%; 95.2%; 85.1% respectively) with moderate level of sensitivity (70.5%) was better predictor of difficult intubation than other tests. The difficult laryngoscopy was associated with difficult intubation (p=0.00).Conclusions: The prevalence of difficult laryngoscopy and intubation was 6.6%.The upper lip bite test was a better predictor of difficult intubation and there was a significant association of difficult laryngoscopy with difficult intubation.Keywords: Difficult laryngoscopy and intubation; screening tests; upper lip bite test.

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